Choline: The Essential Vitamin Nutrient

Choline


Summary: Choline is an essential nutrient, and the precursor for neurotransmitter acetylcholine. Acetylcholine interacts directly with many functions such as the liver, brain, and nerve functions. It further extends to muscle control, energy level, as well as the metabolic process.




INTRODUCTION


Choline is an essential nutrient crucial for liver, brain, and nerve functions. It is also important for muscle motion and energy levels, as well as the metabolic process. It exists as phosphatidylcholine, a substance that comprises the structural part of the fat, hence discoverable in many types of foods. Naturally consisting of particular fats.

What is Choline?

Choline – (also known as choline bitartrate, and trimethylethanolamine) is an essential nutrient. It is crucial for liver, brain, and nerve function. As well as muscle motion, energy levels and the metabolic process. It exists as phosphatidylcholine, a substance that comprises the structural part of the fat, hence discoverable in many types of foods. Naturally consisting of particular fats.

Choline plays a major role in crucial procedures within the body. Mots of which perform multiple times a day. It is a water-soluble nutrient that belongs to other vitamins, such as folate and those in the B vitamin complex household. Much like B vitamins, choline plays a comparable function in regards to supporting energy and brain function, along with keeping the metabolic process active.

When Does Supplementing with Choline Becomes Necessary?

Choline assists in the procedure of methylation, which is utilized to produce DNA, for nerve signaling, and detoxing. It’s also essential for performance of a critical neurotransmitter: acetylcholine.
Acetylcholine also assists nerves in interaction as well as functioning as an anti-aging neurotransmitter. It carries out other fundamental functions. Neither a mineral nor a vitamin, Choline is rather an ‘essential nutrient’, required for many of the body’s functions. And particularly for brain function.
While at this time there isn’t a Recommended Daily Intake for Choline developed by the USDA, it’s crucial to prevent a choline-deficiency. Lack of which is explained further on in the article.

What is the Recommended Daily Intake of Choline?

The Recommended Daily Intake ranges between 280 to 550 mg depending on a number of factors as shown in the table below

Infants (under 1): 125 – 150 mg
Children (1-8): 150 – 250 mg
Kids (8-13): 250 – 375 mg
Girls (14 & over): 425–550 mg
Guys (14 & over): 500 – 550 mg
Pregnant: 450 – 550 mg
Breastfeeding: 500 – 550 mg

What Are The Best Sources of Choline?

Choline is naturally found in foods such as eggs, liver, beef, salmon, cauliflower, Brussel sprouts, and breast milk. Eggs are in some cases called “brain food” because they are known for providing high quantities of choline. The following is some of the foods high in choline, providing high levels of choline naturally, in addition to lots of other nutrients. All portions listed are based upon the advised quantity of 550 mg daily.


What foods are high in Choline?

    Beef Liver: 3 ounces: 283 mg (51% DV)
    Salmon: 1 filet: 242 mg (44% DV)
    Chickpeas: 1 cup raw: 198 mg (36% DV)
    Split Peas: 1 cup raw: 188 mg (34% DV)
    Navy Beans: 1 cup raw: 181 mg (32% DV)
    Eggs: 1 big egg: 147 mg (27% DV)
    Grass-Fed Beef: 3 ounces: 78 mg (14% DV)
    Turkey: 3 ounces: 57 mg (10% DV)
    Chicken Breast: 3 ounces: 50 mg (9% DV)
    Cauliflower: 1 cup raw: 47 mg (8% DV)
    Goat Milk: 1 cup: 39 mg (7% DV)
    Brussel Sprouts: 1 cup raw: 17 mg (3% DV)


BENEFITS & EFFECTS


Central Nervous System Support

Choline helps form tissue within the nervous system that plays a part in brain development and growth. It can improve signaling capacity of nerves, support structural integrity, and protect vital neuronal membranes. (R)

Neuroprotective Against Cognitive Degeneration

Another advantage of choline is its capability to keep your mind mentally sharp as you age.

Since it belongs to cell membranes and neurotransmitters that utilizes nerve signaling, choline also contributes to memory perseverance and preventing dementia, amnesia and other cognitive degeneration conditions.

As we age, our brain become less flexible. Choline does a crucial task here. It preserves brain flexibility by working to maintain levels of acetylcholine, which naturally decrease in the process of aging. Some studies suggest low levels of acetylcholine might cause a cognitive decline, that being inclusive of Alzheimer’s and dementia. (R)

Clients who develop Alzheimer’s often show a deficiency in acetylcholine levels. Some medications prescribed to manage Alzheimer’s do so by simulate choline’s impact of increasing this neurotransmitter’s levels. (R)

Choline Improves Cognitive Function, Attention and Mood

Acetylcholine is vital for brain function. Cognitive decline is often due to lack of sufficient acetylcholine levels within the brain. (R)

In 1391 individuals, greater choline consumption associated with better cognitive efficiency in spoken as well as visual memory. (R)

One research study reveals that subjects taking CDP-choline + caffeine drinks had measurable enhancement in cognitive capabilities (R)

Sixty healthy adult females aged 40– 60 who took CDP-choline for 28 days notice improving attention (R)

This elevating effect is explainable by the additional choline present, which increases attentiveness and promotes clarity. It’s also a link to its production of human growth hormone, which provides energizing, longevity effects. (R) In combination with other nootropics, it offers adequate choline to achieve optimal cognitive enhancement effects, and it prevents the minor headaches often associates use of Piracetam and pretty much all its derivatives.

Choline Improves Memory

The best recognition of it goes to its capacity in improving memory. This effect is mainly due to the increase of choline it makes available for conversion to acetylcholine, which is profoundly correlating with cognitive functions and the ability to create and revive memories. Studies confirm its efficacy as treatment for memory impairment due to aging; including Alzheimer’s and dementia.

