Paul Stamet’s Niacin & Lion’s Mane Nootropic Stack Improved My Cognition & Jiu Jitsu Performance

Paul Stamet’s Niacin-Lion’s Mane Protocol: Good News, It Works!

By James Whelan

I’m a huge fan of nootropics, substances alleged to increase mental performance. The problem with most nootropics is that they have no measurable effect. I call this the “effectiveness problem” and I find it is common to virtually all commercially available supplements.

As the name implies, a supplement typically replenishes a deficit. Even genuinely useful supplements are rarely effective for those of us lucky enough to afford a balanced diet.

The number of supplements that a particular person can benefit from taking regularly is extremely small, and the benefits rarely persist after replenishing the deficit.

“Supplement” is also a legal term used to imply that a substance is a type of food, and therefore not subject to regulation as a pharmaceutical.

Nootropics promise to improve the function of the brain beyond it’s normal healthy state.

Caffeine increases alertness by altering the brain’s natural state rather that addressing a deficit. This is in contrast to Iodine which can prevent or reverse mental retardation, but cannot improve cognitive function in a healthy person.

Despite research to the contrary, most of us believe that we will be happier and better off with a raised IQ. The idea that the brain can be improved beyond it’s natural state is extremely seductive.

The Formula

Lion’s Mane” is a true nootropic because it permanently enhances cognition by improving the brain’s ability to alter itself structurally. The extract is alleged to improve improve the body’s ability to cover nerve tissues with myelin, which is a crucial factor in nerve growth. If true, this property could heal nerve damage and increase a person’s ability to learn. This means that Lion’s Mane consumption could lead too increased quality of life and economic productivity. In my personal experiment with lion’s mane, I have found this to be the case.

“The next quantum leap in the evolution of the human species?”

During my three years at law school and during a subsequent 2 year period, I suffered weekly severe epileptic seizures which left me feeling disoriented and harmed my memory. Despite 2 seizure free years to recover, I found that lion’s mane improves the faculties I lost during my illness. My verbal fluency, my ability to recall nouns, my sense of wellbeing, and my Jiu Jitsu performance are all noticeably improved by lion’s mane. Additionally, my written output improves in terms of quality and volume when I take lion’s mane.

I discovered lion’s mane because of Paul Stamets. Paul is a mycologist who specializes in psychedelic and mushrooms, and medicinal applications for compounds found in mushrooms. Stamet’s claims about lion’s mane on the Joe Rogan Experience lead me to investigate further and I decided to take lion’s mane after discovering that it was dirt cheap. The good experience I had with Lion’s Mane (LM) lead me to take Stame’s claims more seriously. My newfound respect made me curious about his experiments with psilocybin and niacin.

Artists interpretation of my 2017 mental state

Stamets hypothesizes that niacin’s ability to stimulate the peripheral nervous system could extend the nootropic benefits of lion’s mane and psilocybin to the entire body rather than limiting them to the central nervous system. If this were possible, it could strengthen the mind/body connection and counter the effects of degenerative nerve diseases. Stamets is very enthusiastic about the potential of this “stack”, in a lecture to other mycologists Stamets goes further, saying that the combination of these three compounds is potentially a second step in the process that began when humans first tried psilocybin.

Sure why not

Stamets advocates the “stoned ape” hypothesis, the idea that contact with entheogens caused the cultural explosion that took place in the late paleolithic period. His claim that the niacin, psilocybin, lion’s mane, stack(NPLS) could produce a shift in human progress equivalent to the original emergence of art and culture 100k years ago, is too bold to ignore.

Stamets mentions NPLS often, but never goes into much detail. He has mentioned the idea multiple times over a number of years, always with great enthusiasm. From what we have heard it seems that the psilocybin component of the stack is a non hallucinogenic dose equivalent to a silicon valley style microdose, the niacin dose must be fairly large to produce an uncomfortable dermal flush ( around 100-1000mg depending on sensitivity) and presumably the lion’s mane dose is 300mg (equivalent to the daily dose recommended by Host Defense Stamets’ supplement company). This is reasonable to suppose because Stamets claims that the regimen will be physically unpleasant rather than recreational.

The inciting incident.

We can also deduce the intended frequency of the an NPLS dose based on Stamet’s comments. Stamets believes that the optimal micro dosing regimen is 5 days on 2 days off (to avoid psilocybin tolerance), and the optimal lion’s mane dose is daily (based on Host Defense product recommendations). Optimal niacin dosage, should be high but not daily due to the possibility of tolerance destroying the flush effect and the risk of side effects. 3–5 days per week seems reasonable. Finally, lion’s mane and the microdose can be taken in at the convenience of the “NPLS”er and the niacin should be taken ten minutes later, so that the flush coincides with the effects of the other two substances. In my opinion the above and its variations, can safely be called the Stamets NPLS protocol. So now that the details are clarified, let me tell you how this worked for me.

I suddenly gained the flexibility to perform this useful move.

NPLS markedly improved my mental and athletic performance. After 20 minutes the itchy niacin flush covered my entire body and made me feel like my skin was slightly sunburned. Curiously, the itchy burning feeling quickly gave way to the feeling of being in a hot bath. I became acutely aware of my entire body, and realized that many of the smaller muscles of my back and neck were cramped. As I noticed the cramps I found I was able to get rid of them and as I did, my overall level of physical comfort increased. I found myself becoming more flexible and discovering new points of articulation in my back and shoulders. I assumed that these improvement would go away quickly, similar to the loose feeling one gets from a massage. To my surprise, the increased flexibility and body control seems to be permanent.

The change in my body awareness caused a noticeable change in my Jiu Jitsu performance. I am suddenly able to perform granby rolls effortlessly, and have an improved sense of balance. Previously, my back was too stiff to perform a correct granby roll. The most obvious improvement is in my “hand fighting”, I am much more coordinated now and have improved shoulder mobility which allows me to control my opponent’s arms more effectively. I’m free of stiffness in my hips and shoulders despite training 5–6 days per week. My training partners noticed the difference immediately, and noted that my moments have improved and that my repertoire of moments has changed. I recharge eScooters as a hobby and my ability to climb over fences and natural obstacles has also increased. All this came from one session.

Not exactly a “party drug.”

I strongly recommend lions mane, especially to epileptics recovering from post ictal trauma. I also recommend NPLS to anyone interested in experimenting with nootropics. Although I have not seen anything to remotely suggest that NPLS can launch a second wave of Stoned Ape style evolution, I found it a very powerful tool for dissolving ambient muscle stiffness, relieving cramps, and increasing athletic coordination.


Of the three NPLS ingredients Stamets only sells this one.

Check out the original post by James on here.

Nootropics FAQ

The Ultimate Nootropics FAQ List

Many people out there have no clue whatsoever as to what nootropics are and whether at all nootropics work or not.

And there are also many who immediately ask, are nootropics legal? are nootropics safe? do nootropics even work? what’s their side effects?

We will answer as many frequently asked questions as possible to help you, ourselves, and whoever comes to read this page, to get factual information on nootropics.

If this is your first time here and you have yet to try any nootropic, you are at the right place.

Returning readers: please feel free to add, suggest an edit, or contribute to this list if you have a question you think is beneficial and helpful to other readers.

Without further (er) due, let’s get started from the most basic and most frequently asked question: what is a nootropic?


What Are Nootropics?

The original definition when the term ‘nootropics’ was coined, was this: “Nootropics (often called things like cognitive enhancers, smart drugs, brain boosters, etc) are supplements, drugs, superfoods that improve brain functions. They boost cognition, memory, intelligence, motivation, attention, and concentration.” However, the term gradually expanded to mean cognitive enhancers with little-to-no side effects and toxicity. 

What Differentiates Nootropics from other Supplements?

