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Tianeptine is a potent mood brightener and a nootropic, cherished for its effects on wellbeing and cognition, providing immediate and also extended term benefits. Within an hour of use, it gives mental stability and clarity, functioning as a medium duration productivity tool. Additionally, its beneficial effects compound over extended use, resulting in a long-term impact which reduces feelings of stress, sadness, and anxiety.
What is Tianeptine?
Tianeptine, sold under the brand names Stablon and Coaxial among others, is an atypical antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. Tianeptine has antidepressant and anxiolytic effects with a relative lack of sedative, anticholinergic, and cardiovascular side effects.
It has been found to act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors. μ-Opioid receptor agonists typically induce euphoria, as does Tianeptine at high doses well above the usual therapeutic range. There are concerns about the potential for abuse.
Tianeptine was discovered and patented by the French Society of Medical Research in the 1960s. Currently, Tianeptine is approved in France and manufactured and marketed by Laboratories Servier SA; it is also sold in a number of other European countries under the trade name Coaxial as well as in Asia (including Singapore) and Latin America as Stablon and Tatinol, but it is not available in Australia, Canada, New Zealand, the United Kingdom, or the United States.
Tianeptine was as effective as several classical antidepressants in patients with major depression, dysthymia, or adjustment disorder. Also, extended treatment with Tianeptine decreased the incidence of relapse/recurrence of depression.
In an open, non-comparative clinical study in patients with Parkinsons' disease (PD), Tianeptine decreased the severity of depression and also improved the quality of life in these patients.
Anxiety, Stress, and PTSD Symptoms
In elderly depressive patients, a drug regimen of Tianeptine or escitalopram improved anxiety symptoms and subjective and objective neurocognitive functions.
In panic disorder patients tianeptine appeared to reduce their reaction to panic challenge.
Benefits Memory and Learning
Irritable Bowel Syndrome
Mechanism of Action
The usual dosage is 12mg 3x a day for a healthy weight individual, but some people go up to 25mg at a time.
Tianeptine's side-effects are similar to the side-effects of other SSRI's. These include nausea, constipation, abdominal pain, headaches, dizziness, and changes in dreaming.
Older patients should take a smaller dosage of Tianeptine, as should patients with renal failure.
Dosage does not need to be adjusted in patients with alcoholism or hepatic impairment, or patients on dialysis.
Tianeptine Decreases Emotional Memory
Healthy volunteers were randomized to receive a single dose of Tianeptine (12.5 mg) or placebo, and subsequently completed a battery of tasks measuring emotional processing, including facial expression recognition, emotional memory, and attentional vigilance, as well as working and verbal memory. Tianeptine-treated subjects were less accurate at identifying facial expressions and showed reduced memory related to emotion and reduced attentional vigilance to positive stimuli.
“Tianeptine Sodium and its sibling's Sulfate, Free Acid, and even the new tianeptine oxalate have many more than these 7 benefits, which are just the tip of the iceberg, really. The problem isn't the Tianeptine itself, the problem is finding a reliable vendor to buy tianeptine sodium that doesn't sell it as a chemical for research purpose because those impurities ware hard on your body. I used to get Stablon, but now I only order from Supplements for Work. As good as sodium gets.” – Steven
“I am an evangelist for tianeptine sodium and have personally tested (multiple times) both tianeptine sulfate and Tianeptine in free acid form. Neither two worked as effectively for me as tianeptine sodium. In fact, the free acid was so ineffective I converted it myself to tianeptine sodium.
That said, it's my understanding that tianeptine sulfate is more useful for those who want a steadier, longer lasting effect. What might register as a slight increase in energy and mood in me can be felt as anxiety in others? For them, sulfate is their ideal form.
As for a dose equivalence, if you were used to 15mg Tianeptine sodium 3x/day, you'd want to take roughly 45mg 1x/day to achieve a similar therapeutic effect.
As a side note (to anyone on the fence about trying it), I think Tianeptine is criminally under-appreciated in the US both as a pharmaceutical, and as an antidepressant. But even more than that, Tianeptine is (uniquely) a “pro mood” agent, neuroprotectant, opioid dependence modulator (and my favorite nootropic by far).” – Quora member Christian
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