Neurogenesis

This page contains all website entries whether pages, posts, updates, or blog entries that are tagged under Neurogenesis.

OverviewIngredientsBenefits & EffectsSide EffectsPersonal ExperienceOther Natural Nootropics

Summary: MindLab Pro is a pre-formulated, all natural nootropic supplement. A blend of 11 natural and potent ingredients in 1 pill. It offers a great convenience while delivering measurable and obvious increases in physical and mental performance.

Overview

What Is MindLab Pro?

mindlab pro nootropic formula

I have come across Mind Lab Pro after the rebranding and introduction, and was immediately drawn to its overall presentation. I care about companies images just as much as I care about the product itself. After immersing myself into reading every word on the extensive ingredient list and description of each, I thought to myself, and I owe it to myself to give it a shot. The price was reasonable for the content, and I ordered my first bottle.

Fast forward about a year later, I still have it standing amongst the first on my shelf. Except now I also have my mom and two sisters, as well as a friend or two, all enjoying supplementing and using it on a daily basis.

We all got easily attracted to the product because of its moderate dosage, and commitment to natural ingredients. I don’t mind other nootropics but I know people who wouldn’t come near anything synthetic, so Mind Lab Pro seemed appealing to them. Each serving (2 pills) contains the following 11 “enhanced potency form”


The Formula

What's In MindLab Pro?

With such an impressive list of ingredients formulating together into one (or two) pills, it’s no surprise why Mind Lab Pro made quite a name for itself and maintaining a loyal, returning customers.


Benefits and Effects

What Are MindLab Pro Benefits?

Unlike any other nootropic on the website, it’s a little bit more challenging to list down the benefits and effects of using Mind Lab Pro because it consists of 11 different ingredients, each of which serves many benefits. However, you can click on each component and see the list of its benefits and effects.

I’ve used it short term and long term and have seen results in both ways. What I like the most about Mind Lab Pro is the fact that it has citicoline, which means I can perfectly pair it with a racetam without having to get an additional choline source (currently I take Alpha GPC when taking racetams). As well as the fact that it also has Lion’s Mane Mushroom which I think is one of the most profound nootropics I have come across. So when I wake up in the morning and wanting to head out to work fast and arrive fresh and mentally prepared, (also because I’m almost always late), I would only take 2 pills instead of reaching out to 11 different containers and taking 1 by 1 – I am one who really goes the extra mile for convenience.


Side Effects

What Are The Side Effects of MindLab Pro?

Again, from personal experience, and at least six people that I know from friends and family, none of us have encountered any side effects that were leading back to Mind Lab Pro. I’ve recommended that they take it with a fat source for better absorption and to avoid any stomachache, but I almost always take it first thing in the morning and never had any adverse effects.


Personal Experience

Honestly, if anyone asks me for a recommendation when first starting on nootropics, I would recommend Mind Lab Pro. And I am not even an affiliate nor sponsored by them whatsoever (although I should be…)  – it is a genuine suggestion.

It has many good ingredients and at moderate dosages. Beginners can easily understand the mix and expand their knowledge further intro nootropics if they wanted to. Moreover, I also really enjoy the (if not mistaken) buy two get 3rd free & buy three get 4th free. It makes a good value for money and always comes in handy for last minute packing, late and rushing situations, and can even be carried out in your bag on day to day basis unlike when you’re using a stack of different products. I don’t think I can't even fit all the containers I have from various companies in my car trunk.

Other Natural Nootropics

If you're into all natural nootropics, check you the following:

  1. Bacopa Monnieri
  2. Lion's Mane Mushroom
  3. Ashwagandha, as well as: Natural Herbs page.

Related Topics

The Best Alternatives to Adderall

The Best Natural Nootropics of 2018


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What is Lion’s Mane Mushroom?Benefits & EffectsMechanism of ActionUser ExperiencesFAQs


SummaryLion’s Mane Mushroom has become one of nature's most potent nootropic supplement for the brain. There is evidence that is can permanently enhance brain function as well as protect the brain and promote NGF and neurogenesis.

Lion's Mane Video TTShttps://youtu.be/hP-QMKjTV0g

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Introduction

What is Lion's Mane Mushroom?