To be recognized as a “Nootropic”, a supplement has to meet certain standards. Those standards are:
1. Enhances learning
2. Neuroprotective
3. Improves resistance to the brain 
4. Facilitate interhemispheric transfers of information
5. Increase tonic, cortico-subcortical “control.”
6. Not have the usual pharmacological effects of neuro-psychotropic drugs

What is Neuroprotection?

Neuroprotection refers to the mechanisms and strategies used to protect against nerve injury or degeneration and to prevent the breakdown of the central nervous system. More about it here.

What Are Cognitive Enhancers?

A cognitive enhancer is defined by its ability to augment performance on one or more cognitive measures. The term refer to a wide range of natural and artificial compounds which enhance cognitive function.

Are Nootropics Safe?

Yes. Nootropics are safe. However, today, the word nootropics is not as exclusive as it used to be as when first discovered. Although they are safe, that should not be sufficient for you to assume any product you buy is going to be safe just because it says the word nootropic on it.

What Determine the Safety of Nootropics?

  1. Where you buy your nootropic from, and the legitimacy of the manufacturer
  2. Your individual body reaction to it

Are Nootropics Addictive?

No. Nootropics are not addictive. If they were addictive, they wouldn’t qualify, nor meet the standards, to sell as nootropics. Therefore its crucial that you find the right company and search what other people are saying about it to ensure ingredient quality and purity.

That said, it does not mean there aren’t cases of people who are addicted to nootropics. But those cases are quite complex and unusual. More often than not, they are due to abuse and consumption of very high doses, often called “megadose”. It is common to see addiction and withdrawal discussions especially when it comes to nootropics like Phenibut. In fact, there is an entire subreddit dedicated to Phenibut quitting. So when asking this question you have to first understand what is addiction.

What Is Addiction?

There are two types of addiction when speaking of substance addiction and abuse:

Physical Addiction: which is the condition in which the body has developed a physical dependency, due to chronic use and/or abuse, of a tolerance-forming substance.

Psychological Addiction: which is the condition in which a person develops a mental dependency, often due to abuse and repetition, to a certain substance.

Both dependencies only occur as a result of an individual’s use of a substance. Therefore, the answer to this question is that: nootropics are not addictive, but they can be when abused.

Are Nootropics Legal?

By definition, yes. Nootropics are legal.

In fact, it is one of the standards for a substance to meet, in order to be universally acknowledged as a Nootropic.

However, we all know that only few companies still go with that definition of what makes a nootropic, and therefore, there is almost always a legality questions coming up, and often risk involved, in the process of purchasing nootropics online.

Especially when living in a country or city with strict importing and exporting laws.

How Do Nootropics Work?

Each nootropic has a different way of working, which is called mechanism of work. Moreover, nootropics on their separate pages have a benefits and effects section as well as a ‘how it works,’ in which each is addressed. Nootropics work by modulating neuronal metabolism, cerebral oxygenation, neurotransmitter availability, increasing neurotrophic factors and by affecting other cellular processes. If you’re wondering about the mechanism of work, you can visit any of the pages, for example, click on Mechanism of Action and it will redirect you to the Acetyl L-Carnitine page, in which section #3 explains the exact way that nootropic works within our body…or brains. Kapish?

What Are the Best Nootropics?

Depending on the effect you seek. For example, a person who looking to increase their learning capability would be looking for a different nootropic than a person seeking to improve their memory.

You should choose what to supplement with based on what you want to achieve as well as improve. Some of the popular effects people look for are anxiety treatment, energy, focus, concentration, increasing learning capacity, increasing memory recall, physical performance, enhancing mood, creativity. It is essential to research before you make a purchase though keep in mind that customer reviews are subjective. Each person reacts differently to a particular nootropic. Some of the classic ones that I felt every single one of them consciously:

  • L-Theanine & Caffeine for Focus & Attention – (what I favor the most is the 200mg:100mg ratio)
  • Creatine for reasoning
  • Bacopa Monnieri for memory. Although optimal memory benefits take several weeks to start its action, the anxiolytic effects kick-in shortly after consumption
  • Ashwagandha for stress – king!
  • Lion Mane Mushrooms for neurogenesis

How Long Do Nootropics Take to Work?

It totally depends on the particular nootropic. Some start to work quickly. The effects can be felt in anywhere from 20 minutes to an hour. Others need to build up in the body over the course of several weeks to reach optimal concentrations.

Where Can I Buy Nootropics From?

There are many options online when considering buying nootropics.

However, you have to be careful as there are just as many scam vendors.

Additionally, there are many cases where vendors are scamming customers by adding a particular irrelevant or illegal substance and mixing the product in a way to sell partly pure orders to maximize their profit.

Research the manufacturer’s credibility, and read customers experiences & reviews from members within nootropics communities such as Reddit’s /nootropics sub.

What is Acetyl L-Carnitine (ALCAR)?

Acetyl L-Carnitine (also known as ALCAR) is a multi-functional nutrient nootropic that benefits the body and brain. A potent antioxidant and neuroprotectant, it is a powerful nootropic that promotes energy and longevity. It works synergizes very well with other nootropics and usually is a primary component in most nootropic stacks.

What is Alpha-GPC?

A natural choline compound, Alpha GPC works on its own as a powerful memory booster, and in combination with other nootropics a powerful potentiator notably boosting cognitive enhancement. It’s used for cognitive-promoting qualities, as well as to increase energy and power output during weight-lifting or exercising.

What is Adrafinil?

Adrafinil is a stimulating nootropic that provides remarkable nootropic properties. It metabolizes into the famous Modafinil, making it a smart tool for enduring in longer, mentally demanding tasks.

What is Ashwagandha?

Ashwagandha is an ancient herb often referenced to as “the king of Ayurvedic medicine.” Its favorable effect remains the ability to reduce and often diminish stress and different types of anxiety. Many would even refer to it as the “stress eliminator.” Additionally, Ashwagandha provides neuroprotection and currently under clinical trials.

What is Bacopa Monnieri?

Bacopa monnieri is a powerful natural herb nootropic used for ages for its memory enhancing and anti-aging effects. It reduces anxiety and improves memory formation. It also expands learning capacity, decreases stress and even offers neuroprotection.

What is Coluracetam?

Coluracetam is a less known member of the racetam family of nootropics. In combination with the common cognitive enhancement of racetams, early scientific trials confirm that it is beneficial in the treatment of Major Depressive Disorder as well as with Generalized Anxiety, in addition to its nootropic features.

What is L-Theanine?

L-theanine is a natural amino acid existing almost only in green tea leaves. It works brilliantly in unwinding and relaxing the body and brain without causing drowsiness, while reducing stress and increasing cognitive function. Due to not causing drowsiness, it is the perfect choice to combine with stimulants of any sort to take the edge off.

What is N-Acetyl L-Tyrosine? (NALT)

N-Acetyl L-Tyrosine (NALT) is a more bioavailable form of Tyrosine, an amino acid that’s also a nootropic. It improves mood, memory, and enhances cognitive abilities in many ways. It has great effects of reducing stress and maintaining mental performance during sleep deprivation.

What is Phenylpiracetam?

Phenylpiracetam is a potent and fast-acting smart drug of the racetam family. It enhances cognitive abilities as well as boosts physical strength. The Olympics Anti-Doping committee bans it for being too stimulating for athletes.

What is Noopept?

Noopept is one of the most potent nootropics on the market today. It provides an overall cognition boost along with a small psychostimulatory effect.

Unlike many nootropics, noopept effects kick in within minutes of consumption, making it an attractive choice when facing mentally demanding tasks.

What is Pramiracetam?

Pramiracetam is gaining high attention after a study showing an outstanding success rate of 96% in reversing amnesia, surpassing the one it actually derived from, piracetam. It boosts cognition and improves memory, increases concentration, learning capacity, and furthermore promotes and assists in maintaining and enduring prolonged periods of focus.

