Lemon Balm

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Lemon balm, balm, common balm, or balm mint, is a perennial herbaceous plant in the mint family Lamiaceae and native to south-central Europe, the Mediterranean Basin, Iran, and Central Asia, but now naturalized in the Americas and elsewhere. It grows to a maximum height of 70–150 cm. – Wikipedia

Overview

What is Lemon Balm?

Lemon balm (Melissa officinalis) is a lemon-scented herb of the same family as mint. The herb is native to Europe, North Africa, and West Asia but has spread worldwide. Lemon balm improves mood and cognitive function and helps to relieve stress.

It soothes the symptoms of stress, helps you relax, and promotes healthier, happier moods.

A 2004 study found that taking lemon balm relieves the adverse mood effects of psychological stress — participants who took lemon balm reported an increased sense of calmness and a decreased sense of alertness.

Benefits and Effects

What Are Lemon Balm Benefits?

  1. Reduces Anxiety and Stress Levels
  2. Boost Cognitive Function

Lemon balm may also be used to help reduce signs of anxiety, such as nervousness and excitability.

Research published in 2014 looked at the mood and cognitive effects of lemon balm foods. The supplement was mixed with natural or artificial sweeteners into a beverage and yogurt. Participants in both groups reported positive effects on various mood aspects, including reduced levels of anxiety.

The supplement was mixed with natural or artificial sweeteners into a beverage and yogurt. Participants in both groups reported positive effects on various mood aspects, including reduced levels of anxiety. Although this is promising, more research is needed to truly determine its effectiveness.

Dosage

How To Take Lemon Balm?

Initially, take 300mg and see how you react to it. In stressful situations, you may take up to 600mg in a single dose to maximize the potential benefits.

Agmatine Sulfate

Agmatine is an amino acid that offers cognitive boosting benefits. It has excellent effects on reducing neuropathic pain, and drug addiction (repetitive) habits. Its neuroprotectant and can reduce tolerance to medications like benzodiazepines, morphine, and painkillers. Furthermore it synergizes with SSRI's & cannabis.

What is Agmatine Sulfate?

Agmatine is a form of amino acid that derives from L-Arginine. It has been shown to inhibit receptors for the neurotransmitter acetylcholine, which plays a major role in memory and reasoning.

Agmatine supplement also regulates levels of Nitric Oxide by the affecting nitric oxide synthase enzyme. It controls cellular energy levels by influencing polyamine metabolism and function.

In some studies, it has been shown to enhance the effects of both morphine and fentanyl to increase pain killing, reduce tolerance, and lower addiction, as well as working synergistically with marijuana.

It is also found naturally in every day foods, including beer, wine, coffee, and other fermented foods.

Because it is capable of targeting multiple receptors, agmatine may benefit a spectrum of complex diseases, including diabetes, Alzheimer’s disease, opioid addiction, mood disorders, and even cancer. Furthermore, agmatine may enhance cognitive function, stress resiliency, mood, and athletic performance. The highest levels of agmatine are found in the gut, where it is produced by the microbes living there. It is also found in dietary form, mainly in fermented foods, and in supplemental form like agmatine sulfate. Agmatine is also produced in small amounts within the body by the mitochondria in the liver.

What Are Agmatine Sulfate Benefits?

  • Reduces Pain Sensitivity
  • Reduces Symptoms of Anxiety & Depression
  • Neuroprotection & Longevity
  • Improves Weight Loss & Prevents Weight Gain
  • Supports Muscle Growth
  • Helps Erectile Dysfunction & Infertility
  • Help with Alzheimer's Disease
  • Helps Alcohol & Morphine Withdrawal
  •  

Supporting research:

Reduces Pain Sensitivity

In research studies, Agmatine shows to be an effective way for pain relief. Especially in the case of thermal hyperalgesia, a condition where the body is sensitive to changes in temperatures. The body becomes hypersensitive to heat or cold. Agmatine improves those pain sensations, which is a result of its pro-circulations effect. In studies looking at pain reduction in neuropathic conditions or inflammatory pain, agmatine was not found to produce a statistically significant effect. However, anecdotal, first-hand reports show that it actually did work for neuropathic conditions. So in this specific situation, it seems to be subjective to each individual.

Reduces Symptoms of Anxiety and Depression

Agmatine exhibits antidepressant effects and promotes mood improvement as well as anxiety reduction and relief. It helps the brain and body manage and overcome stress by reducing anxiety and promoting a sense of well-being. By increasing NRF2, agmatine prevents depressive behavior by protecting brain cells from high levels of stress hormone cortisol. [R] Agmatine increases adenylate cyclase in the prefrontal cortex, and decreases levels of adenylate cyclase which associate with depression. [RR]. Furthermore, it blocks the NMDA receptor, prevents calcium overloading, as well as reverses the decrease of monoamines such as norepinephrine, epinephrine, and dopamine. Depression often associates with a reduction of monoamines in the brain [RR]
Studies and Research
A small pilot study on three patients suffering depression, Agmatine supplement caused a complete disappearance of depression symptoms in all patients. It most likely did so through NMDA receptor-blocking and not through serotonin pathways. [R] Agmatine also reduced anxiety in rats when they were put in swimming and maze navigation tests. [R]

