Memory

Memory tag archive. A collection listing every nootropic published on the website tagged under Memory.

Alpha-GPC is a natural choline compound. It works on its own as a powerful memory booster. In combination with other nootropics, it works as a potentiator boosting cognitive capabilities. It's also used as a mild stimulant to boost energy and power output when exercising. Furthermore, it promotes cell regeneration and acts as a neuroprotective agent, against cognitive decline.

Overview

What is Alpha-GPC?

Alpha-GPC is a cholinergic compound naturally present in the body in small amounts and commercially manufactured as an extract of purified soy lecithin. [1]
Although there are dietary resources of Alpha-GPC such as dairy products, organ meats, and wheat germ, concentrations achieved by dietary intake are lower than those obtainable by a supplement. It works rapidly and reliably by delivering necessary choline to the brain. [2]
It provides valuable nootropic qualities, including memory enhancement and protection against brain aging, attributing to longevity. Clinical trials covering thousands of participants confirm Alpha-GPC is a remarkable remedy for memory loss that accompanies Alzheimer’s disease [3], vascular dementia [4], and stroke. [5]

Moreover, it provides neuroprotective, anti-aging benefits. Studies further suggest it is useful in the treatment of generalized anxiety disorder. [6] [7]

Another benefit is its ability to enhance cells membrane health and promote rapid recovery following physical activity. Studies indicate that it also acts as a dopaminergic, encouraging the release of dopamine, meaning it works as a potential treatment for neurodegenerative diseases such as Parkinson’s, in addition to being an overall mood enhancer. [8] [9]

Potent Potentiator

Many consider the real strengths of Alpha-GPC is the potentiating feature when in combination with other nootropics. The choline that it provides the brain with significantly magnify the cognitive enhancing effects of other nootropics, especially the racetams.

I've always liked both Alpha-GPC and Citicoline and appreciated their profound effect, until one day I added Aniracetam 750mg and it was as if I had just took a racetam for the first time. The effects of both nootropics synergize together so well, a year later both of them are on the front line among my nootropic stack.

Alpha-GPC vs Other Choline Sources

According to examine and based on a handful of different studies, Alpha-GPC appears to be the best currently known cholinergic in increasing plasma and brain choline levels, as it has better transportation into the brain than does choline (somewhat similar to CDP-choline) but since it is a greater percentage choline by weight (relative to CDP-choline) taking X dose of either drug gives more choline when using Alpha-GPC.

Benefits and Effects

What Are Alpha-GPC Benefits?

  • Improves Memory Formation and Recall
  • Neuroprotection and Development of New Brain Cells
  • Increases Energy and Speeds up Recovery
  • Increases Attention and Enhances Mood
 

Supporting research:

Improves Memory Formation and Recall

This effect is mainly due to the increase of choline it makes available for conversion to acetylcholine, which is profoundly correlating with cognitive functions and the ability to create and revive memories. Studies confirm it an effective treatment for memory impairment caused by age-related diseases, including Alzheimer’s and several forms of dementia. It has further proven to be capable of recovering memory in volunteers following brief chemically-induced amnesia. [101112]

Neuroprotection and Development of New Brain Cells

It protects and maintains overall brain health by promoting the development of new brain cells and enhancing the body’s capability to repair damaged cell membranes. This attribute is a significant longevity advantage. [13]

Increases Energy and Speeds Up Recovery

Because it stimulates the production of human growth hormone (HGH), Alpha-GPC is valuable for individuals looking to perform better, increase lean muscle mass, feel peak energy during workouts and recover quickly afterward. A pilot study shows that 600 mg of Alpha-GPC taken 90 minutes before bench pressing increases power output by 14%. [141516]

Increases Attention and Enhances Mood

Users report that using Alpha-GPC provides distinguished mental clarity while improving mood. This elevating effect is explained partially by the additional choline it presents, which increases attentiveness and promotes effortless clear-thinking. It's also a link to its production of human growth hormone, which provides energizing, longevity effects. [17]

In combination with other nootropics, it offers adequate choline to achieve optimal cognitive enhancement effects, and it prevents the minor headaches often associating with racetams.

How It Works

How Does Alpha-GPC Work?

Alpha-GPC is comprising of choline, glycerol, and phosphate and its classification is cholinergic. The mechanism of its action is examined with high understanding. However, the manner in which it affects some neuronal functions remains unclear.

A water-soluble supplement that is fast-acting and highly bioavailable orally. It crosses the blood-brain barrier shortly after ingestion, and effects work within an hour. It metabolizes into a combination of choline and byproduct glycerophosphate. Additional choline forming by Alpha-GPC is the essence of its nootropic abilities.

Alpha-GPC

On Acetylcholine

It is a fundamental associate of many cognitive functions including memory formation, learning capacity, and attention. By stimulating the production of acetylcholine, it acts as a neuroprotectant; maintaining neuronal health and preventing potential damage. [Ref 1234]

On Dopamine

Oral ingestion of Alpha-GPC can also be dopaminergic, by increasing dopamine release during neuronal action potentials and possibly by stimulating the expression of receptors. It also has involvement in increasing brain serotonin concentrations following oral administration. [222324]

Dosage

How to Take Alpha-GPC?

Alpha-GPC digests and absorbs smoothly and is gentle on the stomach taken at the typical dose of 300mg. Although many nootropists tend to prefer a dose of 600mg, with a total daily intake ranging from 300 to 1200 mg, either at once or split into two doses. [25]

Personally I find 300mg is effective enough especially because I almost always take it as part of a stack. If not Aniracetam then its PiracetamPhenylpiracetam or Noopept.

On the few occasions where I took it on its own, I still felt very at ease and eager to produce, learn, move.

As with any other nootropic, start with the lowest effective dose and build up gradually as desired.

Storage

“Many users report degradation of alpha-GPC when stored openly or for long periods of time. Alpha-GPC is hygroscopic and will pull moisture in from the surrounding air. 

This will cause the powder to turn into what appears to be a gel. Alpha-GPC with >99% purity will undergo this process at a visible rate (seconds to minutes) and thus requires minimized exposure to the air. 

This hygroscopic quality can cause gel capsules not fully packed with alpha-GPC to dissolve. Proper storage methods need to be used with alpha-GPC and include removing all air from the container, double bagging with plastic bags rated for chemicals (less likely to leak air), and storing bulk/excess inside the freezer. Vacuum sealed bags are highly recommended. 

For people accessing alpha-GPC daily it is advisable to separate a month's supply from excess and storing the excess as best as possible. Vacuum sealing a large supply into many 1 month dividends is a method positively reported by many users. 

It is important to note that hygroscopy is not degradation and leaves the substance still usable; however, the ability to accurately weigh a dose is no longer possible as the substance being weighed will be a mixture of powder and water. 

Liquefied or gelled alpha-GPC may also be indicative of poor storage and thus have an increased likelihood of actual degradation.” 

– Wikipedia

Side Effects

What Are Alpha-GPC Side Effects?

Some side effects rarely occur, such as headaches, fatigue, nervousness, nausea, diarrhea and gastrointestinal distress. It may rarely induce dizziness and low blood pressure in some individuals.

Personally never experienced any side effects from its use. But I've never taken more than 300mg in one dose, and never more than 600mg in a 24-hours frame.

Note: Alpha-GPC interacts adversely with scopolamine. Those using scopolamine are advised to avoid it.

User Experience

Reddit

This might be considered a bit on the excessive side, but I've been taking 300mg of GPC daily for ~2.5 years. I've found it to be one of the most effective ways to treat the severe anxiety that I've suffered throughout most of my life. 

Initially, I periodically experienced the insomnia you mentioned, but that passed within a month or so. 

Every once in a while, I'll go several days without taking the stuff. During those short, sporadic periods of “cycling off”, I've noticed that I feel significantly more “dull” and lethargic than I otherwise do, but that might just be placebo in action. 

I understand that such a lengthy use of an under-researched substance might be a bit careless. 

I suppose the greatest concern would likely be down regulation of choline receptors and reduced choline production, but I doubt that any studies of the effects of long-term heavy choline supplementation currently exist to prove that one way or another.

[find thread here]

Reddit II

As the title says, Alpha GPC has next to eradicated my social anxiety. It's incredible. 

Only downside is I'm having a hard time sleeping at night. Guess my question is, how long can I cycle this stuff safely.

[find thread here]

Reddit III

So I used to take Alpha GPC, as well as a ton of other nootropics for a few months but recently took a couple months off. 

Anyway, I've been trying to get back into them so I took only Alpha GPC this morning. 

I already feel more at ease with everything. I don't have much depression but its crazy how great I feel already. 

I happened to just see this and put it all together.

[find thread here]

Final Thought

Alpha-GPC is a compound with decades of research, and its worldwide appreciation comes from the effects of memory enhancement. 

In addition to the dominant nootropic qualities, it's also an excellent companion to racetams

Moreover, it stimulates the production of human growth hormone. This hormone production improves strength, reduces recovery time, and support the development of lean muscle mass. 

Therefore; it is an excellent nootropic for individuals who enjoy leading an active lifestyle.

Frequently Asked Questions

Personally never experienced any side effects from its use. But I've never taken more than 300mg in one dose, and never more than 600mg in a 24-hours frame. Additionally, according to a study by Food Chem Toxicol in 2011 said Alpha-GPC does not appear to possess mutagenic activity, as well that No Observed Adverse Effect Level (NOAEL) for humans was at least 150 mg/kg over 26 weeks based on extrapolation from dogs.