What is Oxiracetam?

Oxiracetam is one of the most valuable racetam class nootropics. Its ability to boost productivity and problem-solving has made it a favorite – and a best seller.

What is Lion’s Mane Mushroom?

Lion’s Mane Mushroom has become one of nature’s most potent nootropic supplement for the brain. There is evidence that is can permanently enhance brain function as well as protect the brain and promote NGF and neurogenesis.

What is Rhodiola Rosea?

Rhodiola Rosea is a naturally growing flower plant from the wild Arctic regions of Europe, widely used in Chinese, Scandinavian and Russian traditional medicine. It is believed to be the perfect remedy for fatigue and burnouts. Moreover, Rhodiola is useful for the brain; protecting it from toxin damage as well as boosting memory and…

What is Modafinil?

Modafinil is a powerful stimulant that promotes ‘wakefulness’ and treats sleep disorders. It prevents daytime sleepiness and fatigue, as well as offering nootropical benefits such as enhancing mood, increasing mental alertness, increasing motivation, improving reaction time, reducing fatigue, and even enhancing memory.

What is Sunifiram?

Sunifiram is a potent and powerful nootropic that enhances memory, expands learning capacity, and uplifts mood. A recent addition to the racetam family that seems more than promising.

What is Fasoracetam?

Fasoracetam is a newer addition to the racetam family. It’s a nootropic that helps in relieving anxiety, enhancing memory, and improving overall cognition.

What is Aniracetam?

Aniracetam (my dearly beloved go-to racetam), is a multipurpose nootropic providing benefits in several different areas. It produces remarkable anxiolytic effects, thereby improving cognition and enhancing mood. It also sharpens focus, increases verbal fluency, information processing, as well as expands the brain’s capability allowing greater information processing.

What is Piracetam?

Piracetam is a nootropic designed to enhance brain function. Its the primary compound in the racetam family, from which almost 20 different derivatives have been discovered to date. It’s a revolutionizing nootropic that improves memory and remarkably boosts cognitive function.

What is Phenibut?

Phenibut is one of the best selling nootropics today. As a GABAergic agent, it works on the GABA neurotransmitter distinctly reducing anxiety. It also lessens depression, and PTSD symptoms, improving sleep, and providing an overall feeling of ease and well-being.

Do Nootropics Show Up on Drug Tests?

No, they shouldn’t. But false positives do happen.

A false positive is when a drug screen comes back positive for something that was never taken. Drug screens don’t test for the drugs directly. They test for the metabolites that drugs break down into in the body. Sometimes unrelated drugs break down into similar metabolites causing a false reading. Common drugs screens do not look for nootropics. Standard 5-panel drug screens (commonly used for employment) only test for THC, PCP, cocaine, amphetamines, and opiates. Nootropics should not cause a false positive for any of these things. However, it’s always possible. If you have to undergo extensive drug testing, it is recommended that you use caution. And it should also be noted that amphetamines (Adderall, Vyvanse, Dexedrine, etc.) will show up on a standard drug screen. If you have a prescription for one of these medications, then it should not be a problem. Otherwise, you should not take any drugs containing any amphetamines. More on that here.

Can I Drink Alcohol While Taking a Nootropic?

The broad answer is no, you probably shouldn’t. Alcohol affects just about every system of the body, including the brain and the central nervous system. Nootropics work, in part, by changing the levels of certain chemicals in the brain. Mixing the two could cause unwanted side effects.

Some nootropics that have been extensively studied and are prescribed in some European countries have alcohol consumption warnings. Piracetam, for example, comes with the warning that you should not consume alcohol while taking it. It’s always good to err on the side of caution. It’s probably not harmful to have a few drinks with most nootropics. But, be aware, that there could be some interactions. [R]

Can I Use Cannabis While Taking a Nootropic?

Nootropics are drugs that improve memory, focus, attention, and motivation. Cannabis, for most people, has the exact opposite effect. By using cannabis with nootropics, you might be canceling out some of the cognitive enhancing effects. That being said, mixing cannabis with certain nootropics can enhance other effects. Nootropics that affect mood and anxiety levels are often used with cannabis to increase their mood-boosting and anxiety reducing effects. Here are a few common nootropic/cannabis combinations.

Although the use of cannabis and nootropics together has not been scientifically studied, there’s no reason to think that this combination would be dangerous.

So, yes, you can use cannabis and nootropics together. This combo may increase the mood and anti-anxiety effects of some nootropics. However, it may also diminish the cognitive effects. [R]

Do Nootropics Have Side Effects?

Side effects from most nootropics are rare. But like all drugs and supplements, nootropics do have potential side effects. These can range from a mild headache to a full-blown allergic reaction.
By some definitions, nootropics should not have any serious side effects. And most nootropics seem to be pretty safe for most people. But, like anything you put in your body, they can have unwanted results. Some unlikely but possible side effects are:

  1. Headaches
  2. Anxiety
  3. Insomnia
  4. Irritability
  5. Allergic Reaction

Allergic reactions are very rare, but they can potentially happen. This is true not only of nootropics but of anything you put in your body. [R]

What If I Experience Side Effects?

If you experience any minor side effects like a mild headache or insomnia, you should discontinue whatever is causing it. If your symptoms persist or get worse, see a doctor. If you have an allergic reaction (trouble breathing, extreme anxiety/panic, rapid heartbeat, severe rash), seek professional medical help immediately.

Should Nootropics Be Taken Without Food?

This will vary from person to person, and from one nootropic to another. Generally, you can take nootropics with or without food. It shouldn’t make much of a difference. Some nootropics work best when taken on an empty stomach. Others absorb better with food, specifically fatty foods. Always read the label and see if it is recommended that you take it with food.

Where Can I Read More About Nootropics?

These are the websites that I started reading on earlier when I was learning about Nootropics. I think they are some of the greatest resources:

Can I Get Nootropics in the UAE?

Yes, visit this page for more details or to order nootropics if you are in Abu Dhabi or Dubai.


If you have any questions in mind, leave it in the comments and we will add it to the list. Also, if you have a question you think should be added to the list, let me know and I will gladly do so.

10 Best Natural Nootropics

To be honest, I was hesitating for quite some time about whether or not I should actually publish my retake this list of 10 best natural nootropics of 2018 mainly because it was an article written and published by the team of Nootropics Depot itself.

But once I allowed myself an open-minded approach, reading thoroughly, I started seeing a lot of sense in the list. By the time I read through it all, I had realized I have purchased 7 out of the ten items on the list.

And all those purchases were from ND, but none of which had been due to advertisements. Rather, they were based on my own choice and interest as I have placed multiple orders from Nootropics Depot over the past couple of years.

The more I read and analyze the content, the more I realize how it is indeed enlisting some of what I think is amongst the best natural nootropics of…ever.

The team at Nootropics Depot managed to build a brand that stands out from any other manufacturer, and that is something, I can almost guarantee, is acknowledged worldwide. I liked their brand upon discovering the website for the first time, I liked it more after receiving my first box of nootropics traveling all the way from Arizona to Dubai, and I maintained the same level of admiration even after having my ShareASale application declined. If anything, I am now able to see the bigger picture as well as to what led it to the undeniably successful level they’re operating at today.

To compile the list, they use customer data to analyze product popularity, customer feedback, scientific research, as well as their own team’s expertise. In other words, you can safely say that the list was based on the nootropic community coexisting online on reddit’ nootropics, longevity, and whatever platform where nootropics are in discussion, opinions forming, knowledge growing, and endless research shares.

The list is in no particular order; therefore, I will rearrange it to best of my knowledge and experience, and push the 3 I haven’t had the chance to try to the bottom of the list for this apparent reason. And possibly to further push them to my cart from there.