It has further proven to be capable of recovering memory in volunteers following brief chemically-induced amnesia. (R), (R) ,(R)

Choline May Help Schizophrenia, Bipolar, and Autism

Schizophrenia and autism developed due to genetic predispositions may also be avoided by prenatal choline supplements (R)

In rats, it was found that prenatal choline supplements can help reduce the likelihood of at-risk subjects developing these disorders later on in life (R)

In a study performed on subjects with Schizophrenia, subjects taking CDP-choline showed improved cognition and working memory after treatment (R)

A few studies have shown that choline could help treat bipolar disorder and may be a useful complement to pharmaceutical interventions (R)

Increases Energy, Athletic Performance and Power Output, and Speeds up Recovery

Because it stimulates the production of human growth hormone (HGH), Alpha-GPC is valuable for individuals looking to perform better, increase lean muscle mass, feel peak energy during workouts and recover quickly afterward. A pilot study shows that 600 mg of Alpha-GPC taken 90 minutes before bench pressing increases power output by 14%. (R), (R), (R)


MECHANISM OF ACTION



Citicoline restores and repairs neuronal damage, increases dopamine levels in the central nervous system, as well as enhances production of neurotransmitter acetylcholine. Acetylcholine is especially important for those using racetams.

After ingestion, it breaks down into choline, and cytidine. After which it flows throughout the body and  easily crosses the blood-brain barrier. The cytidine then converts into uridine; a nucleotide base essential to neural membrane synthesis. The choline release is cholinergic, increasing levels of choline within the brain.

Choline is a precursor to acetylcholine and  vital to most cognitive functions. In particular to the ones relating to memory and learning.

Racetams are acetylcholine agonists compounds . They increase production and release of acetylcholine. When sufficient choline is available, it creates notable cognitive improvements such as memory improvement and heighten focus. Additionally, it prevents racetam headaches.

On Acetylcholine

It is a fundamental associate of many cognitive functions including memory formation, learning capacity, and attention. (R), (R), (R), (R). By stimulating the production of acetylcholine, it acts as a neuroprotectant; maintaining neuronal health and preventing potential damage.

On Dopamine

Oral ingestion of Alpha-GPC can also be dopaminergic, by increasing dopamine release during neuronal action potentials and possibly by stimulating the expression of receptors (R), (R). It also has involvement in increasing brain serotonin concentrations following oral administration (R).

DOSAGE AND HOW TO TAKE


Alpha-GPC digests and absorbs smoothly and is gentle on the stomach taken at the typical dose of 300mg. Although many nootropists tend to prefer a dose of 600mg, with a total daily intake ranging from 300 to 1200 mg, either at once or split into two doses (R).

Personally I find 300mg is effective enough especially because I almost always take it as part of a stack. Frequently with AniracetamPhenylpiracetam, Coluracetam, or Noopept. On the few occasions where I took it on its own, I still felt very at ease and eager to produce, learn, move.

As with any other nootropic, start with the lowest effective dose and build up gradually as desired.

SIDE EFFECTS


Some side effects rarely occur, such as headaches, fatigue, nervousness, nausea, diarrhea and gastrointestinal distress. It may rarely induce dizziness and low blood pressure in some individuals.

Personally never experienced any side effects from its use. But I’ve never taken more than 300mg in one dose (Alpha-GPC) and never more than 600mg in a 24-hours frame.

CONCLUSION


Choline is an excellent memory enhancing and focus amplifying nootropic that can be (and should be) added to almost any stack. Using it on its own is effective enough for that mild stimulation and to fire your focus. Then pair it with a racetam, and the effects of both are amplified to an amazing extent.

Furthermore, it provides neuroprotection. That is something anyone can benefit from due to many reasons. Such as environmental changes and the accumulation of oxidative stress in today’s world. It is very well tolerated and safe — there are no reports of serious adverse effects (on CDP-choline), and enlighten me if I’m wrong.

Moreover, its an approved medical treatment in Europe for a number of conditions relating to cognitive impairment (R), Ischemic Stroke (R), to mention a few.

Choline nootropics are affordable and easily accessible. Alpha-GPC is supposedly the most expensive out of the choline supplements. I’ve used both that and CDP-choline, both of which had identical effects. As a matter of fact, only now I started realizing that I might have been feeling citicoline more profoundly than I tend to feel Alpha-GPC. (I prefer it generally because it adds so much convenience to my life, when getting it along with a bunch of preformulated good mix in MindLab Pro.

It is worth buying for anyone looking after cognition boost and overall brain health. But especially worth it for those using multiple nootropics at a time, including racetams. Personally, at this point, I would not even bother taking a racetam if I don’t have a choline source to pair it with.

Coluracetam

Coluracetam


Summary: Coluracetam is a new member to the racetam family of nootropics. Early scientific trials confirm that it is beneficial in the treatment of Major Depressive Disorder as well as with Generalized Anxiety, in addition to its a bunch of nootropic value it offers.



Introduction


What is Coluracetam?

Coluracetam is a drug that falls in the racetam family. The way it works and its structure are different from other racetams. Despite it being in the racetam family, this drug has gained a widespread reputation on its uniqueness in memory boosting and reduction of anxiety and depression. It is popular in the nootropic community to raise optic properties.

However, additional studies are needed to realize the mechanism that supports these benefits.

It was initially synthesized in 2005 by the Mitsubishi Tanabe Pharma Corporation in Japan as a probable cure for Alzheimer’s disease. BrainCells, Inc. later licensed it for more study after it did not make to reach its clinical endpoint.

Brain Cells began to conduct experiments on its effects. Most of these tests were on rats due to lack of enough participants to undertake the clinical trial. From the clinical analysis carried out, coluracetam showed to improve memory retention and relieve anxiety.