Alpha-GPC is cholinergic (compounds that increase the levels of acetylcholine or choline in the brain). While Choline is actually a molecule mostly used for turning into acetylcholine, the learning neurotransmitter, as well as live health agent reducing fatty liver buildup.

Alpha-GPC is very water-soluble. It's much more likely to be soluble in water than non-polar solvents such as fat. The reasons why I would say that are as follows: the molecule itself has two ionic sites, ionic organic compounds generally have at least some solubility in water. Two ionic sites significantly increases the likelihood of it being soluble in water. Furthermore, the molecule has many OH a Oxygen moieties. Molecules with a lot of oxygen containing moieties are also likely to be water soluble, due to the hydrogen bonding of water. A good example of this are monosaccharides, they are not ionic, yet dissolve readily in water because of the numerous oxygen containing functional groups on the molecule. Decent answer from a chemist reddit user: everyone_wins

Yes. Alpha-GPC is comprising of choline, glycerol, and phosphate and its classification is cholinergic. The mechanism of its action is examined with high understanding. However, the manner in which it affects some neuronal functions remains unclear. A water-soluble supplement that is fast-acting and highly bioavailable orally. It crosses the blood-brain barrier shortly after ingestion, and effects work within an hour. It metabolizes into a combination of choline and byproduct glycerophosphate. Additional choline forming by Alpha-GPC is the essence of its nootropic abilities.

Although traditionally known as being non-stimulating, some persons do report cognitive stimulation with supplemental alpha-GPC.

Yes, some research studies suggests that oral ingestion of Alpha-GPC can be dopaminergic, by both increasing dopamine release during neuronal action potentials and possibly by stimulating the expression of receptors

A standard dosage of alpha-GPC is 300-600 mg, according to the most common label doses. 300mg for general use, and 600 mg for increasing power output. This dose is in accordance with the study using alpha-GPC to enhance power output (600 mg) and the two studies noting an increase in growth hormone secretion, and is likely a good dose to take for athletes.

Alpha-GPC is comprising of choline, glycerol, and phosphate and its classification is cholinergic. The mechanism of its action is examined with high understanding. However, the manner in which it affects some neuronal functions remains unclear. A water-soluble supplement that is fast-acting and highly bioavailable orally. It crosses the blood-brain barrier shortly after ingestion, and effects work within an hour. It metabolizes into a combination of choline and byproduct glycerophosphate. Additional choline forming by Alpha-GPC is the essence of its nootropic abilities.

Ideally when pairing Alpha-GPC and Piracetam stack, the dose would be:

Piracetam: 1,600 mg and Alpha-GPC: 300 mg.

Same as with Piracetam, when taking an Aniracetam and Alpha-GPC stack, the ideal dosage would be: 750 mg of Aniracetam and 300 mg of Alpha-GPC.

Ideally when pairing Alpha-GPC and Noopept stack, the dosage would be 30mg of Noopept (or 15mg if you prefer 2 doses per day instead than one), and 300mg of Alpha-GPC.

Alpha-GPC can be taken any time, although preferably not late in the evening due to some reports that it stimulates some people. Other than that, you can take it any time with or without food because its water-soluble.

Yes, Alpha-GPC increases growth hormone, but due to a rapid normalization of growth hormone concentrations within 2 hours it may not lead to practical benefits.

Yes, Alpha-GPC is a natural compound.

You can buy Alpha-GPC 150mg Capsules as well as many other nootropics in Dubai online with express delivery and cash on delivery by visiting the store page.

Sunifiram is an experimental, potent and powerful nootropic that enhances memory, expands learning capacity, and uplifts mood. A recent addition to the racetam family that seems more than promising. Sunifiram dosage is usually as small as 5 mg due to its potency. And it is yet to be approved anywhere in the world.

Overview

What is Sunifiram?

Sunifiram is a synthetic derivative of Piracetam. Although there has not been much evidence about its efficacy, it has been proven to be beneficial for the (many) individuals using it. With research and trials ongoing and growing, its use will increase along as well. Sunifiram (also known as DM-235) has been one of the best nootropics that powerfully influence cognition. It enhances mood, lowers stress, and increases energy and focus.

It is an invention from the year 2000. And although it is very new to the market, it is proving to be effective and useful to individuals both in long and short terms. It is an effective nootropic that improves learning and memory, and furthermore enhances cognitive function. It is used in the treatment of neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and amnesia, like most racetams. There are no reports of any severe side effects from its use, making it effective, useful, and safe.

Although it belongs to the racetam class, Sunifiram has a different structure. Therefore, it is sometimes referred to as a piperazine alkaloid rather than racetam. It delivers many of the same memory and learning enhancements as piracetam but is much more potent.

Sunifiram is also an ampakine. It increases the efficacy and activity of neurotransmitter glutamine. This leads to significant changes such as mood and energy improvement along with other cognition benefits.

Sunifiram (developmental codename DM-235) is an experimental drug which has antiamnesic effects in animal studies and with significantly higher potency than piracetam. Sunifiram is a molecular simplification of unifiram (DM-232). As of 2016, sunifiram had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world. Wikipedia

Benefits and Effects

What Are Sunifiram Benefits?

  • Reduces Anxiety, Stress, and Symptoms of Depression
  • Enhances Mood & Boosts Energy
  • Improves Learning Skill and Memory Formation
  • Enhances Focus and Motivation
  • Enhances Visual Perception
  • Increases Libido

 

Supporting research:

Reduces Anxiety, Stress, and Symptoms of Depression

As an antidepressant and anxiety reliever, Sunifiram produces its effects as a mirror image of an ampakine. It reacts with glutamatergic AMPA receptors. That also allows it to act as a mild stimulant.

Enhances Mood & Boosts Energy

Sunifiram is known to increase energy and enhance mood. This is likely due to its antidepressant-like effect.

Improves Learning Skill and Memory Formation

Sunifiram is a potent and powerful nootropic. It enhances memory formation and retention as well as expanding the learning capacity. It is in use in case of diseases that cause memory loss or amnesia. Its use is not yet regulated by the FDA, but still widely in use by many individuals for its nootropic benefits. [R] [R]

Appears to promote long term potentiation in the hippocampus with oral ingestion, which should result in an improvement in memory in animals that have otherwise impaired memory. Examine.com

Enhances Focus and Motivation

Sunifiram enhances focus and concentration. It is known to improve motivation and enable a person to complete mentally-demanding tasks at ease and comfort. The focus heightening and motivation is due to the increase in the release and utilization of acetylcholine; which has a direct impact on cognitive abilities.

Enhances Visual Perception

Sunifiram keeps you out of stress and negative thinking. It makes you have a confident, better outlook on life. It allows you to look at the future positive and ambitiously. Such useful effects are helpful for people at any and every stage of life.

Increases Libido

Increase in the sex drive is often in anecdotal reports. However, there is no clinical evidence on this specific claim and only anecdotal ones support it.

Mechanism of Action

How Does Sunifiram Work?

Sunifiram is a piracetam derivative. But it often comes as a surprise that it has a different chemical structure from the other racetams. It is basically a piperazine alkaloid which can act as an ampakine that will increase the activity of glutamine receptors and increase the stimulation effects. Or it can serve as a cholinergic that stimulates the production and release of acetylcholine.

Sunifiram Structure

AMPAkine Action

Although no such evidence is still available about its use and its action in humans due to the lack of the trials, the primary factor that drives it to work would be the ampakine factor which allows it to provide the stimulation effects by acting at the glutamate receptors. Ampakines are mild stimulants. They can increase alertness and energy. They do not cause restlessness which like other antidepressants or anxiolytics. The increase the energy levels and the activity factor is also one of the significant roles Sunifiram plays. Due to its effect on the glutamate receptors, it leads to functions such as spatial navigation and the formation and storage of memory, which are crucial for many neurological conditions.

Cholinergic Action

Sunifiram acts as a cholinergic as well. Due to this effect, it leads to the production and release of the neurotransmitter acetylcholine. Although the exact mechanism remains unknown. Acetylcholine increases brain function and cognition abilities. The primary functions are memory enhancement, learning speed and capacity which grow and expand very notably. You can also count on the fluid intelligence or ability to solve unique problems with this supplement. Sunifiram is an essential nootropic to students as well as athletes to increase their performance and achieve better results.

Sunifiram appears to act on the glycine binding site of NMDA receptors, which enhances signalling and activates some intracellular proteins (CAMKII and PKCα) which then positively regulate the AMPA receptors. These mechanisms are highly similar to that seen with nefiracetam. Examine.com

The mechanism of action of sunifiram is unknown. Sunifiram, as well as unifiram, were assayed at a wide panel of sites, including the most important receptors, ion channels, and transporters, but showed no affinity for any of the sites. They specifically did not bind to the glutamate, GABA, serotonin, dopamine, adrenergic, histamine, acetylcholine, or opioid receptors at concentrations of up to 1 μM. In addition, the drugs were tested on recombinant AMPA receptors and showed no potentiation of the receptors, indicating that they do not act as AMPA receptor positive allosteric modulators. However, they were able to prevent the amnesia induced by the AMPA receptor antagonist NBQX in the passive avoidance test, suggesting that indirect/downstream AMPA receptor activation may be involved in their memory-enhancing effects. Sunifiram, as well as other nootropics such as piracetam, levetiracetam, and aniracetam are able to antagonize inhibition of glucose transport by barbiturates (e.g., pentobarbital), diazepam, and certain other drugs in human erythrocytes in vitro (Ki = 26.0 uM for sunifiram), and this action has been found to correlate with their potency in reversing scopolamine-induced memory deficits in mice. However, this action has been regarded as very unlikely to represent the main mechanism of action of sunifiram. – Wikipedia

Dosage

How To Take Sunifiram?