These are the top 10 Best Natural Nootropics in 2018 according to ND, and in no specific order:

Best Natural Nootropics of 2018

Lion’s Mane Mushroom Extract (Hericium Erinaceus)

It didn’t take me more than two(hundred) seconds to figure out whether Lion’s Mane Mushroom Extract or the next nootropic would make the #1 best natural nootropic of 2018. I knew the answer immediately when I compared it to the rest and realized that I had not run out of Lion’s Mane Mushroom Extract (specifically, ND’s) since the very first time I bought it. This has got to give it quite the credit. Especially when knowing there is no psychedelic or psychostimulant effect of supplementing with it, although that is to some degree debatable.

Lion’s Mane Mushroom is a unique, down-to-definition nootropic. It is one of the few nootropics I know of that support, as well as promote neurogenesis. And that means exactly just what it implies: it is the process by which neurons are generated from neural stem cells and progenitor cells, nootropically speaking.In other words, it supports the regeneration and birth of neurons within the brain — a discovery that led to most of the speculation about it today.

It is also the main reason why I had been taking it throughout the past year. Secondary to that comes a collection of benefits such as enhanced neuroplasticity, improving depression, cognitive function, antioxidant, and the list goes on and on. You can read more in-depth about it in its respective page since it had earned one.

Cognizin Citicoline

Again I notice that it didn’t take me long to decide whether Citicoline would rank at number two or three given the significant benefits I have personally experienced from both nootropics, as well as from those going to appear later in the list. I had used Citicoline for about six months before I decided to “upgrade” to the better choline source known as Alpha-GPC. I then started using Alpha-GPC as the replacement as my choline source for nearly a year – and still doing so today, taking 300mg per day, and occasionally might increase to 600 mg as desired.

However, I had already decided a while ago that once my large (120ct I believe) runs out, I am switching back to Cognizin Citicoline.
I was convinced to perceive the outcome of Alpha-GPC to win over that of Citicoline. But to my surprise, it turns out I much prefer and enjoy the benefits of Citicoline overall when comparing it to that of Alpha-GPC. But I wasn’t able to decide and tell until I had stopped supplementing with Citicoline for a while. Taking it after such a long and experimental break, upon taking Citicoline I felt as if I had finally put in the last piece of the missing puzzle. And by the way, turns out even that last piece doesn’t solve that puzzle of ours.

But if anything, citicoline will at least be a helping factor and will increase your chances of getting there, in comparison to other nootropics. Experienced users, especially the wiser, such as you and I (we deserve pride ok), already know about the phenomenon of racetam headaches. IF you are new to this, in short, the racetam class of nootropics, and possibly some of the most effective nootropics in the market as of now, are racetams.
They are fantastic for different conditions. Moving onto the next one of the list.

Bacopa Monnieri Extract

Bacopa Monnieri is one of the most interesting natural nootropics in my stack. The amount of studies and research on this flower is endless. Moreover, it’s another nootropic that has been in still is, in use today in Ayurvedic medicine. When it comes to something trusted and practiced in ayurvedic I almost instantly buy into it, I wouldn’t even have to see the facts, although I did, nevertheless.

Bacopa is known for its benefits on memory and secondly for its relaxing effect. “Sedating” some would say – which I only agree with if I had been awake for two days straight.

Most people use it once a day at 300mg, and ideally, results should be notable in about four weeks or so. I used it for a few months at 150mg per day, and for another few at 300mg per day, until I stopped due to the curiosity of trying the next nootropic, I found back then.

Today I rarely use it, but when I do, instead of 300mg I would take 700 mg in one dose for the calming and hippie peaceful vibe in puts me in. For which I agree on it being on this list. However, I feel I have to mention that I found it to be most effective at the lowest dose (I believe it’s around 150mg – I was taking it as one of the ingredients in Mindlab Pro). But I was consistent with a daily intake of it for way over 4-5 months. Next one on my hit list:

Ashwagandha KSM-66

I never realized how much of a natural gangster Ashwagandha sounds like when you add that KSM-66 next to it in the subheading.

Ashwagandha is a very effective adaptogen that people, again, take it on a daily basis and allow adaptation to it over time and is often spoken of as ‘that one natural nootropic that diminishes stress.

Ashwagandha works on the GABA neurotransmitter which is what results in stress and anxiety reduction.
It’s usually taken at 300mg once a day. I remember the first time taking ashwagandha I felt like I was in a bubblegum euphoric heaven without the bubblegum artificial plasticizing smell (which I like, btw).

I was amazed by how strong it had affected me, especially while knowing that my GABA receptors aren’t the easiest to poke and tweak after years of self-medicating with GABA supplements and medications. But that only happened on the very first time I took it. I’ve taken it many many times after but never felt as strong of an effect as the first time. It probably had a lot to do with my subconscious anticipation – I have to say.

I still have and take Ashwagandha every now and then, more often than not double the dose and take 600mg instead of 300mg, but I limit it to once or max twice a week. Reestablishing GABA relationship is not something I have on my mind….for the time being.

Longvida Curcumin Extract

To be honest, I haven’t quite noticed any measurable effects when I used to take curcumin, but I do believe the literature on it. Now after reading a bit more into it, I realize that it might have been the bioavailability of the brand that I had of curcumin, which I am gonna stop typing now, go to the kitchen, take a couple tablets and read the leaflet again – it had been over a year since I had last use it.

Hm. To my surprise, turns out I finished my first bottle and bought another one. I completely forgot about that. I got it from the Netherlands while in a rush going (late) after my flight – that’s why my brain probably did not process that scenario.

But if I had finished one and bought another, it must have been good….

Now curcumin extract is very popular and available in many different places and often for a low price depending on what you settle on when it comes to quality.

What intrigued me about Longvida is that they made it precisely to increase its bioavailability to the maximum. Curcumin’s bioavailability is “one of its most significant drawbacks.” Here’s what they had to say about it. I haven’t dived that deep into it to be in a place of forming or circulating my analysis.

“Longvida is a specialized extract of turmeric that addresses one of Curcumin’s most significant drawbacks: bioavailability.

On paper, the effects of Curcumin are fantastic. Unfortunately, various studies have come to the consensus that regular Curcumin does not absorb readily in the body. There have been multiple solutions to this problem, the most popular of which is by using a bioavailability enhancer from black pepper called Piperine. This seems to work reasonably well, but the permeation of Curcumin through the blood-brain barrier and into the brain is still relatively low with this combination of Curcumin and Piperine. Verdure Sciences figured out a way to put the Curcumin molecule into a solid lipid particle called an SLCP. The SLCP acts as a sort of micro-capsule which can transport Curcumin through the blood-brain barrier and into the brain. Due to this, Longvida is one of the few formulations of Curcumin that can exert a significant effect on our brains.

So why do we want Curcumin in our brains? To start, Curcumin has excellent oxidation and inflammation regulating effects in the brain, which help with overall brain health and cognitive function. Curcumin has also been shown to enhance DHA synthesis. This is beneficial as DHA makes up a large portion of our brain and it has been demonstrated that elevated levels of DHA can boost cognition. Curcumin also regulates glutamatergic function in the brain. This is important for keeping our brains in tip-top shape, especially during periods of high stress. As the cherry on top, Curcumin can enhance brain-derived neurotrophic factor (BDNF) significantly. BDNF is a primary regulator of neuroplasticity and cognition. By boosting BDNF levels, we can expect a significant boost in cognitive health support.”

They had me at BDNF.

PS: the brand I have is Solgar. It wasn’t precisely produced with a nootropical objective in mind.

