Anxiety

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Tianeptine is a potent mood brightener and a nootropic, cherished for its effects on wellbeing and cognition, providing immediate and also extended term benefits. Within an hour of use, it gives mental stability and clarity, functioning as a medium duration productivity tool. Additionally, its beneficial effects compound over extended use, resulting in a long-term impact which reduces feelings of stress, sadness, and anxiety.

What is Tianeptine?

Tianeptine, sold under the brand names Stablon and Coaxial among others, is an atypical antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. Tianeptine has antidepressant and anxiolytic effects with a relative lack of sedative, anticholinergic, and cardiovascular side effects.

It has been found to act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors.[16] μ-Opioid receptor agonists typically induce euphoria, as does Tianeptine at high doses well above the usual therapeutic range. There are concerns about the potential for abuse.

Tianeptine was discovered and patented by the French Society of Medical Research in the 1960s. Currently, Tianeptine is approved in France and manufactured and marketed by Laboratories Servier SA; it is also sold in a number of other European countries under the trade name Coaxial as well as in Asia (including Singapore) and Latin America as Stablon and Tatinol, but it is not available in Australia, Canada, New Zealand, the United Kingdom, or the United States.

Depression

Tianeptine was as effective as several classical antidepressants in patients with major depression, dysthymia, or adjustment disorder. Also, extended treatment with Tianeptine decreased the incidence of relapse/recurrence of depression.

In an open, non-comparative clinical study in patients with Parkinsons’ disease (PD), Tianeptine decreased the severity of depression and also improved the quality of life in these patients.

Anxiety, Stress, and PTSD Symptoms

In elderly depressive patients, a drug regimen of Tianeptine or escitalopram improved anxiety symptoms and subjective and objective neurocognitive functions.

In panic disorder patients tianeptine appeared to reduce their reaction to panic challenge.

Benefits Memory and Learning

Anti-inflammatory Effects

Pain Relief

Irritable Bowel Syndrome

Mechanism of Action

Dosage

The usual dosage is 12mg 3x a day for a healthy weight individual, but some people go up to 25mg at a time.


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Side Effects

Tianeptine’s side-effects are similar to the side-effects of other SSRI’s. These include nausea, constipation, abdominal pain, headaches, dizziness, and changes in dreaming.

Older patients should take a smaller dosage of Tianeptine, as should patients with renal failure.

Dosage does not need to be adjusted in patients with alcoholism or hepatic impairment, or patients on dialysis.

Tianeptine Decreases Emotional Memory
Healthy volunteers were randomized to receive a single dose of Tianeptine (12.5 mg) or placebo, and subsequently completed a battery of tasks measuring emotional processing, including facial expression recognition, emotional memory, and attentional vigilance, as well as working and verbal memory. Tianeptine-treated subjects were less accurate at identifying facial expressions and showed reduced memory related to emotion and reduced attentional vigilance to positive stimuli.


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User Experiences

“Tianeptine Sodium and its sibling’s Sulfate, Free Acid, and even the new tianeptine oxalate have many more than these 7 benefits, which are just the tip of the iceberg, really. The problem isn’t the Tianeptine itself, the problem is finding a reliable vendor to buy tianeptine sodium that doesn’t sell it as a chemical for research purpose because those impurities ware hard on your body. I used to get Stablon, but now I only order from Supplements for Work. As good as sodium gets.” – Steven

“I am an evangelist for tianeptine sodium and have personally tested (multiple times) both tianeptine sulfate and Tianeptine in free acid form. Neither two worked as effectively for me as tianeptine sodium. In fact, the free acid was so ineffective I converted it myself to tianeptine sodium.

That said, it’s my understanding that tianeptine sulfate is more useful for those who want a steadier, longer lasting effect. What might register as a slight increase in energy and mood in me can be felt as anxiety in others? For them, sulfate is their ideal form.

As for a dose equivalence, if you were used to 15mg Tianeptine sodium 3x/day, you’d want to take roughly 45mg 1x/day to achieve a similar therapeutic effect.

As a side note (to anyone on the fence about trying it), I think Tianeptine is criminally under-appreciated in the US both as a pharmaceutical, and as an antidepressant. But even more than that, Tianeptine is (uniquely) a “pro mood” agent, neuroprotectant, opioid dependence modulator (and my favorite nootropic by far).” – Quora member Christian


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Summary: CBD is a non-psychoactive cannabis extract. It is a potent anti-inflammatory that fights cancer, helps with IBS, schizophrenia, anxiety, and needless to say, promote quality of sleep.

what is cbd oil
Cannabidiol CBD Skeletal Structure

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Introduction

What is CBD Cannabidiol?

CBD is one of the (more or less) 113 cannabinoids identified in help plants. Also, it accounts for up to 40% of the plant’s extract. That is a lot. A lot of extensive research is ongoing about cannabidiol, most of which is on anxiety, cognition, movement disorders, and pain. [1]

CBD is one of over 60 compounds found in cannabis that belong to a class of ingredients called cannabinoids.

THC is one of the other 60 compounds, and it is what got mainstream attention, and everyone got to know it because its an ingredient in cannabis and produces the psychoactive effect.

Although CBD is also an ingredient in marijuana, it doesn’t seem to provide the same psychoactive effects the way THC does, yet still offers many benefits nevertheless.

CBD is a component of sativa. Moreover, it can be beneficial in many different ways with more and more research showing up every day along with an equal amount of marketing advertisements. It may be helpful on such a broad spectrum that is from anti inflammation to antioxidation to anxiolytic to antipsychotic. That’s the anti’s part. Furthermore, it is a potential medicine for the treatment of neuroinflammation, epilepsy, anxiety, and even schizophrenia. [2]

What is CBD Oil?

Cannabidiol, also known as CBD, is oil that is extracted from the annual herbaceous flowering plant cannabis. The oil taken from the plant’s secretions is used as a food supplement and as a medicine (we retail it as a food supplement). It was discovered in 1940 and the plant has over 400 additional compounds, which have been used throughout the world for millennia.

CBD is a product that helps to communicate with the body to complete its natural maintenance and regenerative functions. Activating these CB1 & CB2 receptors in your body will give it balance, helping the natural signals of these bodily systems flow.

Legal Status

With the United Nations: Cannabidiol is not scheduled under the Convention on Psychotropic Substances or any other UN drug treaty. In 2018, the World Health Organization recommended that CBD remains unscheduled. [R]

I think that by itself explains the explosion of online vendors and the increase in the sale of CBD oil as well as CBD isolate.


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Benefits and Effects

What Are the CBD Benefits?

  1. CBD Reduces Anxiety and Depression
  2. CBD Treats Seizures, Epilepsy & Neurological Disorders
  3. CBD Benefits Multiple sclerosis (MS)
  4. Relieves Pain and Inflammation
  5. CBD Benefits Schizophrenia
  6. Anti-Cancer Properties
  7. Additional Benefits

CBD Reduces Anxiety and Depression

A 2011 study aimed to compare the effects of a simulation public speaking test on healthy control patients and treatment-naive patients with a social anxiety disorder. A total of 24 never-treated patients with a social anxiety disorder were given either CBD or placebo 1.5 hours before the test. Researchers found that pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alertness in anticipation of their speech. The placebo group presented stress, anxiety, cognitive impairment and discomfort. [3]

CBD has also shown antidepressant-like effects in several animal studies. [4]

Social Anxiety Disorder

Early research shows that taking cannabidiol at a dosage of 300 mg daily didn’t improve anxiety in people with social anxiety disorder. However, another research suggests that taking a higher dose (400-600 mg) notably improves anxiety, especially that which is related to public speaking and medical tests in people with social anxiety disorders. [5]

Depression

According to researchers, CBD has antidepressant effects in mice. These depression-reducing effects of CBD in mice were fast, maintained over time, and as strong as a standard antidepressant (common tricyclic medication imipramine, also known as Tofranil) [R] [R]

Treats Seizures, Epilepsy & Neurological Disorders

A 2014 survey conducted by researchers at Stanford University on 19 subjects who suffered epilepsy and had previously tried up to 12 antiepileptic drugs. 84% of the participants had a reduction in seizure frequency while taking CBD. Furthermore, 11% reported complete diminishing symptoms of seizure altogether. [6]

CBD Benefits Multiple sclerosis (MS)

Aside from all the research I came across supporting this, I just remembered that one of my friends’ sisters who has been suffering multiple sclerosis for a long time, told us the day she tried cannabis had been a turning point in her life regarding easing her symptoms to new levels. Moreover, with my knowledge of the plant, I can believe everything about this study, and it makes total sense to me.

Relieves Pain and Inflammation

CBD significantly suppresses neuropathic pain as well as chronic inflammation in rodents without causing tolerance. It inhibits the neuronal transmission within the pain pathways. With those findings and many more surfacing from all over the world, researchers are now suggesting that CBD and other ingredients of cannabis – those that don’t produce psychoactive effects, might be representing a novel class of therapeutic remedies for treating chronic pain. [7]

Furthermore, it is also said to lower the incidence of diabetes, relieve nausea, promote cardiovascular health, and much more. It sounds like an all-in-one ointment that you have to keep around in the house for when necessary. It can heal a wound if you have one or in another day gets you to relax and unwind. I thought I’m over it after my experiment, but now after researching it again a year later, I think I might give it another shot — although definitley not vaping it this time.

CBD Benefits Schizophrenia

While the psychoactive THC in cannabis seems to trigger psychotic episodes, especially in those with schizophrenia, CBD has opposite, antipsychotic effects. More and more studies are pointing to CBD as a natural alternative to antipsychotic drugs but with far fewer side effects. [R]

Anti-Cancer Properties

CBD decreases the energy production in cancers, triggering their death. It makes cancer cells kill themselves (apoptosis), stopping both cancer growth and spreading. [R] [R]

Furthermore, in test-tube and animal studies, CBD has demonstrated anti-tumor effects. In animals, it has been shown to prevent the spread of breast, prostate, brain, colon, and lung cancer. [R]

Additional Benefits

Antipsychotic effects

Studies suggest that CBD may help people with schizophrenia and other mental disorders by reducing psychotic symptoms [R]

Substance Abuse Disorder Treatment

CBD has been shown to modify circuits in the brain related to drug addiction. In rats, CBD has been shown to reduce morphine dependence and heroin-seeking behavior. [R]

Diabetes Prevention

In diabetic mice, treatment with CBD reduced the incidence of diabetes by 56% and significantly reduced inflammation. [R]


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Mechanism of Action

How Does CBD Work?

CBD supports your complete wellbeing by working with your Endocannabinoid System (ECS). In the 1990s, the first Endocannabinoid System receptors were cloned: CB1 and CB2. CB1 receptors have an effect on the brain, and nervous system and how our bodies feel overall. CB2 receptors influence appetite and immune system function. CB2 receptors also control the management of pain throughout the nervous system. It uses 2-AG and binds with enzymes throughout the Endocannabinoid system. The Endocannabinoid system also uses (2-AG) or 2-arachidonoylglycerol to control these body systems.

Cannabidiol has antipsychotic effects. The exact cause for these effects is not apparent. However, cannabidiol seems to prevent the breakdown of a chemical in the brain that affects pain, mood, and mental function. Preventing the breakdown of this chemical and increasing its levels in the blood seems to reduce psychotic symptoms associated with conditions such as schizophrenia. Cannabidiol might also block some of the psychoactive effects of delta-9-tetrahydrocannabinol (THC). Furthermore, cannabidiol seems to reduce pain and anxiety. [R]

The Endocannabinoid System

The Endogenous Cannabinoid System, also known as the ECS system, are cell receptors that communicate with various parts of the body to tell them when to start or to tell the process when to stop such as:

  1. The brain
  2. Organs
  3. Connective Tissues
  4. Glands
  5. Immuno Cells

The goal of the ECS is to achieve the overall balance of the body’s systems. The ECS chemical keys are the CB1 and CB2 receptors within the body, which lock and unlock systems of the body. Since cannabinoids play a significant role within the body’s functions, they constitute an important tool to maintain our overall wellbeing.


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Dosage

How to Take CBD?

CBD dosage can vary anywhere from 100 mg up to even 3 g per day, depending on the health issue on target.For protecting the brain (such as in Alzheimer’s) and reducing inflammation and muscle twitching (MS), doses of 100 to 600 mg of CBD were used in clinical studies. In some studies, patients took as much CBD oil as they needed to feel pain or muscle spasm relief.

Doses up to 800 mg CBD daily were used for psychosis and schizophrenia.

The highest CBD doses used in studies were up to 3.5 g of CBD oil daily for very severe drug-resistant seizures in children and young adults with epilepsy. 300 mg per day was enough to reduce anxiety in clinical studies.

Typically, it is recommended to take 150 mg of CBD oil twice a day for tackling anxiety, and for inflamation relief.

For multiple sclerosis: A spray delivering 2.5 mg of cannabidiol under the tongue per dose is positivley reported.

How is CBD Oil Used?

CBD oil is used to support the overall wellbeing of the body and mind. Today, it is used widely as a food supplement that activates receptors that communicate with the different systems of the body. CBD supports your overall feeling of wellbeing throughout the body, but does not give a sensation of “being high”, which is why THC, the other well-known active substance from the Cannabis plant, has been prohibited in most countries and considered a drug.


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Side Effects

What Are The CBD Side Effects?

CBD is generally well tolerated, and safe at high doses, and with chronic use in humans. [R]

Cannabidiol sprays used under the tongue have been used in doses of 2.5 mg for up to 2 weeks.

Some reported side effects of cannabidiol include dry mouth, low blood pressure, lightheadedness, and drowsiness.

This is what I can second as well, from my personal experience with CBD.


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User Experience

My Personal Experience

Although my method of administration was slightly different, during my experimental period with CBD oil I was inhaling it through a vape.

I can confirm that at many times it had an incredible effect on me especially regarding anxiety and on my hypertension. However, most often than not, I was experiencing side effects rather than the benefits. To me, those were dry mouth, which is tolerable and expected. However, I often suffered somewhat an anxiety rebound instead of ease. And I believe it stemmed from analyzing and paying attention to how my heart starts beating fast and I feel altogether uncomfortable. It’s like being on a bad trip and without even the psychoactive effect.

I tried several types. Some of the very potent and concentrated and some were diluted and had lower concentrations. I had very mixed feelings about it and decided to give away the oil along with the vape all together a long time ago. However, I might give it another try this time leaving the vape away and taking it orally instead.


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Frequently Asked Questions

Does CBD Oil Help Anxiety?

CBD was recommended to me for anxiety and depression about a month ago.
I’ve suffered anxiety and depression for as long as I can remember. I managed it for a while with vitamins and exercise, but a little over a year ago the depression and anxiety became overwhelming. They helped, but it was still there. Antidepressants and anti-anxiety meds have been recommended, but the idea of an adverse reaction making it worse was terrifying. A few months ago PMDD (pre menstral dysphoric disorder) appeared. A week or so before my period, anxiety went in to overdrive. I would wake up terrified. I was afraid to leave my house, go to work, I convinced myself I was a terrible mother and my daughter would be better off somewhere else. Horrible, awful, crippling fear. Even auditory hallucinations. I felt borderline psychotic, like I wasn’t in control of my thoughts. All created soley by out of whack hormones. And this happened every month!! Enter CBDs. I started taking 20Mg CBD capsules every morning about a month ago. Within a couple days, I felt better. In less than a week, anxiety and depression significantly dissipated and I just feel normal. I’m positive and energetic. I’m eating better, exercising again, and I don’t have a lead weight on my chest that prevents me from making decisions or doing what I need to. PMDD hasn’t shown up whatsoever. I’ve had unusually strong cravings for chocolate milkshakes the last couple days, but I’ll take that over the bs I was going through. My experience with CBDs has been phenominal, with absolutely no side effects. Everyone is different, but its helped me immensly with anxiety and depression.

What Does CBD Oil Do?