Sunifiram works effectively at a dosage of 5 to 10 mg –  at a maximum of three times per day. This is the safe dose which is often taken sublingual for maximum efficacy and absorption.

It is advised that one starts with the smallest doses to prevent side effects and toxicity. Although it is not in documentation, tolerance can grow with excessive usage, so it is better to take it occasionally instead of daily basis.

 

only 4-8 mg 2-3 times a day is needed with this ultra potent nootropic. When you’re talking about the Bugatti of the nootropics world, less is more. A little goes all the way!

Stack

For Boosting Cognitive Function

By pairing sunifiram with one or more of the racetams like piracetamoxiracetam, or Noopept, we can achieve this increase which has been the most common and most favorite Sunifiram combo. A choline source like Alpha GPC is an important part of this combo due to the increased choline depletion by the former nootropics.

For Mood Enhancement

Combining Aniracetam with sunifiram is a good option for mood enhancement. You can combine L-theanine, which increases production of dopamine, serotonin, and GABA with sunifiram. Sulbutiamine, which is a potent enhancer of cholinergic, dopaminergic, and glutamatergic functions can be a good combination as well. Choline source should always be present in those combos to prevent getting a headache.

Side Effects

What Are Sunifiram Side Effects?

Due to being fairly new and not as widely popular as the rest of the racetams, no severe side effects of sunifiram have surfaced yet. Nevertheless, clinical trials are still ongoing, and it is yet to get FDA approval. Use with caution.

User Experience

Reddit

On a Reddit user wrote down a thorough experience of sunifiram:

For years I have been a hardcore coffee drinker and other than that I had not used any other substances to enhance my cognition in any way. A few months ago I started a doctor-supervised weight loss program that included the use of 30 mg of Phentermine daily as an appetite suppressant.

Unfortunately, Phentermine is an amphetamine that gave me an extreme energy rush that was affecting my focus and concentration. I could not sit and study because I was getting easily distracted by anything. This was starting to affect my performance in my current classes and at work so I tried using 200 mg of L-Theanine and reduce my caffeine intake with moderately positive effects.

After losing about 100 lbs, I am ready to stop the Phentermine and continue my healthy eating habits for a long-term weight loss maintenance. This Phentermine is addictive so my doctor is reducing the dose gradually to minimize the withdrawal effects. However, I started feeling slightly depressed and foggy. This is when I decided to go on my own and experiment with Noots to see if they would help.

My doctor is not familiar with any nootropics nor did he think anything like that would be appropriate since the effects of phentermine withdrawal would pass in a few weeks.

I did some research about nootropics that would help me with this situation and decided to go shopping. I was low on cash but had a credit on Amazon so the only strong nootropic that I found was Sunifiram. Despite the warnings that there are no sufficient studies on the long-term effects, I decided to assume all risks and give it a try.

The Experience

I started five days ago with 10mg of Sunifiram administered sublingually. Approximately 10-15 minutes after the first dose I felt what others have called “sunny”. It is hard to explain but it was somewhat overwhelming and the effect did not last long.

The following day I took the same dose and got the same but short effect. I did have a mild headache after waking up but nothing unbearable. I started to get the full effect on Day 3. Suddenly I was able to focus on whatever I wanted and the ideas flowed easily. I had struggled to finish a paper for days but this time I finished it in less than an hour.

Today is Day 5 of using Sunifiram and I have to say it has been a positive experience so far. I wish I could explain better my experience but I have not used anything with comparable results. It is not an extreme rush of energy nor a sedative effect. I just feel a sense of clarity that I had not felt before.

I don't want to take the risk of using Sunifiram for long-term cognition enhancement given the unknown effects of continued use, so I will stop taking it as soon as I finish this class. Once I have some cash to spend, I might look into other alternatives like PiracetamNoopept or something similar.

TLDR

Sunifiram was my first experience with a “smart drug”. During the first two days the effects were mild and nearly unnoticeable. After the third day I felt a positive improvement in my mood and focus. Since there are no sufficient studies on the long term use of this substance, I will discontinue its use and seek other Nootropics with better background research.

Conclusion

Sunifiram is one of the nootropics having huge and fast-growing demand, so its not easily accessible. Its potency, efficacy, and effectiveness have been superb. Although it does not have a lot of trials under its belt, it is nevertheless one which has been encouraging and promoted as a safe and effective nootropic.

Not for everyday use, but it can be a good companion to have in your stack. Increasing energy, cognitive abilities, and physical performance are the prime features of this product which make it one worth trying out.

Frequently Asked Questions

Sunifiram is an experimental, potent racetam. It shares most of racetams benefits and effects. The dosage is usually as small as 5 mg due to its potency. And it is yet to be approved anywhere in the world.

In the US, Sunifiram is unscheduled, and not FDA approved.

Being an ‘experimental' drug, and a very potent one, its important to take very low doses (5 mg, 10 mg tops) and do your research to find news and updates on the matter. You can find the post I cited from Nootropics City under Conclusion which has more information regarding that.

I have found a few different vendors, none of which I tried, rather, only listing for research purpose. Nootropics City, Nootropics Retail, as well as NewMind – all offer Sunifiram in powder as well as capsules.

Unless you are quite experienced in racetams, I wouldn't recommend anything over 5 mg as a starting point. People reported side effects after deciding to increase the dose for more results.

Sunifiram has a half-life of 1-2 hours

Not really at all. Adderall (amphetamine) causes release of dopamine and norepinephrine to increase focus and cause physical and mental stimulation. Sunifiram is a positive allosteric modulator of AMPA channels (increases the activity when a glutamate molecule is bound, but not when nothing is bound), which are a subtype of glutamate receptors. The effect of this is to increase memory formation via long term potentiation, which occurs when NMDA and AMPA (both subtypes of glutamate receptors) channels are both activated in the same neuron. When this happens more glutamate receptors are put into the neuron to make it more likely to fire in the future. Sunifiram increases AMPA firing so increases the odds of a long term potentiation event happening, and therefore memory formation. It does not act as a CNS stimulant like adderall though, and those two drugs really serve different purposes.

Noopept is one of the most potent nootropics available. It boosts overall cognition with a slight psychostimulatory effect. Effects kick-in within minutes of consumption, making it a handy choice right when dealing with or getting to mentally-demanding tasks.

What is Noopept?

Noopept is a nootropic that's been receiving significant appreciation for quite some time. It has close links to the favorite racetam group of nootropics which are known for their exceptional benefits on cognitive function as well as their neuroprotective qualities.

Its effects kick-in almost instantly after consumptions which is one of the reasons behind its popularity. Many nootropics could take anywhere from one day to three months for their optimal effect to take action. But when it comes to noopept, results are usually felt minutes after ingestion. It shares similar onset of action as somewhat related racetam phenylpiracetam.

“N-Phenylacetyl-L-prolylglycine ethyl ester is promoted as a nootropic and is a prodrug of cycloprolylglycine. Other names include the brand name Noopept, developmental code GVS-111; proposed INN omberacetam. Its synthesis was first reported in 1996. Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration, it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question.” – Wikipedia

In Russia and a few of the surrounding countries, Noopept is prescribed for its nootropic qualities. The demand for it is dramatically rising and is currently retailing worldwide, amongst the best selling nootropics on the major vendor websites.

It also acts similar to the way Piracetam does – however, it is said to be somewhere over 1,000 more potent. That is why people tend to reach desired effect or outcome from as little as 10 mg and usually not exceeding 30 mg as total, per day. It smoothly settles itself onto the brain’s receptors.

Even with a dose as small as 10mg, many report it to be quite comparable, and many (myself included) actually favor it over Piracetam.

Noopept is also inexpensive comparing to other nootropics because of its high potency.

Its effectiveness and inexpensive price led to it being a classic, very popular, and in many case, a favorite, amongst the nootropic community.

According to Nootropics City:

Noopept is a very potent Ampakine nootropic drug, and the nootropics brand name for the research peptide “N-phenylacetyl-L-prolyglycine ethyl ester.” Noopept capsules is an entirely synthetic molecule, and has a similar effect to Piracetam, though its effects are quoted as up to 1000 times stronger. Effects are very much like a “mega dose” of piracetam (when a nootropic is taken in dosages up to 8 times the usual amount) and even provides a slight psycho stimulatory effect when taken in low to moderate dosages.

Typical dosages of Noopept range from 10mg at the lower end, to a maximum effective dosage of 30mg per day. When higher dosages are taken then this, tiredness can result, negating many of Noopept’s benefits, alongside tolerance and an increase in Noopept’s negative side effects. Noopept, for best results, should be taken 3 times daily (preferably once with each meal) and should be taken with a choline source (preferably CDP Choline) for maximum results. Noopept, like Piracetam, displayed many neuroprotective effects in rats and mice during testing. More studies are needed to confirm exactly what causes Noopept’s supposed neuroprotective effect.