Prima Purified Shilajit Extract

Now with Shilajit, quoting ND, its an “interesting natural substance. Shilajit oozes out of rocks high up in various mountain ranges, such as the Himalayas, during summer months. The current theory is that it is composed of humification products of various plants and mosses. This would explain its complex chemical makeup and the presence of various humic compounds such as fulvic acid. This also explains the often high heavy metal levels found in crude Shilajit that is widely available. This is because the rocks that Shilajit oozes out of can be significant sources of heavy metals.”

This sold it to me without really processing all of that. Today I noticed the second part of the description where it talks about how shilajit increases the bioavailability of CoQ10 which is one of my favorite nootropics. Therefore, I’m going to pause this section here and take my daily CoQ10 now with Shilajit, which I haven’t in a while. I will continue writing this once done with the rest of the list. As to personal experience with previous use, I wouldn’t add it on this list.

The science behind it sounds compelling and makes a lot of sense nevertheless. It explains that the most notable effects of Shilajit are cell rejuvenation, which in turn boosts overall cognitive function. That is supposed to be sent to our mitochondria, and by so promote healthy levels of oxidation in there. Thereby, the mitochondria produce more ATP, and ATP is one of the significant sources of energy for our cells. And that’s how Shilajit is enhancing cognition overall.

The more efficiently our mitochondria run, the more ATP they can produce. ATP is one of the primary energy sources for our cells, and thus by allowing our mitochondria to produce more ATP, Shilajit can enhance cell function. Similar to Creatine, this should boost overall brain function.”

Polygala Tenuifolia 20:1 Extract

This is one of the newer to the inventory I believe, so I haven’t had the chance to try it yet. Therefore I can’t share a personal opinion. According to Nootropic Depot though, Polygala is a serotonin, dopamine, and norepinephrine reuptake inhibitor.

“This mechanism of action results in calm focus and a significant increase in energy levels. It also helps support healthy stress levels. These effects are further enhanced by Polygala tenuifolia’s ability to enhance neuroplasticity.” then go further into explaining;

“Neuroplasticity is a process by which brains grow and adapt. In certain parts of the brains, such as the hippocampus, neuroplasticity is a crucial regulator of mood. Often, the low mood can be traced back to decreased neuroplasticity in the hippocampus. Not only does neuroplasticity influence mood and well-being, but it is also one of the primary mechanisms through which memories are formed.

What makes Polygala especially interesting is that it is also an NMDA receptor blocker. It has been shown that blocking the NMDA system can make monoamine systems, such as the dopaminergic system, more sensitive. This should, in the context of Polygala tenuifolia, promote even higher levels of focus in conjunction with its triple reuptake inhibitor effect. The NMDA receptor also plays a crucial role in memory processing”,

“….Polygala tenuifolia, in addition to supporting memory, boosting focus, promoting healthy stress levels, and relaxation, also help protect the brain. It does this by promoting healthy levels of oxidation in the brain.”

Judging by this description, I wouldn’t be surprised that it made it to the list, sitting at the top as the best natural nootropic off the list. I’m very curious now.

Next:

Caffeine & L-Theanine Combination

If you’ve made it far enough in your nootropics journey to be reading this sentence, then it goes without a saying why combining caffeine with l-theanine would make it to the list. In case you didn’t, you can read about it here.

The only combination I use of this 100:200 mg caffeine/theanine ratio is Nootropic Depot’s, so I’ve seen and can understand why a company or consumer would want an enhanced version of the supplement.

Frankly, I don’t respond very well to caffeine so having my bulletproof coffee in the morning keeps me away from using caffeine/theanine. I do, nevertheless, take l-theanine with my coffee every day.

However, ND list this in as an enhanced formula with 150mg caffeine instead of the commonly known 100:200mg ratio. Additionally, they are using a technology called ZumXR that enhances the absorption and delivery of both in a way that they complement each other even more than they do when taken together, which now is almost going to be called “the old fashioned way.”

They explain more about the extended release saying: “DynaMAX utilizes a slightly higher ratio of caffeine to L-theanine than the regular 1:2, with 150mg caffeine to 200mg L-theanine. This ratio preserves the calming effects of L-theanine but allows the caffeine to exert a little bit more stimulation.
In addition to this, we decided to add Dynamine methylliberine, a novel derivative of caffeine made by Compound Solutions, Inc. which is found in small amounts in coffee beans.

When it came to to the caffeine forms, we also decided to come up with a unique caffeine blend that combines instant release anhydrous caffeine with both delayed and extended release microencapsulated caffeine using the ZumXR technology. The result is quick and powerful, but the smooth effect that we are willing to bet can stand up to a good cup of coffee and far surpasses mainstream energy drinks!

Upon taking DynaMAX, after about 15 minutes, Dynamine methylliberine starts working its magic. This is usually experienced as a mood lift with gentle stimulation. After about another 15 minutes, the caffeine kicks in which gets potentiated by the Dynamine methylliberine. This results in quite a profound sense of stimulation and focus. However, before it becomes overwhelming, the L-Theanine steps in and smooths out this stimulation.

After about two hours, when the effects seem to be decreasing a little bit, the delayed release caffeine kicks in. This can be experienced as a quick jolt of energy that will keep you locked into whatever you are focusing or working on. The extended caffeine then carries the effects all the way to the 8-hour mark, letting you down slowly without much of a crash.”

They continue onto saying “consider DynaMAX as a coffee alternative or energy drink alternative, or like a bit more advanced version of the tried and true combination of caffeine/L-theanine.”

Nigella Sativa Extract (Black Seed Oil)

Talks about black seed oil as a nootropic has been circulating for a while on Reddit and such platforms. But outside the nootropic community, black seed oil has been in use for many years. If anything, I’m almost sure it was more widely used back in the day than it is today. I remember my grandma stuffing it in foods whenever she found the opportunity to do so. Little did I know she was all about nootropics…

Now in our current days, researchers studied the seeds extracts with all the fancy pansy technologies that weren’t accessible to our ancestors back then. They were able to prove its beneficial effects of producing a calming effect and reducing stress, as well as supporting memory.

A little science from the ND guys explains: “most commercial black seed oils have around a maximum of 1% thymoquinone, which is in stark contrast to our black seed oil extract that has a large 5% thymoquinone…..the main benefit of thymoquinone is a pronounced calming effect that does not affect cloud cognition. This is great as it allows for a more relaxed focus which can be a great asset during times of high stress. Furthermore, it is also a great immune system booster. Again, this will help during periods of high stress where the chances of getting sick are much higher than usual. At this point, the added benefits of significant boosts to cognition is just the cherry on top for black seed oil extract.”

And quite frankly it makes a lot of sense based on my readings on black seed oil. Last but not least (because the list is not structured as to 1 being the top one):

Cordyceps Mushroom 10:1 Extract (Cordyceps militaris)

Now out of all the nootropics mentioned, this one I have yet to hear of. But the fact that its a mushroom extract, I’m gonna allow myself the pleasure of finding out why it made it to the list of 10 best nootropics of 2018. The description written on cordyceps mushroom on ND’s article makes me very open to it:

“Cordyceps is a unique, stringy, and bright orange mushroom. Cordyceps has very pronounced effects on endurance and overall energy levels. However, it is often overlooked as a brain health supplement. The fact of the matter is that Cordyceps mushrooms have a unique ability to support cognitive health.”
They go on to explain the mechanism of action on how those benefits are achieved: “one of the major pathways by which memories are encoded in the process of long-term potentiation (LTP). LTP is the process by which stimulation of the NMDA receptor causes a signaling cascade in glutamatergic neurons which ultimately leads to the insertion of AMPA receptors on these neurons.

Activation of AMPA receptors makes the likelihood of the NMDA receptor getting activated much higher. As we mentioned earlier, activation of NMDA receptors during the process of LTP can lead to the insertion of an AMPA receptor. Since AMPA receptor activation increases the sensitivity of NMDA receptors, the more AMPA receptors there are means, the more readily LTP will occur. The basic premise of LTP is that the neuron keeps forming stronger connections through NMDA and AMPA receptors.