Benefits & Effects


Coluracetam Improves Memory and Learning

Coluracetam benefits proves to work in enforcing cognitive and memory function in rats and similar effects on humans. Brain Cells Inc. conducted a study which reveals an improvement of mind in rats after receiving AF64A for eight days. The development continued to last even beyond treatment. Alzheimer’s disease leads to lower levels of acetylcholine. By growing acetylcholine in the hippocampus, coluracetam will increase symptoms of Alzheimer’s disease such as learning disorders and poor memory (R) (R).

Coluracetam Reduces Treatment-Resistant Depression

In a study of 101 individuals with depression, who did not achieve result treatment with antidepressants, it had a constructive impact on the apparent improvement in the quality of life at 80 mg 3 times a day. However, this is the only study on humans. The capacity it holds to minimize glutamate noxiousness may be liable for its positive impacts in the depression treatment. (R)

Coluracetam Reduces Anxiety

In a rat study, dosing 21 days of coluracetam shows a 20% improvement in anxiety, which was higher than the 12% effect valium impact in a single dose in the same study. (R)

Promotes Neurogenesis

Some studies mention that  it helps with neurogenesis. The primary mechanism is still not clear, but it relates to the administration of it for several weeks, which increase in acetylcholine in the hippocampus area.

“Patents state that it promotes nerve cell growth (neurogenesis). The mechanism is unknown, yet is thought to be related to the increase in hippocampal acetylcholine when coluracetam is dosed daily for a few weeks.” (R)

Helps with Schizophrenia

Coluracetam increases the activity of ChAT in rats with nerve cell damage. This increase suggests it may benefit patients with schizophrenia through this same enzyme. More research directly on people with schizophrenia is undergoing. (R) (R)

Enhances Eyesight

Coluracetam has shown its optic strengths such as improved color recognition, vision, and vividness. Specifically, it promotes nerve growth for the degenerative retinal disease. Numerous studies mention better color vision and sharpening of the eyesight, but no scientific research has confirmed these effects. (R)


Mechanism of Action


How Does Coluracetam Work?

It works through the process of high-affinity choline uptake. That’s its mechanism of action.

The brain chemical responsible for storing cognitive abilities and memories is acetylcholine.

This chemical is part of the cholinergic system, which is affected when Coluracetam increases the level of acetylcholine within our brain.

Studies on acetylcholine shows that an increase in the chemical levels can prove vital for improving learning, memory, and cognition.

It works by enhancing the acetylcholine levels in various regions, including the hippocampus, which is responsible for memory.

This chemical is part of the cholinergic system, which is affected when Coluracetam increases the level of acetylcholine in the brain. Many studies done on acetylcholine shows that an increase in the chemical levels can prove very important for improving learning, memory formation, and typically cognitive abilities. It works by enhancing the acetylcholine levels in various regions, including the hippocampus, which is responsible for memory.


Dosage


How to Take Coluracetam?

Typically, the recommended starting dose is 20mg due to that being the manufactured one.

There are claims that researchers testing coluracetam dosage of 240 mg per day are finding no side effects. However, the source link to that claim is broken. [R]. [R]

My Personal Experience: The maximum I’ve taken is 60mg in single dose. It caused me a slight headache and yield no special outcome.

Advise: Take it with a choline source. It can be in supplement form (Alpha-GPC. Citicoline), or from foods in your own diet.

Pairing coluracetam with a choline source will both, increase its effect, and prevent an associating headache.


Side Effects


There isn’t enough evidence regarding the side effects of coluracetam. The human brain and body are well receiving this nootropic drug. Taking coluracetam does not have many side effects, but when they appear, they are similar to other recitals. Some of the concerns are nausea and irritability which are rare.


Conclusion


Coluracetam doesn’t have extensive amount of research, the studies available do show a great potential for its use.

It is one of the more recent-going-mainstream racetams, side by side with Fasoracetam. However, recently, the FDA has approved an “enhanced” form of Fasoracetam for the treatment of ADHD. The relating information on that announcement can be found on the blog post here.


External Readings & References


Coluracetam – Wikipedia

Coluracetam – Scientific Review – Examine



Alpha-GPC

Alpha-GPC


Summary: Alpha-GPC is a natural choline compound. It works on its own as a powerful memory booster. In combination with other nootropics, it works as a potentiator boosting cognitive capabilities. It’s also used as a milt stimulant to boost energy and power output when exercising. Furthermore, it promotes cell regeneration and acts as a neuroprotective agent, against cognitive decline.




Introduction


What is Alpha-GPC?

Alpha-GPC is a cholinergic compound naturally present in the body in small amounts and commercially manufactured as an extract of purified soy lecithin (R).

Although there are dietary resources of Alpha-GPC such as dairy products, organ meats, and wheat germ, concentrations achieved by dietary intake are lower than those obtainable by a supplement. It works rapidly and reliably by delivering necessary choline to the brain. (R)

It provides valuable nootropic qualities, including memory enhancement and protection against brain aging, attributing to longevity. Clinical trials covering thousands of participants confirm Alpha-GPC is a remarkable remedy for memory loss that accompanies Alzheimer’s disease (R), vascular dementia (R), and stroke (R).

Moreover, it provides neuroprotective, anti-aging benefits. Studies further suggest it is useful in the treatment of generalized anxiety (R), (R).

Another benefit is its ability to enhance cells membrane health and promote rapid recovery following physical activity. Studies indicate that it also acts as a dopaminergic, encouraging the release of dopamine, meaning it works as a potential treatment for neurodegenerative diseases such as Parkinson’s, in addition to being an overall mood enhancer (R), (R).