CBD has show promise for many health related issues, but still needs to be studied more closely. In fact, the World Health Organization (WHO) just realesed their findings on CBD ad the recognized they could not find any side effects associated with CBD and they found it MAY be useful for various issues, including:
Alzheimer’s disease: anti-inflammation, antioxidant, antiapoptotic in in vitro and in vivo models of Aβ-evoked neuroinflammatory and neurodegenerative responses.
Parkinson’s disease: Attenuation of the dopaminergic impairment in vivo; neuroprotection; improvement of psychiatric rating and reduction of agitation, nightmare and aggressive behaviour in patients.
Multiple sclerosis: Improved signs of EAE in mice, antinflammatory and immunomodulatory properties.
Huntington’s disease: Neuroprotective and antioxidant in mice transgenic models; no significant clinically important differences in patients.
Hypoxia-ischemia injury: Short term neuroprotective effects; inhibition of excitotoxicity, oxidative stress and inflammation in vitro and in rodent models.
Pain: Analgesic effect in patients with neuropathic pain resistant to other treatments.
Psychosis: Attenuation of the behavioural and glial changes in animal models of schizophrenia; anti-psychotic properties on ketamine-induced symptoms
Anxiety: Reduction of muscular tension, restlessness, fatigue, problems in concentration, improvement of social interactions in rodent models of anxiety and stress; reduced social anxiety in patients.
Depression: Anti-depressant effect in genetic rodent model of depression.
Cancer: Antiproliferative and anti-invasive actions in a large range of cancer types; induction of autophagy-mediated cancer cell death; chemopreventive effects.
Nausea: Suppression of nausea and conditioned gaping in rats
Inflammatory diseases: Antinflammatory properties in several in vitro and in vivo models; inhibition of inflammatory cytokines and pathways.
Rheumatoid arthritis: Inhibition of TNF-α in an animal model
Infection: Activity against methicillin-resistant Staphylococcus aureus
Inflammatory bowel and Crohn’s diseases: Inhibition of macrophage recruitment and TNF-α secretion in vivo and ex vivo; reduction in disease activity index in Crohn’s patients.
Cardiovascular diseases: Reduced infarct size through anti-oxidant and anti-inflammatory properties in vitro and in vivo.
Diabetic complications: Attenuation of fibrosis and myocardial dysfunction

Related Natural Nootropics

  1. Bacopa Monnieri
  2. Ginkgo Biloba
  3. Ashwagandha
  4. Cordyceps Mushroom
  5. Lion’s Mane Mushroom

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What is Agmatine Sulfate?Benefits & EffectsMechanism of ActionDosageSide EffectsFAQs

Summary: Agmatine is an amino acid that offers a wide of cognitive boosting benefits. It also has excellent effects on reducing neuropathic pain, as well as drug addiction habits. It is neuroprotectant and can reduce tolerance built to many medications like benzodiazepines, morphine, and other painkillers. It also synergizes with SSRI’s & cannabis.

Agmatine Sulfate Youtube Video TTS

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Introduction

What is Agmatine Sulfate?

Agmatine is a form of amino acid that derives from L-Arginine. It has been shown to inhibit receptors for the neurotransmitter acetylcholine, which plays a major role in memory and reasoning.

Agmatine supplement also regulates levels of Nitric Oxide by the affecting nitric oxide synthase enzyme. It controls cellular energy levels by influencing polyamine metabolism and function.

In some studies, it has been shown to enhance the effects of both morphine and fentanyl to increase pain killing, reduce tolerance, and lower addiction, as well as working synergistically with marijuana.

It is also found naturally in every day foods, including beer, wine, coffee, and other fermented foods.

Because it is capable of targeting multiple receptors, agmatine may benefit a spectrum of complex diseases, including diabetes, Alzheimer’s disease, opioid addiction, mood disorders, and even cancer. Furthermore, agmatine may enhance cognitive function, stress resiliency, mood, and athletic performance. The highest levels of agmatine are found in the gut, where it is produced by the microbes living there. It is also found in dietary form, mainly in fermented foods, and in supplemental form like agmatine sulfate. Agmatine is also produced in small amounts within the body by the mitochondria in the liver.


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Benefits & Effects

What Are Agmatine Sulfate Benefits?

  1. Reduces Pain Sensitivity
  2. Reduces Symptoms of Anxiety & Depression
  3. Neuroprotection & Longevity
  4. Improves Weight Loss & Prevents Weight Gain
  5. Supports Muscle Growth
  6. Helps Erectile Dysfunction & Infertility
  7. Help with Alzheimer’s Disease
  8. Helps Alcohol & Morphine Withdrawal

Supporting research:

Agmatine sulfate benefits the body and mind in many different ways and depending on the method it is taken. Some of the most notable agmatine benefits are:

Reduces Pain Sensitivity

In research studies, Agmatine shows to be an effective way for pain relief. Especially in the case of thermal hyperalgesia, a condition where the body is sensitive to changes in temperatures. The body becomes hypersensitive to heat or cold.

Agmatine improves those pain sensations, which is a result of its pro-circulations effect.

In studies looking at pain reduction in neuropathic conditions or inflammatory pain, agmatine was not found to produce a statistically significant effect. However, anecdotal, first-hand reports show that it actually did work for neuropathic conditions. So in this specific situation, it seems to be subjective to each individual.

Reduces Symptoms of Anxiety & Depression

Agmatine exhibits antidepressant effects and promotes mood improvement as well as anxiety reduction and relief. It helps the brain and body manage and overcome stress by reducing anxiety and promoting a sense of well-being.

By increasing NRF2, agmatine prevents depressive behavior by protecting brain cells from high levels of stress hormone cortisol. [R]

Agmatine increases adenylate cyclase in the prefrontal cortex, and decreases levels of adenylate cyclase which associate with depression. [R, R].

Furthermore, it blocks the NMDA receptor, prevents calcium overloading, as well as reverses the decrease of monoamines such as norepinephrine, epinephrine, and dopamine. Depression often associates with a reduction of monoamines in the brain [R, R]

Studies & Research

A small pilot study on three patients suffering depression, Agmatine supplement caused a complete disappearance of depression symptoms in all patients. It most likely did so through NMDA receptor-blocking and not through serotonin pathways. [R]

Agmatine also reduced anxiety in rats when they were put in swimming and maze navigation tests. [R]

Neuroprotection & Longevity

Agmatine acts as an anti-oxidant and is continuously under more research for its anti-aging and longevity potential. It has been found to exhibit neuroprotective effects against oxidative damage and injuries to the Central Nervous System (CNS). It is also believed to limit the activity of glutamate receptors and thus, the over-excitation of neurons within the brain.

Additionally, by inhibiting iNOS and nNOS and increasing eNOS, Agmatine protects against brain damage from stroke. Increasing eNOS protects the brain by dilating the blood vessels to increase blood flow. This prevents damage during times of lack of oxygen from reduced blood flow to the brain (also known as ischemic stroke).

Agmatine decreases iNOS and nNOS, two enzymes that contribute to brain damage from stroke. [R]

A Study on Effects of Agmatine Sulfate on Nerve Injury:
  • OBJECTIVE:
    Evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.
  • METHODS:
    The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.
  • RESULTS:
    Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004).
  • CONCLUSION:
    Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration. PMID: 28122652

Improves Weight Loss & Prevents Weight Gain

Individuals who struggle to gain weight can benefit from Agmatine supplements. In some studies, subjects increased food consumption rates by 44% to 54% in 24 hours.

Moreover, in the following studies, Agmatine shows an increase in fat burning, a decrease in fat composition, and an increase in muscle mass [R], which also contributes to the next benefit of Agmatine:

Supports Muscle Growth

Agmatine stimulates the production of luteinizing hormone (LH). Increasing these hormone levels lead to an increase in testosterone levels.

By increasing testosterone levels, Agmatine contributes to an optimal hormonal environment for muscle growth, enhances athletic performance, and fastens recovery. [R]

Agmatine also increases insulin sensitivity and the uptake of glucose into the muscle. Increasing insulin sensitivity results in more effective shuttling of amino acids as well as glucose into the tissues for growth and repair. [R] [R]

Helps Erectile Dysfunction & Infertility

Studies show that L-arginine is involved in the process of cell replication, in addition to enhancing blood circulation, so it can help improve both sperm production and motility.

Men dealing with cardiovascular issues due to low levels of NO in the blood are more prone to experience erectile dysfunction and fertility problems because an erection requires a relaxation of smooth muscles, which Nitric Oxide triggers.

Although it doesn’t apply to every person, a significant rate of male infertility cases (92%) is treatable with L-arginine supplements in combination with dilators, antioxidants and/or anti-inflammatories. [R]

Research suggests that high-stress levels lower L-arginine levels in the sperm production pathway. Therefore, men with chronic stress specifically can benefit from Agmatine supplement.

According to Dr. Axe, a combination of L-arginine, L-glutamate and yohimbine hydrochloride is a common way of treating erectile dysfunction. And it works better than L-arginine alone. [R]

“In fact,” he says, “many of the most frequently prescribed medications for ED work similarly to L-arginine: by increasing nitric oxide production.”

Furthermore, there’s research suggesting treatment with N-Acetyl Cysteine (NAC) and L-arginine together can help balance hormones naturally and restore normal sexual function in women with polycystic ovary syndrome and estrogen imbalances.

Other studies suggest that L-arginine with herbs such as chasteberry, green tea extract, and antioxidant supplements improve pregnancy rates in women struggling to conceive. [R]

Help with Alzheimer’s Disease

Insulin resistance could cause an increase of plaque and neurofibrillary tangles in the brain, which are the signs of Alzheimer’s disease. Agmatine prevents cognitive decline by rescuing insulin signaling and avoiding potential accumulation of those tangles. [R]

Helps Alcohol & Morphine Withdrawal

Agmatine reduces and to an extent, prevents, symptoms of alcohol withdrawal such as “wet dog shakes,” anxiety, flashes, and shakings. [R] [R]

Agmatine sulfate
Agmatine Sulfate Skeletal Structure

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Mechanisms of Action

How Does Agmatine Sulfate Work?

Agmatine has several mechanisms. It can inhibit N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors, as well as activate imidazoline receptors. Agmatine can also inhibit nitric oxide synthase enzymes, which allows it to regulate elevated levels of nitric oxide. Agmatine can inhibit calcium channels and specific serotonin receptors as well. Further research is needed to determine the full extent of agmatine mechanisms. [R]

Agmatine was found to exert modulatory actions directly and indirectly at multiple key molecular targets underlying cellular control mechanisms of cardinal importance in health and disease. It is considered capable of exerting its modulatory actions simultaneously at multiple targets. The following outline indicates the categories of control mechanisms and identifies their molecular targets:

Neurotransmitter receptors and receptor ionophores. Nicotinic, imidazoline I1 and I2, α2-adrenergic, glutamate NMDAr, and serotonin 5-HT2A and 5HT-3 receptors. Ion channels. Including: ATP-sensitive K+ channels, voltage-gated Ca2+ channels, and acid-sensing ion channels (ASICs).

Membrane transporters. Agmatine specific-selective uptake sites, organic cation transporters (mostly OCT2 subtype), extraneuronal monoamine transporters (ENT), polyamine transporters, and mitochondrial agmatine specific-selective transport system. Nitric oxide (NO) synthesis modulation. Both differential inhibition and activation of NO synthase (NOS) isoforms is reported.

Polyamine metabolism. Agmatine is a precursor for polyamine synthesis, competitive inhibitor of polyamine transport, inducer of spermidine/spermine acetyltransferase (SSAT), and inducer of antizyme. Protein ADP-ribosylation. Inhibition of protein arginine ADP-ribosylation. Matrix metalloproteinases (MMPs). Indirect down-regulation of the enzymes MMP 2 and 9. Advanced glycation end product (AGE) formation. Direct blockade of AGEs formation. NADPH oxidase. Activation of the enzyme leading to H2O2 production.

Wikipedia


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Dosage

How to Take Agmatine Sulfate?

There is currently no standard dosage for agmatine sulfate because there haven’t been enough human studies for determination. These numbers are rough estimates to give an idea of typical, experimental dosing:

  1. For treatment of neuropathic pain: 1,000 to 2,500 mg of agmatine (daily)
  2. For improving cognitive function: 200 to 500 mg of agmatine (daily)
  3. For vasodilation and enhanced recovery: 500 to 1000 mg of agmatine (30 minutes pre-workout)

Note: Agmatine is not absorbed well when taken with dietary protein, because it uses the same transporters as arginine

Quoting Examine:

“There are no standard dosages for agmatine because of the lack of human evidence for its effects. However, a single human study used 1,300-2,670mg of agmatine, daily for the treatment of neuropathic pain. The estimated human dose for improving cognition is 1.6-6.4mg/kg of agmatine, taken orally.

This is based off of the 10-40mg/kg dosage range for rats, and is equivalent to 217-435 mg for a 150lb person. Supplementation should not exceed 6.4mg/kg of bodyweight. Studies on agmatine use a daily dosing protocol.

Agmatine is not absorbed well when taken with dietary protein, because it uses the same transporters as arginine. Further research is needed to determine if oral agmatine supplementation provides the same benefits as were observed in animal studies.”

“The generally accepted daily dosage range for Agmatine Sulfate is between 250 mg and 2.5 grams. Avoid taking higher than necessary dosages to reduce the risk of side effects.”


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Side Effects

What Are Agmatine Sulfate Side Effects?

According to studies conducted so far, it appears that Agmatine Sulfate is safe even in relatively high doses. While there have been few studies conducted thus far, they have not shown any side effects to be associated with this supplement.

If you follow the recommended Agmatine sulfate dosage protocol and do not have any pre-existing contraindications for use, the risk of serious adverse effects is very low. Minor side effects included nausea, diarrhea, and vomiting in a small percentage of participants, which cleared up after a few days of discontinuing use. [R]


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User Experiences

Agmatine Sulfate Reddit User Experience

“Not only does it have varied anti-addiction properties to Opioids, amphetamines, caffeine, nicotine & alcohol, but it also seems to make other drugs, and medicines more potent in their effects. It also shares the properties of Ketamine’s antidepressant effects, via the mTOR AMPA pathway. A small study found a robust antidepressant effect; all patients reported remission of depression. Considering that, shutting down Serotonin production via parachlorophenylalanine, did not reverse the antidepressant effects, shows how punchy this substance is. It’s also a painkiller. I’d recommend this be added to everyone’s stack, provided they aren’t too fond of Alcohol, as I noticed it definitely seems to blunt the good feelings of certain drugs.” Reddit user


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Frequently Asked Questions

What is Agmatine Sulfate?

Agmatine Sulfate is a biogenic amine that is derived from the amino acid L-Arginine. This happens by a process called decarboxylation, which is better known as the removal of carboxylic acid group from the amino acid.

Is Agmatine safe?

Yes. And here is a 5 year-long, daily high dosage of Agmatine in order to measure and proof its safety:

Clinical follow-up consists of periodic physical examinations and laboratory blood and urine analyses. All measurements thus far remain within normal values and good general health status is sustained throughout the study period, up to 5 years. This case study shows for the first time that the recommended high dosage of agmatine may be consumed for at least 5 years without evidence of any adverse effects. [R]

How long does Agmatine take to work?

Agmatine starts working as soon as it enters the bloodstream, which is typically 15 – 30 minutes after consumption. Users can expect to experience an increase in muscle pumps, vascularity and muscular endurance within this timeframe. [R]

How much Agmatine should I take?

The generally accepted daily dosage range for Agmatine Sulfate is between 250 mg and 2.5 grams. Avoid taking higher than necessary dosages to reduce the risk of side effects.

Can you take Agmatine with creatine?

This is the reason creatine and protein work so well together, in a nutshell. Bodybuilders can cut out the creatine middle man by supplementing with agmatine sulfate directly. … You take creatine to improve the protein effects. You take nitric oxide to improve the creatine effects.

Further and Related Readings

  1. Agmatine – Wikipedia
  2. Agmatine – Scientific Review – Examine

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IntroductionBenefits & EffectsSide EffectsDosageUser ExperienceFAQ

Summary: N-Acetyl Cysteine (NAC) is a prodrug for L-cysteine, a precursor to the antioxidant glutathione, an essential antioxidant in the body. NAC supports glutathione replenishment which has been found to bind to the glutamate recognition sites of the NMDA and AMPA receptors. It also promotes healthy inflammatory responses.

NAC Video TTS

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Introduction

What is N-Acetyl Cysteine?

N-Acetyl Cysteine (also known as Acetylcysteine or NAC) is a prodrug for L-cysteine, a precursor to the antioxidant glutathione, an essential antioxidant in the body. NAC supports glutathione replenishment which has been found to bind to the glutamate recognition sites of the NMDA and AMPA receptors. It also promotes healthy inflammatory responses. Acetylcysteine was initially patented in 1960 and licensed for use in 1968. It is on the World Health Organization’s List of Essential Medicines and is easily accessible for a very affordable price.