Neuroprotection and Longevity

Agmatine acts as an anti-oxidant and is continuously under more research for its anti-aging and longevity potential. It has been found to exhibit neuroprotective effects against oxidative damage and injuries to the Central Nervous System (CNS). It is also believed to limit the activity of glutamate receptors and thus, the over-excitation of neurons within the brain. Additionally, by inhibiting iNOS and nNOS and increasing eNOS, Agmatine protects against brain damage from stroke. Increasing eNOS protects the brain by dilating the blood vessels to increase blood flow. This prevents damage during times of lack of oxygen from reduced blood flow to the brain (also known as ischemic stroke). Agmatine decreases iNOS and nNOS, two enzymes that contribute to brain damage from stroke. [R]
Study on Effects of Agmatine Sulfate on Nerve Injury

 

  • OBJECTIVE: Evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.

 

  • METHODS: The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.

 

  • RESULTS: Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004).

 

  • CONCLUSION: Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration.
 

 PMID: 28122652

Improves Weight Loss and Prevents Weight Gain

Individuals who struggle to gain weight can benefit from Agmatine supplements. In some studies, subjects increased food consumption rates by 44% to 54% in 24 hours. Moreover, in the following studies, Agmatine shows an increase in fat burning, a decrease in fat composition, and an increase in muscle mass [R], which also contributes to the next benefit of Agmatine:

Supports Muscle Growth

Agmatine stimulates the production of luteinizing hormone (LH). Increasing these hormone levels lead to an increase in testosterone levels. By increasing testosterone levels, Agmatine contributes to an optimal hormonal environment for muscle growth, enhances athletic performance, and fastens recovery. [R] Agmatine also increases insulin sensitivity and the uptake of glucose into the muscle. Increasing insulin sensitivity results in more effective shuttling of amino acids as well as glucose into the tissues for growth and repair. [R] [R]

Helps Erectile Dysfunction (ED) and Infertility

Studies show that L-arginine is involved in the process of cell replication, in addition to enhancing blood circulation, so it can help improve both sperm production and motility. Men dealing with cardiovascular issues due to low levels of NO in the blood are more prone to experience erectile dysfunction and fertility problems because an erection requires a relaxation of smooth muscles, which Nitric Oxide triggers. Although it doesn't apply to every person, a significant rate of male infertility cases (92%) is treatable with L-arginine supplements in combination with dilators, antioxidants and/or anti-inflammatories. [R] Research suggests that high-stress levels lower L-arginine levels in the sperm production pathway. Therefore, men with chronic stress specifically can benefit from Agmatine supplement. According to Dr. Axe, a combination of L-arginine, L-glutamate and yohimbine hydrochloride is a common way of treating erectile dysfunction. And it works better than L-arginine alone. [R] “In fact,” he says, “many of the most frequently prescribed medications for ED work similarly to L-arginine: by increasing nitric oxide production.” Furthermore, there’s research suggesting treatment with N-Acetyl Cysteine (NAC) and L-arginine together can help balance hormones naturally and restore normal sexual function in women with polycystic ovary syndrome and estrogen imbalances. Other studies suggest that L-arginine with herbs such as chasteberry, green tea extract, and antioxidant supplements improve pregnancy rates in women struggling to conceive. [R]

Help with Alzheimer's Disease

Insulin resistance could cause an increase of plaque and neurofibrillary tangles in the brain, which are the signs of Alzheimer’s disease. Agmatine prevents cognitive decline by rescuing insulin signaling and avoiding potential accumulation of those tangles. [R]

Helps Alcohol & Morphine Withdrawal

Agmatine reduces and to an extent, prevents, symptoms of alcohol withdrawal such as “wet dog shakes,” anxiety, flashes, and shakings. [R] [R]

How Does Agmatine Sulfate Work?

