Phenylpiracetam

What is Phenylpiracetam?Piracetam vs PhenylpiracetamBenefits & EffectsMechanism of ActionDosageSide EffectsFAQs


Summary: Phenylpiracetam is a potent and fast-acting racetam type nootropic. It enhances cognitive abilities and boosts physical strength, stamina, energy, as well as reduces symptoms of depression and anxiety. Being stimulatory, it is banned by the Olympics Anti-Doping committee to the participating athletes.

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What is Phenylpiracetam?

Phenylpiracetam (also known, and sold under the brand name Phenotropil) is one of the most effective, most efficient and most potent racetam nootropics which is widely used, and have been available on the market for many years. With the safe and effective use, many regards Phenylpiracetam a “lifesaver” and “faithful companion” in times of need. Quite dramatic descriptions.

Although it is a new nootropic in comparison to classic racetams such as Piracetam, over the past few years, it gained popularity due to its practical use.

Phenylpiracetam – as the name indicates, is a derivative of piracetam, with the phenyl addition. Which is why it shares so many properties with piracetam. However, it seems to be much more powerful. It is anywhere between 30 to 60 times more potent, and therefore effective, in its action.

Phenylpiracetam (Phenotropil, Carphedon) is a scarcely studied piracetam derivative. It’s notable for its stimulatory subjective effects. It appears on the list of banned substances for Olympic sports. In-vitro experiments suggest phenylpiracetam binds to nicotinic acetylcholine receptors. In animal models phenylpiracetam seems to increase NMDA and nicotinic acetylcholine receptor density, which may suggest it has potential as a cognitive enhancer.[204] Similarly, in animal experiments phenylpiracetam seems to exert anti-depressant effects. [111] No studies have been done to show phenylpiracetam improves cognitive performance in otherwise healthy individuals. Phenylpiracetam seems to be the most stimulatory piracetam derivative.

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Piracetam vs Phenylpiracetam

Phenylpiracetam is the same chemical structure of Piracetam, but with the addition of a large phenyl grouping off the 4 position of the pyrrolidone ring that all racetams share. Phenylpiracetam has very low water solubility but is slightly lipid soluble. The LogP of Phenylpiracetam is .16, and its solubility in water is 1-2mg/ml at 25 Celsius. The melting point of phenylpiracetam is 149-152 Celsius. Phenylpiracetam also has a stereocenter, meaning it can come in both R and L enantiomers. All phenylpiracetam available is racemic, or a 50/50 mixture of both enantiomers.

For the sake of illustration, and to paint the idea well, look at the two following picture. First comes the piracetam skeletal formula, or chemical structure:

Second is Phenylpiracetam skeletal formula, in which you see Piracetam above the red line, and under the line is the phenyl addition, making it into phenylpiracetam:

The phenyl addition on its own:

phenylpiracetam piracetam

phenyl-phenylpiracetam

Phenylpiracetam is quite popular for its neuroprotective properties which are the dominant feature of many racetam nootropics. But in comparison to piracetam, its neuroprotective attributes are more effective.

It is also psychostimulatory, in other words, it is a stimulant. For that reason, Phenylpiracetam enhances physical performance, which is the primary reason behind its increased consumption among athletes.

Due to these attributes, Phenylpiracetam has become a favorite amongst other nootropics, and its sales have also increased over the past few years due to the positive response it keeps receiving.


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Benefits and Effects

What Are Phenylpiracetam Benefits?

  1. Improves Cognitive Function, Memory, and Attention
  2. Reduces Anxiety and Depression
  3. Boosts Energy and Increases Physical Mobility
  4. Enhances Physical Performance
  5. Additional Benefits

Supporting research:

Phenylpiracetam Improves Cognitive Function, Memory, and Attention

In studies of subjects with cognitive impairment, phenylpiracetam improves cognitive function and enhances overall memory impressively after a month of treatment. The study’s abstract notes:

“Ninety-nine patients with encephalopathy developed in the remote period after acute lesions of cerebral blood circulation, brain traumas and cerebral gliomas surgery have been studied. Phenotropil was used in a dosage of 200 mg per day during one month.

