Phenibut

Phenibut


Summary: Phenibut is a a GABAergic agent that works on the GABA neurotransmitter distinctly reducing anxiety. It also lessens depression, and PTSD symptoms, improving sleep, and providing an overall feeling of ease and well-being. Due to the euphoric-like effects it offers, users prefer to stick to occasional use rather than frequent in respect of its abuse and addiction risk potential.



Introduction


What is Phenibut?

Phenibut might not have as widespread use as other nootropics on the market. However, it has demonstrated numerous benefits over tens of decades through both formal studies and anecdotal documentation. It’s a nootropic designed to simulate the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts on the central nervous system. It marketed as a psychotropic with a positive effect on mental capability and improved neurological functioning. The anxiety diminishing effects of phenibut are the most praised of all its attributes. Once anxiety is resolved, natural sleep patterns and enhanced cognitive processes shortly start following.

Phenibut was invented in the Soviet Union almost half a century ago. A fascinating, documented anecdote reveals that Russian cosmonauts were supplementing with phenibut especially during the 1975 mission Apollo-Soyuz at the joint of the USSR and US. It remains in use to date in Russia as a treatment and remedy to many conditions including anxiety, depression, prevention of motion sickness, even alcohol withdrawal syndrome, to name a few. Not to mention, of course, its nootropic attributes.

Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others, is a central nervous system depressant with anxiolytic and stimulant effects which is used in the treatment of anxiety, insomnia, and for a variety of other indications.

Wikipedia

Benefits & Effects


Phenibut Reduces Anxiety

This attribute is the most appreciated benefit of phenibut which is documented by Izyaslav Lapin (R). Anxiety is often the result of overactivity in brain’s concentration and overthinking and analyzation of unnecessary, or irrelevant matters; often with the inability to realize the direction to which the train of thought is heading. Turning down and resting the continuous and distracting neuron processing frees the negative thought preoccupation which in turn opens a fresher, vibrant, and often productive range of possibilities.

Phenibut Increases Sociability

The anxiolytic effect leads to openness towards social interaction which by itself is an issue almost always associating with anxiety disorders. Studies suggest phenibut to be a promoter of enhanced cognitive processing, but the fundamental reason practically still due to the anxiety relief. Those seeking to improve interaction in social settings report better results with the supplement in comparison with alcohol or prescription medication such as benzodiazepines. While attempted anxiety-reduction using traditional tranquilizers often lead to drowsiness and reduction in motor skill and cognitive ability, phenibut seems to mitigate the feelings, except without the associating and undesired side effects that associate with traditional prescription medication. (R)

Promotes Healthy Sleep Patterns and Quality

People living through the depression, anxiety, stressful life events, while going through hormonal changes such as menopause, often report degenerating sleep quality, sleep disturbance, and insomnia. While melatonin is a remarkable and beneficial supplement to consider, some require pharmaceutical sleep aid for more sedating and sleep-inducing effects. Lack of continuous quality sleep can cause an impairment in cognitive processing, opening the way to more anxiety and more sleep disturbance. Used consciously, Phenibut an excellent supplement that can restore significant, natural sleep patterns, duration, and quality. The ability to fall asleep, remain asleep, maintaining an extended period of healthy, rejuvenating deep sleep is attainable with phenibut. (R) (R)

Phenibut May Improve ADHD

Since phenibut improves attention, it may also help with ADHD symptoms. In one clinical trial of 50 children with ADHD, it improved cognition, self-control, sustained, attention, and memory after 1 month (500-700 mg/day). One month is a short time for evaluating ADHD effects; long-term studies need to determine if the beneficial effect can be sustained.

Selfhacked

My Thought on That Note:

Well I am ADHD and have taken Phenibut and similar “GABA-acting” drugs, such as gabapentin for about a year. Its interesting that, at the time, I had not been diagnosed with ADHD yet and was not aware nor had a clue what ADHD is. I self-medicated with gabapentin and phenibut along the way, and now years later, looking back at how routinely I was taking it, I realize the reason I was hooked and amazed by it was its effect on me as an ADHD, prior to any anxiety triggers that might associate. It was a transformative medication – but overtime, mister W (withdrawals) had been sitting and just waiting for me to get off it in order to introduce himself – and that horrible experience was almost equally as transformative.


Mechanism of Action


Gamma-aminobutyric acid (also known as GABA) is the chief inhibitory neurotransmitter in our central nervous system.

The blood-brain barrier makes supplementing with GABA close to being ineffective due to its inability to bypass the blood-brain barrier.

However, phenibut crosses the barrier due to the addition of the phenyl group molecule. Once in the brain, it slows the neuronal excitability, resulting in the effects as mentioned earlier.

GABA frees up channels in the neurons, reduces the function of other neurotransmitters, and diminish collective fears and anxieties in the neuron. It remains vague whether or not phenibut binds to the GABA receptor, although some studies suggest that it only does so in high concentrations.

Lapin’s research found that phenibut increases the levels of dopamine as well. Dopamine is another vital neurotransmitter in the central nervous system. It regulates emotions and creates the reaction of what we call motivation.


Dosage


How to Take Phenibut?

Phenibut is a potent compound.

Start at the lowest effective dose and monitor your response to it, then adjust according to your needs.

A dose of 250 mg is a good starting point for first-timers.

Phenibut effects build up gradually, so avoid taking a second dose without a reasonable timeframe in between. Initial kick-in is around 45 minutes after consumption, and optimal peak effect is usually 2 hours later.


Side Effects


Similarly to anything we put inside our body, the best source of measurement and criticism is the human body itself. 

To avoid adverse effects, start at a low dose and see your body’s reaction and adaptation to it. Often individuals report dizziness and drunk-life sensation as a side effect. On the other hand, many people use to supplement with phenibut for the very same impact.

The experience is entirely subjective. Rarely users report fatigue, nausea, and stomach discomfort. People on epilepsy medication or MAO inhibitors are advised to consult a professional doctor before taking phenibut. Alcohol should be consumption should cautiously within reasonable limits ion due to the synergistic effects of alcohol and phenibut.

Avoid taking on a daily basis.

Phenibut has high abuse potential. If taken regularly, be mindful of possible withdrawal effects upon discontinuation. It’s wise to limit intake to once or twice a week. Thereby maintain a low tolerance, enjoy its benefits, and avoid building a destructive habit of use.

Do not underestimate the power of phenibut and do your research if you decide to include it in your stack.


Legal Status


Is Phenibut Legal?

As of 2018, Phenibut is not a controlled substance in any country apart from Australia and Hungary.

In 2015, it was suggested that the legal status of phenibut in Europe should be reconsidered due to its recreational potential.

In February 2018, the Australian Therapeutic Goods Administration declared it a prohibited (schedule 9) substance, citing health concerns due to withdrawal and overdose.[R]

As of 14 November 2018, Hungary added phenibut and 10 other items to its New Psychoactive Substances ban list.

Wikipedia

Conclusion


Phenibut is a useful anxiety-relieving supplement that does not cause the infamous drowsiness often accompanying anxiety medication. It is well-studied and standing amongst the top in line when it comes to anxiety relief, sleep regulation, and cognitive improvement.

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