Potent Potentiator

However, many consider the real strengths of Alpha-GPC is the potentiating feature when in combination with other nootropics. The choline that it provides the brain with significantly magnify the cognitive enhancing effects of other nootropics, especially the racetams.

I’ve always liked both Alpha-GPC and Citicoline and appreciated their profound effect, until one day I added Aniracetam 750mg and it was as if I had just took a racetam for the first time. The effects of both nootropics synergize together so well, a year later both of them are on the front line among my nootropic stack.


Benefits & Effects


Alpha-GPC Improves Memory Formation and Recall

This effect is mainly due to the increase of choline it makes available for conversion to acetylcholine, which is profoundly correlating with cognitive functions and the ability to create and revive memories. Studies confirm it an effective treatment for memory impairment caused by age-related diseases, including Alzheimer’s and several forms of dementia. It has further proven to be capable of recovering memory in volunteers following brief chemically-induced amnesia. (R) (R,R)

Neuroprotection and Development of New Brain Cells

It protects and maintains overall brain health by promoting the development of new brain cells and enhancing the body’s capability to repair damaged cell membranes. This attribute is a significant longevity advantage. (R)

Alpha-GPC Increases Energy and Speeds up Recovery

Because it stimulates the production of human growth hormone (HGH), Alpha-GPC is valuable for individuals looking to perform better, increase lean muscle mass, feel peak energy during workouts and recover quickly afterward. A pilot study shows that 600 mg of Alpha-GPC taken 90 minutes before bench pressing increases power output by 14%. (R), (R), (R)

Increases Attention and Enhances Mood

Users report that using Alpha-GPC provides distinguished mental clarity while improving mood. This elevating effect is explained partially by the additional choline it presents, which increases attentiveness and promotes effortless clear-thinking. It’s also a link to its production of human growth hormone, which provides energizing, longevity effects. (R)

In combination with other nootropics, it offers adequate choline to achieve optimal cognitive enhancement effects, and it prevents the minor headaches often associating with racetams.


Mechanism of Action


Alpha-GPC is comprising of choline, glycerol, and phosphate and its classification is cholinergic. The mechanism of its action is examined with high understanding. However, the manner in which it affects some neuronal functions remains unclear. A water-soluble supplement that is fast-acting and highly bioavailable orally. It crosses the blood-brain barrier shortly after ingestion, and effects work within an hour. It metabolizes into a combination of choline and byproduct glycerophosphate. Additional choline forming by Alpha-GPC is the essence of its nootropic abilities.

On Acetylcholine

It is a fundamental associate of many cognitive functions including memory formation, learning capacity, and attention. (R), (R), (R), (R). By stimulating the production of acetylcholine, it acts as a neuroprotectant; maintaining neuronal health and preventing potential damage. 

On Dopamine

Oral ingestion of Alpha-GPC can also be dopaminergic, by increasing dopamine release during neuronal action potentials and possibly by stimulating the expression of receptors (R), (R). It also has involvement in increasing brain serotonin concentrations following oral administration (R). 


Dosage


How to take: Alpha-GPC digests and absorbs smoothly and is gentle on the stomach taken at the typical dose of 300mg. Although many nootropists tend to prefer a dose of 600mg, with a total daily intake ranging from 300 to 1200 mg, either at once or split into two doses (R).

Personally I find 300mg is effective enough especially because I almost always take it as part of a stack. If not Aniracetam then its Phenylpiracetam or Noopept. On the few occasions where I took it on its own, I still felt very at ease and eager to produce, learn, move.

As with any other nootropic, start with the lowest effective dose and build up gradually as desired.


Side Effects


Some side effects rarely occur, such as headaches, fatigue, nervousness, nausea, diarrhea and gastrointestinal distress. It may rarely induce dizziness and low blood pressure in some individuals.

Personally never experienced any side effects from its use. But I’ve never taken more than 300mg in one dose, and never more than 600mg in a 24-hours frame.

Alpha-GPC interacts adversely with scopolamine. Those using scopolamine are advised to avoid it.


User Experience


Here is 3 random alpha-gpc reddit community thoughts and experiences:

This might be considered a bit on the excessive side, but I’ve been taking 300mg of GPC daily for ~2.5 years. I’ve found it to be one of the most effective ways to treat the severe anxiety that I’ve suffered throughout most of my life. Initially, I periodically experienced the insomnia you mentioned, but that passed within a month or so. Every once in a while, I’ll go several days without taking the stuff. During those short, sporadic periods of “cycling off”, I’ve noticed that I feel significantly more “dull” and lethargic than I otherwise do, but that might just be placebo in action. I understand that such a lengthy use of an under-researched substance might be a bit careless. I suppose the greatest concern would likely be downregulation of choline receptors and reduced choline production, but I doubt that any studies of the effects of long-term heavy choline supplementation currently exist to prove that one way or another.

davinsburg

As the title says, Alpha GPC has next to eradicated my social anxiety. It’s incredible. Only downside is I’m having a hard time sleeping at night. Guess my question is, how long can I cycle this stuff safely?

Entropy-Reigns

So I used to take Alpha GPC, as well as a ton of other nootropics for a few months but recently took a couple months off. Anyway, I’ve been trying to get back into them so I took only Alpha GPC this morning. I already feel more at ease with everything. I font have much depression but its crazy how great I feel already. I happened to just see this and put it all together.

IamSlink

Conclusion


Alpha-GPC is a compound with decades of research, and its worldwide appreciation comes from the effects of memory enhancement. In addition to the dominant nootropic qualities, it’s also an excellent companion to racetams. Moreover, it stimulates the production of human growth hormone. This hormone production improves strength, reduces recovery time, and support the development of lean muscle mass. Therefore; it is an excellent nootropic for individuals who enjoy leading an active lifestyle.