A CT survey revealed that in a stable state of brain changes phenotropil exerted the mostly pronounced influence on movement disturbances: decreased an extent of pareses in limb and face muscles, improved motor coordination, higher brain functions, memory, attention, counting.” [1]

Phenylpiracetam Reduces Anxiety and Depression

In the same study, one of the revelations in the state of brain changes that Phenylpiracetam caused were:

  1. Higher mobility and daily activity
  2. Lower and less feelings of discomfort
  3. Lower anxiety
  4. Reduction depression

“Patients exhibited higher mobility and daily activity, along with lower discomfort, anxiety and depression. EEG study showed more intensive alpha- and beta-rhythms, a decrease of paroxysmal activity and slow waves as well as a general tendency to its normalization.” [2]

Phenylpiracetam Boosts Energy and Increases Physical Mobility

A study patient with chronic fatigue syndrome finds that a one-month treatment of phenylpiracetam reduces fatigue notably.

The study included 1170 patients with brain ischemia, aged 45-65 years, treated with phenotropil in dose 100 mg during 2 and 3 months. Clinical examination and MFI-20 subscales were administered.

The results of the study:

“The high incidence of asthenic syndrome was observed across all MFI-20 subscales. The decrease in asthenic syndrome severity was significant already in the end of the first month of treatment with phenotropil. Such dynamics maintained to the end of the second and third month of treatment. More than 2-fold decrease in the severity of asthenia symptoms was achieved in all subgroups 3 months after treatment. More rapid and apparent decrease in asthenic syndrome was observed in younger patients.” [3]

Furthermore, a notable increasing of movement and physical activity is seen in this study, though it is conducted on rodents. The abstract of the study reads:

“Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have been evaluated using the exploratory cross-maze test. It was found that BALB/c mice in comparison to C57BL/6 mice are characterized by greater anxiety and lower efficiency of exploratory behavior in the previously unfamiliar environment. All tested drugs clearly improved the exploratory behavior in BALB/c mice only. In BALB/c mice, piracetam, phenotropil, noopept, and semax also reduced anxiety, while phenotropil additionally increased locomotor activity. Thus, the nootropic drugs displayed clear positive modulation of spontaneous orientation in the mice strain with initially low exploratory efficiency (BALB/c) in the cross-maze test. Some drugs (pantogam, nooglutil) exhibited only nootropic properties, while the other drugs exhibited both nootropic effects on the exploratory activity and produced modulation of the anxiety level (piracetam, fenotropil, noopept, semax) and locomotor activity (fenotropil).” [4]

Phenylpiracetam Enhances Physical Performance

Here is another very interesting rodent study in which Phenylpiracetam was found to increase the speed and distance traveled during an open-race test. Some of the highlights of that study:

“After a single administration, it increased locomotor and antidepressant activity in the open‐field and forced swimming tests, respectively, as well as enhanced memory in the PAR test. Racemic phenotropil and S‐phenotropil also stimulated locomotor activity and induced some antidepressant effect after acute administration.”

It’s quite an interesting, and extensive study. You may find the study here: [5]

Additional Phenylpiracetam Benefits

Anecdotal reports claim It was used by Russian soldiers and astronauts to achieve high physical strength and mental abilities. Although it makes sense and I do believe it personally, those studies are very hard to find due to having taken place a very long time ago, and in another period of time, and another language (Russian).


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Mechanism of Action

How Does Phenylpiracetam Work?

Phenylpiracetam is a piracetam which comes with a phenyl group attached to it. It has similar functions and potency as that of piracetam, which is its parent molecule. However, the addition of the phenyl group has increased its effectiveness in many ways which have led to the increased usage and exposure of Phenylpiracetam in the market.

Furthermore, it easily crosses the blood-brain barrier. Thus it has CNS effects. Most users compare its impact to that of Adderall and modafinil. It is more potent than other racetams and has a high bioavailability, making it a great first line agent to take in case if you are having an exhaustive day ahead.

Its half-life is about 3-5 hours.

No mechanism is in the documentation for the action it produces and the way it processes them and makes them work. However, it has energy and performance boosting properties, and it has a close resemblance to phenyl-ethylamine, which has stimulatory effects. Phenylpiracetam has a close affinity with neurotransmitters such as norepinephrine and dopamine transporters.


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Dosage

How To Take Phenylpiracetam?