“Acetylcysteine, also known as N-acetylcysteine, is a medication that is used to treat paracetamol overdose, and to loosen thick mucus in individuals with cystic fibrosis or chronic obstructive pulmonary disease. It can be taken intravenously, by mouth, or inhaled as a mist. Some people use it as a dietary supplement.” Wikipedia


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Benefits & Effects

What Are N-Acetyl Cysteine Benefits?

  1. Improves Cognitive Function
  2. Reduces Symptoms of Depression
  3. Helps Symptoms of Bipolar Disorder and Mania
  4. Reduces Symptoms of OCD (Obsessive Compulsive Disorder)
  5. Improves Male Fertility
  6. Boosts Skin Health
  7. May Improve Autism
  8. Reduces Muscle Fatigue
  9. Reduces Antibiotic Side Effects
  10. Reliefs ADHD Symptoms
  11. Other Benefits

Supporting Research:

N-Acetyl Cysteine Improves Cognitive Function

Combinations of NAC with other antioxidants improve cognition in both healthy older people and those with mild cognitive impairment. (R) (R)

NAC has many studies on enhancing cognitive function in Alzheimer’s, Parkinson’s, and schizophrenia. Currently, it’s under research for boosting cognitive performance after general anesthesia. (R)


N-Acetyl Cysteine Reduces Symptoms of Depression

NAC helps people with depression by balancing glutamate levels within the brain. Doing so, it reduces inflammation and increases the growth of new brain cells. R

In a study of more than 500 participants, NAC shows an improvement in symptoms of depression and overall functionality. At 2000mg per day, it improves mood in people diagnosed with depression. (R), (R)

N-Acetyl Cysteine Helps Symptoms of Bipolar Disorder and Mania

NAC improves chronic health issues such as heart disease and hormonal imbalance in people with Bipolar Disorder. In a 6-month study, NAC indirectly shows to affect overall health, antioxidant and inflammation levels, as well as mood. (R)

Another study on 17 subjects with bipolar disorder, NAC shows improvements in low moods and reduction in overall associating symptoms after six months of supplementation. (R)

In a study of 15 individuals suffering from mania, NAC also shows improvement after a six-month regime. The group receiving NAC had a reduction in symptoms versus the one receiving placebo. However, mood swings seem to worsen as a result. (R)

N-Acetyl Cysteine Reduces Symptoms of OCD (Obsessive Compulsive Disorder)

NAC balances glutamate levels as well as increases antioxidants within the brain. In a study of 44 subjects with OCD, a NAC dose of 2000mg added to standard medication shows to improve symptoms, even in severe cases. R

Another study of 48 subjects who didn’t respond to typical treatment, NAC shows to improve symptoms after a 3-month period safely. (R)

NAC is useful for obsessive-compulsive disorders according to extensive research. It shows promising benefits and has very few side-effects. (R)

N-Acetyl Cysteine Improves Male Fertility

In addition to helping women with PCOS (Polycystic ovary syndrome), NAC may help increase fertility in men. Oxidative stress damages the sperm’s DNA, which results in reducing fertility. (R)

A study done on 120 infertile men receiving NAC, improvements were notable in semen quality and antioxidant status after a period of three months. (R)

Other studies look at the fertility benefits of NAC in combination with other antioxidants such as B vitamins, vitamin C and D. The combination improves the sperm count in those with low sperm count. (R)

In an extensive study of almost 500 infertile men, NAC with selenium show improvement in fertility after a six month period. (R)

Sub-fertility Conditions

Some men are sub-fertile — they are less fertile without an apparent reason. In 84 of subfertile men trying to conceive, NAC combination supplement called Condensyl (with vitamins, zinc, fig extract, and vitamin E) increased pregnancy rates. It raises the “fertility potential” of subfertile men increasing the rate of successful pregnancy. (R)

The typical NAC dose for improving fertility in those studies was 600 mg/day.

N-Acetyl Cysteine Boosts Skin Health

Interestingly, NAC can be used as a cream or gel to improve skin health. It boosts glutathione in the skin protecting it from damage. Furthermore, NAC reduces skin inflammation and normalizes skin cell division. It’s used for eczema, skin irritation, radiation-induced skin damage, wound healing, and acne. In a study of 100 participants, a 5% NAC gel shows to reduce mild to moderate acne. (R)

Overall, NAC skin formulations are promising and very safe. Case reports and animal studies support this wide range of skin benefits of NAC.

N-Acetyl Cysteine May Improve Autism

NAC seems to benefit children with autism. In a study of 33 autistic children, NAC (900-2,700 mg/day) shows to reduce irritability after three months period. (R)

In 2 different studies with 80 autistic children, those receiving NAC as an add-on to their medication (risperidone) show less irritability and hyperactivity after two months period. (R), (R)

N-Acetyl Cysteine Reduces Muscle Fatigue

Overall, NAC tends to help muscles improve blood flow during intense training as well as recover faster after a workout.

It also seems to help older individuals in improving fitness and enhancing endurance in athletes on the short-term. However, long-term NAC with exercise may prevent muscle recovery.

N-Acetyl Cysteine Reduces Antibiotic Side Effects

Antibiotic side effects arise from free radicals damage. As a potent antioxidant, NAC (1,200 mg/day) reduces side effects, prevents kidney and ear damage from several strong antibiotics in 2 studies of 100 people. (RR)

NAC also protects the liver from the harmful effects of anti-tuberculosis drugs as shown in a study of 60 participants. Those receiving NAC show intact liver after treatment, while 40% of those who didn’t take NAC suffer liver damage. (R)

N-Acetyl Cysteine

N-Acetyl Cysteine Reliefs ADHD Symptoms

In a study of nearly 100 ADHD participants, NAC shows to reduce ADHD symptoms in patients with as well as improving cognition, impulsivity, and overall symptoms.

Participants were receiving up to 5g per day during this study. (R)

Other N-Acetyl Cysteine Benefits

According to Health Line, the following are the 9 top benefits of NAC:

  1. Essential for Making the Powerful Antioxidant Glutathione
  2. Helps With Detoxification to Prevent or Diminish Kidney and Liver Damage
  3. May Improve Psychiatric Disorders and Addictive Behavior
  4. Helps Relieve Symptoms of Respiratory Conditions
  5. Boosts Brain Health by Regulating Glutamate and Replenishing Glutathione
  6. May Improve Fertility in Both Men and Women
  7. May Stabilize Blood Sugar By Decreasing Inflammation in Fat Cell
  8. May Reduce Heart Disease Risk by Preventing Oxidative Damage
  9. Ability to Boost Glutathione Levels May Improve Immune Function

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Side Effects

What Are N-Acetyl Cysteine Side Effects?

N-Acetyl Cysteine is a safe substance with very few known side effects. Although occasionally, it can cause nausea, diarrhea, or constipation.

Large doses in a mouse model showed that acetylcysteine could potentially cause damage to the heart and lungs. They found that acetylcysteine was metabolized to S-nitroso-N acetylcysteine (SNOAC), which increased blood pressure in the lungs and right ventricle of the heart (pulmonary artery hypertension) in mice treated with acetylcysteine.

The effect was similar to that observed following a 3-week exposure to an oxygen-deprived environment (chronic hypoxia).

The authors also found that SNOAC induced a hypoxia-like response in the expression of several important genes both in vitro and in vivo.

Wikipedia


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Dosage

How To Take N-Acetyl Cysteine?

The typical dose for general wellness and gut health is 500mg per day taken in the morning on an empty stomach 800to2,400mg are the most common across clinical studies. However, for a chronic health condition, consider a higher dose. Studies concerning addiction and mental health issues use doses closer to 3000 mg/day.

Daily doses should be taken at 2-3 times a day.


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User Experience

Both the reviews/experiences below are customer reviews posted on Nootropic Depot’s product page. You can only write a review for a product you actually purchased:

NAC is the supplement of choice for helping to mitigate nasal congestion. I’ve found even with a cold, taking a large dose divided up into several small doses separated by 2-4 hours throughout the day significantly controls the nose situation. Recently while going through this routine, I also noticed heightened mental clarity which quickly was attributed to the NAC as nothing else in my regular stack had changed. Combined with the fact the loose powder is inexpensive, NAC has high opinion from me. Con, it tastes terrible. It seriously tastes like butt if that was made from rubber. Capsulating it yourself is highly recommended!

NAC is an essential part of my daily routine. I take 2000mg every morning and if I feel a cold coming on I also take 1000 or 2000mg of an evening. Every winter I get a cold which precipitates a severe chest infection. It is now halfway through winter and I have not yet even caught a cold, despite the fact that the rest of my family has been sick with colds. My nose usually runs all winter but the mucous dissolving properties of NAC somehow even ameliorate that. I use Nootropics Depot’s NAC because I know it’s pure and independently tested. It comes in user friendly packaging, it’s inexpensive, the postage is tracked and it arrives quickly.


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Frequently Asked Questions

What is N Acetyl L Cysteine Powder?

N Acetyl L Cysteine, also known as N Acetyl Cysteine or NAC, is an acetylated form of L Cysteine. NAC is one of few natural mucolytic agents. Mucolytic agents help thin out mucus which makes it easier to cough up mucus. NAC is also used to enhance the production of glutathione when it is normally depleted. Glutathione benefits are plentiful and thus, supplementing with NAC can provide many of the glutathione benefits we would see with glutathione supplementation.

What are N Acetyl L Cysteine Benefits?

Supports respiratory health
Promotes skin health
Supports organ health
Promotes vitality

What is N Acetyl L Cysteine Good For?

Studies observing glutathione levels after taking a NAC supplement found that NAC elevated glutathione levels. This is significant because the supplementation of glutathione on its own did not significantly increase glutathione levels. Since NAC is able to increase glutathione, NAC benefits have been linked to skin health, organ health, and promoting vitality. Additionally, taking a NAC supplement is believed to have some detoxification effects since it allows more glutathione to be produced. In addition, NAC benefits include organ protective properties when exposed to alcohol. A study on rats found that a NAC supplement taken 30 min before alcohol exposure seemed to produce a protective effect while administration 4 hrs after alcohol exposure elevated organ tissue damage. Additionally, these protective behaviors increased when alcohol consumption was stopped. Additional trials confirmed that the protective properties NAC has against alcohol only work when taken prior to alcohol consumption. Again, it is important to note that NAC should only be taken prior to consumption of moderate quantities of alcoholic drinks. NAC should never be taken after the consumption of alcoholic drinks as it may have an opposite and detrimental effect on the liver. This is important to note as many hangover supplements, intended to be taken after the consumption of alcoholic drinks, contain N Acetyl L Cysteine. The cystine-glutamate antiporter on astrocytes is known to regulate synaptic levels of glutamate by taking up cystine, the oxidized dimer form of Cysteine, in exchange for glutamate release. It is believed that additional Cysteine through N Acetyl L Cysteine supplementation may provide more substrate to further reduce glutaminergic stimulation. This is important, as glutamate can over-excite neurons, which can cause neuronal damage. This is part of the reason why some people avoid the consumption of monosodium glutamate, which is more commonly known as MSG. It is falsely believed that the consumption of MSG will result in too much glutamate in the brain, which could then cause neurotoxic effects. The claims that MSG has negative effects in the brain have long been disproven, however, glutamate levels may increase independently from MSG consumption. It is believed that higher Cysteine levels in the brain may lower glutaminergic transmission by lowering the amount of glutamate release. It has been found that glutamate levels can be reduced within 1 hour of orally administering a NAC supplement, making NAC a great neuroprotective agent. Other N Acetyl L Cysteine uses were studied after the relationship between glutathione and NAC supplementation were established. Researchers were interested in NAC for its vitality enhancing effects. Studies on sprint performance found vitality enhancing effect when subjects used a NAC supplement but only a slight increase in vitality from baseline was achieved with a large dose.

What Are N Acetyl Cysteine Food Sources?

The body converts N Acetyl L Cysteine which converts into Cysteine which is then converted to glutathione. Cysteine is an amino acid produced by the body but it requires methionine to do so. Cysteine is primarily found in animal proteins such as chicken, pork, sausage, turkey, fish and duck. Dairy sources of cysteine include yogurt, ricotta cheese, eggs, and cottage cheese. Cysteine is also found in some plant sources for vegetarians and vegans. Foods such as broccoli, red pepper, onion, granola and oat flakes are all good sources of Cysteine. Other sources include garlic, bananas, linseed, soy beans, and wheat germ. Low levels of Cysteine can delay growth in children and lower immunity. Weakness and muscle loss may also occur as a result of a low Cysteine die

How much N Acetyl Cysteine should I take?

As a dietary supplement, take one 500mg of N-Acetyl L-Cysteine once daily.

Where to buy N Acetyl Cysteine Powder?


Nootropics Depot offers 200 gram, 400 gram and 1 kilogram jars of high quality N-Acetyl L-Cysteine powder. Nootropics Depot’s N-Acetyl L-Cysteine has been lab-tested and verified for both product purity and identity.

NOTE: Please consider voting regarding posting direct purchasing link to products.


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What is Pramiracetam?Benefits & EffectsMechanism of ActionDosageSide EffectsFAQs

Summary: after a study showing an outstanding success rate of 96% in reversing amnesia, surpassing the original and most popular racetam (Piracetam) – Pramiracetam started drawing more and more attention until eventually getting to stand out amongst racetams the way it does today. Additionally, it boosts cognition and improves memory, increases concentration, learning capacity, and supports engaging in, and maintaining prolonged focus sessions.

Pramiracetam Video TTS

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Introduction

What is Pramiracetam?

Pramiracetam is one of the best-selling nootropics today due to being the highest in potency out of all racetam nootropics.

It has a distinctive mechanism of action that allows for efficient utilization of brain capabilities, thereby improving memory recall, learning capacity, concentration, and focus. Serves as an excellent supplement on its own and furthermore, a powerful potentiator to other nootropics, intensifying as well as prolonging effects. It is quickly rising towards a well-deserving reputation for its profound effects.

A synthetic derivative of piracetam, Pramiracetam is an invention of Parke-Davis from the 1970s. It is a highly effective nootropic, up to 30 times more potent than piracetam. It is marketed in Europe under brand names Neupramir, Pramistar, and Remen; often as a prescription for individuals with dyslexia, ADHD, dementia, and memory impairment due to neurodegenerative conditions. It was a patent in the US in 1979 but without the support nor the approval of the US FDA.

Regardless, it is popularly used off-label as a different approach to cognitive challenges and memory impairments. Its also undergoing further trials as a potential treatment for a variety of nervous system disorders.

Pramiracetam is a central nervous system stimulant and nootropic agent belonging to the racetam family of drugs. It is marketed by Menarini under the brand name Pramistar as a treatment for memory and attention deficits in aging people with neurodegenerative and vascular dementias in Italy and some Eastern European countries.

Wikipedia


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Benefits and Effects

What Are Pramiracetam Benefits?

  1. Enhances Overall Cognitive Function
  2. Enhances Memory Formation
  3. Reduces Symptoms of Depression & Relieves Anxiety
  4. Increases Learning Capacity
  5. Promotes Thought & Sense of Clarity
  6. Increases Social Fluency & Sociability
  7. Enhances Sensory Perception
  8. Helps in Memory Restoration and Recall

Supporting research:

Enhances Overall Cognitive Function

Pramiracetam optimizes brain performance and produces noticeable cognitive enhancement, especially regarding memory, in both formation of as well as consolidation. Due to the euphoric-like focus, it induces along with a sense of “emotional blunting,” users report the feel of it being comparable to Ritalin.