Further Readings


Choline: The Essential Vitamin Nutrient

N-Acetyl Cysteine (NAC)

Agmatine


Adrafinil

Adrafinil

SummaryAdrafinil is a stimulating nootropic that fights fatigue, increases the brain’s capacity of processing information, boosts energy, as well as enhances subjective well-being. It metabolizes in the body into the widely popular Modafinil (Adrafinil vs Modafinil comparison below). It’s a useful supplement for pulling through long, mentally demanding tasks, learning new topics, or working in shifts as opposed to fixed schedule.




Introduction


What is Adrafinil?

Adrafinil is a synthetic nootropic supplement that acts as a central nervous system stimulant. Previously known as Olmifon, and often mistaken with Modafinil, it is a stimulant that does not produce amphetamine-like effects.

It is a precursor to Modafinil. That means it leads to increased concentrations of modafinil in the body.  Adrafinil combats fatigue, boosts energy, improves attention, concentration and focus. It’s also known to enhance mood, motivation, and reaction time. Its potential cognitive benefits extends further to improving memory and increasing the brains capacity of learning, digesting, and processing information.

An invention from the 1970’s by French pharmaceutical company Lafon Laboratories, which manufactured, branded and marketed the invention in Europe under the name Olmifon. It spread throughout Europe and became widely prescribed by practitioners as a treatment for narcolepsy and related sleep disorders that has symptoms of heavy and excessive daytime drowsiness. As well as widely used off-label for its nootropic and stimulating effects.

In 2011, production of Olmifon ended when the french regulating authorities reversed its legality.

Its unregulated in the US, Canada, and most other countries around the world. It can be found in drugstores and online on many, many vendors and it is very widely used by people for combating fatigue, enhancing energy, stimulation, and boosting overall cognitive function

Adrafinil is a eugeroic that was formerly used in France to promote alertness, attention, wakefulness, mood, and other parameters, particularly in the elderly.

Wikipedia

Adrafinil vs Modafinil Comparison

Many people often compare adrafinil vs modafinil upon hearing of it. Usually because they try to get modafinil and find out its prescription medication, so they go for the non-[rescription, online-available alternative.

What popularizes it the most as a nootropic is the fact that its the closest legal, prescription-free to the “limitless” modafinil. But for those who knew and were familiar with it before this movie association know its profound effect and can differentiate between it and that of modafinil. In fact, many users actually report preferring adrafinil vs modafinil for certain, slightly different nootropic effects that each produces.

Although Adrafinil metabolizes into Modafinil after ingestion, it still requires a higher dosage to reach the level of effectiveness that one would feel from modafinil. For example, modafinil is mostly prescribed in dosages of 100 to 200 mg. Adrafinil often sells in the lowest dosage being 300mg. So in order to achieve the same concentration level of modafinil using adrafinil, one would have to be aware of this and measure the dosage following that pattern, as required.

Modafinil is often prescribed therapeutically in doses of 50mg being the lowest effective. For comparison, taking 300mg Adrafinil, which is the smallest manufacturing dose, would actually be more effective than the lowest effective dose of modafinil.

Although it cannot be an exact figure due to the fact that breakdown and metabolizing varies from each individual to another, a general and easy way of understanding and remembering the math of adrafinil vs modafinil in terms of dosages, or at least how I personally measure it when taking either one, is that that 100mg of Modafinil is more or less equals to 300mg Adrafinil.

Personal Thought

From my personal, own experience: the effect of Adrafinil 300mg  is much more felt in comparison to Modafinil 100mg. During the period I was prescribed Modafinil, I would have to take 200mg in order to achieve what I would achieve from 300mg of Adrafinil. 

Benefits & Effects


Increases Mental Clarity & Heightens Focus

Although it is initially developed for its wakefulness-promoting qualities, Adrafinil continues showing significant cognitive benefits as well. For individuals suffering daytime exhaustion due to night work or sleep difficulties, adrafinil increases the physical and mental energy required for an active life. It also improves mental clarity and heightens focus.

Promotes Wakefulness & Boosts Energy

Adrafinil is an overall beneficial stimulant, preventing daytime drowsiness and dramatically increasing energy and attentiveness without the hyperactivity and jitteriness associated with stimulants. Users report a profound sense of well-being, stress reduction, and overall enrichment experiences. Those outcomes are primarily due to Adrafinil’s impact on dopamine.

Improves Learning Capacity & Memory Formation

In addition to promoting wakefulness and increasing energy, adrafinil holds many nootropic benefits such as improved learning capacity, better memory creation, as well as recollection. Reports indicate that it sharpens focus and increases the ability to maintain it, along with providing mental clarity, and easing mentally demanding work, especially that which extends over a prolonged period.


Mechanism of Action


How Does Adrafinil Work?

Adrafinil acts on the adrenergic system, the part of the nervous system that releases adrenaline. Typically considered in charge of the “fight or flight” response, a rapid release of adrenaline boosts energy and increases alertness. While not all of adrafinil’s actions are entirely understood, it is assumed to replicate the positive effect of adrenaline release by supporting adrenergic neurotransmitters.

The Breakdown

Adrafinil is a synthetic prodrug, which means that its an inactive compound that metabolizes into an active form inside the body. The process of metabolizing it produces the drug, modafinil, which is an FDA-approved treatment for necropsy and similar sleep disorders. The pharmacological effects of adrafinil are practically identical to those of Modafinil.

Though the exact chemical mechanisms of it are unclear, researchers hypothesize that in its metabolized form it functions as an adrenergic receptor agonist. One of its first actions is the enhanced production and release of the neurotransmitter hypocretin, which in turn triggers the increased production of dopamine, histamine, and norepinephrine; all of which are directly related to alertness and energy, which considerably explains adrafinil’s stimulant qualities.