Agmatine has several mechanisms. It can inhibit N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors, as well as activate imidazoline receptors. Agmatine can also inhibit nitric oxide synthase enzymes, which allows it to regulate elevated levels of nitric oxide. Agmatine can inhibit calcium channels and specific serotonin receptors as well. Further research is needed to determine the full extent of agmatine mechanisms. [R] Agmatine was found to exert modulatory actions directly and indirectly at multiple key molecular targets underlying cellular control mechanisms of cardinal importance in health and disease. It is considered capable of exerting its modulatory actions simultaneously at multiple targets. The following outline indicates the categories of control mechanisms and identifies their molecular targets:
Agmatine sulfate
Agmatine Sulfate Skeletal Structure
Neurotransmitter receptors and receptor ionophores. Nicotinic, imidazoline I1 and I2, α2-adrenergic, glutamate NMDAr, and serotonin 5-HT2A and 5HT-3 receptors. Ion channels. Including: ATP-sensitive K+ channels, voltage-gated Ca2+ channels, and acid-sensing ion channels (ASICs). Membrane transporters. Agmatine specific-selective uptake sites, organic cation transporters (mostly OCT2 subtype), extraneuronal monoamine transporters (ENT), polyamine transporters, and mitochondrial agmatine specific-selective transport system. Nitric oxide (NO) synthesis modulation. Both differential inhibition and activation of NO synthase (NOS) isoforms is reported. Polyamine metabolism. Agmatine is a precursor for polyamine synthesis, competitive inhibitor of polyamine transport, inducer of spermidine/spermine acetyltransferase (SSAT), and inducer of antizyme. Protein ADP-ribosylation. Inhibition of protein arginine ADP-ribosylation. Matrix metalloproteinases (MMPs). Indirect down-regulation of the enzymes MMP 2 and 9. Advanced glycation end product (AGE) formation. Direct blockade of AGEs formation. NADPH oxidase. Activation of the enzyme leading to H2O2 production.  – Wikipedia

How to Take Agmatine Sulfate?

There is currently no standard dosage for agmatine sulfate because there haven’t been enough human studies for determination. These numbers are rough estimates to give an idea of typical, experimental dosing:

For treatment of neuropathic pain: 1,000 to 2,500 mg of agmatine (daily)

For improving cognitive function: 200 to 500 mg of agmatine (daily)

For vasodilation and enhanced recovery: 500 to 1000 mg of agmatine (30 minutes pre-workout)

Note: Agmatine is not absorbed well when taken with dietary protein, because it uses the same transporters as arginine

Quoting Examine;

“There are no standard dosages for agmatine because of the lack of human evidence for its effects. However, a single human study used 1,300-2,670mg of agmatine, daily for the treatment of neuropathic pain. The estimated human dose for improving cognition is 1.6-6.4mg/kg of agmatine, taken orally.

This is based off of the 10-40mg/kg dosage range for rats, and is equivalent to 217-435 mg for a 150lb person. Supplementation should not exceed 6.4mg/kg of bodyweight. Studies on agmatine use a daily dosing protocol.

Agmatine is not absorbed well when taken with dietary protein, because it uses the same transporters as arginine. Further research is needed to determine if oral agmatine supplementation provides the same benefits as were observed in animal studies.”

“The generally accepted daily dosage range for Agmatine Sulfate is between 250 mg and 2.5 grams. Avoid taking higher than necessary dosages to reduce the risk of side effects.”

What Are Agmatine Sulfate Side Effects?

According to studies conducted so far, it appears that Agmatine Sulfate is safe even in relatively high doses. While there have been few studies conducted thus far, they have not shown any side effects to be associated with this supplement. If you follow the recommended Agmatine sulfate dosage protocol and do not have any pre-existing contraindications for use, the risk of serious adverse effects is very low. Minor side effects included nausea, diarrhea, and vomiting in a small percentage of participants, which cleared up after a few days of discontinuing use. [R]

Reddit

“Not only does it have varied anti-addiction properties to Opioids, amphetamines, caffeine, nicotine & alcohol, but it also seems to make other drugs, and medicines more potent in their effects. It also shares the properties of Ketamine's antidepressant effects, via the mTOR AMPA pathway. A small study found a robust antidepressant effect; all patients reported remission of depression. Considering that, shutting down Serotonin production via parachlorophenylalanine, did not reverse the antidepressant effects, shows how punchy this substance is. It's also a painkiller. I'd recommend this be added to everyone's stack, provided they aren't too fond of Alcohol, as I noticed it definitely seems to blunt the good feelings of certain drugs.” [Ref]

Agmatine Sulfate is a biogenic amine that is derived from the amino acid L-Arginine. This happens by a process called decarboxylation, which is better known as the removal of carboxylic acid group from the amino acid. 

Yes. And here is a 5 year-long, daily high dosage of Agmatine in order to measure and proof its safety: Clinical follow-up consists of periodic physical examinations and laboratory blood and urine analyses. All measurements thus far remain within normal values and good general health status is sustained throughout the study period, up to 5 years.

Agmatine starts working as soon as it enters the bloodstream, which is typically 15 – 30 minutes after consumption. Users can expect to experience an increase in muscle pumps, vascularity and muscular endurance within this timeframe. 

The generally accepted daily dosage range for Agmatine Sulfate is between 250 mg and 2.5 grams. Avoid taking higher than necessary dosages to reduce the risk of side effects.

This is the reason creatine and protein work so well together, in a nutshell. Bodybuilders can cut out the creatine middle man by supplementing with agmatine sulfate directly. … You take creatine to improve the protein effects. You take nitric oxide to improve the creatine effects.

You can buy Agmatine Sulfate 250mg Capsules as well as many other nootropics in Dubai from the shop page.

Ashwagandha

Ashwagandha is a powerful and popular natural nootropic offering many health benefits. Especially on its ability to eliminates stress, anxiety, and reducing depression symptoms. It boosts testosterone levels, supports muscle mass, reduces body fat and increases strength and performance.

