Piracetam

Piracetam


Summary: Piracetam is a nootropic designed to enhance brain function. Its the primary compound in the racetam family, from which almost 20 different derivatives have been discovered to date. It’s a revolutionizing nootropic that improves memory and remarkably boosts cognitive function.


Introduction


What is Piracetam?

Piracetam is a nootropic that enhances memory and brain function. It’s been around for a surprisingly long period, thus becoming a “classic” amongst the rest on the list. It allows creative and logical thoughts to run together into a stream of higher-level reasoning. It is the father of all nootropics and often the first choice for individuals looking to improve cognitive abilities.

Nootropics such as Phenylpiracetam, Fasoracetam, and Pramiracetam are all derivatives of this compound.

Synthetic molecule designed to enhance brain function. Piracetam is the basic ‘racetam’ molecule of a family of related compounds

Examine

Furthermore, it increases the amount of knowledge the brain can process, as well as preserve, for future reference. Piracetam is an invention by Romanian psychologist and chemist Dr. Corneliu E. Giurgea dating over 50 years ago, to create a supplement to enhance memory and learning capacity. It is in medical use in Europe, Russia, and South America, amongst other countries, as a treatment for a type of muscle spasm called molycous. However, due to its nootropic effects, it became one of the most prominent cognitive enhancers. Confined studies show that Piracetam reverses the effects of Alzheimer’s disease as well as dementia in elderly individuals. There is also sufficient evidence proposing that it prevents brain damage caused by excessive alcohol intake.

Piracetam is a medication in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It is approved in the United Kingdom but is not approved in the United States. In the UK, piracetam is prescribed mainly for myoclonus, but is used off-label for other conditions.

Wikipedia

Benefits & Effects


Piracetam Improves Memory

Piracetam is popular first and foremost because of its positive, profound impact on improving memory. In a meta-analysis of 19 different double-blind studies, Piracetam shows an exceptional improvement relating to memory. However, it is important noting that memory improvement effects build up gradually. The studies show minor improvement after a 7-day administration and a significant increase after a 14-day administration. Today, most individuals benefiting from Piracetam do so entirely for its memory-enhancing result. (R) (R)

Piracetam Enhances Cognitive Function

There is a healthy amount of studies administering the effects of piracetam on cognition enhancement. Piracetam improves cognitive performance especially in individuals with neurodegenerative conditions. While most studies are governing elderly individuals with chronic disease, there is nevertheless sufficient evidence proving it to be beneficial for healthy, young adults. Piracetam is especially helpful for individuals suffering from chronic conditions. Healthy individuals tend to embrace it for the nootropic traits. (R, R, R)

Piracetam is Neuroprotective and Prevents Neurodegeneration

Piracetam supports neuroprotection as well as encouraging healthy brain growth and protects as well as prevents it from neurodegeneration related to aging. In this particular area, it serves greater as a preventative rather than a treatment. Prevention is of often the best medicine there is. (R, R)

Piracetam Increases Self-Awareness and Promotes Clarity of Thought

There is evidence indicating that piracetam improves sensory perception by increasing acetylcholine activity in the hippocampus. In this particular example, it suggests an increase in self-awareness, zen-like state as well as an increased feeling of overall well-being. Many report colors are appearing brighter and more vivid. Furthermore, many report a heightened sense of perception and a higher level of vibration, along with a feeling of connectedness to nature and other beings. (R)

Piracetam Reduces Anxiety, Stress, and Eases Depression

In a study by the Department of Pharmacology in India examining the antianxiety effects of Piracetam taken orally over the period of 7 and 14 days, it confirms that; although a single dose does not seem to induce immediate anxiolytic effect, a delayed anti anxiety impact was rather apparent. It is especially evident in individuals with anxiety due to alcohol withdrawal. Anecdotal reports imply piracetam is a useful tool for managing stress and anxiety levels, and to a certain extent, easing depression symptoms. However, clinical research is limited relating to depression. Therefore, piracetam should not be a source to rely on should you be clinically diagnosed with depression. Use with caution. With that said, it is nevertheless useful and worth experimenting if your anxiety is somewhat generalized or social (R, R) – (high-five btw, makes two of us!)