Take into account with Noopept capsules: Remember, Noopept is entirely a research molecule (as are most nootropics) understand what you are taking, do your own personal research on it, and weigh the positives and negatives before taking Noopept. Take Noopept capsules in a regular, consistent dosing pattern of 10mg per day, and continue to supplement in the form of a U shaped curve, ie: Start off with a low dosage, increase accordingly, then taper back down towards the end of your Noopept regiment.

Noopept capsules should be cycled on and off for 1-3 months at a time for best results. Be sure to take Noopept when a particularly rigorous mental task is being performed.

What Are Noopept Benefits?

  • Supports Memory and Learning
  • Neuroprotective and Promotes Longevity (Anti-Aging)
  • Increases Nerve Growth Factor and BDNF
  • Improves Association Between Left and Right Brain Hemispheres

 

Supporting research:

Supports Memory and Learning

Noopept primary interest is how it improves memory and ease the learning process. It helps in memory creation, with additional benefits such as memory consolidation and speed of recall. Noopept helps the correct management of all sorts of stimuli as they are under process by the cerebellum, which permits better memory retrieval.

In other terms, signal handling by our sensations is more smooth as they are carrying forward into our memory. Through the continued use of Noopept, individuals report information to be more easily digested and processed, giving them the availability to be ready-for-use in everyday activities. One might remember names, places; maybe a word chatted in contact, a tune thought to be forgotten, and such. Memory failures will diminish or to the least will be kept to a very minimum. [1]

Neuroprotective and Promotes Longevity (Anti-Aging)

Studies prove that noopept possesses excellent neuroprotective attributes. The stimulation of the neurons produced by the supplement blocks oxidative damage in the human brain.

Many patients dealing with cognitive impairment can benefit from a consistent dosage of noopept to avoid further cognitive decline. [2]

Increases Nerve Growth Factor and BDNF

NGF (Nerve Growth Factor) is a protein in the body that is involved in the growth, preservation, and continuation of nerve cells, including brain cells. Nerve growth factor is also deemed to be very important in neurogenesis; the body’s ability to generate new cells.

By raising NGF levels in the cerebellum, it allows for new neural connections. The result indicates potentially improved mental skills in nearly all areas of cognition. [3]

BDNF (Brain-Derived Neurotrophic Factor) is another protein in the body that has s role to the NGF mentioned above. BDNF is one of the most critical molecules that associate with memory, playing an essential role in both short and long-term memory formation. [45]

Improves Association Between Left and Right Brain Hemispheres

Both the right and left hemispheres of the brain to have their localized functions. Through the use of noopept, each of those functions is developing through the synthesis of various memories, ideas, and stimuli. There are nuances among these functions that improve the way we think. That is why many people have claimed that their quality of life had a significant improvement when taking noopept on a regular basis.

How Does Noopept Work?

Noopept seems to be effective – and longer lasting than Piracetam, due to its effect on the NMDA receptors. It works in a similar way and has similar mechanisms as Piracetam, but at a much lower dosage – when it comes to whole brain function. The research available along with the anecdotal reports seem to strongly support this claim.

Noopept review
Noopept Skeletal Structure

“Oral ingestion of Noopept results in a very rapid absorption and metabolism of Noopept, although the kinetics of metabolites (which are thought to be bioactive) is not yet known. A true bioavailability study has not been conducted, although it appears that an oral dose is about the equivalent of one tenth an injected dose (10% bioavailability).”

Examine.com

Noopept users report results of improved clarity, better memory, and focus. More studies are undergoing to determine precisely how it provides those privileges to the brain. Studies on animals have shown that Noopept increased alpha/beta1 activity in all brain areas (R).

Noopept’s mechanism of action is similar to the other racetams. Noopept works on the AMPA and NDMA receptor sites and their pathways of function. It also has an affinity for the Acetylcholine system and the ACh receptor sites. Both of these factors contribute to Noopept’s array of nootropic benefits. Like Aniracetam, Noopept appears to produce an anxiolytic (anti-anxiety) response in animal and human models. This is not a guaranteed result and seems to vary widely between subjects. Like with Aniracetam, Noopept seems stimulate Dopamine receptor sites (D2 and D3) as well as the ACh nicotinic receptor sites. Noopept also seems to stimulate certain Serotonin receptors and this may also contribute to its mood boosting qualities.

Nootropics City

On Memory and Cognitive Decline

Noopept seems to be especially effective, and demonstrates the greatest benefits to patients with mild cognitive decline. It is now undergoing clinical trials for the treatment of cognitive deficiency of post-traumatic origin and cerebrovascular cause.

The cerebellum benefits include antioxidant activity as well as anti-inflammatory qualities,  along with repression of toxicity by the removal of excessive glutamate, and calcium. Similarly, blood rhythm and flow signifies further improvement. Two possible mechanisms of action for enhancing cognition are a sensitizing effect on acetylcholine processes or induction of neurotrophin production, both of which theoretically enhance memory formation.

Noopept absorption is a process by the digestive system and succeeding to cross the blood-brain barrier readily. The brain utilizes it almost entirely, very little goes to waste.

Noopept marks glutamate receptor sections where it chains with the glutamate and inhibit breakdown. Glutamate, being one of the most influential neurotransmitters, supports and increases cognitive functioning. It works fast once it is in the bloodstream, maximizing concentration following only 15 to 20 minutes.

Anecdotal reports often recall the “sudden abundance of clarity and precision” delivered by the immediate advantage of added oxygen to the brain and enhanced glucose use. Furthermore, its frequently reported that it also improves eyesight and perception, expanding one's awareness to his or her surroundings and perceiving colors and objects to be more alive, vibrant, and vivid.

How to Take Noopept?

If you prefer to prolong the effect throughout the day, the recommended Noopept dosage would be to take it in three doses of 10mg, or two doses of 15mg, or just one dose of 30mg.

  • 10 mg: divide into three doses throughout the day
  • 15 mg: divide into two doses twice a day
  • 30 mg: one dose per day

Do not exceed the 30mg Noopept dosage in one day – and ideally, no longer than 60 days cycle if taken everyday. After that, allow yourself some time off before you start another cycle. Alternatively, you can take it on and off as needed. Experimenting is the best way to find out what works for your own body.

Given how fast the body metabolizes it, and due to its rather short half-life, it is best to take small doses multiple times a day instead of a large one at once; thereby prolonging the effects. In the beginning, it is wise to start with the smallest effective dose with careful observation, before progressing into a higher dose.

Noopept Powder Form

In powder form, take Noopept sublingually or as a drink with water. Effects will kick-in almost immediately. According to the label, take Noopept for 1.5 to 3 weeks and then, if necessary, to begin another cycle after a 1-month break. Alternatively, many users follow 56 days on and four days off. Do not take Noopept late in the evening as its energizing effects may interfere with sleep.

And furthermore; “to supplement Noopept, take 10 – 30 mg, once a day, for up to 56 days at a time. More research is needed to determine the optimal human dose for Noopept.” again, quoting Examine.

Noopept Nasal Spray (Intranasal)

Many people seem to discuss different mixtures to getting the most ideal ratio for a Noopept Nasal spray, but there isn't any solid information that I could put on here. If you're interested in user experiments and anecdotal experiences, there are a couple different threads you can find by searching ‘Noopept Nasal' on reddit nootropics subreddit here.

Alpha-GPC or Citicoline (or whatever your choline preference may be). This will massively potentiate the effect, and will prevent the occasion occurrence of Noopept's headaches.

What Are Noopept Side Effects?

These side effects of Noopepts are mostly occurring when higher doses are consumed:

  • Headache
  • Restlessness (or overstimulation)
  • Dizziness
  • Irritability

Some studies suggest that it magnifies the effects of stimulants such as amphetamines, so caution is advisable for individuals using ADHD medication. I can personally advise that as well. I've felt that sense of overstimulation in a couple different occasion when taking a 30 mg dose of Noopept shortly after taking my ADHD medication. I now find that a 15 mg dose works best for me whether once or twice per day.

My Personal Experience

Noopept was amongst the very first nootropics I got to try taking it in a one dose of 30 mg in the early afternoon with 300mg of Alpha-GPC.

Probably the most effective, and most profound feeling I ever got off a nootropic to this day. I really thought I hit the jackpot. I was able to sit throughout the day at work fully engaged and focused on my whatever I was working on, without any sort of complaining whatsoever. And that was at my corporate job, not at my home office. I was amazed by that.

I had to see if it was in my head or if it had been really that effective, and so I had both my best friend and my sister to try it out on different occasions – both of them ended up asking me to try it a few more times. My friend went on to buy her own while doing her finals at an international affairs academy programme and I never heard her talk so positively about any supplement or nootropic whatsoever the way she talked and liked Noopept.

Unfortunately though, today, after quite a long time since I first discovered it, it seems to have half the effect it had on me back in the day even if I don't take it for a month or so. But it makes complete since due to the similarities of other racetams that I supplement with frequently – mostly Aniracetam. But the feeling I experienced in the very first few times of Noopept was something I had never felt with any other nootropic.

