What is Agmatine Sulfate?
Agmatine is a form of amino acid that derives from L-Arginine. It has been shown to inhibit receptors for the neurotransmitter acetylcholine, which plays a major role in memory and reasoning.
Agmatine supplement also regulates levels of Nitric Oxide by the affecting nitric oxide synthase enzyme. It controls cellular energy levels by influencing polyamine metabolism and function.
In some studies, it has been shown to enhance the effects of both morphine and fentanyl to increase pain killing, reduce tolerance, and lower addiction, as well as working synergistically with marijuana.
It is also found naturally in every day foods, including beer, wine, coffee, and other fermented foods.
Because it is capable of targeting multiple receptors, agmatine may benefit a spectrum of complex diseases, including diabetes, Alzheimer’s disease, opioid addiction, mood disorders, and even cancer. Furthermore, agmatine may enhance cognitive function, stress resiliency, mood, and athletic performance. The highest levels of agmatine are found in the gut, where it is produced by the microbes living there. It is also found in dietary form, mainly in fermented foods, and in supplemental form like agmatine sulfate. Agmatine is also produced in small amounts within the body by the mitochondria in the liver.
Benefits and Effects
What Are Agmatine Sulfate Benefits?
- Reduces Pain Sensitivity
- Reduces Symptoms of Anxiety & Depression
- Neuroprotection & Longevity
- Improves Weight Loss & Prevents Weight Gain
- Supports Muscle Growth
- Helps Erectile Dysfunction & Infertility
- Help with Alzheimer’s Disease
- Helps Alcohol & Morphine Withdrawal
Reduces Pain Sensitivity
Reduces Symptoms of Anxiety and Depression
Studies and Research
Neuroprotection and Longevity
Study on Effects of Agmatine Sulfate on Nerve Injury
- OBJECTIVE: Evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.
- METHODS: The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.
- RESULTS: Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004).
- CONCLUSION: Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration.
Improves Weight Loss and Prevents Weight Gain
Supports Muscle Growth
Helps Erectile Dysfunction (ED) and Infertility
Help with Alzheimer's Disease
Insulin resistance could cause an increase of plaque and neurofibrillary tangles in the brain, which are the signs of Alzheimer’s disease. Agmatine prevents cognitive decline by rescuing insulin signaling and avoiding potential accumulation of those tangles. [R]
Helps Alcohol & Morphine Withdrawal
Mechanisms of Action
How Does Agmatine Sulfate Work?
How to Take Agmatine Sulfate?
There is currently no standard dosage for agmatine sulfate because there haven’t been enough human studies for determination. These numbers are rough estimates to give an idea of typical, experimental dosing:
For treatment of neuropathic pain: 1,000 to 2,500 mg of agmatine (daily)
For improving cognitive function: 200 to 500 mg of agmatine (daily)
For vasodilation and enhanced recovery: 500 to 1000 mg of agmatine (30 minutes pre-workout)
Note: Agmatine is not absorbed well when taken with dietary protein, because it uses the same transporters as arginine
“There are no standard dosages for agmatine because of the lack of human evidence for its effects. However, a single human study used 1,300-2,670mg of agmatine, daily for the treatment of neuropathic pain. The estimated human dose for improving cognition is 1.6-6.4mg/kg of agmatine, taken orally.
This is based off of the 10-40mg/kg dosage range for rats, and is equivalent to 217-435 mg for a 150lb person. Supplementation should not exceed 6.4mg/kg of bodyweight. Studies on agmatine use a daily dosing protocol.
Agmatine is not absorbed well when taken with dietary protein, because it uses the same transporters as arginine. Further research is needed to determine if oral agmatine supplementation provides the same benefits as were observed in animal studies.”
“The generally accepted daily dosage range for Agmatine Sulfate is between 250 mg and 2.5 grams. Avoid taking higher than necessary dosages to reduce the risk of side effects.”
What Are Agmatine Sulfate Side Effects?
Agmatine Sulfate is a biogenic amine that is derived from the amino acid L-Arginine. This happens by a process called decarboxylation, which is better known as the removal of carboxylic acid group from the amino acid.
Yes. And here is a 5 year-long, daily high dosage of Agmatine in order to measure and proof its safety: Clinical follow-up consists of periodic physical examinations and laboratory blood and urine analyses. All measurements thus far remain within normal values and good general health status is sustained throughout the study period, up to 5 years.
Agmatine starts working as soon as it enters the bloodstream, which is typically 15 – 30 minutes after consumption. Users can expect to experience an increase in muscle pumps, vascularity and muscular endurance within this timeframe.
The generally accepted daily dosage range for Agmatine Sulfate is between 250 mg and 2.5 grams. Avoid taking higher than necessary dosages to reduce the risk of side effects.
This is the reason creatine and protein work so well together, in a nutshell. Bodybuilders can cut out the creatine middle man by supplementing with agmatine sulfate directly. … You take creatine to improve the protein effects. You take nitric oxide to improve the creatine effects.