Pramiracetam Enhances Memory

Due to stimulating the hippocampus, the section of the cerebellum that’s accountable toward the formation of new memories, pramiracetam is raising in acknowledgment as a sharp memory enhancer. Users report significant improvement in memory formation and speed of recall; a claim confirmed by animal studies. (R)

Additionally, extensive studies find that it significantly improves long-term memory, and able to reverse amnesia to surprising levels. The findings of that study led to the synthesizing and production the drug.  (R) (R)

Pramiracetam Reduces Depression and Anxiety

Pramiracetam reports show it improves cognitive deficits associating with traumatic brain injuries. Studies demonstrate and confirm its neuroprotective effects. Studies show that its overall impact on lowering symptoms of depression and anxiety was higher than improving memory. Nevertheless, it was beneficial for both. (R)

Increases Learning Capacity

Users allegedly report pramiracetam makes learning faster, more efficient, as well as more pleasant. Such finding can be explained, at least in part, by pramiracetam facilitation of higher neuroplasticity and support of long-term memory. The latter seems to be more accurate as per the following study: (R)

Pramiracetam Increases Sense of Clarity

Anecdotal reports from the nootropic community tell that pramiracetam provides them with a strong sense of mental awareness, clarity, with a deeper understanding of life; similar to many of those reporting the same effects from piracetam.

Pramiracetam Promotes Social Fluency

Furthermore, a lot of people taking pramiracetam report enjoying socializing whereas before, they avoided social settings for lack of interest. This could be due to the cognitive boost or the emotional blunting effect, which is likely to reduce social anxieties (R).

Enhances Sensory Perception

Another report backed by a clinical study shows that pramiracetam indeed enhances sensory perception and heightens observation. That is including amplified and more vibrant sound and more precise, richer visual perception with distinct color contrast. (R)

Pramiracetam Aids Memory Restoration

In clinical experiments, pramiracetam has been noted to be an efficient remedy approach for memory impairment and other cognitive difficulties caused by brain injuries(R). It is also one of the various nootropics that are carried out to examine in the US as a potential treatment for memory impairment associated with Alzheimer’s disease amongst other neurological disorders. There is a study that shows it to be capable of reversing chemically produced amnesia in healthy volunteers of 18-65 years of age(R).

Pramiracetam

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Mechanism of Action

How Does Pramiracetam Work?

Similar to several nootropics, pramiracetam affects the release of neurotransmitters, brain chemicals that carry signals from one nerve cell to another. Though pramiracetam performs it indirectly, in different fashion than that of other racetams, and it excites the brain in different methods as well. Pramiracetam is fat-soluble which means the bloodstream absorbs it via fatty acids. It reaches peak concentrations and highest bioavailability, usually within 30 minutes, and has a somewhat long half-life of 4 to 6 hours.

Racetams work by directly stimulating neurotransmitter receptor sites, thus increasing production and release of specific neurotransmitters. However;  pramiracetam doesn’t directly produce alterations in neurochemical levels, neither does it seem to possess an affinity for any vital neurotransmitter.

Choline is a precursor of acetylcholine, a neurotransmitter thoroughly engaging in cognitive processes including learning pace, thought recall, and attention. By inciting choline uptake, it indirectly modulates the release of acetylcholine and triggers increased activity within the hippocampus. Due to this part of the brain being crucial to revival function, the generalized stimulation that pramiracetam formulates can enhance both the creation of new memories and the retention of reference or long-term memories.

Cerebral Blood Flow

The improving action in the hippocampus also improves cerebral blood flow, which enhances attentiveness and boosts cognitive capabilities. Besides, Pramiracetam has additional mechanisms of action. Neuroscientists hypothesize that in addition to influencing the brain, pramiracetam serves outer sections that rely upon the adrenal glands. (R)

Concerning Membrane Fluidity

Animal studies imply that pramiracetam may additionally improve or repair brain membrane fluidity, which promotes cell signaling (R). Pramiracetam does not seem to alter either alertness or emotional states actively. This advantage is understandable by pramiracetam low impact on the generation and release neurotransmitters that possess the most notable results on tranquility, stress, and anxiety levels such as serotonin, GABA, and dopamine.


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Dosage

How to Take Pramiracetam?

Recommended Pramiracetam dosage is 1200 mg per day, split into two 600 mg or three 400 mg doses throughout the day.

This is the lowest effective dose. On an individual level, it should be adjusted as required to accomplishing the desired effect.

Currently, the evidence using pramiracetam in humans uses either 400mg thrice daily or 600mg twice daily; both of these dosing regimens totals 1,200mg of pramiracetam daily.

It is unsure if pramiracetam should be taken with meals, and it is not clear if 1,200mg is the optimal dosage or not. This does, however, does appear effective.

Examine


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Side Effects

What Are Pramiracetam Side Effects?

Studies testing Pramiracetam doses found it to be safe and not causing any side effects at doses of 400 mg and up to 1,600 mg (R).

Furthermore, a study concerning Alzheimer’s disease shows it’s safe even at doses as high as 4,000 mg. (R)

Headache may occur due to low acetylcholine levels in the brain. Therefore, it is wise to pair racetams drugs with a choline source (such as Alpha GPC). Not only will choline prevent or eliminate the headache, they will furthermore work synergistically together firing cognitive function. (R)


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Conclusion

Pramiracetam is a powerful nootropic that is relatively new to many of the nootropics community. Yet is rapidly attaining a well-deserved recognition. Due to having more complications in synthesizing, it costs more than most other racetams. Users often complain about that, however, the distinct potency proposes that lower doses are required to achieve the results. Users also have mixed reactions to the Ritalin-like emotional blunting outcome of the supplement. For some, it creates refreshing objectivity and easing of social anxiety, while others find it makes them feel somewhat disengaged. Pramiracetam is generally unique nootropic, notably enhancing memory creation and recollection, learning pace, and overall mental clarity. Its usually a worthy addition to nootropic stacks. Often existing there as an agent for prolonging their effects. Pramiracetam is safe, effective, fast-acting, and reasonably long-lasting.


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Frequently Asked Questions

Where to buy Pramiracetam?

Pramiracetam is available on many vendors if you simply do a quick Google search. If I had to pick one of the many choices, I would recommend Nootropics Depot because I have personally used almost every racetam they offer, and I trust their product quality.

Can you snort Pramiracetam?

Although it is reportedly possible, it’s not recommended due to the large powder amount required as well as the associated pain. Unlike certain substances that yield results with small amount, snorting Pramiracetam wouldn’t be worth the effort.

How long does Pramiracetam last?

Pramiracetam reaches its peak concentration in about 30 minutes after ingestion and has an average half-life of 5 hours.

What does Pramiracetam do?

Pramiracetam enhances memory formation and memory recall, increases learning ability, reduces social anxiety, and could potentially treat amnesia as well as prevent neurodegeneration.

When to take Pramiracetam?

Ideally, the best timing to take Pramiracetam would be once after breakfast, and another dose after lunch, keeping a 5-hour time interval between the two dosages.

How to take Pramiracetam?

Although it is recommended to take Pramiracetam after food for optimal absorption, it can still be taken without food. So if absorption is your concern, it does not matter much. It depends on your personal preference.

How long does Pramiracetam last?

On average, Pramiracetam effect lasts somewhere between 4 to 6 hours.

Why is Pramiracetam so expensive?

Regardless of all the forum talks of Pramiracetam being so expensive, and whether this used to be true in the past or not; the actual price of Pramiracetam powder from Nootropics Depot is $9.99 for 5g, and $26.99 for 15g.

How much choline to take with Pramiracetam?

Personally, I would take and recommend 300 mg of Alpha-GPC with each Pramiracetam dose. If you prefer Citicoline instead (as the choline source) then the recommended dosage would be 250 mg

For more Frequently Asked Questions, check out the following pages:

  1. The Ultimate Nootropics FAQ List
  2. Racetams 101: Guide & FAQs

Further and Related Readings

  1. Aniracetam
  2. Sunifiram
  3. Oxiracetam
  4. Fasoracetam
  5. Coluracetam
  6. Citicoline (CDP-choline)
  7. Noopept

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IntroductionBenefits & EffectsMechanism of ActionDosageSide EffectsFAQs

Summary: Bacopa monnieri is a powerful natural herb nootropic used for ages for its memory enhancing and anti-aging effects. It reduces anxiety and improves memory formation. It also expands learning capacity, decreases stress and even offers neuroprotection

Bacopa Video TTS

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Introduction

What is Bacopa Monnieri?

Bacopa monnieri (also known as Brahmi) is one of the most acknowledged and widely respected nootropics. A traditional Ayurvedic medicine that has a good reputation of being a potent cognitive enhancer, stress and anxiety reliever, and brain protector. It improves memory formation and recall speed, it stimulates learning, enhances thought clarity, and increase brain function. It acts as a brain protectant, and studies confirm it as a potential remedy for dementia and similar conditions. Furthermore, it reduces anxiety and provides a feeling of calm and tranquility, all while eliminating stress. Users report it an excellent relaxant that improves sleep quality, leading to rejuvenating and refreshing rest. Its nootropic effects are comparable to those of Piracetam, one of the most popular smart drugs in the world. The supplement is produced from the plant extracts.


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Benefits & Effects

What Are Bacopa Monnieri Benefits?

  1. Enhances Memory Formation
  2. Improves Learning and Cognition
  3. Reduces Anxiety and Stress
  4. Neuroprotective and Promotes Longevity (Anti-Aging)
  5. Reduces Symptoms of Depression

Supporting research:

Bacopa Monnieri Enhances Memory Formation

Enhancement in memory formation, as well as recall speed, is one of Bacopa’s primary benefits. Studies show that it significantly enhances memory in older people, and ongoing research is investigating its potential as a treatment of memory issues relating to neurological disorders.  (J Altern Complement Med. 2010 Jul;16(7):753-9. doi: 10.1089/acm.2009.0342.)

Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. [1]

Improves Learning and Cognition

Bacopa Monnieri improves cognitive processing, making learning new things faster and easier. Studies show that it significantly enhances spatial learning, and it has also been confirmed to improve learning capacity in subjects under stress. Most users say that taking bacopa while studying makes it easier to understand and process new information. Reports carried out by clinical trials at India’s Central Drug Institute (CDRI) in Lucknow state that children taking bacopa show improved academic skills.[2]

Reduces Anxiety and Stress

Bacopa Monnieri is effective in reducing anxiety and stress. Clinical trials show that it significantly decreases anxiety and depression in volunteers, and animal studies compare bacopa to other plant extracts for the effective treatment of anxiety and similar disorders. [3] [4]

Neuroprotective and Promotes Longevity (Anti-Aging)

Bacopa is effective in reducing oxidative stress effects on the brain. It possesses potent antioxidant properties that protect the brain against environmental stressors associated in the cognitive decline relating to aging and associated with Alzheimer’s and other neurological diseases.[5]

Reduces Symptoms of Depression

In a study of individuals over 65 years old receiving 300mg dosage, the results show a notable decrease in depression symptoms as well as anxiety. [6]

Bacopa Monnieri waterhyssop
Bacopa is a genus of 70–100 aquatic plants belonging to the family Plantaginaceae. It is commonly known as water hyssop.

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Mechanism of Action

How Does Bacopa Monnieri Work?

Bacopa’s nootropic and anxiolytic effects are due to its capability of enhancing neural communication as well as modulating the release of several neurotransmitters such as dopamine, serotonin, and GABA.

Memory and Cognitive

Although it works over time by a variety of functions, bacopa improves memory and cognitive abilities by increasing synaptic communication. It promotes dendrites generation, thereby enhancing neural signaling. The improvement in neural impulse transmission is key to cognitive enhancement. The active ingredient in Bacopa monnieri extract (Bacoside-A) has been shown to stimulate nerve cells and cause synapses to be more receptive to nerve impulses. Studies show that Bacoside-A can prevent dopamine receptor dysfunction. Dopamine is a powerful neurotransmitter responsible for the brain’s reward and pleasure systems.

It also improves production of the enzyme Tryptophan Hydroxylase (TPH2); vital to many central nervous system actions such as the biosynthesis of serotonin. Furthermore, Bacopa stimulates activity in the hippocampus by increasing the activity of kinases, which are proteins that regulate cellular pathways. Because the hippocampus is involved in almost all cognitive activity, this is one of the main methods that allows bacopa to boost brain function.

Anxiety and Stress Relief

Bacopa monnieri produces its unique calming effects through several actions. One of the most crucial anxiety reduction effects is within its power to modulate the activity of certain neurotransmitters like those that regulate the uptake of serotonin, which is connecting to mood and anxiety.

Another active ingredient in bacopa is hersaponin, an alkaloid that provides a relaxing and soothing effect. Bacopa’s active ingredients also support the activity of GABA, another major neurotransmitter that acts to prevent anxiety by restricting the signaling of neuron over-excitement due to stress.


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Dosage

How To Take Bacopa Monnieri?

The minimum effective dose of Bacopa Monnieri is 300mg, taken with food or fat source. Some people, myself included, find it more effective at a higher dosage.

I take 300 to 600mg depending on the purpose, while people like Dave Asprey recommend a daily dose of 750mg.


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Side Effects

What Are Bacopa Monnieri Side Effects?

Bacopa monnieri side effects are uncommon. It is generally safe and effective, nevertheless, side effects can occur just as with any other nootropic.

Bacopa side effects range from minor (digestion issues and fatigue) to severe (thyroid disorders and urinary tract complications). Minor side effects usually disappear as the body adapts to the herb.

Rodent studies suggest bacopa may reduce sperm count, so it’s wise to avoid it if you are planning to conceive. However, it didn’t have any impact on sex drive nor testosterone. Moreover, sperm count returns to normal once supplementation stops. [7]

Severe side effects may include thyroid disorders, urinary tract problems, gastrointestinal blockage, adverse impact on ulcers and lung conditions, and bradycardia.

So start with the lowest effective dose, and observe your body’s reaction to it. If adverse effects occur, stop use.


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Conclusion

Bacopa monnieri enhances cognitive abilities, reduces anxiety, and treats a variety of conditions. Although it works over time, the anxiety-relieving effects are immediate.

Its a precious addition to nootropic stacks. If you’re looking for a natural nootropic to boost your cognition, relieve anxiety, and protect your brain against oxidative stress, Bacopa would make an excellent choice.


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Frequently Asked Questions

Does the smart drug Bacopa monnieri work?

Yes it does and it is great. You can even grow it yourself on the balcony. It does bring more oxygen to the brain hence you feel stimulated. But can’t compare to synthetic nootropics.

If you want a good harmonizing (stress relief) with energizing stack. Take

1x Bacopa 300mg
1x Rhodiola rosea 300mg
1x Alpha-GPC 300mg

You can 1x 5-HTP 50mg (optional)

And throughout your day, if you drink coffee add 1x L-theanine 100-200mg in it.

How much Bacopa Monnieri should I take?

The minimum effective dose of Bacopa Monnieri is 300mg, taken with food or fat source. Some people, myself included, find it more effective at a higher dosage.

I take 300 to 600mg depending on the purpose, while people like Dave Asprey recommend a daily dose of 750mg.

Bacopa monnieri side effects are uncommon. It is generally safe and effective, nevertheless, side effects can occur just as with any other nootropic.

How long does it take Bacopa Monnieri to work?

The acute relaxation effects of Bacopa Monnieri start working as soon as it enters the bloodstream, which is typically 15 – 30 minutes after consumption.

The potential benefits of Bacopa Monnieri for improving memory and cognition will generally take effect within 4-6 weeks.

What are some uses of a Bacopa monnieri?

It can:

Enhance Memory Formation
Improve Learning and Cognition
Reduce Anxiety and Stress
Neuroprotective and Promote Longevity
Reduce Symptoms of Depression

Bacopa monnieri commonly called as ‘Brahmi’ is a perennial herb belonging to Plantaginaceae family of the flowering plants. In India it has been used traditionally in Ayurvedic medicine as memory enhancer. It is also used in treatment of anxiety, digestive disorders, asthma, bronchitis and heart problems.

Further & Related Readings

  1. Ashwagandha
  2. Ginkgo biloba
  3. Lion’s Mane Mushroom
  4. Rhodiola Rosea
  5. Ultimate Nootropics FAQ

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Introduction Benefits & EffectsMechanism of ActionDosageSide EffectsUser ExperienceConclusion


Summary: Sunifiram is an experimental, potent and powerful nootropic that enhances memory, expands learning capacity, and uplifts mood. A recent addition to the racetam family that seems more than promising. Sunifiram dosage is usually as small as 5 mg due to its potency. And it is yet to be approved anywhere in the world.

Sunifiram Video TTS

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Introduction

What is Sunifiram?

Sunifiram is a synthetic derivative of Piracetam. Although there has not been much evidence about its efficacy, it has been proven to be beneficial for the (many) individuals using it. With research and trials ongoing and growing, its use will increase along as well. Sunifiram (also known as DM-235) has been one of the best nootropics that powerfully influence cognition. It enhances mood, lowers stress, and increases energy and focus.