What makes Cordyceps unique, is that one of the compounds contained in it, cordycepin, makes AMPA receptors more sensitive. Through this mechanism of action, cordycepin can make the process of LTP much more likely to occur, and thereby can produce a significant cognition-enhancing effect. Due to its unique mechanism of action, in addition to the endurance-enhancing effects and overall health-boosting effects, we believe Cordyceps is one of the best natural nootropics available to buy.”

Although the list ends here, I feel like MindLab Pro deserves to be on the list as well due to the fact that it has 13 different, natural nootropics. I can barely split a piracetam or noopept capsule in half – evenly…and they somehow manage to shove all 13 nootropics into the capsule. Nothing beats that product in terms of convenience. Nothing.


PS: Nootropics Depot products are now listed and can be placed through Amazon, while still handled by ND.

Original Nootropic Depot’s article can be found here.

L-Theanine & Caffeine

L-Theanine & Caffeine: Making the Best of Both Worlds

Summary: L-Theanine & Caffeine combination is one of the safer and most popular nootropic stacks out there. Most of the time, it is what people start with when experimenting with nootropics due to its simple understanding, profound effect, and vast availability of data. The typical combination ratio is 100mg caffeine to 200mg L-theanine.

  • Caffeine: a central nervous system stimulant. It is also the world’s most widely consumed drug. Humanity is a mass of junkies, but that’s off-topic. On the other hand;
  • L-Theanine:  an amino acid found in certain plant species, and mostly known for being one of the compounds of green tea. You can read more about L-theanine as a nootropic here.
  • Stack: taking more than one nootropic at a time (2 or more) because they synergize well together, increasing and complementing one another’s effects.
  • Synergy: the creation of something that is greater than the simple sum of its parts – (nice definition, I had to throw it in there).

Caffeine


When we hear of caffeine, the first thoughts that pop in our heads (and to many, the only) are something along the lines of stimulants, energy, wakefulness. Most people tend to overlook the actual benefits of caffeine. Not necessarily the 6 pumps vanilla sugar-filled chocolate drizzle frappuccino. What I refer to here is caffeine in its pure form, the chemical, central nervous system stimulant.

Some examples of the less known health benefits of caffeine:

  1. Caffeine boosts memory and especially memory consolidation, as shown in a Japanese study at Johns Hopkins University.
  2. Caffeine stimulates hair growth (in blading men and women). [1]

It also reduces mouth and throat cancer risk by 50%, reduces the risk of stroke by as much as 22%, and even decreases the risk of type diabetes. The list goes on and on but we are more focusing on the nootropic, cognition-related benefits. Some of which are the following:

  1.  Boosts overall memory, as well as formation and especially memory consolidation. [2]
  2. It fights erectile dysfunction and increases semen volume [3] [4]
  3. Improves reaction time and logical reasoning, especially in sleep-deprived individuals. [5]
  4. Boosts energy as well as athletic performance, and weight training. [6]

That, of course, doesn’t mean it doesn’t have a negative side to it though.

L-Theanine


L-theanine, on the other hand, is much less known comparing to caffeine. But it is very well known to those within the nootropic community.

Although it is existing in green tea, the concentration is too low to produce notable nootropic effects. Therefore, nootropically speaking, a higher concentration of l-theanine is required than that found in green tea for example. Which is what led to the production and widespread l-theanine supplement in capsule form.

L-theanine benefits include promoting relaxation and contributing to better sleep quality. Moreover:

  1. It boosts GABA, serotonin and dopamine levels in the brain, as well as lowers excitatory chemicals. Thereby, L-theanine reduces stress and anxiety.
  2. Enhances attention, focus, and learning ability.
  3. Improves sleep quality

Synergy


Now, speaking logically, what do you think would happen if you take both caffeine and theanine together, at the same time (caffeine l-theanine stack)?

It would give you the best of both worlds:

The stimulation, alertness, and wakefulness, without the associating crash, jitters, or anxiety that often come along with or after caffeine consumption.

Due to L-theanine calming and relaxing effects, this combination is one of the most popular nootropic stacks. It is simple, and both cimound have a vast amount of studies on them. So not a lot of digging is required to pull information on them.

Combining the two together results in this, or a very similar experience. Might even be better (or worse if you’re the unlucky one):

“You can concentrate on your work more thoroughly, be more creative, and achieve more success with the absence of headaches, crashes, and anxiety. The combination gives you the power to perform better than taking either alone.” [7]

Dosage


Although newer formulations have been surfacing around, the widely known caffeine & l-theanine dosage is a 1:2 ratio. In most cases, that being 100mg caffeine & 200mg L-theanine.

Vendors such as Nootropic Depot have already come up with an “enhanced” formula for caffeine/theanine with a ratio of 1.5:2, and the addition of extended release technology that sums up to optimal use of both compounds.

I still have it on my to-do list to try the sample I got with my last order…soon……..

Personal Experience


I don’t respond very well to coffee. I love it but its the unforbidden love to me because too much caffeine intake increases my hyperactivity. But when it comes to caffeine/theanine combo, it seems to take care of that and lead me to a hyper-focus state. Especially given that I’m ADHD, I can get very engaged into something and lose track and sense and even existence of time all together.

However, although I have caffeine/theanine from ND, I don’t really find myself using it frequently. And that is mainly due to the fact that I drink a cup of bulletproof coffee first thing after waking up. Even though the caffeine concentration is lower in my morning coffee than the common 100mg, I drink my cup followed by a 200mg L-theanine. I found that this works the best for me, allowing me to reap the benefits of both, the synergy of the two compounds, as well as enjoy my bulletproof coffee and practice intermittent fasting (in my personal dictionary, this could also mean starvation and weight loss, but let’s stay on topic here).

Further Readings


If you would like to read more into the combination and synergy of the two compounds, you may enjoy the following studies and articles:

Nootropics in Dubai

Nootropics in Dubai & the UAE


Modalert, Provigil, and Modafinil are back in stock & available for next day delivery!


Nootropics in Dubai, Nootropics in Abu Dhabi, and the rest of the Emirates


Fellow UAE residents:

I have been receiving a lot of messages on my inbox and reddit regarding the legality, customs, imports, and regulations of Nootropics in Dubai, Abu Dhabi, or in the UAE all together – which seems to be a bit (or very) risky – depending on many different factors such as provider, importing laws, legality of active ingredient, process of ministry of health approval, and frankly, your luck to some extent.

However, that doesn’t mean you have no other options. If you are interested in placing an order, you may do so by filling the form below to know stock availability and any other question you may have. We will get back to you within 24 hours – at max.


Processing & Shipping


In most cases, orders within Abu Dhabi get delivered on the same day. Orders in Dubai are delivered the next day.

We use Fetchr as our reliable courier of choice (if you don’t know Fetchr, check out their website here).

It’s a brilliant delivery service that, unlike the popular couriers – it doesn’t require personal details, documents, and all those unnecessary requirements. And orders can be tracked through their mobile app.


Current Stock


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Learn more about Nootropics on this FAQ page, and don’t hesitate to contact us!

Nootropics 101

What Are Nootropics?

(beginner’s guide & frequently asked questions) 


There are so many people out there who have no clue whatsoever what are Nootropics and whether do Nootropics work or not. And there are also many who would immediately ask, are Nootropics legal?

Here we are going to try and answer all the questions you have and help you get a better insight into this fantastic – yet risky to an extent – field.

So, let’s get started.

What Are Nootropics? And What Is A Nootropic?


Well well well, I’m glad you asked.

Nootropics (which are often referred to as “smart drugs,” cognitive enhancers, and intelligence enhancers, to name a few) are drugs, supplements, and functional and superfoods that improve brain overall functions.