What is Ashwagandha?

Ashwagandha (also known as Withania somnifera) is an excellent herb in Ayurvedic medicine. It has become a popular nootropic due to its multiple health benefits.

It is able to eliminate stress and anxiety. And research suggests it also helps in improving depression symptoms.

It also increases testosterone levels and significantly boosts sperm quality and fertility in men. Furthermore, it increases muscle mass, reduces body fat and increases strength.

Current users are rediscovering the traditional herb as a valuable brain-booster that improves cognition by combating the impacts of stress and helping mood enhancement.

Recent research confirms it as a promising adaptogen helping prevent the consequences of recurring anxiety.

Users find that it's also a powerful anxiolytic; reducing stress and thereby enhances mood, decreases restlessness, insomnia, and sleep issues alike.

Withania somnifera, known commonly as ashwagandha, Indian ginseng, poison gooseberry, or winter cherry is a plant in the Solanaceae or nightshade family. – Wikipedia

Ashwagandha is a herb that belongs to the night shade family of plants. The nightshade family of plants is a very interesting one and includes a lot of vegetables that make up large parts of many diets. Notable nightshade members are potatoes, tomatoes, chili peppers, goji berries and even tobacco! Another name for the nightshade family is Solanaceae. 

This is where Ashwagandha gets its Latin name from; Withania somnifera. Ashwagandha is a short perennial shrub, with a large root system that develops small deep orange fruits. The fruits resemble a small cherry and the leaves look frosty due to the many tiny hairs that are on them. This one of the reasons why Ashwagandha is also referred to as ‘winter cherry’. 

Traditionally, the Ashwagandha root is used, however new research has found high concentrations of key components in the leaves too. 

Various manufacturers have taken notice of this. One of the most notable being Natreon who produce a specialized extract of Ashwagandha called Sensoril. 

Sensoril is made from the leaves of Ashwagandha, giving it a unique chemical composition, which produces noticeable calming effects.

Sensoril Ashwagandha

Sensoril Ashwagandha is standardized to 10% glyco withanolides making it a potent and calming extract. Sensoril is made from a blend of Ashwagandha root and leave extracts, which is part of the reason why it is so potent. Sensoril is best taken during periods of high stress, or to help enhance sleep quality.

Ashwagandha KSM-66

Ashwagandha KSM-66 is extracted using milk. Traditionally, Ashwagandha root powder is mixed with milk to enhance absorption, and thus  Ixoreal Bioscience decided to use milk as its extraction solvent. The end result is an Ashwagandha root only extract that is very well balanced. Effect-wise, KSM-66 is very uplifting and can help support healthy stress levels.

Basic Ashwagandha

Basic Ashwagandha is made from both Ashwagandha root and leaves, and is standardized to 4-5% withanolides. Effects wise, it appears to be a perfect blend of both KSM-66 and Sensoril. This Ashwagandha extract is uplifting and calming without being too calming or too energizing. Many people tend to prefer this Ashwagandha extract because it is so well balanced. In a blind test we did around the office, a vast majority of us preferred the regular Ashwagandha. However, if you are looking for specific effects, such as an extract that is very calming or an extract that is very uplifting, then this is not the Ashwagandha extract for you. – Nootropics Depot

What Are Ashwagandha Benefits?

  • Reduces Anxiety and Improves Depression
  • Reduces Cortisol Levels
  • Improves Cognitive Function
  • Reduces Arthritis Symptoms
  • Reverses Deficits Pathology in Alzheimer’s Disease
  • Helps in Weight Loss and Weight Control
  • Improves Muscle Strength
  • Treats Male Sexual Dysfunction
  • Decreases Blood Pressure
  • Combats Chemotherapy Fatigue
  • Rejuvenation and Overall Health Improvement

 

Supporting research:

Reduces Anxiety and Depression

Ashwagandha is best known for its ability to fight stress and to ease different types of anxieties (R) by eliminating stressors. It serves the body's overall health, and empowers the immune system. Thereby preventing the damage of excessive cortisol. It enhances mood, sense of well-being, and all-around cognition.

Clinical trials verify Ashwagandha possess robust anxiety relief capabilities. As well as reducing symptoms of generalized & social anxiety.  Particularly useful for those suffering chronic stress (R).

Another study further reveals its potential as a treatment for mild depression and panic disorder (R).

Reduces Cortisol Levels

A 60-day regimen of Ashwagandha seems to efficiently decrease levels of serum cortisol in individuals with chronic stress. The finding is significant because high cortisol levels lead to health complications. Those range from immune system weakness to bone density. In many cases it further extends to weight gain, high blood pressure, and heart disease.

Improves Cognitive Function

Studies on Ashwagandha enhancing memory and intelligence are few. However, at the same time, studies are confirming that anxiety is a significant cause of cognitive decline, impairing memory and attentiveness. Stress deregulates the body and brain natural processes. Normalizing those functions is, therefore, the critical element to restoring optimal cognition (R).