The general Phenylpiracetam dose is usually 100 to 200 mg per dose, and can be taken in up to 2 to 3 doses per day at max. Although I wouldn’t go that far myself. The higher end is often for specific conditions and are less frequent than the lower end dosage.

Personally, I prefer taking one 200 mg dose, once only. The effects are much more present and pleasing at that dosage. I feel like anything more than 200mg would be too stimulatory for me, especially given that I often take it along with other nootropics as part of a stack.

Its also important to note that Phenylpiracetam tolerance builds up quickly. Therefore, minimize your use to when you need it rather than making it a part of a daily stack. Once to twice per week is a good practice.

A little bit more science from Examine.com about recommended dosage, active amounts, and other details:

Phenylpiracetam is taken at a dosage of 100-200mg acutely, and this dose is taken 2-3 times per day (totalling a daily range of 200-600mg). The lower range seems effective, but the optimal dosage is not yet known.

The R-isomer appears to be more active on the common usages of phenylpiracetam (stimulation and cognition) than does the S-isomer, and while the racemic mixture (commonly sold version) is effective for cognitive decline it is not certain if it works for nootropic purposes in youth.


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Side Effects

What Are Phenylpiracetam Side Effects?

The major issues and side effects that appear with Phenylpiracetam are the same that occur with other racetams.

The most common side effect of Phenylpiracetam is a headache. which is due to the choline reserves depletion. Using a choline source such as Alpha-GPC or Citicoline would quickly resolve the issue.

Due to that, I try to always pair Phenylpiracetam and a choline source together instead of waiting to see whether or not I am going to have a headache. That, plus I wouldn’t mind the potentiating boost of the additional choline.

Rarely reported side effects are related to the GI tract, such as digestion issues, and constipation.


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User Experience

From a Nootropic’s Depot customer:

This is a great product, don’t get me wrong. Personally, however, my tolerance built up almost instantaneously. First use was wonderful, worked exactly as advertised. Took it a second time 2 days later. Still felt the effects, but was noticeably diminished. Waited a week before taking it again and felt like that first use. Decided to take it the very next day and felt it somewhat, but hardly. Abstained for a week and decided to take 2 in the morning. The effects were comparable to the first time. Took the same dose 3 days later and didn’t notice the effects at all. Waited a week before taking it again, took two again and felt the effects like the previous week but it wore off rather quickly. Since then I’ve only taken it once a week in the latter part of the day when I work a double at my job. This product definitely works, but in my opinion should be used very sparingly. I acknowledge the fact that I tend to develop tolerance to most substances quickly, so if you consider yourself to have that same trait this review would likely apply to you.

Phenylpiracetam without a doubt works, and quite well at that. This was my introduction to the racetam family. I’m eager to try the others now, but wanted to start with one that provided an energy boost. I definitely picked the right one. Within an hour after use you will feel the effects, and they last around 5 hours for me. Sometimes I would take 2-3 capsules instead of 1, and it never made me feel jittery or anxious like too much caffeine would. Highly recommend this product if you are looking for a clean boost in energy and motivation. Works well along side caffeine in my opinion as well.

“This is a great product, don’t get me wrong. Personally, however, my tolerance built up almost instantaneously. First use was wonderful, worked exactly as advertised. Took it a second time 2 days later. Still felt the effects, but was noticeably diminished. Waited a week before taking it again and felt like that first use. Decided to take it the very next day and felt it somewhat, but hardly. Abstained for a week and decided to take 2 in the morning. The effects were comparable to the first time. Took the same dose 3 days later and didn’t notice the effects at all. Waited a week before taking it again, took two again and felt the effects like the previous week but it wore off rather quickly. Since then I’ve only taken it once a week in the latter part of the day when I work a double at my job. This product definitely works, but in my opinion should be used very sparingly. I acknowledge the fact that I tend to develop tolerance to most substances quickly, so if you consider yourself to have that same trait this review would likely apply to you.


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Conclusion

Phenylpiracetam has attained the attention and popularity among the nootropic users for its powerful, dynamic impacts and effects. It is a potent activator of the CNS activities. Its ability to increase the energy and physical performance have made it a favorite for many in the field of study and sports as well. As time passes, these highly active ingredients are only going to gain more attention.


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Frequently Asked Questions

What is Phenylpiracetam used for?