Reddit

On reddit's nootropics sub, a user wrote:

“Noopept: Probably the most potent memory and cognition enhancing nootropic I’ve tried besides Phenylpiracetam…noopept really makes a huge difference for me in terms of mental clarity, memory recall, and fluid thinking. I’ll be on this for life 100%”

Another reddit user wrote his experience titled: ‘My Experience with Noopept and Adderall' and it says:

Before the downvote brigade comes out and downvotes me to hell, I am prescribed adderall, it works wonders for me, and no nootropic could ever replace adderall for me. I've been on it for probably 15 years. It does its job, but I still have issues with performance anxiety where if I start thinking about my performance it slowly spirals into being so anxious about not being able to do well that I can't even retain the information in a sentence. CBD oil helps a little bit.

My focus has never really been mine to ‘give', it's more at the whim of when and where it works, no matter how hard I may try to concentrate. Noopept is changing that.

Anywho, WOW is all I have to say. I have tried noopept many times, but never did I do it consistently. I hate that I hadn't before because this is borderline life changing. Here's what happened:

My friend ordered some Russian noopept for the both of us, as he's from Russia and wanted to try it out. I had tried the sublingual and powdered versions of it and they had always given me brain fog, so I was a bit wary, but his dad had said that he had used it in college and that you have to keep taking it to get over that yucky feeling. So I figured I'd give it a shot, it was the original stuff after all. So I took he threw me a box of it in class the day it came in, and we took some right there.

Day 1: The first dose in the morning didn't kick in until about an hour, took it on an empty stomach. It was the same yucky, brain foggy stuff I was used to, but he was so excited about it I was gonna give it a few days before I was gonna stop and tell him. We took a second dose a few hours later and felt noticeably worse. We kinda brushed it off and hoped his dad's advice was correct.

Day 2: Same thing, took it in the morning, and at lunch, but couldn't concentrate at all. Except later that day, I got this burst of clarity around the time I was expecting it to wear off, which was unusual. But before the clarity happened, I was feeling downright awful, enough so that I wasn't going to take another dose. It felt like nicotine poisoning almost. I told him about it and he said he felt similarly. But then this clarity, it was like I had a cup of coffee but I hadn't. It was weird.

Day 3: I take it with breakfast and holy crap, I feel great. It's like I can just read a sentence without my eyes jumping around the page!!! (Something that I would consider quite the feat!) It was like my focus was mine to give, like I could read an entire line of code and actually process it without having to re-read it at all!

Day 4 and 5: I continue taking it with food and now I understand why people say its effects compound. I still have plenty of focus to give, more so, and I feel like some of my anxiety has gone. Very satisfied.

Now here it is on Day 7 on a Sunday, I didn't take it yesterday and I feel like the effects are still there. I had focus to give yesterday and today and I haven't taken it. Like I don't know what to say, except that I wonder if this is how neurotypical people feel on a regular basis. It's nuts.

My only concern I have here is its interaction with adderall tolerance. I haven't noticed anything yet, but has anybody that has taken these 2 together experienced any effects on their adderall/amphetamine tolerance? (vyvanse, dexedrine, etc.) That would be the only thing that would get me to stop with noopept is if it has a severe effect on tolerance.

Anyway, I just wanted to share my experience with the two, and I hope it's helpful! I also wasn't on any other nootropics this week to test this out.

UPDATE: I have been taking 10mg twice a day on weekdays and the only physical side effect I've noticed is I'm more sensitive to temperature and I've been sweating more, even sitting still. Off of it my pits don't sweat but on it they do.

The benefits of Noopept are numerous, but the best thing about it is that its effects are cumulative.

Noopept has quickly grown in demand and has earned its space within people’s nootropic stacks due to its impressive results, ease of small doses, and its reasonable, affordable cost.

Whether an expert nootropic user or merely getting to learn about it all, noopept is an excellent choice for an overall cognitive function boost.

Frequently Asked Questions

Noopept is a nootropic that's been receiving significant appreciation for quite some time. It has close links to the favorite racetam group of nootropics which are known for their exceptional benefits on cognitive function as well as their neuroprotective qualities.

Noopept marks glutamate receptor sections where it chains with the glutamate and inhibit breakdown. Glutamate, being one of the most influential neurotransmitters, supports and increases cognitive functioning.

Noopept is a powerful Nootropic compound. It protects your brain from stresses and toxins (neuroprotection). It is great at improving cognitive performance and memory. Furthermore, it shields from degenerative brain disorder relating to aging.

Noopept works fast once it is in the bloodstream, maximizing concentration following only 15 to 20 minutes. Its effects kick-in almost instantly after consumptions which is one of the reasons behind its popularity. Many nootropics could take anywhere from one day to three months for their optimal effect to take action.

  • 10 mg – divide into three doses throughout the day
  • 15 mg – divide into two doses twice a day
  • 30 mg – one dose per day

If you prefer to prolong the effect throughout the day, take Noopept in three doses of 10mg, or two doses of 15mg, or just one dose of 30mg.

In powder form, take Noopept sublingually or as a drink with water. Effects will kick-in almost immediately.

There's no “right way” to do it. Place under tongue, close mouth and rest tongue gently on the Noopept. Just hold it there for a while. Once it's mostly gone, swoosh it around a bit and swallow the rest. Try not to swallow the saliva that builds up in your mouth because then you are most likely swallowing some of the drug that hasn't been absorbed yet.

Noopept's half-life depends on the individual. The duration of Noopept is around 3 – 6 hours. Effects of Noopept increase after using it for a few days.

 

If you are in Dubai, you can buy Noopept 30mg Capsules as well as many other nootropics online from the shop page.

Lion’s Mane Mushroom has become one of nature's most potent nootropic supplement for the brain. There is evidence that is can permanently enhance brain function as well as protect the brain and promote NGF and neurogenesis.

What is Lion's Mane Mushroom?

Lion’s Mane Mushroom (also known as Hericium erinaceus), or rarely “monkey head mushroom,” is a traditional medicine that’s developing a strong fan base around the world. It has been voted as one of the top 10 natural nootropics of 2018 in terms of best selling, according to Nootropics Depot, as well as most beneficial. The list also included L-TheanineCiticoline, as well as L-Theanine & Caffeine synergistic combo.

The profound effects it has on cognitive function while being neuroprotectant, as well as supporting NGF production, make it an appealing nootropic. The nerve growth factor is a discovery from 1986 that led Dr. Rita Levi-Montalcini to win a Nobel Prize. NGF is one of the primary building blocks of neuroplasticity.

Furthermore, it is part of a group of molecules responsible for neurodevelopment. A go-to tonic for years, Lion’s Mane (Hericium Erinaceus) is native to Japan, China, Europe, and North America. It offers many benefits to the brain. It's in use as an alternative medicine to treat neurodegenerative disorders.

It is becoming more popular after the discovery of connections to promoting neurodevelopment. It raises the quantity of NGF in the brain, which improves cognition by decreasing inflammation, promoting neural growth, and enhancing brain health. Furthermore, studies verify that Lion’s Mane is a powerful neuroprotectant that can be valuable in the treatment of a variety of conditions ranging from cardiovascular health to obesity and even to certain types of cancer. Thus, Lion's Mane has become a novel nootropic.

What Are Lion's Mane Mushroom Benefits?

  • Enhances Memory and Brain Function
  • Promotes Nerve Growth Factor and
  • Neuroprotection
  • Reduces Anxiety and Symptoms of Depression
  • Reduces Inflammation,
  • Boosts Immunity, and
  • Helps Digestion
  • Supports Heart and Circulatory System, and Prevents Strokes
  • Improves Mental Health and Overall Well-Being

 

Supporting research:

Enhances Memory and Brain Function

Lion’s Mane Mushroom benefits are diverse. One of which is that it boosts cognition, especially in memory and recall speed. Additionally, it helps in maintaining concentration, increasing mental stamina, and heightening focus. It is one of the most praised nootropics due to being organic and natural. Furthermore, it provides a variety of benefits, often surpassing pharmaceutical products. 

A study in Japan on subjects diagnosed with a mild cognitive decline receiving Lion’s Mane mushroom extract at a daily dose of 3 g for 16 weeks found a measurable increase in scores on the cognitive function scale. And amazingly, without adverse effects. [R], [R]

Promotes Nerve Growth Factor and Neuroprotection

Lion's Mane Mushroom extract has an impressive ability preventing and healing damaged nerves. Studies support the claim of Lion’s Mane promotion of neurogenesis. The promotion of neurogenesis is also called neurodevelopment or generation. Neurogenesis results in long-lasting and continuous improvements in brain health (R) (R). In a study by Tohoku University on Lion's Mane and nerve growth states Lion’s Mane has most profound impact on nerve regeneration.

Post digestion, Lion’s Mane distributes through the body – crossing the blood-brain barrier. Then becomes capable of stimulating the generation of enzymes that release the Nerve Growth Factor, and additionally repairing nerve myelin. Those capabilities turn out useful in the cases of Alzheimer’s, dementia, neurodegeneration, muscular weakness, Parkinson’s Disease, and other neurological disorders. (R) (R)

Reduces Anxiety and Symptoms of Depression

Studies show that Lion’s Mane Mushroom benefits depression as well as anxiety symptoms after several weeks of supplementation. In a clinical trial where thirty women have been receiving Lion's Mane for four weeks versus women receiving placebo, it concluded that lion's mane intake indeed reduces depression and anxiety. (R), (R)

Reduces Inflammation, Boosts Immune System, Supports Healthy Digestion

Due to its potent anti-inflammatory properties, lion’s mane mushroom might improve the function of your stomach and digestive system. In many studies, lion’s mane mushroom has been shown to protect from or shrink gastric ulcers.