Individuals who frequently worry, stress out, or suffer from depression are the ones to benefit most from Ashwagandha.

Reduces Arthritis Symptoms

A 2015 Indian study comprising more than 100 patients with rheumatoid arthritis showed that after using Ashwagandha for several weeks, more than half those participants had a notable reduction in arthritic symptoms, including pain, movement difficulties, sore and swollen joints. (R)

Reverses Deficits Pathology in Alzheimer’s Disease

Alzheimer's is the continuous impairing in memory and cognitive functions. After a 30-day course treatment using Ashwagandha, a complete reverse of the behavioral deficits is marked. This result shows how ashwagandha reverses the behavior of Alzheimer’s disease. It is achievable by the improvement of low-density lipoprotein protein in liver. (R)

Helps in Weight Loss and Weight Control

A study of 52 people diagnosed with chronic stress revealed that two daily doses of 300 mg of Ashwagandha resulted in a significant reduction in stress and food cravings, along with a decrease in serum cortisol and body mass. (R)

Improves Muscle Strength

A series of studies on healthy men reveal that using 300 mg to 1250 mg of Ashwagandha on a daily basis show a measurable increase in muscle strength and intensity. In comparison to participants receiving a placebo, those on the Ashwagandha were able to increase their bench press and leg extension. Moreover, notable increases in muscle mass, testosterone, and muscle recovery. (R)

Treats Male Sexual Dysfunction

A pilot study of 46 men suffering weak sperm production found a remarkable result when using 675 mg of Ashwagandha daily for two weeks. Another finding from that clinical trial is an impressive rise of 167% in sperm count, a 53% rise in semen mass, and a 57% rise in sperm fluidity. Animal studies similarly confirm Ashwagandha enhance sexual performance, improve testicular sperm production, and boost serum testosterone levels. [R]

Decreases Blood Pressure

Studies indicate that Ashwagandha leads to a measurable decrease in blood pressure. In research involving 100 participants using Ashwagandha for about six months, an average 1.6% decrease in systolic pressure and 5.6% decline in diastolic pressure is witnessed, along with a minor reduction in heart rate.

Combats Chemotherapy Fatigue

A 2013 trial involving more than 100 breast cancer individuals in all stages of the disease revealed that Ashwagandha efficiently reduced fatigue and weakness caused by chemotherapy. It also enhanced the quality of living. Even though it is not a treatment for cancer, it is a genuinely useful addition to the therapy for cancer patients. [R]

Rejuvenation and Overall Health Improvement

A comprehensive analysis of studies, data, and research on Ashwagandha confirm that it provides a variety of therapeutic effects without toxicity. The review concludes that Ashwagandha possesses anti-inflammatory, anti-tumor, anti-stress, antioxidant, immunomodulatory, and rejuvenating qualities. It can exert a positive impact on the central nervous system. [R]

How Ashwagandha Works

The exact mechanisms by which Ashwagandha works remain non-entirely understood, but it appears that the active components are alkaloids and steroidal lactones that are collectively known as withanolides.

It is this combination of elements that are thought to have the potential for physiological action.

Effect on GABA

One of the acknowledged mechanisms of the withanolide components of Ashwagandha is the modulation of circulating levels of MAO and GABA in the cerebellum. GABA is an amino that acts as an inhibitory neurotransmitter, countering to some extent the effects of the stimulatory neurotransmitter glutamate and therefore helping as a natural tranquilizer. Animal studies show that Ashwagandha further indicates GABA-like attributes and improves calmness without producing drowsiness. It has also been revealed to possess anti-depressant effects (R). It appears to work exceptionally well in combination with  SSRIs for compulsion-related mental disorders. As well as with GABAergic anxiolytics, including alcohol.

As An Antioxidant

The active withanolides in Ashwagandha are also thought to produce stable antioxidant properties, which makes them a helpful brain protectant. Antioxidants are chemical molecules that restrict conceivably damaging oxidizing causes from harming cells in the cerebellum and body. Cells remained influenced by oxidation can convert to free radicals, particles that harm circling cells. The free radicals triggers a series response of cellular damage that affects the aging process and a variety of complications.

As An Anti-inflammatory

Ashwagandha seems to be a powerful anti-inflammation tool. Inflammation is a response of the body’s immune system; however, when the immune system is pushed to overactivity, inflammation converts into a health obstacle. Inflammation is correlating with a variety of disorders. From arthritis and joint discomfort to obesity, heart disease, fatigue, blood vessel damage, and even cancer. The anti-inflammatory attributes of Ashwagandha are at the core of many of its benefits. That includes shielding as well as enriching the immune system. Furthermore enhancing memory, improving the learning experience and reaction time, and preventing brain cell degeneration.

On Dendrite Development

Ashwagandha promotes the development of dendrites, branching neuronal extensions that carry and generate electrochemical stimulation from cell to cell. Increasing dendrite development is a marker of connectivity improvement in the cerebellum.

How To Take Ashwagandha?