The remarkable mood and cognitive effects it produces result from different actions, such as the positive modulation of glutamate receptors, and inhibiting the breakdown of glutamate. Those actions lead to better neuronal communication, which improves memory and focus and creates better cognitive functions.

Serotonin Neurotransmitter

It also stimulates the release of serotonin, which enhances mood by reducing anxiety levels. It also inhibits the breakdown of dopamine, a neurotransmitter that is mainly responsible when it comes to the brain’s pleasure and reward responses.


Dosage


How to Take Adrafinil?

Recommendations vary greatly among different users.

The lowest dose Adrafinil is produced in is 300 mg. However, most nootropist would say, and prefer, a dose of 600mg taken once in the morning. And the highest yet credible dosage is 1,200mg taken as 2 doses. A morning dose of 600mg and an afternoon “boost” dose of another 600mg.

At the doses of 300 to 600mg, it is a safe and very effective nootropic. It is a potent nootropic, therefore it’s advised to give your body a chance to adapt to it at lower doses and only gradually increase as you feel required after evaluating the effect of 300mg.

Due to its potency and wakefulness-promoting properties, it is advisable to take it in the morning or early afternoon only to avoid interfering with the sleep cycle, otherwise you wouldn’t be able to fall asleep easily at night. (although that doesn’t apply to those who know that time is actually an illusion).

It is also advisable to take it on an empty stomach to allow for optimal absorption. It kicks in and effects start to be felt around 45 minutes to an hour after ingestion.

For continuous and prolonged use, it is very advisable to use on a sequence (or cycle) of two weeks on, and one week off to detox and maintain tolerance as well as prevent potential dependency for certain people.


Side Effects


What Are Adrafinil Side Effects?

The most typical side effects of adrafinil are headaches, dizziness, nausea, and stomach discomfort. The most severe relates to liver function. Additionally, there is potential for increased risk of high blood pressure and heart problems when taking high doses.

Should you experience any side effects, stop using and seek professional medical advice.


Conclusion


Adrafinil’s mixture of mental and physical benefits make it valuable for individuals looking for more energy, stamina, and psychological acuity. Its a powerful nootropic with potent stimulant qualities. Used responsibly, it offers a unique and profound nootropic boost that one grows to appreciate.


User Experience


Here is three random experiences from adrafinil reddit nootropic community on their thought of adrafinil:

I love adrafinil for a once-every-couple-of-weeks ‘I need to work 11 hours today’ usage. I can take 300mg at 6:30 or 7 in the morning, and still be alert and clear headed at the office when 7 or 8pm rolls by. But I try not to use it any more than once a week, because of the possible liver implications.

WhatAboutLightly

Adrafinil is very strange for me. I noticed somewhat sporadic efficacy. Additionally, for me, I was getting bad headaches. I called them “core headaches” as they seemed to originate from the very “core” of my brain. and not in the front like other areas. now I am still uncertain if this was because of adrafinil or phenylpiracetam. but once I started experiencing core headaches frequently even without taking any nootropic whatsoever, I quit adrafinil. It did go away after a while, but again I am not sure if this was just a rebalance or due to…other things I have been up to. Good write up though. I am not certain I can answer any of the questions since I haven’t gone back to adrafinil yet…thinking of trying modafinil if I can manage to procure it, and see if that has a cleaner, more mildly-stimulating/focusing effect like I was looking for.

multipl3x

My simple protocol for Adrafinil is to only take it if I sleep poorly. and know that I still need to perform the next day. For me that means that I take it infrequently, but it’s a lifesaver every time.

stevetheguy

Further Readings


The Ultimate Nootropics Frequently Asked Questions List

Aniracetam

Aniracetam


Summary: Aniracetam is a multipurpose nootropic that provides several benefits. It produces remarkable anxiolytic effects, thereby improving cognition and enhancing mood by ridding anxieties. It also sharpens focus, increases verbal fluency, information processing, as well as expands the brain’s capability of digesting and processing information. Furthermore it produces sense of clarity and well-being.




Introduction


Aniracetam (systematically known as N-anisoyl-2-pyrrolidinone, and trade names Ampamet, Memodrin, and Pergamid ) is an invention from the 1970’s which has been since standing as one of the most popular racetams. It is more potent than Piracetam, the original racetam that led to the invention of the large family of racetams that exists today. However, Aniracetam and Piracetam work in different fashions, respectively. Aside from being a best-selling across racetams on many vendor websites, it’s also peaking among the most expensive ones. The majority of individuals using Aniracetam, myself included, report its anxiolytic and mood enhancing effects as remarkable, profound, and most noticeable.

The majority of individuals using Aniracetam report its anxiolytic and mood enhancing effects as remarkable, profound, and most noticeable.

Furthermore notable is the increase in social and verbal confidence as well as improvement of verbal fluency. Both advantages are likely to the anxiety-relieving characteristic of Aniracetam. In individuals with generalized and social anxieties, the effects are profound: relaxing and relieving anxiety levels to a significant degree due to feeling the overall mood enhancement and worrying less about random thoughts such as ones that are unchangeable. Freeing the accumulated anxiety leads to make space available for better, positive thoughts, thus leading to an open and welcoming approach to situations as well as human connections.

Aniracetam’ anti-anxiety and mood enhancing properties, strong cognitive improvements, and its minimal side effects, has made it one of the most popular nootropics. Besides improving mood and reducing anxiety, it also promotes creativity, verbal fluency, and memory.

Although immediate effects from taking Aniracetam are notable,  the most significant improvements are notable after a prolonged period of daily consumption.