They boost cognition, memory, intelligence, motivation, attention, and concentration. For a supplement to meet the universal standard to be recognized a nootropic, it would have to abide by the following:

  1. Enhance learning
  2. Resist impairing agents
  3. Improve resistance to the brain “aggression.”
  4. Facilitate interhemispheric transfers of information
  5. Increase tonic, cortico-subcortical “control.”
  6. Not have the usual pharmacological effects of neuro-psychotropic drugs

Since then “nootropics” gradually expanded to either be synonymous with cognitive enhancers or refer to the subset of non-stimulant cognitive enhancing compounds with very few side effects and low toxicity.

That means all nootropics are cognitive enhancers, however, not all cognitive enhancers can meet the standards to be nootropics. A cognitive enhancer is defined by its ability to augment performance on one or more cognitive measures. The term refer to a wide range of natural and artificial compounds which enhance cognitive function.

Moving on.

How Do Nootropics Work?


Each nootropic has a different way of working, which is called mechanism of work. Moreover, nootropics on their separate pages have a benefits and effects section as well as a ‘how it works,’ in which each is addressed. Nootropics work by modulating neuronal metabolism, cerebral oxygenation, neurotransmitter availability, increasing neurotrophic factors and by affecting other cellular processes. If you’re wondering about the mechanism of work, you can visit any of the pages, for example, click on Mechanism of Action and it will redirect you to the Acetyl L-Carnitine page, in which section #3 explains the exact way that nootropic works within our body…or brains. Kapish?

What Are the Best Nootropics?


Depending on the effect you seek. For example, a person who looking to increase their learning capability would be looking for a different nootropic than a person seeking to improve their memory. You see what I mean?

You should choose what to supplement with based on what you want to achieve as well as improve. Some of the popular effects people look for are anxiety treatment, energy, focus, concentration, increasing learning capacity, increasing memory recall, physical performance, enhancing mood, creativity. It is essential to research before you make a purchase though keep in mind that customer reviews are subjective. Each person reacts differently to a particular nootropic. Some of the classic ones that I felt every single one of them consciously:

  1. L-Theanine with Caffeine for Focus & Attention – (what I favor the most is the 200mg:100mg ratio)
  2. Creatine for reasoning
  3. Bacopa Monnieri for memory. Although optimal memory benefits take several weeks to start its action, the anxiolytic effects kick-in shortly after consumption
  4. Ashwagandha for stress – king!
  5. Lion Mane Mushrooms for neurogenesis

Are Nootropics Legal?


Well, that’s a little bit more complicated to answer than a yes or no.

Generally, yes, most nootropics are legal. However, some are unregulated, some are unregistered, and some are straight up illegal. It depends a lot on where you live, which country, and which state or city.

 

Short (TL DR) Descriptions


  • Acetyl L-Carnitine (ALCAR)

Acetyl L-Carnitine (also known as ALCAR) is a multi-functional nutrient nootropic that benefits the body and brain. A potent antioxidant and neuroprotectant, it is a powerful nootropic that promotes energy and longevity. It works synergizes very well with other nootropics and usually is a primary component in most nootropic stacks.

  • Alpha-GPC

A natural choline compound, Alpha GPC works on its own as a powerful memory booster, and in combination with other nootropics a powerful potentiator notably boosting cognitive enhancement. It’s used for cognitive-promoting qualities, as well as to increase energy and power output during weight-lifting or exercising.

  • Adrafinil

Adrafinil is a stimulating nootropic that provides remarkable nootropic properties. It metabolizes into the famous Modafinil, making it a smart tool for enduring in longer, mentally demanding tasks.

  • Ashwagandha

Ashwagandha is an ancient herb often referenced to as “the king of Ayurvedic medicine.” Its favorable effect remains the ability to reduce and often diminish stress and different types of anxiety. Many would even refer to it as the “stress eliminator.” Additionally, Ashwagandha provides neuroprotection and currently under clinical trials for its benefits on…

  • Bacopa Monnieri

Bacopa monnieri is a powerful natural herb nootropic used for ages for its memory enhancing and anti-aging effects. It reduces anxiety and improves memory formation. It also expands learning capacity, decreases stress and even offers neuroprotection.

  • Coluracetam

Coluracetam is a less known member of the racetam family of nootropics. In combination with the common cognitive enhancement of racetams, early scientific trials confirm that it is beneficial in the treatment of Major Depressive Disorder as well as with Generalized Anxiety, in addition to its nootropic features.

  • L-Theanine

L-theanine is a natural amino acid existing almost only in green tea leaves. It works brilliantly in unwinding and relaxing the body and brain without causing drowsiness, while reducing stress and increasing cognitive function. Due to not causing drowsiness, it is the perfect choice to combine with stimulants of any sort to take the edge off.

  • N-Acetyl L-Tyrosine

N-Acetyl L-Tyrosine (NALT) is a more bioavailable form of Tyrosine, an amino acid that’s also a nootropic. It improves mood, memory, and enhances cognitive abilities in many ways. It has great effects of reducing stress and maintaining mental performance during sleep deprivation.

  • Phenylpiracetam

Phenylpiracetam is a potent and fast-acting smart drug of the racetam family. It enhances cognitive abilities as well as boosts physical strength. The Olympics Anti-Doping committee bans it for being too stimulating for athletes.

  • Noopept

Noopept is one of the most potent nootropics on the market today. It gives an overall cognition boost along with a small psychostimulatory effect. Unlike many nootropics, noopept effects kick in within minutes of consumption, making it an attractive choice when facing mentally demanding tasks.

  • Pramiracetam

Pramiracetam is gaining high attention after a study showing an outstanding success rate of 96% in reversing amnesia, surpassing the one it actually derived from, piracetam. It boosts cognition and improves memory, increases concentration, learning capacity, and furthermore promotes and assists in maintaining and enduring prolonged periods of focus.

  • Oxiracetam

Oxiracetam is one of the most valuable racetam class nootropics. Its ability to boost productivity and problem-solving has made it a favorite – and a best seller.

  • Lion’s Mane Mushroom

Lion’s Mane Mushroom has become one of nature’s most potent nootropic supplement for the brain. There is evidence that is can permanently enhance brain function as well as protect the brain and promote NGF and neurogenesis.

  • Rhodiola Rosea

Rhodiola Rosea is a naturally growing flower plant from the wild Arctic regions of Europe, widely used in Chinese, Scandinavian and Russian traditional medicine. It is believed to be the perfect remedy for fatigue and burnouts. Moreover, Rhodiola is useful for the brain; protecting it from toxin damage as well as boosting memory and…

  • Modafinil

Modafinil is a powerful stimulant that promotes ‘wakefulness’ and treats sleep disorders. It prevents daytime sleepiness and fatigue, as well as offering nootropical benefits such as enhancing mood, increasing mental alertness, increasing motivation, improving reaction time, reducing fatigue, and even enhancing memory.+

  • Sunifiram

Sunifiram is a potent and powerful nootropic that enhances memory, expands learning capacity, and uplifts mood. A recent addition to the racetam family that seems more than promising.

  • Fasoracetam

Fasoracetam is a newer addition to the racetam family. It’s a nootropic that helps in relieving anxiety, enhancing memory, and improving overall cognition.

  • Aniracetam

Aniracetam (my dearly beloved go-to racetam), is a multipurpose nootropic providing benefits in several different areas. It produces remarkable anxiolytic effects, thereby improving cognition and enhancing mood. It also sharpens focus, increases verbal fluency, information processing, as well as expands the brain’s capability allowing greater information processing.

  • Piracetam

Piracetam is a nootropic designed to enhance brain function. Its the primary compound in the racetam family, from which almost 20 different derivatives have been discovered to date. It’s a revolutionizing nootropic that improves memory and remarkably boosts cognitive function.