Sunifiram dosage
Sunifiram Structure

It is an invention from the year 2000. And although it is very new to the market, it is proving to be effective and useful to individuals both in long and short terms. It is an effective nootropic that improves learning and memory, and furthermore enhances cognitive function. It is used in the treatment of neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and amnesia, like most racetams. There are no reports of any severe side effects from its use, making it effective, useful, and safe.

Although it belongs to the racetam class, Sunifiram has a different structure. Therefore, it is sometimes referred to as a piperazine alkaloid rather than racetam. It delivers many of the same memory and learning enhancements as piracetam but is much more potent.

Sunifiram is also an ampakine. It increases the efficacy and activity of neurotransmitter glutamine. This leads to significant changes such as mood and energy improvement along with other cognition benefits.

Sunifiram (developmental codename DM-235) is an experimental drug which has antiamnesic effects in animal studies and with significantly higher potency than piracetam. Sunifiram is a molecular simplification of unifiram (DM-232). As of 2016, sunifiram had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world. Wikipedia


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Benefits and Effects

What Are Sunifiram Benefits?

  1. Reduces Anxiety and Stress
  2. Improves Symptoms of Depression
  3. Enhances Mood & Boosts Energy
  4. Improves Learning Skill and Memory Formation
  5. Enhances Focus and Motivation
  6. Enhances Visual Perception
  7. Increases Libido

Supporting research:

Sunifiram Reduces Anxiety, Stress, and Symptoms of Depression

As an antidepressant and anxiety reliever, Sunifiram produces its effects as a mirror image of an ampakine. It reacts with glutamatergic AMPA receptors. That also allows it to act as a mild stimulant.

Sunifiram Enhances Mood & Boosts Energy

Sunifiram is known to increase energy and enhance mood. This is likely due to its antidepressant-like effect.

Sunifiram Improves Learning Skill and Memory Formation

Sunifiram is a potent and powerful nootropic. It enhances memory formation and retention as well as expanding the learning capacity. It is in use in case of diseases that cause memory loss or amnesia. Its use is not yet regulated by the FDA, but still widely in use by many individuals for its nootropic benefits. [R] [R]

Appears to promote long term potentiation in the hippocampus with oral ingestion, which should result in an improvement in memory in animals that have otherwise impaired memory.

Examine.com

Sunifiram Enhances Focus and Motivation

Sunifiram enhances focus and concentration. It is known to improve motivation and enable a person to complete mentally-demanding tasks at ease and comfort. The focus heightening and motivation is due to the increase in the release and utilization of acetylcholine; which has a direct impact on cognitive abilities.

Sunifiram Enhances Visual Perception

Sunifiram keeps you out of stress and negative thinking. It makes you have a confident, better outlook on life. It allows you to look at the future positive and ambitiously. Such useful effects are helpful for people at any and every stage of life.

Sunifiram Increases Libido

Increase in the sex drive is often in anecdotal reports. However, there is no clinical evidence on this specific claim and only anecdotal ones support it.


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Mechanism of Action

How Does Sunifiram Work?

Sunifiram is a piracetam derivative. But it often comes as a surprise that it has a different chemical structure from the other racetams. It is basically a piperazine alkaloid which can act as an ampakine that will increase the activity of glutamine receptors and increase the stimulation effects. Or it can serve as a cholinergic that stimulates the production and release of acetylcholine.

AMPAkine Action

Although no such evidence is still available about its use and its action in humans due to the lack of the trials, the primary factor that drives it to work would be the ampakine factor which allows it to provide the stimulation effects by acting at the glutamate receptors. Ampakines are mild stimulants. They can increase alertness and energy. They do not cause restlessness which like other antidepressants or anxiolytics. The increase the energy levels and the activity factor is also one of the significant roles Sunifiram plays. Due to its effect on the glutamate receptors, it leads to functions such as spatial navigation and the formation and storage of memory, which are crucial for many neurological conditions.

Cholinergic Action

Sunifiram acts as a cholinergic as well. Due to this effect, it leads to the production and release of the neurotransmitter acetylcholine. Although the exact mechanism remains unknown. Acetylcholine increases brain function and cognition abilities. The primary functions are memory enhancement, learning speed and capacity which grow and expand very notably. You can also count on the fluid intelligence or ability to solve unique problems with this supplement. Sunifiram is an essential nootropic to students as well as athletes to increase their performance and achieve better results.

Sunifiram appears to act on the glycine binding site of NMDA receptors, which enhances signalling and activates some intracellular proteins (CAMKII and PKCα) which then positively regulate the AMPA receptors. These mechanisms are highly similar to that seen with nefiracetam. Examine.com

The mechanism of action of sunifiram is unknown. Sunifiram, as well as unifiram, were assayed at a wide panel of sites, including the most important receptors, ion channels, and transporters, but showed no affinity for any of the sites. They specifically did not bind to the glutamate, GABA, serotonin, dopamine, adrenergic, histamine, acetylcholine, or opioid receptors at concentrations of up to 1 μM. In addition, the drugs were tested on recombinant AMPA receptors and showed no potentiation of the receptors, indicating that they do not act as AMPA receptor positive allosteric modulators. However, they were able to prevent the amnesia induced by the AMPA receptor antagonist NBQX in the passive avoidance test, suggesting that indirect/downstream AMPA receptor activation may be involved in their memory-enhancing effects. Sunifiram, as well as other nootropics such as piracetam, levetiracetam, and aniracetam are able to antagonize inhibition of glucose transport by barbiturates (e.g., pentobarbital), diazepam, and certain other drugs in human erythrocytes in vitro (Ki = 26.0 uM for sunifiram), and this action has been found to correlate with their potency in reversing scopolamine-induced memory deficits in mice. However, this action has been regarded as very unlikely to represent the main mechanism of action of sunifiram.

Wikipedia


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Dosage

How to Take Sunifiram?

Sunifiram works effectively at a dosage of 5 to 10 mg –  at a maximum of three times per day. This is the safe dose which is often taken sublingual for maximum efficacy and absorption.

It is advised that one starts with the smallest doses to prevent side effects and toxicity. Although it is not in documentation, tolerance can grow with excessive usage, so it is better to take it occasionally instead of daily basis.

Suggested dose:

only 4-8 mg 2-3 times a day is needed with this ultra potent nootropic. When you’re talking about the Bugatti of the nootropics world, less is more. A little goes all the way!

Possible side effects:

it is possible to experience headaches from choline depletion with excessive use. This can be combated by consuming sources of choline. In rare cases individuals have experienced nausea.

– Nootropics City

Sunifiram Stack

For Boosting Cognitive Function

By pairing sunifiram with one or more of the racetams like piracetam, oxiracetam, or Noopept, we can achieve this increase which has been the most common and most favorite Sunifiram combo. A choline source like Alpha GPC is an important part of this combo due to the increased choline depletion by the former nootropics.

For Mood Enhancement

Combining Aniracetam with sunifiram is a good option for mood enhancement. You can combine L-theanine, which increases production of dopamine, serotonin, and GABA with sunifiram. Sulbutiamine, which is a potent enhancer of cholinergic, dopaminergic, and glutamatergic functions can be a good combination as well. Choline source should always be present in those combos to prevent getting a headache.


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Side Effects

What Are Sunifiram Side Effects?

Due to being fairly new and not as widely popular as the rest of the racetams, no severe side effects of sunifiram have surfaced yet. Nevertheless, clinical trials are still ongoing, and it is yet to get FDA approval. Use with caution.


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User Experience

On a Reddit user wrote down a thorough experience of sunifiram:

For years I have been a hardcore coffee drinker and other than that I had not used any other substances to enhance my cognition in any way. A few months ago I started a doctor-supervised weight loss program that included the use of 30 mg of Phentermine daily as an appetite suppressant.

Unfortunately, Phentermine is an amphetamine that gave me an extreme energy rush that was affecting my focus and concentration. I could not sit and study because I was getting easily distracted by anything. This was starting to affect my performance in my current classes and at work so I tried using 200 mg of L-Theanine and reduce my caffeine intake with moderately positive effects.

After losing about 100 lbs, I am ready to stop the Phentermine and continue my healthy eating habits for a long-term weight loss maintenance. This Phentermine is addictive so my doctor is reducing the dose gradually to minimize the withdrawal effects. However, I started feeling slightly depressed and foggy. This is when I decided to go on my own and experiment with Noots to see if they would help.

My doctor is not familiar with any nootropics nor did he think anything like that would be appropriate since the effects of phentermine withdrawal would pass in a few weeks.

I did some research about nootropics that would help me with this situation and decided to go shopping. I was low on cash but had a credit on Amazon so the only strong nootropic that I found was Sunifiram. Despite the warnings that there are no sufficient studies on the long-term effects, I decided to assume all risks and give it a try.

The Experience

I started five days ago with 10mg of Sunifiram administered sublingually. Approximately 10-15 minutes after the first dose I felt what others have called “sunny”. It is hard to explain but it was somewhat overwhelming and the effect did not last long.

The following day I took the same dose and got the same but short effect. I did have a mild headache after waking up but nothing unbearable. I started to get the full effect on Day 3. Suddenly I was able to focus on whatever I wanted and the ideas flowed easily. I had struggled to finish a paper for days but this time I finished it in less than an hour.

Today is Day 5 of using Sunifiram and I have to say it has been a positive experience so far. I wish I could explain better my experience but I have not used anything with comparable results. It is not an extreme rush of energy nor a sedative effect. I just feel a sense of clarity that I had not felt before.

I don’t want to take the risk of using Sunifiram for long-term cognition enhancement given the unknown effects of continued use, so I will stop taking it as soon as I finish this class. Once I have some cash to spend, I might look into other alternatives like Piracetam, Noopept or something similar.

TL;DR:

Sunifiram was my first experience with a “smart drug”. During the first two days the effects were mild and nearly unnoticeable. After the third day I felt a positive improvement in my mood and focus. Since there are no sufficient studies on the long term use of this substance, I will discontinue its use and seek other Nootropics with better background research.

u/
Sykotiko


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Conclusion

Sunifiram is one of the nootropics having huge and fast-growing demand, so its not easily accessible. Its potency, efficacy, and effectiveness have been superb. Although it does not have a lot of trials under its belt, it is nevertheless one which has been encouraging and promoted as a safe and effective nootropic.

Not for everyday use, but it can be a good companion to have in your stack. Increasing energy, cognitive abilities, and physical performance are the prime features of this product which make it one worth trying out.

Where to Buy Sunifiram?

Although I haven’t tried Sunifiram nor have I purchased from this vendor myself, I am listing them here for those coming to this page to find vendors. So far the ones I found and seem reputable are:

  1. Nootropics City for Sunifiram Capsules
  2. Nootropics Retail for Sunifiram Powder

Within the UAE, you can order sunifiram from our store.

Interesting Finds

While researching a bit more on Sunifiram, I came across an article on Nootropics City titled ‘Why was Sunifiram Taken Off the Market,’ and dates back to 2004. I thought it would be an interesting read to someone looking for all and any information about Sunifiram. It says:

“In 2000, Sunifiram was introduced to the market. It is well known as DM-235. While clinical trials are done before releasing any drug on the market, as a brand name or a generic one, it is not the only parameter that measures that it will react to general people in the same way. Hence, some drugs are taken off the shelves. Now, why was Sunifiram was taken off the market when some people were responding well towards it. What is the safety information that one should know related to this drug?

The real reason for Sunifiram to be off the market is that there were few safe studies conducted on it. This made it difficult for many physicians to prescribe it to their patients. It is now seen as a recreational drug and a stimulant. Some stimulants like this may be legit but dangerous. It is always best to keep in touch with the ones that have a proven track record, not only in clinical results but in public domain also.

It was introduced as a nootropic to help patients recover mental alertness. The effect of the composition is stronger, and it certainly raises safety issues. Some of its negative properties have made it to remain on the shelves for a little longer. Even healthcare professionals advise its limited usage considering there are other nootropics also on the market that have positive effects.

With its composition, the drug is capable of releasing AMPA receptors that are in the brain. The tolerance level of some patients may have triggered its negative reviews. In fact, some reports also suggested that the drug had toxic effects on consumption. Even small milligram dosages seemed to be bad for the rest of the system. It is also responsible for increased heartbeats in patients who have increased the dosage.

Some of the effects cannot be reversed, and this makes it important to take it off the shelves. It is a very strong drug. Even though it is legal, one must take a medical opinion before consuming it. The Internet offers several slices of information about this drug and its replacements.

What makes it so forceful as a memory booster?

It is an ampakine that immediately brings on the ‘horsepower’ to the brain. The brain has AMPA receptors. When they are activated with the help of an ampakine like Sunifiram, it increases the energy. When people have stress on performance in certain jobs, they have been known to consume it. It ensures that there is no other external distraction that can interfere with the mind’s working. People who have short-term memories also have consumed this drug. Since it is strong in its content, it tends to make ‘colors brighter’, ‘sounds clearer’ and general ambience becomes well defined. This could be a dangerous trend.

Studies

  1. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice.
  2. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor.

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Frequently Asked Questions

What is Sunifiram?

Sunifiram is an experimental, potent racetam. It shares most of racetams benefits and effects. The dosage is usually as small as 5 mg due to its potency. And it is yet to be approved anywhere in the world.

What is Sunifiram Legal Status? Is Sunifiram legal?

In the US, Sunifiram is unscheduled, and not FDA approved.

How To Take Sunifiram?

Being an ‘experimental’ drug, and a very potent one, its important to take very low doses (5 mg, 10 mg tops) and do your research to find news and updates on the matter. You can find the post I cited from Nootropics City under Conclusion which has more information regarding that.

Where to Buy Sunifiram?

I have found a few different vendors, none of which I tried, rather, only listing for research purpose. Nootropics City, Nootropics Retail, as well as NewMind – all offer Sunifiram in powder as well as capsules.

What is Sunifiram Dosage?

Unless you are quite experienced in racetams, I wouldn’t recommend anything over 5 mg as a starting point. People reported side effects after deciding to increase the dose for more results.

Where to Buy Sunifiram Powder?

Nootropics Retail,

Where to find Sunifiram capsules?

Nootropics City

What is Sunifiram half-life?

Sunifiram has a half-life of 1-2 hours

Is sunifiram stimulating like Adderall?

Not really at all. Adderall (amphetamine) causes release of dopamine and norepinephrine to increase focus and cause physical and mental stimulation.
Sunifaram is a positive allosteric modulator of AMPA channels (increases the activity when a glutamate molecule is bound, but not when nothing is bound), which are a subtype of glutamate receptors. The effect of this is to increase memory formation via long term potentiation, which occurs when NMDA and AMPA (both subtypes of glutamate receptors) channels are both activated in the same neuron. When this happens more glutamate receptors are put into the neuron to make it more likely to fire in the future. Sunifaram increases AMPA firing so increases the odds of a long term pontentiation event happening, and therefore memory formation. It does not act as a CNS stimulant like adderall though, and those two drugs really serve different purposes.

Further and Related Readings

  1. Coluracetam, Fasoracetam, Phenylpiracetam, Pramiracetam
  2. Alpha-GPC, Citicoline (CDP), Choline
  3. Ultimate Nootropics FAQ, Nootropics 101

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What is L-Theanine?L-Theanine BenefitsHow to Take L-Theanine? FAQs


Summary: L-theanine is a natural amino acid, often called the “natural xanax”. It almost only exists in green tea leaves. It works brilliantly in unwinding and relaxing the body and brain without causing drowsiness, while reducing stress and increasing cognitive function. Due to not causing drowsiness, it is the perfect choice to combine with stimulants of any sort to take the edge off.

L-theanine Video TTS

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Introduction

What is L-Theanine?

L-theanine is a relaxing, non-sedating amino acid that is synergistic with stimulants to ‘take the edge off.’ Especially with coffee, it synergizes so well resulting in clean energy, furthermore preventing the nasty caffeine crash that many people experience after caffeine intake. It is also useful on its own, promoting relaxation and minimizing stress without causing drowsiness. A combination of L-theanine with caffeine at a 2:1 ratio is increasing in popularity as a remarkably synergetic combination that boosts cognition and attention.

It is an amino acid that naturally exists in green tea leaves as its main active ingredient, and that is the only source that provides it. It is famous for its fantastic nootropic features such as improving memory, expanding learning capacity, as well as providing a calming, zen-like effect.