Lion’s Mane Mushroom (also known as Hericium erinaceus), or rarely “monkey head mushroom,” is a traditional medicine that’s developing a strong fan base around the world. It has been voted as one of the top 10 natural nootropics of 2018 in terms of best selling, according to Nootropics Depot, as well as most beneficial. The list also included L-Theanine, Citicoline, as well as L-Theanine & Caffeine synergistic combo.

The profound effects it has on cognitive function while being neuroprotectant, as well as supporting NGF production, make it an appealing nootropic. The nerve growth factor is a discovery from 1986 that led Dr. Rita Levi-Montalcini to win a Nobel Prize. NGF is one of the primary building blocks of neuroplasticity.

Furthermore, it is part of a group of molecules responsible for neurodevelopment. A go-to tonic for years, Lion’s Mane (Hericium Erinaceus) is native to Japan, China, Europe, and North America. It offers many benefits to the brain. It's in use as an alternative medicine to treat neurodegenerative disorders.

It is becoming more popular after the discovery of connections to promoting neurodevelopment. It raises the quantity of NGF in the brain, which improves cognition by decreasing inflammation, promoting neural growth, and enhancing brain health. Furthermore, studies verify that Lion’s Mane is a powerful neuroprotectant that can be valuable in the treatment of a variety of conditions ranging from cardiovascular health to obesity and even to certain types of cancer. Thus, Lion's Mane has become a novel nootropic.


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Benefits & Effects

What Are Lion's Mane Mushroom Benefits?

  1. Enhances Memory and Brain Function
  2. Promotes Nerve Growth Factor and Neuroprotection
  3. Lion Mane Reduces Anxiety and Symptoms of Depression
  4. Reduces Inflammation, Boosts Immunity, and Helps Digestion
  5. Supports Heart and Circulatory System, and Prevents Strokes
  6. Improves Mental Health and Overall Well-Being

Supporting research:

Enhances Memory and Brain Function

Lion’s Mane Mushroom benefits are diverse. One of which is that it boosts cognition, especially in memory and recall speed. Additionally, it helps in maintaining concentration, increasing mental stamina, and heightening focus. It is one of the most praised nootropics due to being organic and natural. Furthermore, it provides a variety of benefits, often surpassing pharmaceutical products. 

A study in Japan on subjects diagnosed with a mild cognitive decline receiving Lion’s Mane mushroom extract at a daily dose of 3 g for 16 weeks found a measurable increase in scores on the cognitive function scale. And amazingly, without adverse effects. [R], [R]

Promotes Nerve Growth Factor and Neuroprotection

Lion's Mane Mushroom extract has an impressive ability preventing and healing damaged nerves. Studies support the claim of Lion’s Mane promotion of neurogenesis. The promotion of neurogenesis is also called neurodevelopment or generation. Neurogenesis results in long-lasting and continuous improvements in brain health (R) (R). In a study by Tohoku University on Lion's Mane and nerve growth states Lion’s Mane has most profound impact on nerve regeneration.

Post digestion, Lion’s Mane distributes through the body – crossing the blood-brain barrier. Then becomes capable of stimulating the generation of enzymes that release the Nerve Growth Factor, and additionally repairing nerve myelin. Those capabilities turn out useful in the cases of Alzheimer’s, dementia, neurodegeneration, muscular weakness, Parkinson’s Disease, and other neurological disorders. (R) (R)

Lion Mane Reduces Anxiety and Symptoms of Depression

Studies show that Lion’s Mane Mushroom benefits depression as well as anxiety symptoms after several weeks of supplementation. In a clinical trial where thirty women have been receiving Lion's Mane for four weeks versus women receiving placebo, it concluded that lion's mane intake indeed reduces depression and anxiety. (R), (R)

Reduces Inflammation, Boosts Immune System, Supports Healthy Digestion

Due to its potent anti-inflammatory properties, lion’s mane mushroom might improve the function of your stomach and digestive system. In many studies, lion’s mane mushroom has been shown to protect from or shrink gastric ulcers. Moreover, according to a survey by the Mushroom Research Centre at the University of Malaya, experts from the field concluded that the bioactive compounds in lion’s mane extract are responsible for the gastroprotective action. (R)

Another research from China published in the International Journal of Medicinal Mushrooms verifies that “results indicate that polysaccharide fraction is the active component of the H. erinaceus mycelium culture, which protects against gastric ulcers.”