Typically, Ashwagandha dose ranges between 300 mg to 600 mg as the highest. Its not advisable to take more than 600mg when using on daily basis.

Take Ashwagandha with food and divide into two doses per day. If you prefer once a day, do so in the morning after breakfast.

It is not-advisable to use Ashwagandha in combination with JK inhibitors or MAO inhibitors.

There is not one universal Ashwagandha dosage due to the different levels of standardization. However, in general, an Ashwagandha powder extract dosage is going to be around 300-500 mg. This general Ashwagandha dosage falls in line with the various extracts we carry. For example, the Ashwagandha dosage for KSM-66 is 300 mg and the Ashwagandha dosage for our basic Ashwagandha powder extract is 500 mg. The Ashwagandha dosage for Sensoril is a little bit of an outlier, at 125 mg, but this is due to the fact that it is such a potent extract. – Nootropics Depot

What Are Ashwagandha Side Effects?

The most common side effects of Ashwagandha include:

  • Indigestion
  • Diarrhea
  • Gastric discomfort
  • Drowsiness

 

Ashwagandha is safe and digests well in reasonable doses. No severe side effects report using high doses over a short period. These side effects are brief; if they grow in severity or persist over a long time, discontinue using it and seek medical advice.

Ashwagandha is both a potent adaptogen that supports the brain and body in handling and managing stress. It's a safe, well-tolerated anxiolytic proven to relief anxiety.

In addition to mood enhancement, it assists in regulating the sleep cycle, and improve memory. It further increases brain signaling by promoting neuronal vitality. It is efficient and with no record of severe side effects or toxicity; all while at an affordable price. This makes it a very worthwhile nootropic.

Reddit

“Ashwaganda seems to have reduced my social anxiety. In a v subtle way as well – I don’t find Ashwaganda mood altering, it’s rather there’s just an absence of anxiety. So subtle I only reflected on it & then realised I’d had reduced social anxiety. I’m using KSM 66 & using a high dose – 600mg/day.”

Nootropics Depot

“This was my first experience with Ashw. and it has been an excellent one. I take it before bedtime and it provides me with a better night of REM sleep, including dreams that are sometimes extremely involved. I love the stuff and have recommended it to my coworkers who have sleep difficulties.”

“I've tried all three versions of ashwagandha that ND sells, and this is my favorite. It just also happens to be the cheapest! Sensoril is great for bed, but makes me sleepy during the day. KSM 66 works well during the day, but isn't as calming as I would like. This version provides that nice balance between them.“

Benefits:

  • Reduces Anxiety and Improves Depression Symptoms
  • Reduces Cortisol Levels
  • Improves Cognitive Function
  • Reduces Arthritis Symptoms
  • Reverses Deficits Pathology in Alzheimer’s Disease
  • Helps in Weight Loss and Weight Management
  • Improves Muscle Strength
  • Treats Male Sexual Dysfunction
  • Decreases Blood Pressure
  • Combats Chemotherapy Fatigue
  • Rejuvenation and Overall Health Improvement

 

Side effects of Ashwagandha (although not necessarily):

  • Indigestion
  • Diarrhea
  • Gastric discomfort
  • Drowsiness

Ashwagandha leaf extract helps to manage your weight by lowering the level of stress hormones called Cortisol. Elevated cortisol levels increase hunger and craving for sweets, fried food, and soft drinks. These cravings result in increased calorie consumption leading to weight gain. Ashwagandha reduces the level of cortisol and decreases stress-induced cravings. This helps in better weight management. Tip: Take Ashwagandha leaf extract in churna form. Take 1-2gm churna twice a day with lukewarm water after taking a light meal.

It can be consumed regularly for months because of its health benefits. It helps gaining weight to o if consumed with milk at night..but as too much of anything can also be dangerous so one should consume in restricted quantity.

You can buy Ashwagandha KSM-66 as well as many other nootropics in Dubai by going to the shop page.

Clonazepam

Pending review. Contribute to this article.

clonazepam chemical structure klompin nootropics information nootro.info
Clonzepam Chemical Structure


Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between 6 and 12 hours.

Common side effects include sleepiness, poor coordination, and agitation. Long-term use may result in tolerance, dependence, and withdrawal symptoms if stopped abruptly. Dependence occurs in one-third of people who take clonazepam for longer than four weeks. There is an increased risk of suicide, particularly in people who are already depressed. If used during pregnancy it may result in harm to the baby. Clonazepam binds to GABAA receptors, thus increasing the effect of the chief inhibitory neurotransmitter γ-aminobutyric acid (GABA).

Clonazepam was patented in 1960 and went on sale in 1975 in the United States from Roche. It is available as a generic medication. The wholesale cost in the developing world is between US$0.01 and US$0.07 per pill. In the United States, the pills are about US$0.40 each. In 2016 it was the 42nd most prescribed medication in the United States with more than 18 million prescriptions. In many areas of the world it is commonly used as a recreational drug.