Benefits & Effects


Aniracetam Improves Memory

In two different rodent studies, Aniracetam proved to improve behavioral performance, and even reverse memory loss (R)

In the second study on rodents aniracetam improved amnesia-like memory loss that was a result of sleep deprivation. (R)

Aniracetam Provides Neuroprotection

Aniracetam acts as a neuroprotectant for brain cells. It helps to protect the brain damage that occurs from external influences. Furthermore, it assists in reversing brain damage caused by excessive alcohol consumption (R), (R), (R).

Aniracetam Heightens Focus and Concentration

Aniracetam is remarkable in heightening concentration and focus. It exhibits effects such as increasing noradrenaline release in the brain, which is the reason for the stimulating effect of cognition boost as well as in concentration and focus (R), (R).

Aniracetam Relieves Anxiety

Aniracetam shows strengths in reducing anxiety. Studies show that it affect anxiety by increasing social interactions and improving performance in fear and stress tests. With an increase in serotonin and dopamine, individuals feel a noticeable reduction in anxiety. Thus, becoming a general anxiety relieving agent. Although there are studies that support and verify this process, it is also useful to read personal experiences from Reddit and Longevity communities, where many reports it being far better than Piracetam, Coluracetam, Phenylpiracetam and similar nootropics in the field of anxiety reduction (R), (R).

Aniracetam Relieves Depression Symptoms

It’s been proved to be useful as an antidepressant in rodent studies. In Japan, it has been used to treat stroke, depression, and anxiety. The release of dopamine and serotonin enhances mood and associating positive feelings. The impact of Aniracetam on AMPA receptors help with easing depression rising from cognitive degeneration conditions such as Parkinson’s disease. The effects of Aniracetam on depression are a result of the increase in acetylcholine and dopaminergic receptor stimulation (R), (R).

Improves Memory and Learning Capacity

One of the main advantages of using Aniracetam is the profound findings on memory improvement and expansion of learning capacity. It enhances the formation of memories as well as the consolidation. Aniracetam increases the blood flow in the brain’s frontal cortex. The primary function of the frontal cortex is assisting in holistic thinking and the ability to form and connect ideas and thoughts. A study on the cognitive function of rodents observes that it also helps in improving parts of the memory and learning to promote an increase in productivity and task completion, which also assists individuals with ADHD (R), (R).

Aniracetam Supports Alzheimer’s

Aniracetam is helpful for elderly individuals. A study on patients with Alzheimer’s-related dementia found a significant improvement in comparison to another group receiving high doses of Piracetam. Over a year period, individuals receiving Aniracetam showed higher cognitive function abilities and an increase in overall emotional stability. Studies show the likelihood of Aniracetam as a preventative as well as a remedy for Alzheimer and disorders that result from central nervous system damage (R).

Additional Benefits of Aniracetam

Aniracetam is said to promote and improve REM stage sleep according to this study. (R)


Mechanism of Action


How Does Aniracetam Work?

Aniracetam is fat soluble which mean the compound breaks down at a slow pace thereby extending its effect. It has a half-life of 3 hours. Its pyrrolidinone structure makes it fall into the group of racetams. It’s one of the most common structures when it comes to this class of drugs. It has an additional methoxy group with an anisoyl ring at the para position. It is absorbed and metabolized in less than 30 minutes thereby rapidly crossing the blood-brain barrier (R), (R). Although not all of its mechanisms are understood, an extensive amount of research compiling on Aniracetam and they hint that it works by modulating the following:

Glutamate Neurotransmission

Aniracetam is essential in improving information and memory retention because of its effectiveness in transmitting glutamate. This neurotransmitter is vital in the activation of neurons. The glutamate receptors connect strongly with storage of information and preservation of memory. Aniracetam has a long-term effect on improving neuroplasticity (R), (R).

Dopaminergic Neurotransmission

In rodents, the oral ingestion of 50 mg/kg has effects of minimizing the rates of dopamine in the striatum and decreasing dopamine rates in the striatum and hypothalamus. The levels of serotonin reduce in the hypothalamus but add in the striatum and cortex, where it decreases hypothalamus turnover and increases brainstem, striatum and cortex turnover (R).

Acetylcholine Neurotransmission

Aniracetam has effects of improving the cognitive functions by enhancing the action throughout. This is important in attention span, memory and learning speed. It works by associating to acetylcholine receptors, stopping receptor desensitization and endorsing the synaptic discharge of acetylcholine (R).


Dosage


How to Take Aniracetam?

Aniracetam has a short half-life of about 1 to 3 hours. Therefore, many users advice to take it in 2 to 3 doses throughout the day to prolong the effect. I only take one 750 mg dose in the morning and am satisfied with this regime.

Aniracetam powder form is also available, though not as in favor as the capsule form due to its strong, bitter taste.

The recommended as well as typical dosage is 750 to 1500 mg, subjective to the individual. Taking smaller doses of as little as 400 mg has been found to be effective. Hence, it is wise to start at the lowest effective dose and build up from there as desired.


Stack


Best Aniracetam Stack for Working

For work as well as learning, Aniracetam can produce remarkable benefits and effects when taken alongside other nootropics and supplements.

It goes without a saying that stacking Aniracetam with a choline source like Citicoline or Alpha-GPC is a must. Leaving the potentiating effect aside, what makes it a must is the fact that many racetams work by utilizing the acetylcholine levels in the brain. Once acetylcholine is utilized and starts getting to a low or depletion levels, the user would then feel a headache. And depending on what racetam did you take and at which dose, it can be a very nasty one.

Aside from that, it really works as a great potentiator. You will feel like both nootropics are working at a better level.

Another nootropic that I like to stack with Citicoline & Aniracetam is Lion’s Mane Mushroom.

Although many don’t feel an onset effect, I find that it works very well in that stack even if I am taking it on random basis. Often, I would only use this stack for the days where I have to go to work early and know that I will be there all day from 8 to 4. (or maybe 9 to 3 but you get my point).