L-Theanine, for the most part, is a relaxing but not sedating amino acid that is synergistic with stimulants such as caffeine as it can ‘take the edge off’. It is effective by itself in the standard supplemental dosages as well, and although it can be attained via a diet high in green tea ingestion that is the only dietary source of L-Theanine.

Examine.com

L-Theanine has also been in the list of 6 best natural nootropics as second to caffeine.


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Benefits & Effects

What Are L-Theanine Benefits?

  1. Reduces Anxiety & Stress
  2. Improves Memory, Attention, and Cognition
  3. Enhances Sleep Quality
  4. Promotes Longevity and Increases Lifespan
  5. Reduces Symptoms of Depression
  6. Promotes Relaxation without causing Drowsiness
  7. Significantly Reduces Symptoms of Schizophrenia
  8. Enhances Blood Flow and Stimulates Nitric Oxide Production
  9. Reduces Negative Effects of Caffeine & Improves Cognitive Boosting Effects
  10. Additional Benefits

Supporting Research:

L-Theanine Reduces Anxiety & Stress

A review by researchers of a small set of trials concluded that there are benefits of L-theanine in reducing acute stress and anxiety in people with stressful conditions. [R]

Oral intake of L-theanine in rats at feasible dosages reduces circulating biomarkers of stress with or without an actual stressor being present. Therefore, it reduces the adverse effects of stress such as memory impairment. Reductions of perceived stress reported in human subjects given oral theanine at the standard dosages. [R] [R] [R]

L-Theanine Improves Memory, Attention, and Cognition

In a 16-week long study on individuals with mild cognitive impairment, supplementing with l-theanine shows an improved delayed recognition as well as immediate recall comparing to those receiving a placebo during a mental exercise. Furthermore, attention span and alertness levels increased during the memory test. [R]

L-Theanine Enhances Sleep Quality

Theanine enhances sleep quality. In a study measuring sleep time with individuals supplementing with L-theanine, sleep time increases by 11 and up to 21%, therefore making it a valuable compound for achieving better nighttime sleep. (R)

L-Theanine Promotes Longevity and Increases Lifespan

In a study using the model organism C. elegans, L-theanine shows to promote longevity and promote healthy and increased lifespan. Due to those findings, the study suggests that the compound might have similar effects on mammals and humans (R)

L-Theanine Reduces Symptoms of Depression

L-Theanine intake for a period of eight weeks during an open-label study helped easing depressive symptoms, anxiety, sleep disturbance, as well as cognitive impairments in subject suffering major depressive disorder. (R)

L-Theanine Promotes Relaxation without causing Drowsiness

Theanine is proving to be a great agent in promoting relaxation without the accompanying effect of drowsiness. The company developing ‘suntheanine’, l-theanine supplement, won the 1998’s Food Ingredient Research Award for the outstanding research and findings. (R)

L-Theanine Significantly Reduces Symptoms of Schizophrenia

In persons diagnosed schizophrenia receiving 400mg L-theanine in addition to antipsychotic medication for eight weeks were able to reduce anxiety as well as psychopathology symptoms significantly. (R)

L-Theanine Enhances Blood Flow and Stimulates Nitric Oxide Production

Theanine appears to promote nitric oxide formation at relatively low concentrations and is likely practically relevant following oral ingestion. (R)

L-Theanine Reduces Negative Effects of Caffeine & Improves Cognitive Boosting Effects

Theanine and caffeine are typically found together in tea. A combination of caffeine and theanine together significantly improves alertness, reduce fatigue, and improves task-switching accuracy.

High dose caffeine (250 mg, equivalent to 2.5 cups of coffee) has some negative effects, such as jitters and increased blood pressure. Theanine was able to mitigate the increase in blood pressure.

“L-Theanine decreases the negative and jittery effects of caffeine in rats.

However, human studies found that L-Theanine helps reduce caffeine jitters, although the changes were not significant.

L-Theanine changes the pharmacological profile of caffeine in humans, as the combination of caffeine and L-Theanine have somewhat different cognitive enhancement effects. “- Selfhacked

Additional L-Theanine Benefits

Large studies in humans have not been undertaken; however, several smaller-scale studies (fewer than 100 participants) have shown increased alpha wave generation and lowered anxiety, along with benefits to sleep quality in people with ADHD. [R]


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Mechanism of Action

How Does L-Theanine Work?

L-theanine has a comparable chemical composition to glutamate, an amino acid that assists in the transmission of nerve impulses in the brain. Thereby, providing a host of benefits for the mind. It has a remarkable ability of crossing the blood-brain barrier, which means that it reaches the brain directly. Furthermore, it has positive effects on stress levels proving to increase both dopamine and serotonin levels in brain; which are two of the brain’s feel-good chemicals. Green tea is known to be effective at helping people relax due to the positive impact on those neurotransmitters.

L-Theanine dosage
L-theanine skeletal structure

Theanine is an antagonist of the NMDA receptors (albeit with fairly weak efficacy) and can inhibit synaptic release of glutamate via blocking the transporter competitively. Theanine may also reduce glutamate levels, but this is also a fairly weak mechanism requiring a high concentration of theanine – Examine


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Dosage

How to Take L-Theanine?

The effective l-theanine dose is 200mg. For optimal nootropic results, take l-theanine with caffeine (coffee or supplement, whatever suits you) at a 2:1 ratio. As a stack, it would be:

  1. L-Theanine 200mg
  2. Caffeine 100mg

For those interested, you can actually purchase a supplement pre-made that has 200 mg Theanine & 100 mg Caffeine pressed into one capsule. I’ve personally used and still use Nootropic Depot’s.

Note: if you have anxiety or hypertension, you may want to skip caffeine entirely as it aggravates the symptoms.

Experimenting is the best way to find out how you react to it.


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Side Effects

What Are L-Theanine Side Effects?

L-theanine is very safe as very high doses have failed to cause toxicity. However, that doesn’t mean you should go for such high dosage. (R)

L-theanine is exceptionally reliable. Furthermore, it is classified Generally Recognized as Safe by the Fraud and Deception FDA in the US.


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Conclusion

L-Theanine is a natural safe amino acid offering many benefits. It’s a popular choice for individuals wanting a simple and effective way to boost their mental performance. Alone, with caffeine, or even with an advanced nootropic stack; L-theanine is worth trying.


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Frequently Asked Questions

What is L-Theanine and how does it work?

L-theanine is one of the main psychoactive constituents of green tea (camellia sinensis) generally used as a dietary supplement to promote relaxation, lift mood, and reduce anxiety without sedation. Beyond that, it’s been shown to generate creativity and higher learning via the ability to ignore distracting information during complex tasks. Now the science: L-theanine induces a calm state of mind by promoting alpha waves in the brain, and has been shown to increase dopamine, GABA, and glycine levels in various areas of the brain, as well as modulate BDNF (Brain derived neurotrophic factor) and NGF (Nerve Growth Factor) levels. In fact, in one recent animal study l-theanine consumption was associated with about a 25% increase in BDNF and about a 100% increase in NGF in the hippocampus. L-Theanine has structural similarities to glutamine and both neurotransmitters that are produced from it (GABA and glutamate) help balance and maintain stress levels while maintaining a state of wakeful relaxation. Lately, L-theanine has been growing in popularity due to its synergistic effects with caffeine to help boost focus. Systematic reviews show that L-theanine significantly mitigates the anxiety inducing side-effects of caffeine to create a balanced focus.

Should I take L-Theanine every time I drink coffee? Are there any adverse effects from long-term L-Theanine usage?

Yes, and no. Let me explain. L-Theanine is a phenomenal compound when mixed with coffee, due to the stacking of effect, as well as the reduction in some of the negative effects of caffeine itself. For example, in my biohacking course The Alchemist’s Guide To Biohacking, I talk about how I stack coffee blended with grass-fed butter, coconut oil, MCT, L-Theanine, macadamia or almond butter, and sometimes raw honey almost every single morning. It’s a part of my daily routine, and probably my most favourite (and definitely tastiest) part of it, if I have to choose one. However, like all compounds I take on a regular basis, I try to observe a 6/1 or 6/2 cycle with them, meaning six weeks on, then one or two weeks off, depending on the compound. This is to reduce dependency, as well as ensure my body isn’t getting used to the effects, resulting in me possibly having to take more. I’m currently in an off phase now with pine pollen, one of my go-to herbal supplements to boost my testosterone levels. With L-Theanine, I tend to take a week off at the same time I give myself a week off from coffee/caffeine, as it helps to do both at the same time for me.

Has anyone used L-Theanine as a meditation aid?

When you take L-theanine your thinking will seemingly slow down considerably, but you are not fully conscious when L-Theanine is in your bloodstream. It shuts off certain areas of the brain and limits the bandwidth of brain waves to predominantly alpha waves (1). Full meditative consciousness requires great brain wave bandwidth from delta – to high gamma waves and full activity of the neurotransmitter systems. It is best to meditate completely sober, then your brain will adapt properly to fully receive consciousness. Theanine is beneficial though, after it has metabolized by the body. It acts like an adaptogen and increases strength of brain. Your alertness increases 24 h after consumption and meditation is easier for 48 h. This is because brain have adapted to the presence of L-theanine, and once it has been metabolized, the brain neurons will fire with greater intensity, until brain is again adapted to absence of L-Theanine. L-theanine, a natural constituent in tea, and its effect on mental state.

Further and Related Readings

  1. L-Theanine & Caffeine Stack: Making the Best of Both Worlds
  2. Acetyl-L-Carnitine aka ALCAR
  3. N-Acetyl L-Tyrosine aka NALT
  4. The Ultimate Nootropics FAQ List

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Back to Nootropics Information homepage.

What is Phenylpiracetam?Piracetam vs PhenylpiracetamBenefits & EffectsMechanism of ActionDosageSide EffectsFAQs


Summary: Phenylpiracetam is a potent and fast-acting racetam type nootropic. It enhances cognitive abilities and boosts physical strength, stamina, energy, as well as reduces symptoms of depression and anxiety. Being stimulatory, it is banned by the Olympics Anti-Doping committee to the participating athletes.

Phenylpiracetam Video TTS

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What is Phenylpiracetam?

Phenylpiracetam (also known, and sold under the brand name Phenotropil) is one of the most effective, most efficient and most potent racetam nootropics which is widely used, and have been available on the market for many years. With the safe and effective use, many regards Phenylpiracetam a “lifesaver” and “faithful companion” in times of need. Quite dramatic descriptions.

Although it is a new nootropic in comparison to classic racetams such as Piracetam, over the past few years, it gained popularity due to its practical use.

Phenylpiracetam – as the name indicates, is a derivative of piracetam, with the phenyl addition. Which is why it shares so many properties with piracetam. However, it seems to be much more powerful. It is anywhere between 30 to 60 times more potent, and therefore effective, in its action.

Phenylpiracetam (Phenotropil, Carphedon) is a scarcely studied piracetam derivative. It’s notable for its stimulatory subjective effects. It appears on the list of banned substances for Olympic sports. In-vitro experiments suggest phenylpiracetam binds to nicotinic acetylcholine receptors. In animal models phenylpiracetam seems to increase NMDA and nicotinic acetylcholine receptor density, which may suggest it has potential as a cognitive enhancer.[204] Similarly, in animal experiments phenylpiracetam seems to exert anti-depressant effects. [111] No studies have been done to show phenylpiracetam improves cognitive performance in otherwise healthy individuals. Phenylpiracetam seems to be the most stimulatory piracetam derivative.

Reddit’s Begginer Guide

Piracetam vs Phenylpiracetam

Phenylpiracetam is the same chemical structure of Piracetam, but with the addition of a large phenyl grouping off the 4 position of the pyrrolidone ring that all racetams share. Phenylpiracetam has very low water solubility but is slightly lipid soluble. The LogP of Phenylpiracetam is .16, and its solubility in water is 1-2mg/ml at 25 Celsius. The melting point of phenylpiracetam is 149-152 Celsius. Phenylpiracetam also has a stereocenter, meaning it can come in both R and L enantiomers. All phenylpiracetam available is racemic, or a 50/50 mixture of both enantiomers.

For the sake of illustration, and to paint the idea well, look at the two following picture. First comes the piracetam skeletal formula, or chemical structure:

Second is Phenylpiracetam skeletal formula, in which you see Piracetam above the red line, and under the line is the phenyl addition, making it into phenylpiracetam:

The phenyl addition on its own:

phenylpiracetam piracetam

phenyl-phenylpiracetam

Phenylpiracetam is quite popular for its neuroprotective properties which are the dominant feature of many racetam nootropics. But in comparison to piracetam, its neuroprotective attributes are more effective.

It is also psychostimulatory, in other words, it is a stimulant. For that reason, Phenylpiracetam enhances physical performance, which is the primary reason behind its increased consumption among athletes.

Due to these attributes, Phenylpiracetam has become a favorite amongst other nootropics, and its sales have also increased over the past few years due to the positive response it keeps receiving.


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Benefits and Effects

What Are Phenylpiracetam Benefits?

  1. Improves Cognitive Function, Memory, and Attention
  2. Reduces Anxiety and Depression
  3. Boosts Energy and Increases Physical Mobility
  4. Enhances Physical Performance
  5. Additional Benefits

Supporting research:

Phenylpiracetam Improves Cognitive Function, Memory, and Attention

In studies of subjects with cognitive impairment, phenylpiracetam improves cognitive function and enhances overall memory impressively after a month of treatment. The study’s abstract notes:

“Ninety-nine patients with encephalopathy developed in the remote period after acute lesions of cerebral blood circulation, brain traumas and cerebral gliomas surgery have been studied. Phenotropil was used in a dosage of 200 mg per day during one month.

A CT survey revealed that in a stable state of brain changes phenotropil exerted the mostly pronounced influence on movement disturbances: decreased an extent of pareses in limb and face muscles, improved motor coordination, higher brain functions, memory, attention, counting.” [1]

Phenylpiracetam Reduces Anxiety and Depression

In the same study, one of the revelations in the state of brain changes that Phenylpiracetam caused were:

  1. Higher mobility and daily activity
  2. Lower and less feelings of discomfort
  3. Lower anxiety
  4. Reduction depression

“Patients exhibited higher mobility and daily activity, along with lower discomfort, anxiety and depression. EEG study showed more intensive alpha- and beta-rhythms, a decrease of paroxysmal activity and slow waves as well as a general tendency to its normalization.” [2]

Phenylpiracetam Boosts Energy and Increases Physical Mobility

A study patient with chronic fatigue syndrome finds that a one-month treatment of phenylpiracetam reduces fatigue notably.

The study included 1170 patients with brain ischemia, aged 45-65 years, treated with phenotropil in dose 100 mg during 2 and 3 months. Clinical examination and MFI-20 subscales were administered.

The results of the study:

“The high incidence of asthenic syndrome was observed across all MFI-20 subscales. The decrease in asthenic syndrome severity was significant already in the end of the first month of treatment with phenotropil. Such dynamics maintained to the end of the second and third month of treatment. More than 2-fold decrease in the severity of asthenia symptoms was achieved in all subgroups 3 months after treatment. More rapid and apparent decrease in asthenic syndrome was observed in younger patients.” [3]

Furthermore, a notable increasing of movement and physical activity is seen in this study, though it is conducted on rodents. The abstract of the study reads:

“Exploratory behavior, locomotor activity, and anxiety in inbred mice of C57BL/6 and BALB/c strains subchronically treated with placebo or various types of nootropic (cognition enhancing) drugs (piracetam, phenotropil, noopept, semax, pantogam, nooglutil) have been evaluated using the exploratory cross-maze test. It was found that BALB/c mice in comparison to C57BL/6 mice are characterized by greater anxiety and lower efficiency of exploratory behavior in the previously unfamiliar environment. All tested drugs clearly improved the exploratory behavior in BALB/c mice only. In BALB/c mice, piracetam, phenotropil, noopept, and semax also reduced anxiety, while phenotropil additionally increased locomotor activity. Thus, the nootropic drugs displayed clear positive modulation of spontaneous orientation in the mice strain with initially low exploratory efficiency (BALB/c) in the cross-maze test. Some drugs (pantogam, nooglutil) exhibited only nootropic properties, while the other drugs exhibited both nootropic effects on the exploratory activity and produced modulation of the anxiety level (piracetam, fenotropil, noopept, semax) and locomotor activity (fenotropil).” [4]

Phenylpiracetam Enhances Physical Performance

Here is another very interesting rodent study in which Phenylpiracetam was found to increase the speed and distance traveled during an open-race test. Some of the highlights of that study:

“After a single administration, it increased locomotor and antidepressant activity in the open‐field and forced swimming tests, respectively, as well as enhanced memory in the PAR test. Racemic phenotropil and S‐phenotropil also stimulated locomotor activity and induced some antidepressant effect after acute administration.”