Moreover, according to a survey by the Mushroom Research Centre at the University of Malaya, experts from the field concluded that the bioactive compounds in lion’s mane extract are responsible for the gastroprotective action. (R)

Another research from China published in the International Journal of Medicinal Mushrooms verifies that “results indicate that polysaccharide fraction is the active component of the H. erinaceus mycelium culture, which protects against gastric ulcers.”

Lion’s mane also significantly improve symptoms of two major inflammatory disorders of the digestive system; inflammatory bowel disease, and gastritis. Another study in Japan found that lion’s mane was able to reduce inflammation in fatty tissue, the factor in the formation of metabolic syndrome, a group of conditions that increase the risk of heart diseases, strokes, and diabetes. (R)

Lion’s mane can improve immune system function like the polysaccharide content in the fungus according to mice studies. [R]

Lion’s mane additional benefits is its antibacterial effects against what is now known to be “the world's most successful virus in human history.” (RR)

Supports Heart and Circulatory System Health and Prevents Strokes

Experiments observed that extracts of lion’s mane block the spread of LDL cholesterol, sometimes referred to as the “bad” cholesterol, while simultaneously raising HDL, the good cholesterol. (RR)

A stroke, which happens as a result of lack of sufficient blood supply to the brain, is often caused by blood clots. An extract of lion’s mane mushroom may be useful in the prevention of blood clots accumulate. Thereby helping decrease the risk of stroke, according to a study by the Graduate School of Pharmaceutical Sciences in Japan. (R)

Improves Mental Health and Overall Well-Being

Lion’s mane helps feeling better by improving sleep rhythm and reducing the effects of mental health issues. The powerful extracts from the mushroom have been shown to combat fatigue (R).  

They also possess the ability to regulate the body's circadian rhythms, which is especially important for people at risk of developing dementia. (R)

How Does Lion's Mane Mushroom Work?

Lion’s Mane mechanism of action is completely different from other nootropics. Lion’s Mane enhances cognition by increasing the amount of nerve growth factor in the brain (NGF). Nerve growth factor is one of a group of molecules named neurotrophins that are essential for the growth, development, maintenance, and survival of neurons.

Nerve Growth Factor (NGF)

A discovery in the 1980s that led Dr. Rita Levi-Montalcini to win a Nobel Prize – NGF is confirmed to be one of the primary building blocks of neuroplasticity. The presence of sufficient NGF improves cognition by stimulating growth as well as axons branching.

Inadequate NGF, on the other hand, decreases brain functionality by leading to neuronal degeneration and eventually, the death of nerve cells. The more axons existing, and the better health they possess, the more efficiently impulses are transmitting. The more efficiently impulses are transmitting; the better cognition and overall brain function are.

Myelination

Another way in which NGF enhances cognition is by promoting myelination. Myelin works much like an electrical insulator, raising the speed which impulses progress onward the axons by increasing the electrical resistance of neural cell walls. Furthermore it inhibits the pulse from dissipating the axon.

Myelination lays the groundwork for the restoration and regrowth of damaged axons, providing a track along which regrowth occurs. This activity is a crucial process in preserving the brain from the ravages of aging and is useful in the treatment of neurological complications.

Some of which are multiple sclerosis and psychiatric disorders including depression, schizophrenia, dementia, as well as autism and Alzheimer’s disease.

Ongoing research hint that NGF production stimulated by Lion’s Mane may have anti-anxiety and mood enhancing effects. Furthermore, it could also facilitate weight-loss by improving metabolism.

How To Take Lion Mane Mushroom?

The lowest effective dosage is 500 mg and the limit per day is 3000 mg.

However, higher doses don't necessarily result in more benefits.

A 1000 mg dosage once or twice a day is what I find the most beneficial for my needs.

I remember coming across posts on Reddit r/Nootropics where people were going really, really next level megadosing this. None of which reported anything more than a “slight” psychostimulant effect though – I am going to try to find that thread.

What Are Lion's Mane Mushroom Side Effects?

There are barely any side effects that arise from taking Lion’s Mane.

The most common side effect is an itchy skin which is likely due to the increase in Nerve Growth Factor.

It most likely is the cause and could be a good sign that NGF levels are increasing.

Lion's Mane is an exceptional, one of a kind,  organic nootropic that has many health benefits; additional to its nootropic ones.

Research and clinical trials support its wide variety of perks. It's a nootropic to consider if you are looking for profound benefits to memory, cognition, detoxification, physical, and brain function.

It is one of the few nootropics I have been continuously refilling from the very first use.

Reddit

An on-going Lion's Mane Mushroom experience thread by Reddit users:

After reading about its memory and nervous system injury healing properties, I figured I'd give it a try. I simply purchased a bottle and take two after putting food in my stomach.

Previously I had spent a year on adderall and endured more physical anxiety than I should have had to. I do feel more…evened out, if that makes senseLess on edge and less anxious than I'd ordinarily be. Still on the lookout for other effects, and still willing to accept it could all be a placebo, but I'm remaining curious.

In most cultures other than the US, bitter is an acceptable flavor, and nutritionally acceptable. You can explore other cuisines where the line between medicine and food are more blurred. TCM (Traditional Chinese Medicine) frequently uses bitter herbs/mushrooms/etc in a soup, with other ingredients to balance the flavors. In Asian medicine, mushrooms are consumed as food, and as teas, as well as extracts. You could use the mushrooms in a soup where the broth contains the water used for rehydration, you can boil the mushrooms to make a tea or extract and add flavourings to those.

Satvik is a living term. This changes according to the situations and purposes. Satvik is something that is pure in purpose. All mushrooms grow in a decaying substrate. They grow in places devoid of sunlight. They are scavenger in nature and feed off the dead substrate. They are normally heavy to digest, cold in nature and increase Kapha according to Charak Samhita. I personally believe that mushroom is not exactly satvik in nature as they grow in a decaying medium. However, as said before, satvik is a contextual term. Satva guna is a state of mind. Basically, food that is earned through pure and righteous means, in a non-violent way, the food that does not cause distress or disgust to anyone and endows not only health but bliss to the soul, mind, and body, is called satvik.

It is important to sustain human life at any cost because human life is the only entrance to the state of salvation. Therefore, any food that helps to sustain life for the evolution of the soul is considered satvik. For example, if there is nothing else to eat, in an area with a sparse availability of vegetables, fruits, and grains, in that case even non-vegetarian food(considered rajasic) can be consumed and will not affect the satvik state of mind. But even vegetarian food that is foul smelling, stale, cooked or earned with an unhappy mind, and unappealing to the tongue is not satvik. Mushroom has a natural tendency to trigger susceptibility towards rhinitis and cause other Kapha related problems. Anything that has a natural tendency to cause harm is not considered satvik. For this reason, also, I think that they should be consumed only when other vegetables are not available or affordable; or consumed once in a while. Otherwise, it is not satvik.

Lion's Mane promotes NGF which has in test tube experiment generated 60% neurite outgrowth. It human experiments it has notably diminished mild cognitive impairment, the precursor of Alzheimer's dementia. It reduces amyloid-beta production, which form plaques toxic to healthy neurons, due to its anti-inflammatory properties. So far, there are no cures for Alzheimer's disease. Prevention is multifold: a life-style of regular adequate sleep (brain repair time includes clearing debris), both aerobic and weight-bearing exercise (promotes mitochondria synthesis and efficiency), and ideally intermittent fasting (promotes autophagy – the process where cells of the body are forced to use cellular scraps for synthesis of what is needed). Autophagy strategy is extremely effective for long-lived health. As an aside, B12 deficiency can cause dementia as well and can compound vulnerability to Alzheimer's.

You can buy Lion’s Mane Mushroom Capsules as well as many other nootropics in Dubai from Nootropix webstore.

A reputable brand for shipping quality nootropics locally.

Bacopa monnieri is a powerful natural herb nootropic used for ages for its memory enhancing and anti-aging effects. It reduces anxiety and improves memory formation. It also expands learning capacity, decreases stress and even offers neuroprotection.

What is Bacopa Monnieri?

Bacopa monnieri (also known as Brahmi) is one of the most acknowledged and widely respected nootropics. A traditional Ayurvedic medicine that has a good reputation of being a potent cognitive enhancerstress and anxiety reliever, and brain protector. It improves memory formation and recall speed, it stimulates learning, enhances thought clarity, and increase brain function.

It acts as a brain protectant, and studies confirm it as a potential remedy for dementia and similar conditions. Furthermore, it reduces anxiety and provides a feeling of calm and tranquility, all while eliminating stress.

Users report it an excellent relaxant that improves sleep quality, leading to rejuvenating and refreshing rest. Its nootropic effects are comparable to those of Piracetam, one of the most popular smart drugs in the world. The supplement is produced from the plant extracts.

What Are Bacopa Monnieri Benefits?