On the same occasion, I would also take N-Acetyl L-Tyrosine 350mg. I found that it helps me tremendously in keeping myself working on an ongoing task rather than taking a 5 minutes break every 2 minutes. I am ADHD, and NALT has been one of the greatest discoveries for me in that regard. It also lets me focus better.

If I have time to have coffee before heading out, I would also add L-Theanine to the stack. The synergizing effect of caffeine and L-Theanine is one of my favorite (and now seems old school) combos.

Last but anything from being least, Acetyl L-Carnitine (ALCAR). When I first started experimenting with it I found it very effective on me and was taking 500mg three times a day. Eventually though, I was developing a weird allergy-like symptoms as well as feeling light, needle-like numbing in random parts of my body.

I can’t blame it on ALCAR just like that but after a while of carefully observing, I noticed that it had almost disappeared since I lowered the dosage to 0 for a while, and then got back to taking 500mg per day only. Now when I think about it, I did not get those symptoms pretty much since that time. Interesting note to self.

So in a morning where I am going to be at work all day, which is a massive corporation that drains me sometimes, this would be my stack:

Of course the stack is ever changing, but when it comes to Aniracetam, I remember that stack being one I liked and found to be very effective on me. It made me focused at work, energized throughout the day (esp. on days where I also took Adrafinil), diminished my occasional social anxiety, and made me very productive at my job.

Every now and then, I would take a 15 to 20mg of Noopept and take it after lunch break (not that I have lunch during those breaks, I’m just drawing the timing picture here) to get a little boost and prolong the effects of…all the above.

Best Aniracetam Stack for Anxiety or Stress

Another Aniracetam Stack that I really like for either when you are running late (I say this mainly for the ADHD readers, I know the struggle very well…), or just not in the mood to go after 10 containers getting one pill from each, and rather like the convenience. I often use this one when I am on the go and its

It’s a very easy and convenient stack. Simply 3 pills and you are good to go. Sometimes I would take another serving of MindLab in the afternoon as needed. The maximum allowance is 2 servings (4 pills) every 24 hours. I think its the best nootropic formula in that situation.

Note to self: re-order MindLab Pro – you used the last remaining pill today.


Side Effects


What Are Aniracetam Side Effects?

Side effects of supplementing are mild and only occur when consuming high doses. High doses can result in digestive discomfort and nervousness.

Headaches are often reported. It is due to lowered acetylcholine levels in the brain due to racetams utilizing them. Therefore, it is almost a rule to pair racetam drugs with a choline source (such as Alpha-GPC or CDP-choline). Not only will choline prevent or eliminate the headache, but it will also work synergistically together firing cognitive function (R).


Conclusion


Diverse effects of Aniracetam make it an outstanding nootropic. It promotes calmness and improves mood. Moreover, it enhances performance and reduces social anxiety. It is useful for performing artists, public speaking, and overall anxiety reduction. It has shown positive results on cognitive functions making learning quicker and more pleasant.

Furthermore, it heightens focus and concentration over prolonged periods, making it appealing to students and researchers. Aniracetam users report a boost in creativity and an improvement in visuals and self-awareness. It has proved to offer many advantages taken at recommended doses with infrequent adverse effects.

Aniracetam reviews are very encouraging and reddit experiences will make you want to buy yourself some right away.


User Experience


Below are a few randomly selected user experiences from people within the Reddit nootropic community:

My first aniracetam trial at only 250 mg made me feel a little out of it for a couple hours, and “loopy” would probably be the right word had I started out with three times that much. This may refer to what is often described as an anxiolytic effect. On the other hand, once this passed I felt more clear than usual. Others have reported such a “biphasic” effect as well. There are a number of things you can do, one of which is obviously not to use it again. Others are to try a lower dose, especially to begin with, until you become more accustomed to how it affects you. When you take it matters too; if you get this biphasic effect then take that into account when timing your use. With some experience, you also may find stacking it with another supplement, for example, phenylpiracetam, helpful. In any case, I always start low when trying anything new just as a general safety practice and to avoid unpleasant surprises.

scientropic

I’ve been experimenting with nootropic stacks for awhile now and I decided to foray into the racetams. Per Dave Asprey (Bulletproof Exec) I decided to start with aniracetam because of its comparative potency to other the racetams, as well as it’s anxiolytic effect. I bought 30g online (I googled and found Health Supplement Wholesalers, fair-priced) and immediately noticed several changes in various aspects of my day to day life. First and foremost I have found myself much more resilient to stress than I would normally be. Things that would spin me up in the past are barely even noticeable, and it is exponentially easier to shrug off all but the largest of stressors as if they did not even occur. I have had an elevated mood also. Feelings of happiness and contentment come much more easily to me, and I will catch myself smiling without understanding why. It is a very pleasant change from my previous baseline. I have a much easier time focusing on tasks, and accomplishing goals. My mind feels not only ready, but excited to take on challenges and meet them. Mental plasticity is a definite benefit of this product. One of my favorite aspects to this is there is no type of mental fog, but instead complete clarity. I feel very sharp and aware, noticing things about my surroundings that I would not have noticed before. It has even given me a new appreciation for music as the tranquility and clarity of mind have allowed me to listen and pick out parts of the music that I would never have noticed before. I highly recommend getting some to anyone seeking any or all of these benefits, as everyone I’ve shared it with has asked me where to buy it for themselves. Pretty excited I found this; I’m anxious to try the other racetams as well.

DarrenRM

Certainly not placebo imo. I’ve tried numerous supplements and a couple other nootropics with the same hope that I would be able to make a significant difference, but with out any luck. Aniracetam has been the only one to actually provide me with tangible results. But you guys are free to speculate and make your judgements.

simplicitea

Further Readings