It’s quite an interesting, and extensive study. You may find the study here: [5]

Additional Phenylpiracetam Benefits

Anecdotal reports claim It was used by Russian soldiers and astronauts to achieve high physical strength and mental abilities. Although it makes sense and I do believe it personally, those studies are very hard to find due to having taken place a very long time ago, and in another period of time, and another language (Russian).


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Mechanism of Action

How Does Phenylpiracetam Work?

Phenylpiracetam is a piracetam which comes with a phenyl group attached to it. It has similar functions and potency as that of piracetam, which is its parent molecule. However, the addition of the phenyl group has increased its effectiveness in many ways which have led to the increased usage and exposure of Phenylpiracetam in the market.

Furthermore, it easily crosses the blood-brain barrier. Thus it has CNS effects. Most users compare its impact to that of Adderall and modafinil. It is more potent than other racetams and has a high bioavailability, making it a great first line agent to take in case if you are having an exhaustive day ahead.

Its half-life is about 3-5 hours.

No mechanism is in the documentation for the action it produces and the way it processes them and makes them work. However, it has energy and performance boosting properties, and it has a close resemblance to phenyl-ethylamine, which has stimulatory effects. Phenylpiracetam has a close affinity with neurotransmitters such as norepinephrine and dopamine transporters.


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Dosage

How To Take Phenylpiracetam?

The general Phenylpiracetam dose is usually 100 to 200 mg per dose, and can be taken in up to 2 to 3 doses per day at max. Although I wouldn’t go that far myself. The higher end is often for specific conditions and are less frequent than the lower end dosage.

Personally, I prefer taking one 200 mg dose, once only. The effects are much more present and pleasing at that dosage. I feel like anything more than 200mg would be too stimulatory for me, especially given that I often take it along with other nootropics as part of a stack.

Its also important to note that Phenylpiracetam tolerance builds up quickly. Therefore, minimize your use to when you need it rather than making it a part of a daily stack. Once to twice per week is a good practice.

A little bit more science from Examine.com about recommended dosage, active amounts, and other details:

Phenylpiracetam is taken at a dosage of 100-200mg acutely, and this dose is taken 2-3 times per day (totalling a daily range of 200-600mg). The lower range seems effective, but the optimal dosage is not yet known.

The R-isomer appears to be more active on the common usages of phenylpiracetam (stimulation and cognition) than does the S-isomer, and while the racemic mixture (commonly sold version) is effective for cognitive decline it is not certain if it works for nootropic purposes in youth.


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Side Effects

What Are Phenylpiracetam Side Effects?

The major issues and side effects that appear with Phenylpiracetam are the same that occur with other racetams.

The most common side effect of Phenylpiracetam is a headache. which is due to the choline reserves depletion. Using a choline source such as Alpha-GPC or Citicoline would quickly resolve the issue.

Due to that, I try to always pair Phenylpiracetam and a choline source together instead of waiting to see whether or not I am going to have a headache. That, plus I wouldn’t mind the potentiating boost of the additional choline.

Rarely reported side effects are related to the GI tract, such as digestion issues, and constipation.


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User Experience

From a Nootropic’s Depot customer:

This is a great product, don’t get me wrong. Personally, however, my tolerance built up almost instantaneously. First use was wonderful, worked exactly as advertised. Took it a second time 2 days later. Still felt the effects, but was noticeably diminished. Waited a week before taking it again and felt like that first use. Decided to take it the very next day and felt it somewhat, but hardly. Abstained for a week and decided to take 2 in the morning. The effects were comparable to the first time. Took the same dose 3 days later and didn’t notice the effects at all. Waited a week before taking it again, took two again and felt the effects like the previous week but it wore off rather quickly. Since then I’ve only taken it once a week in the latter part of the day when I work a double at my job. This product definitely works, but in my opinion should be used very sparingly. I acknowledge the fact that I tend to develop tolerance to most substances quickly, so if you consider yourself to have that same trait this review would likely apply to you.

Phenylpiracetam without a doubt works, and quite well at that. This was my introduction to the racetam family. I’m eager to try the others now, but wanted to start with one that provided an energy boost. I definitely picked the right one. Within an hour after use you will feel the effects, and they last around 5 hours for me. Sometimes I would take 2-3 capsules instead of 1, and it never made me feel jittery or anxious like too much caffeine would. Highly recommend this product if you are looking for a clean boost in energy and motivation. Works well along side caffeine in my opinion as well.

“This is a great product, don’t get me wrong. Personally, however, my tolerance built up almost instantaneously. First use was wonderful, worked exactly as advertised. Took it a second time 2 days later. Still felt the effects, but was noticeably diminished. Waited a week before taking it again and felt like that first use. Decided to take it the very next day and felt it somewhat, but hardly. Abstained for a week and decided to take 2 in the morning. The effects were comparable to the first time. Took the same dose 3 days later and didn’t notice the effects at all. Waited a week before taking it again, took two again and felt the effects like the previous week but it wore off rather quickly. Since then I’ve only taken it once a week in the latter part of the day when I work a double at my job. This product definitely works, but in my opinion should be used very sparingly. I acknowledge the fact that I tend to develop tolerance to most substances quickly, so if you consider yourself to have that same trait this review would likely apply to you.


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Conclusion

Phenylpiracetam has attained the attention and popularity among the nootropic users for its powerful, dynamic impacts and effects. It is a potent activator of the CNS activities. Its ability to increase the energy and physical performance have made it a favorite for many in the field of study and sports as well. As time passes, these highly active ingredients are only going to gain more attention.


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Frequently Asked Questions

What is Phenylpiracetam used for?

Phenylpiracetam is more potent than piracetam and is used for a wider range of indications. In combination with a vasodilator drug, piracetam appeared to have an additive beneficial effect on various cognitive disabilities. [R]

Does Phenylpiracetam get you high?

Phenylpiracetam boosts memory, cognition level, stamina and energy levels. Having those benefits to someone who has deficiencies in one or more of them would lead him to experiencing a euphoric state, which many people may refer to as being high. Therefore, ultimately, the answer to the question of does phenylpiracetam get you high would be yes.

Is Phenylpiracetam a stimulant?

Yes, in comparison to the general nootropics, Phenylpiracetam is considered to be stimulating nootropic. Moreover, Phenylpiracetam is banned by the World Anti-Doping Agency (Olympics) due to its reported psychostimulatory and cold resistance properties . But it is not a hard stimulant like amphetamines, methamphetamine, and other pharmaceutical & street drugs. It would be the better alternative – although its not recommended for day to day use due to quick tolerance-building. Ideally, taking Phenylpiracetam once to twice a week is the best way to use it without worrying about tolerance build-up or abuse potential.

Is Phenylpiracetam Legal?

Phenylpiracetam legality status depends on country to country basis. In the US, Phenylpiracetam is uncontrolled, unscheduled compound. Which means it is legal to buy and posses. While in Russia, Phenylpiracetam is a prescription drug (sold under brand name Phenotropil). Therefore, in Russia, you need a prescription to legally posses Phenylpiracetam.

How much Phenylpiracetam should I take?

The general Phenylpiracetam dose is usually 100 to 200 mg per dose, and can be taken in up to 2 to 3 doses per day at max. Although I wouldn’t go that far myself. The higher end is often for specific conditions and are less frequent than the lower end dosage. Personally, I prefer taking one 200 mg dose, once only. The effects are much more present and pleasing at that dosage. I feel like anything more than 200mg would be too stimulatory for me, especially given that I often take it along with other nootropics as part of a stack. It’s also important to note that Phenylpiracetam tolerance builds up quickly. Therefore, minimize your use to when you need it rather than making it a part of a daily stack. Once to twice per week is a good practice.

What is the best way to cycle Phenylpiracetam?

I would say limit the usage to once or twice per week as needed. Anything more than that would start the tolerance build-up. Another individual’s advise, from his personal experience: Avoid taking phenylpiracetam for more than two consecutive days. I’ve found that by day 3 tolerance develops, even if I’m taking low doses (e.g. 50 mg). A solid schedule might be taking phenylpiracetam every other day. Better yet, twice a week only.

What does Phenylpiracetam stack with?

Aniracetam, low dose of Noopept, Alpha-Gpc, Lion’s Mane Mushroom. Many other nootropics as well if you are only taking one phenylpiracetam capsule of 150mg. But in general Phenylpiracetam stacks well with most nootropics. Though most frequently its stacked with cholinergics.

Why do many people prefer phenylpiracetam over Piracetam?

“It’s no secret that Phenylpiracetam is often preferred to Piracetam by some people. This is largely due to the fact that it is stronger than Piracetam. You see, phenylpiracetam was first synthesized in 1983 as a modification of the nootropic Piracetam. The primary alteration to Phenylpiracetam from its predecessor is the addition of a phenyl group– a small change that has made phenylpiracetam significantly more potent than Piracetam, even at much smaller dosages. Phenylpiracetam cognitive enhancing effects are reportedly achieved by increasing the density and number of acetylcholine, dopamine, GABA, and glutamate receptors in the brain. Through this mechanism, research suggests that Phenylpiracetam increases functional activity at the neurotransmitter binding sites most important for memory and cognition.” Also: The stimulant qualities, which disappear after regular use. I estimate it is at first like one strong cup of coffee, weakening on subsequent doses. I think that is the reason that phenylpiracetam hasn’t replaced piracetam altogether. The advantages of phenylpiracetam have to be weighed against the greater cost. For daily or at least regular use, the price point of plain piracetam is better.

What are Phenylpiracetam capsules?

Phenylpiracetam capsules is a nootropic compound derivative of the parent compound in the Racetam family, Piracetam. It was first created in 1983 by a team of Russian scientists, and has recently become more well-known outside of Russia. Phenylpiracetam differs from Piracetam in the addition of a bulk phenyl grouping off the 4 position on the 2-pyrrolidone base structure. A phenyl grouping is a six-sided cyclic ring consisting of benzene, minus a hydrogen, leaving an open carbon bond available. Phenylpiracetam has very low water solubility but is slightly lipid soluble. It has a molar mass of 218.3 g/mol and a molecular formula of C12H14N2O2. CAS: 77472-70-9 – IUPAC: (R,S)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide

What’s the difference between Phenylpiracetam and Piracetam?

Phenylpiracetam is the same chemical structure of Piracetam, but with the addition of a large phenyl grouping off the 4 position of the pyrrolidone ring that all racetams share. Phenylpiracetam has very low water solubility but is slightly lipid soluble. The LogP of Phenylpiracetam is .16, and its solubility in water is 1-2mg/ml at 25 Celsius. The melting point of phenylpiracetam is 149-152 Celsius. Phenylpiracetam also has a stereocenter, meaning it can come in both R and L enantiomers. All phenylpiracetam available is racemic, or a 50/50 mixture of both enantiomers.

What is it like to combine modafinil with phenylpiracetam?

“If taken in in doses within the normal range then, anecdotally, you’re not likely to notice the phenylpiracetam. The subjective effects felt from a typically prescribed dose of Modafinil (or recommended dose of it’s alternative pro-drug cousin Adrafinil) are, in my experience, significantly more pronounced than those of any “racetam”. That said, anyone who can get what they need (be it an increase in vigilance and/or cognitive enhancement) from phenylpiracetam alone would do well to consider staying monogamous to that truer “cleaner” class of nootropic.”

How does taking Phenylpiracetam feel different from taking modafinil?

“I can’t disagree more with anyone who suggests the superiority of one over the other. Everyone reacts differently to subtances, even the exact same substance at the same dose delivered to folks of the same gender, body weight, age, whatever. The first rule is to understand this. Personally, I have the choice to take either, and I always take phenyl instead. Modafinil works well for me the first day, maybe the second, but it will burn me out very quickly. It makes me feel terrible fast. Phenyl doesn’t have this effect. Supplement with citicholine (or another choline source like centrophenoxine, alpha-GPC, or dietary choline) and fish oil (or DHA enhanced flax seed oil) to get the best effects. Take the choline source and the DHA source together, and take the phenylpiracetam an hour later. Try both if you can. I really hate provigil and nuvigil, Dexedrine is far more dangerous and unhealthy than pro/nuvigil or any racetam, but if its not going to become a habit it might be worth looking into. Dexedrine is about as strong as you can get without using crystal meth. Again, it may affect you terribly or in a great way. It depends on the brain, not the substance. Experiment responsibly.”

Does eating food effects Phenylpiracetam?

Eating a meal will likely hinder absorption with phenylpiracetam and especially noopept. I would recommend taking phenylpiracetam on an empty stomach (ie first thing in the morning). Noopept can be taken sublingually (under the tongue) and bypass the need to absorb it in your GI. It’s absorbed much more efficiently this way and it does not matter if you’ve recently eaten anything. If you’re asking if eating food while under the effects of phenylpiracetam or noopept, the answer is no.

What does phenylpiracetam synergize with?

Phenylpiracetam stacks well with most other nootropics. The most common type of nootropic that it’s stacked with is the cholinergics. And of the cholinergics, the most common ones taken with phenylpiracetam are Alpha-GPC and CDP-Choline. The reason for this is twofold: First, some people get headaches with phenylpiraceam and other racetams. It is thought that this side effect is caused by reduced acetylcholine levels. Taking a choline source with it increases acetylcholine levels in the brain, eliminating the headaches. The second reason that cholinergics go well with phenylpiracetam is that the latter works (in part) by affecting acetylcholine in the brain. By taking the former, you have more of this neurotransmitter for the phenylpiracatam to work with. This leads to a synergistic effect. Taking phenylpiracetam with either Alpha-GPC or CDP-Choline seems to be more effective than taking either of these by themselves.

More FAQs can be found on here [link]

Related Nootropics

Phenylpiracetam is one of a nootropic-family type called racetams. Some of which are:

Other nootropics that might be of interest:


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OverviewWhat is Aniracetam?Benefits and EffectsDosageFocus StackAnxiety StackSide EffectsUser Experiences


Summary: Aniracetam is a multipurpose nootropic that provides several benefits. It produces remarkable anxiolytic effects, thereby improving cognition and enhancing mood by ridding anxieties. It also sharpens focus, increases verbal fluency, information processing, as well as expands the brain’s capability of digesting and processing information. Furthermore it produces sense of clarity and well-being.

Aniracetam TTS on Youtube

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Overview

What is Aniracetam?

Aniracetam (systematically known as N-anisoyl-2-pyrrolidinone, and trade names Ampamet, Memodrin, and Pergamid ) is an invention from the 1970’s which has been since standing as one of the most popular racetams. It is more potent than Piracetam, the original racetam that led to the invention of the large family of racetams that exists today. However, Aniracetam and Piracetam work in different fashions, respectively. Aside from being a best-selling across racetams on many vendor websites, it’s also peaking among the most expensive ones. The majority of individuals using Aniracetam, myself included, report its anxiolytic and mood enhancing effects as remarkable, profound, and most noticeable.

The majority of individuals using Aniracetam report its anxiolytic and mood enhancing effects as remarkable, profound, and most noticeable.

Furthermore notable is the increase in social and verbal confidence as well as improvement of verbal fluency. Both advantages are likely to the anxiety-relieving characteristic of Aniracetam. In individuals with generalized and social anxieties, the effects are profound: relaxing and relieving anxiety levels to a significant degree due to feeling the overall mood enhancement and worrying less about random thoughts such as ones that are unchangeable. Freeing the accumulated anxiety leads to make space available for better, positive thoughts, thus leading to an open and welcoming approach to situations as well as human connections.

Aniracetam’ anti-anxiety and mood enhancing properties, strong cognitive improvements, and its minimal side effects, has made it one of the most popular nootropics. Besides improving mood and reducing anxiety, it also promotes creativity, verbal fluency, and memory.

Although immediate effects from taking Aniracetam are notable,  the most significant improvements are notable after a prolonged period of daily consumption.


