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“CRL-40,941 (also known as fladrafinil and fluorafinil) is a eugeroic closely related to adrafinil and modafinil. It is the bis(p-fluoro) ring-substituted derivative of adrafinil. CRL-40,941 was found to produce antiaggressive effects in animals, which adrafinil does not produce. It is purportedly 3 – 4 times stronger than adrafinil.”

CRL-40,941, Wikipedia

Fladrafinil, the new Adrafinil replacement, is now the go-to solution for times of low energy levels, lethargy, unproductiveness, or brain fog.

Fladrafinil boosts wakefulness and enhances brain function during working hours. Without causing any crashes after it wears off.

It makes you feel active and sharp in the workplace, even with little (or no) sleep.

Let’s dive into this Fladrafinil review.

What is Fladrafinil?

Fladrafinil (also known as CRL 40 941, Fluorafinil) is a eugeroic nootropic synthesized as the replacement of Adrafinil after it got banned from manufacturing.

According to scientific research, its chemical structure includes a ‘bis (p-fluoro) ring’ – a substituted derivative of Adrafinil, a compound first discovered in the 1970s and patented in France.

Due to its potency, it’s seen wide use by students and individuals looking to improve brain function, memory, energy, and focus.

It’s important to keep in mind that, although it shares the effects of Modafinil and Adrafinil, it still has a few differences.

Studies tell us Fladrafinil increases motivation and have an anti-aggressiveness effect. A quality not many other eugeroics have.

With a much lower dose of the compound, 2-[bis(4-fluorophenyl) methyl sulfinyl]-N-hydroxyacetamide, you may experience a prolonged state of wakefulness and focus, with a rare likelihood of experiencing crashes or other side effects.

Mechanism of Action

How Does Fladrafinil Work?

Fladrafinil effectively mimics the effects of Adrafinil and Modafinil.

It is often used to treat narcolepsy, which Wikipedia defines as “a chronic sleep disorder characterized by overwhelming daytime drowsiness and sudden attacks of sleep.”

Further to that it adds “people with narcolepsy often find it difficult to stay awake for long periods of time, regardless of the circumstances condition.”

Once ingested, Fladrafinil is metabolized into modafinil and similarly affects the central nervous system.

Benefits and Effects

Fladrafinil (aka Fluorafinil, or CRL-40-941) produces the same cognitive effects, benefits, and experiences as Adrafinil and other stimulating nootropics.

Anecdotal reports emphasize increased attention, focus, and concentration.

Benefits of Fladrafinil (CRL-40,941)

  1. Wakefulness
  2. Alertness
  3. Concentration
  4. Focus
  5. Memory formation and recall
  6. Cognition
  7. Lower aggression
  8. Calmative properties

Although the nootropic has similar effects as several other nootropics, it is advised to be used by people who have little experience with stimulating nootropics. 


How to Take Fladrafinil?

Fladrafinil is significantly more potent than Adrafinil.

Therefore, the recommendation is to lower the dose compared to Adrafinil’s.

If it’s your first time, you should limit your dosage to 30 to 80 mg. 

Based on your reaction, you can decide if the dosage is effective for you or a higher dosage may be more beneficial. 

However, do not exceed 200 mg within a single day. 

And be advised that Fladrafinil might have side effects if taken together with other medications or if you have certain medical conditions.

You must do your research before relying on any one source.

Side Effects

As of now, there have been no reported serious medical issues related to taking Fladrafinil.

It is said that Fladrafinil may be an excellent use to counter anxiety, stress, and pain at the recommended dosage and frequency.

The Fladrafinil product has not undergone extensive laboratory research since it is a reasonably new compound.

If you are in doubt, it is best to consult your doctor or medical experts before taking Fladrafinil or any other compound for that matter.

*to be updated