Phenylpiracetam is more potent than piracetam and is used for a wider range of indications. In combination with a vasodilator drug, piracetam appeared to have an additive beneficial effect on various cognitive disabilities. [R]

Does Phenylpiracetam get you high?

Phenylpiracetam boosts memory, cognition level, stamina and energy levels. Having those benefits to someone who has deficiencies in one or more of them would lead him to experiencing a euphoric state, which many people may refer to as being high. Therefore, ultimately, the answer to the question of does phenylpiracetam get you high would be yes.

Is Phenylpiracetam a stimulant?

Yes, in comparison to the general nootropics, Phenylpiracetam is considered to be stimulating nootropic. Moreover, Phenylpiracetam is banned by the World Anti-Doping Agency (Olympics) due to its reported psychostimulatory and cold resistance properties . But it is not a hard stimulant like amphetamines, methamphetamine, and other pharmaceutical & street drugs. It would be the better alternative – although its not recommended for day to day use due to quick tolerance-building. Ideally, taking Phenylpiracetam once to twice a week is the best way to use it without worrying about tolerance build-up or abuse potential.

Is Phenylpiracetam Legal?

Phenylpiracetam legality status depends on country to country basis. In the US, Phenylpiracetam is uncontrolled, unscheduled compound. Which means it is legal to buy and posses. While in Russia, Phenylpiracetam is a prescription drug (sold under brand name Phenotropil). Therefore, in Russia, you need a prescription to legally posses Phenylpiracetam.

How much Phenylpiracetam should I take?

The general Phenylpiracetam dose is usually 100 to 200 mg per dose, and can be taken in up to 2 to 3 doses per day at max. Although I wouldn’t go that far myself. The higher end is often for specific conditions and are less frequent than the lower end dosage. Personally, I prefer taking one 200 mg dose, once only. The effects are much more present and pleasing at that dosage. I feel like anything more than 200mg would be too stimulatory for me, especially given that I often take it along with other nootropics as part of a stack. It’s also important to note that Phenylpiracetam tolerance builds up quickly. Therefore, minimize your use to when you need it rather than making it a part of a daily stack. Once to twice per week is a good practice.

What is the best way to cycle Phenylpiracetam?

I would say limit the usage to once or twice per week as needed. Anything more than that would start the tolerance build-up. Another individual’s advise, from his personal experience: Avoid taking phenylpiracetam for more than two consecutive days. I’ve found that by day 3 tolerance develops, even if I’m taking low doses (e.g. 50 mg). A solid schedule might be taking phenylpiracetam every other day. Better yet, twice a week only.

What does Phenylpiracetam stack with?

Aniracetam, low dose of Noopept, Alpha-Gpc, Lion’s Mane Mushroom. Many other nootropics as well if you are only taking one phenylpiracetam capsule of 150mg. But in general Phenylpiracetam stacks well with most nootropics. Though most frequently its stacked with cholinergics.

Why do many people prefer phenylpiracetam over Piracetam?

“It’s no secret that Phenylpiracetam is often preferred to Piracetam by some people. This is largely due to the fact that it is stronger than Piracetam. You see, phenylpiracetam was first synthesized in 1983 as a modification of the nootropic Piracetam. The primary alteration to Phenylpiracetam from its predecessor is the addition of a phenyl group– a small change that has made phenylpiracetam significantly more potent than Piracetam, even at much smaller dosages. Phenylpiracetam cognitive enhancing effects are reportedly achieved by increasing the density and number of acetylcholine, dopamine, GABA, and glutamate receptors in the brain. Through this mechanism, research suggests that Phenylpiracetam increases functional activity at the neurotransmitter binding sites most important for memory and cognition.” Also: The stimulant qualities, which disappear after regular use. I estimate it is at first like one strong cup of coffee, weakening on subsequent doses. I think that is the reason that phenylpiracetam hasn’t replaced piracetam altogether. The advantages of phenylpiracetam have to be weighed against the greater cost. For daily or at least regular use, the price point of plain piracetam is better.

What are Phenylpiracetam capsules?