Protracted withdrawal

Protracted withdrawal applies to signs that linger until the end of acute withdrawal. Patients who have abused Klonopin and have taken very high doses of the medication that experience longer withdrawal times.

Individuals may feel a general malaise, cravings, anxiety, depressive symptoms. Some somatic symptoms, such as nausea, lightheadedness, headache, mild fever or chills, and so on, may continue to occur. A further period of rebound anxiety may also occur near the end of this stage.

There is a portion of the literature on opioid withdrawal in general, including Klonopin and other benzodiazepines, which explains the third phase of withdrawal, which consists mostly of psychological symptoms such as mood swings, periods of irritability, periods of anhedonia (difficulty feeling pleasure) and depressive symptoms that tend to occur in the body. This post-acute withdrawal syndrome (PAWS) is not generally recognized as a stage of withdrawal by other experts, nor is it officially mentioned in the Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association; however, it is acknowledged as valid by some individuals in the field of addiction.

This is suggested that people who do not have PAWS symptoms treated are at higher risk of relapse.

Medications used to help in the removal of Klonopin

Withdrawal from benzodiazepine, such as Klonopin, can be potentially dangerous due to the possibility of seizures (though this possibility is rare).

As a consequence, therapeutic detoxification is often necessary for the removal of benzodiazepine. Several medications can be used to assist with the withdrawal process, including:

  • Selective serotonin reuptake inhibitors, such as Paxil and Prozac, can be useful in treating some of the effects of Klonopin withdrawal.

When a patient has complications such as seizures, doctors may use anticonvulsant drugs (e.g., Tegretol or carbamazepine to manage seizures).

Some of these anticonvulsants can also aid with the withdrawal process linked to the discontinuation of Klonopin.

The melatonin hormone has been beneficial in helping individuals who experience insomnia during the withdrawal process.

Melatonin is a hormone that causes sleep. Many signs of Klonopin withdrawal and reversal of tolerance can also be treated.

Any number of medications can be used to treat particular symptoms during the withdrawal period.

Research suggests that the most successful way of controlling withdrawal from benzodiazepines, such as Klonopin, is to implement a tapering mechanism where the patient in withdrawal continues to obtain progressively smaller doses of the medication before the formal withdrawal.

Beyond Detox

After an individual is considered to be physically stable, the emotional side effects of withdrawal are discussed more thoroughly.

Cognitive Behavioral Therapy ( CBT) and Motivational Interview (MI) are two types of therapy that can be used during benzodiazepine addiction care.

Individuals also attend both group and individual CBT sessions, which can often include research and instructional sessions aimed at discovering the root of addiction and preventing potential stressors and causes in the potential.

MI can help increase the level of internal motivation of an individual by offering rewards for clean drug testing. Peer and family support networks are also essential components of a holistic system for treating opioid addiction.

Care standards can change during withdrawal as the individual needs and circumstances change.
Relapse is typical in individuals who are addicted to benzodiazepines and are particularly dangerous after detoxification.

Someone who has been used to using drugs at a certain amount, but has not used them for a while, and then returns to previous rates of use, may end up suffering from a fatal overdose.
The National Institute for Drug Abuse ( NIDA) registered a fourfold rise in benzodiazepine overdose deaths from 2001-13 to almost 7,000 deaths in 2013.

A relapse may occur as someone tries to self-medicate what may be uncomfortable symptoms of withdrawal.

Therapy and psychological help during benzodiazepine withdrawal are essential to reduce and prevent future relapse and avoid catastrophic consequences.

Clonazepam withdrawal is best handled by incorporating both pharmacological and clinical approaches, beginning with natural detoxification.

 

Mirtazapine

Mirtazapine, sold under the brand name Remeron among others, is an antidepressant primarily used to treat depression. Its full effect may take more than four weeks to occur, with some benefit possibly as early as one to two weeks. Often it is used in depression complicated by anxiety or trouble sleeping. It is taken by mouth.

Common side effects include increased weight, sleepiness, and dizziness. Serious side effects may include mania, low white blood count, and increased suicide among children. Withdrawal symptoms may occur with stopping. It is not recommended together with an MAO inhibitor. It is unclear if use during pregnancy is safe. How it works is not clear, but it may involve blocking certain adrenergic and serotonin receptors. Chemically, it is a tetracyclic antidepressant (TeCA). It also has strong antihistamine effects.

Mirtazapine came into medical use in the United States in 1996. The patent expired in 2004, and generic versions are available. In the United States the wholesale cost as of 2018 is about US$3 per month. In the United Kingdom a month supply costs less than £20 per month.[11] In the United States about 5.5 million prescriptions were written for mirtazapine in 2016.

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Pregabalin

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Pregabalin, marketed under the brand name Lyrica among others, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, and generalized anxiety disorder. Its use in epilepsy is as an add-on therapy for partial seizures. When used before surgery, it reduces pain but results in greater sedation and visual disturbances. It is taken by mouth.