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Benefits and Effects

What Are Aniracetam Benefits?

  1. Improves and Enhances Memory
  2. Provides Neuroprotection and Promotes Longevity (Anti-Aging)
  3. Heightens Focus and Concentration
  4. Relieves Anxiety (Especially Social Anxiety)
  5. Relieves Depression Symptoms
  6. Improves Memory and Learning Capacity
  7. Supports Management of Alzheimer’s Disease
  8. Additional Benefits of Aniracetam

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Supporting Research:

Improves and Enhances Memory

In two different rodent studies, Aniracetam proved to improve behavioral performance, and even reverse memory loss. In the second study on rodents aniracetam improved amnesia-like memory loss that was a result of sleep deprivation. [1] [2]


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Provides Neuroprotection to the Brain

Aniracetam acts as a neuroprotectant for brain cells. It helps to protect the brain damage that occurs from external influences. Furthermore, it assists in reversing brain damage caused by excessive alcohol consumption. [3], [4], [5]


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Heightens Focus and Concentration

Aniracetam is remarkable in heightening concentration and focus. It exhibits effects such as increasing noradrenaline release in the brain, which is the reason for the stimulating effect of cognition boost as well as in concentration and focus. [6], [7]


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Relieves Anxiety and Stress

Aniracetam shows strengths in reducing anxiety. Studies show that it affect anxiety by increasing social interactions and improving performance in fear and stress tests. With an increase in serotonin and dopamine, individuals feel a noticeable reduction in anxiety. Thus, becoming a general anxiety relieving agent. Although there are studies that support and verify this process, it is also useful to read personal experiences from Reddit and Longevity communities, where many reports it being far better than Piracetam, Coluracetam, Phenylpiracetam and similar nootropics in the field of anxiety reduction. [8], [9]


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Relieves Depression Symptoms

It’s been proved to be useful as an antidepressant in rodent studies. In Japan, it has been used to treat stroke, depression, and anxiety. The release of dopamine and serotonin enhances mood and associating positive feelings. The impact of Aniracetam on AMPA receptors help with easing depression rising from cognitive degeneration conditions such as Parkinson’s disease. The effects of Aniracetam on depression are a result of the increase in acetylcholine and dopaminergic receptor stimulation. [10], [11]


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Improves Memory and Learning Capacity

One of the main advantages of using Aniracetam is the profound findings on memory improvement and expansion of learning capacity. It enhances the formation of memories as well as the consolidation. Aniracetam increases the blood flow in the brain’s frontal cortex. The primary function of the frontal cortex is assisting in holistic thinking and the ability to form and connect ideas and thoughts. A study on the cognitive function of rodents observes that it also helps in improving parts of the memory and learning to promote an increase in productivity and task completion, which also assists individuals with ADHD. [12], [13]


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Supports Alzheimer’s Disease Management

Aniracetam is helpful for elderly individuals. A study on patients with Alzheimer’s-related dementia found a significant improvement in comparison to another group receiving high doses of Piracetam. Over a year period, individuals receiving Aniracetam showed higher cognitive function abilities and an increase in overall emotional stability. Studies show the likelihood of Aniracetam as a preventative as well as a remedy for Alzheimer and disorders that result from central nervous system damage [14]


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Additional Benefits

Aniracetam is said to promote and improve REM stage sleep according to this study. [15]


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Mechanism of Action

How Does Aniracetam Work?

Aniracetam is fat soluble which mean the compound breaks down at a slow pace thereby extending its effect. It has a half-life of 3 hours. Its pyrrolidinone structure makes it fall into the group of racetams. It’s one of the most common structures when it comes to this class of drugs. It has an additional methoxy group with an anisoyl ring at the para position. It is absorbed and metabolized in less than 30 minutes thereby rapidly crossing the blood-brain barrier [16], [17]. Although not all of its mechanisms are understood, an extensive amount of research compiling on Aniracetam and they hint that it works by modulating the following:

aniracetam benefits
Aniracetam Skeletal Structure

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Glutamate Neurotransmission

Aniracetam is essential in improving information and memory retention because of its effectiveness in transmitting glutamate. This neurotransmitter is vital in the activation of neurons. The glutamate receptors connect strongly with storage of information and preservation of memory. Aniracetam has a long-term effect on improving neuroplasticity. [18], [19]


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Dopaminergic Neurotransmission

In rodents, the oral ingestion of 50 mg/kg has effects of minimizing the rates of dopamine in the striatum and decreasing dopamine rates in the striatum and hypothalamus. The levels of serotonin reduce in the hypothalamus but add in the striatum and cortex, where it decreases hypothalamus turnover and increases brainstem, striatum and cortex turnover. [20]


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Acetylcholine Neurotransmission

Aniracetam has effects of improving the cognitive functions by enhancing the action throughout. This is important in attention span, memory and learning speed. It works by associating to acetylcholine receptors, stopping receptor desensitization and endorsing the synaptic discharge of acetylcholine. [21]


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Dosage

How to Take Aniracetam?

Aniracetam has a short half-life of about 1 to 3 hours. Therefore, many users advice to take it in 2 to 3 doses throughout the day to prolong the effect. I only take one 750 mg dose in the morning and am satisfied with this regime.

Aniracetam powder form is also available, though not as in favor as the capsule form due to its strong, bitter taste.

The recommended as well as typical dosage is 750 to 1500 mg, subjective to the individual. Taking smaller doses of as little as 400 mg has been found to be effective. Hence, it is wise to start at the lowest effective dose and build up from there as desired.


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Stack

Best Stack for Increasing Focus

For work as well as learning, Aniracetam can produce remarkable benefits and effects when taken alongside other nootropics and supplements.

It goes without a saying that stacking Aniracetam with a choline source like Citicoline or Alpha-GPC is a must. Leaving the potentiating effect aside, what makes it a must is the fact that many racetams work by utilizing the acetylcholine levels in the brain. Once acetylcholine is utilized and starts getting to a low or depletion levels, the user would then feel a headache. And depending on what racetam did you take and at which dose, it can be a very nasty one.

Aside from that, it really works as a great potentiator. You will feel like both nootropics are working at a better level.

Another nootropic that I like to stack with Citicoline & Aniracetam is Lion’s Mane Mushroom.

Although many don’t feel an onset effect, I find that it works very well in that stack even if I am taking it on random basis. Often, I would only use this stack for the days where I have to go to work early and know that I will be there all day from 8 to 4. (or maybe 9 to 3 but you get my point).

On the same occasion, I would also take N-Acetyl L-Tyrosine 350mg. I found that it helps me tremendously in keeping myself working on an ongoing task rather than taking a 5 minutes break every 2 minutes. I am ADHD, and NALT has been one of the greatest discoveries for me in that regard. It also lets me focus better.

If I have time to have coffee before heading out, I would also add L-Theanine to the stack. The synergizing effect of caffeine and L-Theanine is one of my favorite (and now seems old school) combos.

Last but anything from being least, Acetyl L-Carnitine (ALCAR). When I first started experimenting with it I found it very effective on me and was taking 500mg three times a day. Eventually though, I was developing a weird allergy-like symptoms as well as feeling light, needle-like numbing in random parts of my body.

I can’t blame it on ALCAR just like that but after a while of carefully observing, I noticed that it had almost disappeared since I lowered the dosage to 0 for a while, and then got back to taking 500mg per day only. Now when I think about it, I did not get those symptoms pretty much since that time. Interesting note to self.

So in a morning where I am going to be at work all day, which is a massive corporation that drains me sometimes, this would be my stack:

  1. Aniracetam 750mg
  2. Alpha-GPC 300mg
  3. Lion’s Mane Mushroom 500mg
  4. N Acetyl L-Tyrosine 350mg
  5. Acetyl L-Carnitine 500mg
  6. Caffeine 100mg
  7. L-Theanine 200mg (if I’m having coffee)

Of course the stack is ever changing, but when it comes to Aniracetam, I remember that stack being one I liked and found to be very effective on me. It made me focused at work, energized throughout the day (esp. on days where I also took Adrafinil), diminished my occasional social anxiety, and made me very productive at my job.

Every now and then, I would take a 15 to 20mg of Noopept and take it after lunch break (not that I have lunch during those breaks, I’m just drawing the timing picture here) to get a little boost and prolong the effects of…all the above.


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Stack for Anxiety and Stress Relief

Another Aniracetam Stack that I really like for either when you are running late (I say this mainly for the ADHD readers, I know the struggle very well…), or just not in the mood to go after 10 containers getting one pill from each, and rather like the convenience. I often use this one when I am on the go and its

It’s a very easy and convenient stack. Simply 3 pills and you are good to go. Sometimes I would take another serving of MindLab in the afternoon as needed. The maximum allowance is 2 servings (4 pills) every 24 hours. I think its the best nootropic formula in that situation.

Note to self: re-order MindLab Pro – you used the last remaining pill today.


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Side Effects

What Are Aniracetam Side Effects?

Side effects of supplementing are mild and only occur when consuming high doses. High doses can result in digestive discomfort and nervousness.

Headaches are often reported. It is due to lowered acetylcholine levels in the brain due to racetams utilizing them. Therefore, it is almost a rule to pair racetam drugs with a choline source (such as Alpha-GPC or CDP-choline). Not only will choline prevent or eliminate the headache, but it will also work synergistically together firing cognitive function (21).


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User Experiences

Below are a few randomly selected Aniracetam user experiences from people within the Reddit nootropic community:

“My first aniracetam trial at only 250 mg made me feel a little out of it for a couple hours, and “loopy” would probably be the right word had I started out with three times that much. This may refer to what is often described as an anxiolytic effect.

On the other hand, once this passed I felt more clear than usual. Others have reported such a “biphasic” effect as well. There are a number of things you can do, one of which is obviously not to use it again. Others are to try a lower dose, especially to begin with, until you become more accustomed to how it affects you. When you take it matters too; if you get this biphasic effect then take that into account when timing your use. With some experience, you also may find stacking it with another supplement, for example, phenylpiracetam, helpful. In any case, I always start low when trying anything new just as a general safety practice and to avoid unpleasant surprises.”


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Reddit

Another reddit user also wrote:

“I’ve been experimenting with nootropic stacks for awhile now and I decided to foray into the racetams. Per Dave Asprey (Bulletproof Exec) I decided to start with aniracetam because of its comparative potency to other the racetams, as well as it’s anxiolytic effect. I bought 30g online (I googled and found Health Supplement Wholesalers, fair-priced) and immediately noticed several changes in various aspects of my day to day life.

First and foremost I have found myself much more resilient to stress than I would normally be. Things that would spin me up in the past are barely even noticeable, and it is exponentially easier to shrug off all but the largest of stressors as if they did not even occur. I have had an elevated mood also. Feelings of happiness and contentment come much more easily to me, and I will catch myself smiling without understanding why. It is a very pleasant change from my previous baseline. I have a much easier time focusing on tasks, and accomplishing goals. My mind feels not only ready, but excited to take on challenges and meet them.

Mental plasticity is a definite benefit of this product. One of my favorite aspects to this is there is no type of mental fog, but instead complete clarity. I feel very sharp and aware, noticing things about my surroundings that I would not have noticed before. It has even given me a new appreciation for music as the tranquility and clarity of mind have allowed me to listen and pick out parts of the music that I would never have noticed before. I highly recommend getting some to anyone seeking any or all of these benefits, as everyone I’ve shared it with has asked me where to buy it for themselves. Pretty excited I found this; I’m anxious to try the other racetams as well.”


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And a third experience:

“Certainly not placebo imo. I’ve tried numerous supplements and a couple other nootropics with the same hope that I would be able to make a significant difference, but without any luck. Aniracetam has been the only one to actually provide me with tangible results. But you guys are free to speculate and make your judgements.”


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Conclusion

Diverse effects of Aniracetam make it an outstanding nootropic. It promotes calmness and improves mood. Moreover, it enhances performance and reduces social anxiety. It is useful for performing artists, public speaking, and overall anxiety reduction. It has shown positive results on cognitive functions making learning quicker and more pleasant.

Furthermore, it heightens focus and concentration over prolonged periods, making it appealing to students and researchers. Aniracetam users report a boost in creativity and an improvement in visuals and self-awareness. It has proved to offer many advantages taken at recommended doses with infrequent adverse effects.

Aniracetam reviews are very encouraging and reddit experiences will make you want to buy yourself some right away.


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Frequently Asked Questions

Can I take Aniracetam every daiy?

No. While it is completely ok to take Aniracetam on regular basis, as well as daily basis. It does not mean you can or should take it every single day for the rest of your life. Moderation is key. And too much of a good thing isn’t necessarily good. I personally have taken it for periods of months continuously, anywhere between 2 to 4 months. Then I would stop it for a while, “cycle,” if you may. If you are taking it every day, do what I often do, which is stopping (cycling it off) once I run out, then prolong the period until I repurchase and refill.

Can you snort Aniracetam?

No. Aniracetam is fat-soluble. It’s meant to be administered orally. Unlike Noopept, for example, which people have reportedly snorted (taste is terrible and the cons outweigh the pros, not recommended). If you snort Aniracetam, due to the dosage, it wouldn’t really be absorbed much.

How does Aniracetam work?

Aniracetam is fat soluble which mean the compound breaks down at a slow pace thereby extending its effect. It has a half-life of 3 hours. Its pyrrolidinone structure makes it fall into the group of racetams. It’s one of the most common structures when it comes to this class of drugs. It has an additional methoxy group with an anisoyl ring at the para position. It is absorbed and metabolized in less than 30 minutes thereby rapidly crossing the blood-brain barrier.

How to take Aniracetam?

Aniracetam can be taken any time really. Although fat-soluble, it can still be well-absorbed with little and even no food. Therefore, you can take it any time. Personally, I like to take it in the morning after having my breakfast which is usually a cup of coffee. However, it is advised to avoid taking Aniracetam in the evening so it doesn’t stimulate you and keep you up and unable to fall asleep.

How long does it take for Aniracetam to kick in?

Aniracetam is considered to be fast-acting, and able to cross the blood-brain barrier in 30 minutes only.

How long does Aniracetam lasts?

Aniracetam has a short half-life of about 1 to 3 hours. Therefore, many users advice to take it in 2 to 3 doses throughout the day to prolong the effect.

How much Aniracetam can I take on daily basis?

The recommended starting point and the effective dose is 750mg, which is also the dosage I take in the morning. If you prefer to prolong the feeling throughout the day, you may take it in 2 to 3 doses throughout the day. For example, instead of one 750 mg in the morning, you can split that into 3 doses of 250 mg, and take it once in the morning, then in the early afternoon, and again in the early evening. I personally prefer a one-time larger dose, and later in the day, use another potentiator to re-up the feeling (usually that would be CoQ10 or Noopept 15mg)

What is Aniracetam used for?

Aniracetam is often used for memory enhancement, neuroprotection, focus, concentration, anxiety relief, depression, increasing learning capacity, as well as to support in the management of alzheimer’s disease.

Where to buy Aniracetam?

Many vendors online sell Aniracetam and I can only recommend something I have personally tried and still use to this day, which is Nootropics Depot’ Aniracetam. If in Dubai, check this page: Nootropics Dubai. Or simply email us.

How does the mechanism of piracetam differ from that of aniracetam?

Neither drug’s mechanism is fully understood, so you will not get a definitive answer to this question. However, I can tell you what difference is suggested by literature on this subject. Aniracetam is known to possess anxiolytic abilitys that piracetam does not. Receptor binding profiles (among other things) for aniracetam were investigated in vitro to see if there was any obvious explanation for this effect. It was determined that Aniracetam affects Dopamine D2 receptors, as well as Serotonin 2a receptors. The exact nature of its effect on these receptors is not understood; nobody has looked into it in more detail than the initial study. Piracetam’s mechanism of action has been investigated more thoroughly, however and direct interaction with these two receptors has indeed been ruled out. So we can be reasonably certain that Aniracetam differs in this respect from the prototypical compound from which it is derived (Piracetam), but not much more than that.

Where to buy Aniracetam in Dubai, Abu Dhabi, or the UAE?

Our sister company Nootropix is the sole provider of Aniracetam in Dubai or the UAE.

Further and Related Readings

  1. Racetams 101 (FAQ)Nootropics 101
  2. Piracetam, Sunifiram, Oxiracetam, Fasoracetam

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