  • Enhances Memory Formation
  • Improves Learning and Cognition
  • Reduces Anxiety and Stress
  • Neuroprotective and
  • Promotes Longevity (Anti-Aging)
  • Reduces Symptoms of Depression

 

Supporting research:

Enhances Memory Formation

Enhancement in memory formation, as well as recall speed, is one of Bacopa's primary benefits. Studies show that it significantly enhances memory in older people, and ongoing research is investigating its potential as a treatment of memory issues relating to neurological disorders.  

(J Altern Complement Med. 2010 Jul;16(7):753-9. doi: 10.1089/acm.2009.0342.)

Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. [1]

Improves Learning and Cognition

Bacopa Monnieri improves cognitive processing, making learning new things faster and easier. Studies show that it significantly enhances spatial learning, and it has also been confirmed to improve learning capacity in subjects under stress. Most users say that taking bacopa while studying makes it easier to understand and process new information. Reports carried out by clinical trials at India’s Central Drug Institute (CDRI) in Lucknow state that children taking bacopa show improved academic skills.[2]

Reduces Anxiety and Stress

Bacopa Monnieri is effective in reducing anxiety and stress. Clinical trials show that it significantly decreases anxiety and depression in volunteers, and animal studies compare bacopa to other plant extracts for the effective treatment of anxiety and similar disorders. [3] [4]

Neuroprotective and Promotes Longevity (Anti-Aging)

Bacopa is effective in reducing oxidative stress effects on the brain. It possesses potent antioxidant properties that protect the brain against environmental stressors associated in the cognitive decline relating to aging and associated with Alzheimer’s and other neurological diseases.[5]

Reduces Symptoms of Depression

In a study of individuals over 65 years old receiving 300mg dosage, the results show a notable decrease in depression symptoms as well as anxiety. [6]

How Does Bacopa Monnieri Work?

Bacopa's nootropic and anxiolytic effects are due to its capability of enhancing neural communication as well as modulating the release of several neurotransmitters such as dopamine, serotonin, and GABA.

Memory and Cognition

Although it works over time by a variety of functions, bacopa improves memory and cognitive abilities by increasing synaptic communication. It promotes dendrites generation, thereby enhancing neural signaling. The improvement in neural impulse transmission is key to cognitive enhancement. The active ingredient in Bacopa monnieri extract (Bacoside-A) has been shown to stimulate nerve cells and cause synapses to be more receptive to nerve impulses. Studies show that Bacoside-A can prevent dopamine receptor dysfunction. Dopamine is a powerful neurotransmitter responsible for the brain’s reward and pleasure systems.

It also improves production of the enzyme Tryptophan Hydroxylase (TPH2); vital to many central nervous system actions such as the biosynthesis of serotonin. Furthermore, Bacopa stimulates activity in the hippocampus by increasing the activity of kinases, which are proteins that regulate cellular pathways. Because the hippocampus is involved in almost all cognitive activity, this is one of the main methods that allows bacopa to boost brain function.

Anxiety and Stress Relief

Bacopa monnieri produces its unique calming effects through several actions. One of the most crucial anxiety reduction effects is within its power to modulate the activity of certain neurotransmitters like those that regulate the uptake of serotonin, which is connecting to mood and anxiety.

Another active ingredient in bacopa is hersaponin, an alkaloid that provides a relaxing and soothing effect. Bacopa’s active ingredients also support the activity of GABA, another major neurotransmitter that acts to prevent anxiety by restricting the signaling of neuron over-excitement due to stress.

How To Take Bacopa Monnieri?

The minimum effective dose of Bacopa Monnieri is 300mg, taken with food or fat source. Some people, myself included, find it more effective at a higher dosage.

I take 300 to 600mg depending on the purpose, while people like Dave Asprey recommend a daily dose of 750mg.

What Are Bacopa Monnieri Side Effects?

Bacopa monnieri side effects are uncommon. It is generally safe and effective, nevertheless, side effects can occur just as with any other nootropic.

Bacopa side effects range from minor (digestion issues and fatigue) to severe (thyroid disorders and urinary tract complications). Minor side effects usually disappear as the body adapts to the herb.

Rodent studies suggest bacopa may reduce sperm count, so it's wise to avoid it if you are planning to conceive. However, it didn't have any impact on sex drive nor testosterone. Moreover, sperm count returns to normal once supplementation stops. [7]

Severe side effects may include thyroid disorders, urinary tract problems, gastrointestinal blockage, adverse impact on ulcers and lung conditions, and bradycardia.

So start with the lowest effective dose, and observe your body's reaction to it. If adverse effects occur, stop use.

Bacopa monnieri enhances cognitive abilities, reduces anxiety, and treats a variety of conditions. Although it works over time, the anxiety-relieving effects are immediate.

Its a precious addition to nootropic stacks. If you’re looking for a natural nootropic to boost your cognition, relieve anxiety, and protect your brain against oxidative stress, Bacopa would make an excellent choice.

Yes it does and it is great. You can even grow it yourself on the balcony. It does bring more oxygen to the brain hence you feel stimulated. But can’t compare to synthetic nootropics.

If you want a good harmonizing (stress relief) with energizing stack. Take

1x Bacopa 300mg
1x Rhodiola rosea 300mg
1x Alpha-GPC 300mg

You can 1x 5-HTP 50mg (optional)

And throughout your day, if you drink coffee add 1x L-theanine 100-200mg in it.

The minimum effective dose of Bacopa Monnieri is 300mg, taken with food or fat source. Some people, myself included, find it more effective at a higher dosage.

I take 300 to 600mg depending on the purpose, while people like Dave Asprey recommend a daily dose of 750mg.

Bacopa monnieri side effects are uncommon. It is generally safe and effective, nevertheless, side effects can occur just as with any other nootropic.

The acute relaxation effects of Bacopa Monnieri start working as soon as it enters the bloodstream, which is typically 15 – 30 minutes after consumption.

The potential benefits of Bacopa Monnieri for improving memory and cognition will generally take effect within 4-6 weeks.

  • Enhance Memory Formation
  • Improve Learning and Cognition
  • Reduce Anxiety and Stress
  • Neuroprotective and Promote Longevity
  • Reduce Symptoms of Depression

 

Bacopa monnieri commonly called as ‘Brahmi’ is a perennial herb belonging to Plantaginaceae family of the flowering plants. In India it has been used traditionally in Ayurvedic medicine as memory enhancer. It is also used in treatment of anxiety, digestive disorders, asthma, bronchitis and heart problems.

You can buy Bacopa Monnieri 300mg Capsules as well as many other nootropics in Dubai by visiting the shop page.

IntroductionBenefits & EffectsMechanism of ActionDosageSide Effects


Summary: Vinpocetine is a neuroprotective nootropic, an extraction from flower-plant vinca minor. It works as a cognitive enhancer, memory booster, while also uplifting mood and supporting overall well-being.

Vinpocetine benefits
Vinpocetine Skeletal Structure

Introduction

What is Vinpocetine?

Vinpocetine (aka Cavinton, Intelctol), is an extract from flowering plant vinca minor (or myrtle); a flower-family native to Portugal, France, and other parts of central and southern Europe. A 1975 discovery by Hungarian chemist named Csaba Szantay. Only three years after the invention, production of the extract in pill form started. Some of the primary uses of Vinpocetine as a nootropic are memory and cognition improvement, increasing learning capacity, and mood enhancement. Medical applications extend to the treatment of cerebrovascular disorders, dementia, and strokes. It is very safe and has (almost) no side effects. Its excellent safety profile is inspiring more companies to study and research Vinpocetine to explore other possible therapeutic and nootropic benefits. Although less popular comparing to other nootropics, the research as well as the knowledge of it is rapidly growing


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Benefits & Effects

What Are Vinpocetine Benefits?

  1. Improves Memory and Cognition
  2. Increases Focus, Concentration, and Brain Blood Flow
  3. Enhances Learning Capacity, Information Processing, and Attention
  4. Reduces Cognitive Decline and Increases Overall Well-Being
  5. Neuroprotective and Anti-Inflammatory

Supporting research:

Vinpocetine Improves Memory and Cognition

Vinpocetine is widely in use for memory improvement. In Eastern Europe, it is a medical prescription for treating memory-related problems and disorders. Clinical trials confirm its effect on improving memory formation, and individuals receiving Vinpocetine report it’s beneficial especially in remembering and recalling information. Other studies also confirm it as a memory enhancer that can be used by anyone looking to improve their memory. (R)

Increases Focus, Concentration, and Brain Blood Flow

Vinpocetine increases cerebral blood flow and supports better blood circulation without having adverse effects on blood pressure. The better blood flow and circulation leads to an increase in productivity within the brain. This productivity increases and allows for better focus and concentration, as well as allowing for longer and steady attention span. Take notes, fellow ADHD ADHE’s – (attention-deficit hyperactive extraordinary). (R) (R)

Enhances Learning Capacity, Information Processing, and Attention

Vinpocetine improves the body’s ability of converting dietary glucose and fat to ATP, which is the coenzyme that transmits chemical energy for metabolism. Having more ATP ready for use in the brain leads to better intellectual capability, and thereby learning becomes more comfortable and faster. Moreover, the presence of sufficient ATP reduces feelings of mental exhaustion and “brain fog,” as well as supports feelings of mental clarity. (R)

Reduces Cognitive Decline and Increases Overall Well-Being

An increase in overall well-being is a result of a reduction in the rate of cognitive decline. (R) (R)

Neuroprotective and Anti-Inflammatory

Vinpocetine also acts as an anti-inflammation agent in the brain. It reduces expression of the pro-inflammation and vascular cell adhesion molecules which can lead to neuronal death in some conditions (such as Alzheimer's and Parkinson's). The anti-inflammatory qualities of vinpocetine make it a promising neuroprotectant that is likely to have significant anti-aging and longevity benefits.