  • Phenibut

Phenibut is one of the best selling nootropics today. As a GABAergic agent, it works on the GABA neurotransmitter distinctly reducing anxiety. It also lessens depression, and PTSD symptoms, improving sleep, and providing an overall feeling of ease and well-being.

Where To Buy Nootropics?


There are many options online when considering buying nootropics. However, you have to be careful as there are just as many scam vendors. Additionally, there are many cases where vendors are scamming customers by adding a particular irrelevant or illegal substance and mixing the product in a way to sell partly pure orders to maximize their profit.

Research the manufacturer’s credibility, and read customers experiences and reviews within nootropics communities such as Reddit’s /nootropics

STILL WANT TO KNOW MORE?


Leave your question in the comments section below and someone within the community will answer you as soon as possible!

 
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Racetams 101

For a more comprehensive FAQ please visit the Ultimate Nootropics Frequently Asked Questions page here.

What Are Racetams?

Racetams are a category of synthetic nootropics and medications grouped due to sharing the same chemical structure. Therefore; producing similar effects. They vary when it comes to exact structure, strength, dosage, and concentration. However, fundamentally have impacts on the brain in similar ways that support their shared chemical composition. They are admired for their abilities to make the brain work much more effectively, essentially boosting memory, expanding learning capacity, promoting focus, boosting energy –in addition to providing an overall boost to brain function. The synthetic nootropic – and also the substance that led the scientist C.E. Giurgea to coin the term “nootropic” and formulate this class of cognitive enhancers originally was Piracetam. All popular racetams currently derive from Piracetam, although some are much more potent.

How Do Racetams Work?

Racetams work by affecting the assembly of the neurochemical neurotransmitter. Some work by boosting the functioning of the neurotransmitter receptors, whereas others improve the output of the neurochemical and impede the breakdown of neurotransmitter. Every one of those actions will immensely enhance the body’s cholinergic system. The brain takes choline and turns it into neurotransmitter, and whereas scientists admit they don’t perceive neurotransmitter nonetheless, they understand enough to grasp that the brain uses it for everything from learning and focus to decision-making, memory, and alternative cognitive actions.
Racetams additionally facilitate the quantity of gas, glucose, and nutrients traveling from your blood to the brain, giving your mind additional fuel. Improved aldohexose metabolism helps to extend concentration, focus, and need. By boosting neurotransmitter and aldohexose metabolism, racetams are potent tools to add in your nootropic stack. Acetylcholine plays a dominant role within the brain, liable for memory formation, attention, and thinking, further as alternative crucial psychological feature functions.

What Are the Best Racetams Available?

Since the invention of Piracetam, there have been 19 different derivatives to date. Not all of them are nootropics; some are in use for entirely different and medical reasons. The first standard racetams in alphabetical order are Aniracetam, Oxiracetam, Phenylpiracetam, Piracetam, Pramiracetam, and although not exactly a racetam per say, it nevertheless should be in the list; Noopept. Although it’s not technically a racetam, Noopept works in a very similar way to this group, enough to be counting as one. While all of those racetams operate somewhat equally, they are doing have some structural variations. Some facilitate to spice up focus, others to assist producers, some stimulate (but not within the same method as a stimulant), whereas others calm or alleviate anxiety.
The newer additions to the family are Fasoracetam, Coluracetam, and Sunifiram.

Are Racetams Safe?

Many people believe that since racetams are synthetic, they are not safe. That is an assumption without scientific evidence. The facts and numerous studies publicly available at The National Center for Biotechnology Information show that racetams are very reliable; despite various analysis attempting to prove them unsafe. Were they able to confirm they are toxic, it would burst within the medical field leading to limited usage.
The facts and studies from the very invention of them and up to date fail to do so. Most of the negativity around their use comes from anecdotal reports, which have their benefit. However, don’t seem to be a reliable supply of data. Needless to mention: it is vital to start out small, and lookout for adverse effects that may occur. The possibilities of side effects with racetams are usually headaches, brain fog, and sleep disturbances. These are very rare, nevertheless, possible. The most effective way to avoid side effects is to add a choline source such as Alpha GPC. Build up the dose gradually, allowing the body to adapt to it.

What Are Racetams Side Effects?

Racetams are considered to be safe, and yield low toxicity. However, as with all nootropics, you should be aware of the potential side-effects of racetams, not just the actual side effects.
Side-effects for racetams are rare and mild, if any. Most of which occur when an individual do not stick to the recommended dosage, or decide to go on “megadosing” without prior knowledge, then they are more likely to get some unwanted or adverse effects.
Most common racetam side-effects are: headache, nausea, trouble getting to sleep, and irritability.
If you are experiencing this symptoms, simply stop taking your racetams.
Before continuing, discuss usage with your doctor.
Note: Headaches can generally be counteracted or prevented when taking your racetam with a choline source.

How to Take Racetams?

When it comes to dosage or method of administration, each racetam has its different guidelines. Some are recommended to be taken once a day only while some others twice or thrice. Below is the recommended dosage for each racetam.

How to Take Pramiracetam?

A total daily intake of 1200 mg pramiracetam is optimal, split into two 600 mg or three 400 mg doses throughout the day. This is the lowest effective dose. On an individual level, it should be adjusted as required to accomplishing the desired effect.

How to Take Sunifiram?

Sunifiram works effectively at a dosage of 5 to 10 mg – at a maximum of three times per day. This the safe dose which has to be taken sublingually for maximum efficacy and absorption.
It is advised that one starts with the smallest doses to prevent side effects and toxicity.
Although it is not in documentation, tolerance can grow with excessive usage, so it is better to take it occasionally instead of daily basis.

How to Take Fasoracetam?

Given that it is produced 20mg dosage, 20mg would be a good starting point. Anecdotal reports suggest smaller doses of 15 to 30mg per day, while dosages used in clinical trials for ADHD were 100, 200, and 400mg twice a day.
Personally I tried anywhere from 20mg per dose to 60 mg per dose. The difference was barely notable.
As always, pair it with Alpha GPC or any choline source to potentiate the effect and prevent a headache.

How to Take Coluracetam?

The recommended starting dose is 20mg due to that being the manufactured one. There are claims that researchers testing coluracetam dosage of 240 mg per day are finding no side effects. However, the source link to that claim is broken. [R]. [R]
My Personal Experience: The maximum I’ve taken is 60mg in single dose. It caused me a slight headache and yield no special outcome.

How To Take Oxiracetam?

Oxiracetam average dose is 1,200-2,400mg taken in 2 or 3 even doses throughout the day. An example would be:

2x 800mg per day or
3x 400mg per day

How To Take Phenylpiracetam?

The usual dose are between 100-200 mg per dose, up to two or three times a day. However, I prefer taking a 200mg dose once only. The effects are much more present and pleasing.
Tolerance to Phenylpiracetam builds up very quickly. Therefore, minimize your use to when you need it rather than making it a part of a daily stack.

How to Take Aniracetam?

Aniracetam has a short half-life of about 1 to 3 hours. Therefore, many users advice to take it in 2 to 3 doses throughout the day to prolong the effect. I only take one 750 mg dose in the morning and am satisfied with this regime.
Aniracetam powder form is also available, though not as in favor as the capsule form due to its strong, bitter taste.
The recommended as well as typical dosage is 750 to 1500 mg, subjective to the individual. Taking smaller doses of as little as 400 mg has been found to be effective. Hence, it is wise to start at the lowest effective dose and build up from there as desired.

How To Take Piracetam?

The typical dose for adults is between 1,200 to 4,800 mg a day.
The most notable effective dose is 1,600 mg, taken three times a day, making a total of 4,800 mg per day. You can always check and get more information on racetams on reddit.