Lion’s mane also significantly improve symptoms of two major inflammatory disorders of the digestive system; inflammatory bowel disease, and gastritis. Another study in Japan found that lion’s mane was able to reduce inflammation in fatty tissue, the factor in the formation of metabolic syndrome, a group of conditions that increase the risk of heart diseases, strokes, and diabetes. (R)

Lion’s mane can improve immune system function like the polysaccharide content in the fungus according to mice studies. [R]

Lion’s mane additional benefits is its antibacterial effects against what is now known to be “the world's most successful virus in human history.” (R, R)

Supports Heart and Circulatory System Health and Prevents Strokes

Experiments observed that extracts of lion’s mane block the spread of LDL cholesterol, sometimes referred to as the “bad” cholesterol, while simultaneously raising HDL, the good cholesterol. (R, R)

A stroke, which happens as a result of lack of sufficient blood supply to the brain, is often caused by blood clots. An extract of lion’s mane mushroom may be useful in the prevention of blood clots accumulate. Thereby helping decrease the risk of stroke, according to a study by the Graduate School of Pharmaceutical Sciences in Japan. (R)

Improves Mental Health and Overall Well-Being

Lion’s mane helps feeling better by improving sleep rhythm and reducing the effects of mental health issues. The powerful extracts from the mushroom have been shown to combat fatigue (R).  They also possess the ability to regulate the body's circadian rhythms, which is especially important for people at risk of developing dementia. (R)


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Mechanism of Action

How Does Lion's Mane Mushroom Work?

Lion’s Mane mechanism of action is completely different from other nootropics. Lion’s Mane enhances cognition by increasing the amount of nerve growth factor in the brain (NGF). Nerve growth factor is one of a group of molecules named neurotrophins that are essential for the growth, development, maintenance, and survival of neurons.

Nerve Growth Factor (NGF)

A discovery in the 1980s that led Dr. Rita Levi-Montalcini to win a Nobel Prize – NGF is confirmed to be one of the primary building blocks of neuroplasticity. The presence of sufficient NGF improves cognition by stimulating growth as well as axons branching. Inadequate NGF, on the other hand, decreases brain functionality by leading to neuronal degeneration and eventually, the death of nerve cells. The more axons existing, and the better health they possess, the more efficiently impulses are transmitting. The more efficiently impulses are transmitting; the better cognition and overall brain function are.

Myelination

Another way in which NGF enhances cognition is by promoting myelination. Myelin works much like an electrical insulator, raising the speed which impulses progress onward the axons by increasing the electrical resistance of neural cell walls. Furthermore it inhibits the pulse from dissipating the axon. Myelination lays the groundwork for the restoration and regrowth of damaged axons, providing a track along which regrowth occurs. This activity is a crucial process in preserving the brain from the ravages of aging and is useful in the treatment of neurological complications. Some of which are multiple sclerosis and psychiatric disorders including depression, schizophrenia, dementia, as well as autism and Alzheimer’s disease.

Ongoing research hint that NGF production stimulated by Lion’s Mane may have anti-anxiety and mood enhancing effects. Furthermore, it could also facilitate weight-loss by improving metabolism.

[Related: Paul Stamet’s Niacin & Lion’s Mane Nootropic Stack Improved My Cognition & Jiu Jitsu Performance]

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Dosage

How To Take Lion Mane Mushroom?

The lowest effective dosage is 500 mg and the limit per day is 3000 mg. However, higher doses don't necessarily result in more benefits. A 1000 mg dosage once or twice a day is what I find the most beneficial for my needs.

I remember coming across posts on Reddit r/Nootropics where people were going really, really next level megadosing this. None of which reported anything more than a “slight” psychostimulant effect though – I am going to try to find that thread.


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Side Effects

What Are Lion's Mane Mushroom Side Effects?