Improves Verbal Learning and Fluency in Dyslexics

Over a 21 day study, piracetam shows an increase in verbal learning by 8.6% compared to placebo in healthy volunteering individuals. In patients with dyslexia, however, verbal learning shows a significant 15% increase. Piracetam, therefore, proves to be beneficial to individuals with dyslexia. Moreover, children tests in letter analyzing while receiving 3.3mg per day over 36 weeks showed an increase in letter-matching as well as reaction time. (R, R)

Piracetam Helps with Schizophrenia

Piracetam shows to reduce symptoms of uncontrolled movement in individuals with schizophrenia. Furthermore, Piracetam may have a protective effect upon glutamatergic receptors within the hippocampus. (R, R)


Mechanism of Action


Interestingly, piracetam doesn’t seem to show any effect on the GABAergic system even though it is a cyclic derivative of GABA. Piracetam’ mechanism of action relates to how it increases the activity of acetylcholine, a neurotransmitter involved in memory function. It works to improve memory by making the transfer of acetylcholine more effective. It also affects NMDA glutamate receptors which also play a role in the memory formation and learning processes. Scientists believe piracetam works through these possible mechanisms in the brain: compromised neuronal cells experience a loss of fluidity which prevents signaling molecules from crossing the lipid bilayer membrane of the corpus callosum, the part of the brain separating the left and the right hemispheres. Piracetam can restore or even increase the membrane fluidity of these neuronal cells, making neurotransmission a more effective and effortless process.

Overall, Piracetam increases glucose and oxygen consumption in brains which precedes cognitive improvement (as these benefits are global (not favoring certain brain regions) and more significant in cognitively impaired persons, both of which are in accordance with interventions in humans).

The exact mechanisms underlying the enhancement of glucose and oxygen consumption are currently not established.

Piracetam shows affinity for two subsets of AMPA (glutamate) receptors, Glu2 and Glu3, and may attenuate the rate of action potentials. It does not appear to directly act upon the other two glutamate receptors (Kainate and NMDA) although the ability of piracetam to possibly increase receptors in general in aged mice may influence these two receptor classes.

Examine

Protein synthesis is an essential part of memory-storage in the brain. Piracetam can cause an increase in learning and memory when various steroids transport them in the brain. When steroids in the brain are blocked, the effects of nootropics are blocked as well. Recruitment of AMPA receptors that are generally not part of synaptic transmissions, essentially making more receptors available, when would undoubtedly cause an increase in learning. Moreover, of course, acetylcholine increases and increased transmission of this critical neurotransmitter which is one of the most important in memory storage and learning processes.


Dosage


How To Take Piracetam?

The typical dose for adults is between 1,200 to 4,800 mg a day.

The most notable effective dose is 1,600 mg, taken three times a day, making a total of 4,800 mg per day.

For optimal results pair it with 300mg of Alpha GPC, CDP-choline, or your choline source of choice.


Side Effects


Piracetam is considered very safe and side effects rarely occur. (R)

Headaches are often reported. It is due to lowered acetylcholine levels in the brain due to racetams utilizing them. Therefore, it is almost a rule to pair racetams with a choline source.

Not only will choline prevent or eliminate the headache, it will furthermore work synergistically together firing cognitive function. (R)


Conclusion


Overall, Piracetam (alongside Noopept, if I may add) is one of the most fundamental brain boosting nootropics out there. It has very noticeable effects on increasing memory and learning capability, and certainly has the potential to enhance cerebral performance.

Student looking to get the edge on academics, or merely wanting to think smarter and faster in their day to day life, this is a great nootropic to start with to introduce you to the world of nootropics.


External Readings & Resources


PiracetamWikipedia, the free encyclopedia

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