Phenylpiracetam capsules is a nootropic compound derivative of the parent compound in the Racetam family, Piracetam. It was first created in 1983 by a team of Russian scientists, and has recently become more well-known outside of Russia. Phenylpiracetam differs from Piracetam in the addition of a bulk phenyl grouping off the 4 position on the 2-pyrrolidone base structure. A phenyl grouping is a six-sided cyclic ring consisting of benzene, minus a hydrogen, leaving an open carbon bond available. Phenylpiracetam has very low water solubility but is slightly lipid soluble. It has a molar mass of 218.3 g/mol and a molecular formula of C12H14N2O2. CAS: 77472-70-9 – IUPAC: (R,S)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide

What’s the difference between Phenylpiracetam and Piracetam?

Phenylpiracetam is the same chemical structure of Piracetam, but with the addition of a large phenyl grouping off the 4 position of the pyrrolidone ring that all racetams share. Phenylpiracetam has very low water solubility but is slightly lipid soluble. The LogP of Phenylpiracetam is .16, and its solubility in water is 1-2mg/ml at 25 Celsius. The melting point of phenylpiracetam is 149-152 Celsius. Phenylpiracetam also has a stereocenter, meaning it can come in both R and L enantiomers. All phenylpiracetam available is racemic, or a 50/50 mixture of both enantiomers.

What is it like to combine modafinil with phenylpiracetam?

“If taken in in doses within the normal range then, anecdotally, you’re not likely to notice the phenylpiracetam. The subjective effects felt from a typically prescribed dose of Modafinil (or recommended dose of it’s alternative pro-drug cousin Adrafinil) are, in my experience, significantly more pronounced than those of any “racetam”. That said, anyone who can get what they need (be it an increase in vigilance and/or cognitive enhancement) from phenylpiracetam alone would do well to consider staying monogamous to that truer “cleaner” class of nootropic.”

How does taking Phenylpiracetam feel different from taking modafinil?

“I can’t disagree more with anyone who suggests the superiority of one over the other. Everyone reacts differently to subtances, even the exact same substance at the same dose delivered to folks of the same gender, body weight, age, whatever. The first rule is to understand this. Personally, I have the choice to take either, and I always take phenyl instead. Modafinil works well for me the first day, maybe the second, but it will burn me out very quickly. It makes me feel terrible fast. Phenyl doesn’t have this effect. Supplement with citicholine (or another choline source like centrophenoxine, alpha-GPC, or dietary choline) and fish oil (or DHA enhanced flax seed oil) to get the best effects. Take the choline source and the DHA source together, and take the phenylpiracetam an hour later. Try both if you can. I really hate provigil and nuvigil, Dexedrine is far more dangerous and unhealthy than pro/nuvigil or any racetam, but if its not going to become a habit it might be worth looking into. Dexedrine is about as strong as you can get without using crystal meth. Again, it may affect you terribly or in a great way. It depends on the brain, not the substance. Experiment responsibly.”

Does eating food effects Phenylpiracetam?

Eating a meal will likely hinder absorption with phenylpiracetam and especially noopept. I would recommend taking phenylpiracetam on an empty stomach (ie first thing in the morning). Noopept can be taken sublingually (under the tongue) and bypass the need to absorb it in your GI. It’s absorbed much more efficiently this way and it does not matter if you’ve recently eaten anything. If you’re asking if eating food while under the effects of phenylpiracetam or noopept, the answer is no.

What does phenylpiracetam synergize with?

Phenylpiracetam stacks well with most other nootropics. The most common type of nootropic that it’s stacked with is the cholinergics. And of the cholinergics, the most common ones taken with phenylpiracetam are Alpha-GPC and CDP-Choline. The reason for this is twofold: First, some people get headaches with phenylpiraceam and other racetams. It is thought that this side effect is caused by reduced acetylcholine levels. Taking a choline source with it increases acetylcholine levels in the brain, eliminating the headaches. The second reason that cholinergics go well with phenylpiracetam is that the latter works (in part) by affecting acetylcholine in the brain. By taking the former, you have more of this neurotransmitter for the phenylpiracatam to work with. This leads to a synergistic effect. Taking phenylpiracetam with either Alpha-GPC or CDP-Choline seems to be more effective than taking either of these by themselves.

More FAQs can be found on here [link]

Related Nootropics

Phenylpiracetam is one of a nootropic-family type called racetams. Some of which are:

Other nootropics that might be of interest:


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