There are barely any side effects that arise from taking Lion’s Mane. The most common side effect is an itchy skin which is likely due to the increase in Nerve Growth Factor. It most likely is the cause and could be a good sign that NGF levels are increasing.


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Conclusion

Lion's Mane is an exceptional, one of a kind,  organic nootropic that has many health benefits; additional to its nootropic ones. Research and clinical trials support its wide variety of perks. It's a nootropic to consider if you are looking for profound benefits to memory, cognition, detoxification, physical, and brain function. It is one of the few nootropics I have been continuously refilling from the very first use.


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User Experience

An on-going Lion's Mane Mushroom experience thread by Reddit users:

After reading about its memory and nervous system injury healing properties, I figured I'd give it a try. I simply purchased a bottle and take two after putting food in my stomach. Previously I had spent a year on adderall and endured more physical anxiety than I should have had to. I do feel more…evened out, if that makes sense. Less on edge and less anxious than I'd ordinarily be. Still on the lookout for other effects, and still willing to accept it could all be a placebo, but I'm remaining curious.


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Frequently Asked Questions

How do we get the benefits of dried Lion's Mane Mushroom without tasting the bitter water?

In most cultures other than the US, bitter is an acceptable flavor, and nutritionally acceptable. You can explore other cuisines where the line between medicine and food are more blurred. TCM (Traditional Chinese Medicine) frequently uses bitter herbs/mushrooms/etc in a soup, with other ingredients to balance the flavors. In Asian medicine, mushrooms are consumed as food, and as teas, as well as extracts. You could use the mushrooms in a soup where the broth contains the water used for rehydration, you can boil the mushrooms to make a tea or extract and add flavourings to those.

Is Lion's Mane Mushroom sattvic?

Satvik is a living term. This changes according to the situations and purposes. Satvik is something that is pure in purpose. All mushrooms grow in a decaying substrate. They grow in places devoid of sunlight. They are scavenger in nature and feed off the dead substrate. They are normally heavy to digest, cold in nature and increase Kapha according to Charak Samhita. I personally believe that mushroom is not exactly satvik in nature as they grow in a decaying medium. However, as said before, satvik is a contextual term. Satva guna is a state of mind. Basically, food that is earned through pure and righteous means, in a non-violent way, the food that does not cause distress or disgust to anyone and endows not only health but bliss to the soul, mind, and body, is called satvik.

It is important to sustain human life at any cost because human life is the only entrance to the state of salvation. Therefore, any food that helps to sustain life for the evolution of the soul is considered satvik. For example, if there is nothing else to eat, in an area with a sparse availability of vegetables, fruits, and grains, in that case even non-vegetarian food(considered rajasic) can be consumed and will not affect the satvik state of mind. But even vegetarian food that is foul smelling, stale, cooked or earned with an unhappy mind, and unappealing to the tongue is not satvik. Mushroom has a natural tendency to trigger susceptibility towards rhinitis and cause other Kapha related problems. Anything that has a natural tendency to cause harm is not considered satvik. For this reason, also, I think that they should be consumed only when other vegetables are not available or affordable; or consumed once in a while. Otherwise, it is not satvik.

Does eating Lions Mane Mushrooms reverse Alzheimer's?

Lion's Mane promotes NGF which has in test tube experiment generated 60% neurite outgrowth. It human experiments it has notably diminished mild cognitive impairment, the precursor of Alzheimer's dementia. It reduces amyloid-beta production, which form plaques toxic to healthy neurons, due to its anti-inflammatory properties. So far, there are no cures for Alzheimer's disease. Prevention is multifold: a life-style of regular adequate sleep (brain repair time includes clearing debris), both aerobic and weight-bearing exercise (promotes mitochondria synthesis and efficiency), and ideally intermittent fasting (promotes autophagy – the process where cells of the body are forced to use cellular scraps for synthesis of what is needed). Autophagy strategy is extremely effective for long-lived health. As an aside, B12 deficiency can cause dementia as well and can compound vulnerability to Alzheimer's.

Further and Related Readings

  1. Bacopa Monnieri, Melatonin, Ashwagandha
  2. The Ultimate Nootropics FAQ
  3. 6 Best Natural Nootropics

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