Common side effects include headache, dizziness, sleepiness, confusion, trouble with memory, poor coordination, dry mouth, problem with vision, and weight gain. Serious side effects may include angioedema, drug misuse, and an increased suicide risk. When pregabalin is taken at high doses over a long period of time, addiction may occur, but if taken at usual doses the risk is low. Use during pregnancy or breastfeeding is of unclear safety. Pregabalin is a gabapentinoid and acts by inhibiting certain calcium channels.

Pregabalin was approved for medical use in the United States in 2004. It was developed as a successor to gabapentin. It is available as a generic medication in a number of countries, including the United States as of 2019. In the US the wholesale costs is about US$450 per month as of July 2019. While in the United Kingdom a similar dose costs the NHS about £6. In 2016, it was the 83rd most prescribed medication in the United States with more than 9 million prescriptions. In the US, Pregabalin is a Schedule V controlled substance under the Controlled Substances Act of 1970.


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Diazepam

Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that typically produces a calming effect. It is commonly used to treat a range of conditions, including anxiety, alcohol withdrawal syndrome, benzodiazepine withdrawal syndrome, muscle spasms, seizures, trouble sleeping, and restless legs syndrome. It may also be used to cause memory loss during certain medical procedures. It can be taken by mouth, inserted into the rectum, injected into muscle, or injected into a vein. When given into a vein, effects begin in one to five minutes and last up to an hour. By mouth, effects may take 40 minutes to begin.

Common side effects include sleepiness and trouble with coordination. Serious side effects are rare. They include suicide, decreased breathing, and an increased risk of seizures if used too frequently in those with epilepsy. Occasionally excitement or agitation may occur. Long term use can result in tolerance, dependence, and withdrawal symptoms on dose reduction. Abrupt stopping after long-term use can be potentially dangerous. After stopping, cognitive problems may persist for six months or longer. It is not recommended during pregnancy or breastfeeding. Its mechanism of action is by increasing the effect of the neurotransmitter gamma-aminobutyric acid (GABA).

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Propranolol

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Propranolol, sold under the brand name Inderal among others, is a medication of the beta blocker class. It is used to treat high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors. It is used to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks. It can be taken by mouth or by injection into a vein. The formulation that is taken by mouth comes in short-acting and long-acting versions. Propranolol appears in the blood after 30 minutes and has a maximum effect between 60 and 90 minutes when taken by mouth.

Common side effects include nausea, abdominal pain, and constipation. It should not be used in those with an already slow heart rate and most of those with heart failure. Quickly stopping the medication in those with coronary artery disease may worsen symptoms. It may worsen the symptoms of asthma. Caution is recommended in those with liver or kidney problems. Propranolol may cause harmful effects in the baby if taken during pregnancy. Its use during breastfeeding is probably safe, but the baby should be monitored for side effects. It is a non-selective beta blocker which works by blocking β-adrenergic receptors.

Propranolol was patented in 1962 and approved for medical use in 1964. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Propranolol is available as a generic medication. The wholesale cost in the developing world is between US$0.24 and US$2.16 per month as of 2014. In the United States it costs about $15 per month at a typical dose. In 2016 it was the 43rd most prescribed medication in the United States with more than 18 million prescriptions.


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Effexor

Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. It is used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, and social phobia. It is taken by mouth.

Common side effects include loss of appetite, constipation, dry mouth, dizziness, sweating, and sexual problems. Severe side effects include an increased risk of suicide, mania, and serotonin syndrome. Antidepressant withdrawal syndrome may occur if stopped. There are concerns that use during the later part of pregnancy can harm the baby. How it works is not entirely clear but it is believed to involve alterations in neurotransmitters in the brain.

Venlafaxine was approved for medical use in the United States in 1993. It is available as a generic medication. In the United States the wholesale cost per dose is less than US$0.20 as of 2018. In 2016 it was the 51st most prescribed medication in the United States with more than 15 million prescriptions.

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Alprazolam (Xanax)

Alprazolam, sold under the trade name Xanax among others, is a short-acting benzodiazepine. It is most commonly used in short term management of anxiety disorders, specifically panic disorder or generalized anxiety disorder (GAD). Other uses include chemotherapy-induced nausea, together with other treatments. GAD improvement occurs generally within a week. Alprazolam is available by mouth.

Common side effects include sleepiness, depression, headaches, feeling tired, dry mouth, and memory problems. Some of the sedation and tiredness may improve within a few days. Due to concerns about misuse, some do not recommend alprazolam as an initial treatment for panic disorder. Withdrawal or rebound symptoms may occur if use is suddenly decreased. Other rare risks include suicide, possibly due to loss of inhibition. Gradually decreasing the dose over weeks or months may be required. Alprazolam, like other benzodiazepines, acts through the GABAA receptor.

Alprazolam was patented in 1971 and approved for medical use in the United States in 1981. Alprazolam is a Schedule IV controlled substance and is a common drug of abuse. It is available as a generic medication. The wholesale cost in the United States is less than US$0.03 per dose as of 2018. In 2016, it was the 19th most prescribed medication in the United States, with more than 27 million prescriptions.

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