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Mechanism of Action

How Does Vinpocetine Work?

Early studies show that Vinpocetine benefits the brain in many ways, one of which is by improving blood flow, circulation, and utilization of oxygen. Unlike common stimulants, Vinpocetine increases blood flow in the brain without affecting the rest of the body. It targets impaired cells and areas of poor circulation within the brain. Enhancing blood flow, circulation, and oxygenation allows the brain to tolerate conditions of lack of sufficient oxygen (such as ischemia and hypoxia) better. Those conditions can relate to strokes and similar injuries. The elevation of blood flow and oxygenation result the nootropic effect.

Furthermore, improving circulation and oxygenation in the brain also enhances the overall brain function while increasing the production of ATP. All of which are vital for cerebral metabolism. By generating sufficient amounts of ATP, vinpocetine increases the use of glucose thereby improves mental clarity.

Vinpocetine interacts with sodium, calcium, and potassium ion channels within the brain, modulating the release of various neurotransmitters. That includes, but not limited to acetylcholine, noradrenaline, serotonin, and dopamine. Increasing the availability of those neurotransmitters not only affects memory and overall cognition but may also improve mood by relieving feelings of anxiety and enhancing energy and well-being. Vinpocetine also acts as an anti-inflammation agent in the brain. It reduces expression of the pro-inflammation and vascular cell adhesion molecules which can lead to neuronal death in some conditions (such as Alzheimer's and Parkinson's). The anti-inflammatory qualities of vinpocetine make it a promising neuroprotectant that is likely to have significant anti-aging and longevity benefits.


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Dosage

How To Take Vinpocetine?

For general health and prevention purposes, the low dose is 5mg 3x per day at meals and ranges up to 20 mg 3x per day. These doses are for neuroprotection, enhancing cerebral blood flow, and reducing the rate of cognitive decline.

For nootropic purposes, suggestion doses of 30 to 45 mg, 3 times a day, alongside food.


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Side Effects

What Are Vinpocetine Side Effects?

Vinpocetine is very safe and has (almost) no side effects. It is also very well tolerated and has no reported adverse effects. New users rarely experience a soft version of caffeine “buzz” that fades away as tolerance to vinpocetine is increased. Keep in mind that increasing the daily dosage to over 40 mg could decrease benefits.


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Conclusion

Vinpocetine’s unique mechanisms of action, great cognitive enhancement abilities, and insurance of neuroprotection are leading to increasing attention within the nootropic community. It’s a safe brain-booster that works well with other nootropics, thereby becoming an attractive addition to nootropic stacks. It’s affordable and easily accessible.

If you are interested in further optimizing your brain, enhancing its blood circulation, as well as allowing it to function at maximum productivity; vinpocetine is a nootropic worthy of your consideration.


Sulbutiamine is a nootropic that boosts energy levels and reduces fatigue. It's an ideal choice on days when you're feeling tired, slow, or hungover. Furthermore, Sulbutiamine elevates mood and has a substantial impact on memory.

Overview

What is Sulbutiamine?

Sulbutiamine (brand name: Arcalion) is a synthetic derivative of thiamine (vitamin B1). In France, it is used to treat symptoms of weakness or fatigue. It also sells as a dietary supplement. 

A discovery from Japan as part of an effort to develop useful thiamine derivatives. [R]

It is an upgraded version of vitamin B1. Japanese researchers developed it in the 1960s while trying to address a growing vitamin B1 deficiency in the Japanese population. [R]

Sulbutiamine supplement is unusually bioavailable — in other words, you absorb it very well, and unlike standard vitamin B1, sulbutiamine passes through your blood-brain barrier, supplying your brain with the precious B vitamin.[R]

Benefits and Effects

What Are Sulbutiamine Benefits?

  • Decreases Fatigue and Improves Mood
  • Relieves Anxiety, Depression
  • Boosts Motivation
  • Enhances Memory
  • Improves Sexual Health & Performance

 

Supporting research:

Decreases Fatigue, Improves Mood

Several extensive studies have found that sulbutiamine significantly increases energy in people who are feeling fatigued. Sulbutiamine benefits Increase energy & stamina.

Enerion was used in the treatment of 40 patients with psychovegetative syndrome and asthenia. Before treatment, the patients have pronounced asthenia appearances, anxiety disorders, relevant autonomic disorders, mild depression and decrease of working capacity, attention concentration and memory. The treatment conducted as monotherapy during 28 days with enerion dosage 400 mg/day. After treatment, expression of autonomic and asthenic disorders was reduced significantly, along with improvement of psychometric and neurophysiological indices. High efficacy of the medication was in 75% of the patients and moderate one–in 25%.

PMID: 14628585

Relieves Anxiety, Depression, and Social Avoidance

Sulbutiamine has no antidepressive effect but it can hasten the resorption of psycho-behavioural inhibition occurring during major depressive disorder and thereby facilitate the rehabilitation of patients in their social, professional and family life functioning. [R]

Boosts Motivation

There is also some evidence that sulbutiamine increases dopamine and glutamate in your prefrontal cortex, which links to increased motivation and good mood. [R]

It has a growing number of fans in the nootropic community, many of whom report improved mood and heightened mental endurance.

Impact on Memory

Sulbutiamine is made up of two vitamin B1 molecules attached together, which could explain its effect on memory. Vitamin B1 plays an essential role in acetylcholine synthesis in your brain. In fact, it’s the only vitamin that regulates acetylcholine levels, keeping them from getting too low or too high. [R]

What is Acetylcholine?

Acetylcholine is a substance found throughout your nervous system, that acts as a neurotransmitter. Your brain uses most of its acetylcholine to control your muscles, which could explain why taking sulbutiamine helps so much with fatigue. But acetylcholine also plays a key part in memory; it helps you consolidate new memories and remember old ones.” [R]

Improves Sexual Performance

Sulbutiamine treatment for 30 days restored sexual performance in 16 patients out of 20 (open-label) with erectile dysfunction (caused by psychological issues) [R]

Mechanism of Action

How Does Sulbutiamine Work?

Sulbutiamine is a molecule which is two Thiamine (B1) molecules linking together, similar to how Pyritinol is two Pyridoxine (B6) molecules link together.

Sulbutiamine is a isobutyryl thiamine disulfide and sometimes goes by its brand names of Ereon or Arcalion. It is most commonly in use for Asthenia, or weakness (part neurological and part myopathic) as well as treatment of somatic and psychic inhibition. It doesn't possess psychostimulant properties, although it is designed to act centrally (in the brain). [1]

Sulbutiamine synthesizes from Thiamine, where after the opening of the thiazole ring of Thiamine and dimerization to a disulfide compound it is then esterified. [2]

Sulbutiamine is a fat-soluble molecule that crosses the blood-brain barrier more readily than thiamine. Once in your brain, it increases levels of thiamine pyrophosphate (TPP). Thiamine pyrophosphate (TPP) is directly involving in the citric acid cycle in the brain.

This cycle breaks fatty acids, amino acids, and monosaccharides into smaller molecules that produce adenosine triphosphate (ATP) energy for your mitochondria. And provide the building blocks of the electrons needed to generate brain cells. 

Dosage

How To Take Sulbutiamine?

Sulbutiamine supplement recommendation dose is 400mg. However, caution is necessary in regards to cycling sulbutiamine and not supplementing on daily basis.

Sulbutiamine dosage: 200-600 mg/day, taken in the morning. Sulbutiamine is fat-soluble (in fact, that’s the reason it can pass the blood-brain barrier and have all these nootropic properties), so be sure you take it with a fat source; otherwise, you won’t absorb it. [R]

Stack

Effective Sulbutiamine Stack

It’s quite rare to find recommendations of stacking sulbutiamine and out of all that I have come across, I think the best stack, or at least one that I would personally consider, is sulbutiamine, aniracetam, and choline stack. For example:

Sulbutiamine 200mg
Aniracetam 750mg
Alpha-GPC 300mg

Aniracetam & choline stack has been one of the most effective I have ever tried. Sulbutiamine supposedly stacks well with racetams and is a common choice due to similarities of effects on cognitive function. [R]

Side Effects

What Are Sulbutiamine Side Effects?

At standard doses (200-1000 mg), side effects could include a headache, nausea, and trouble sleeping.

People doing self-experiments with sulbutiamine, though, occasionally report anxiety and negative thoughts from taking higher doses (most of these side effects showed up around 1000-2000 mg). Others say they feel anxiety from taking sulbutiamine for too long without a break. [R]

User Experience

Reddit

Here is a sulbutiamine Reddit user experience from someone who's ADD (high five!) and prescribed Adderall:

…I only heard about nootropics for the first time around 9 months ago. Used to take Adderall for many years, but quit over 5 years ago because it was causing daily headaches and I suspected it was causing my chronic insomnia.

I have legit ADD, as well as what I would call brain fog, low level depression, lack of motivation. I've taken sulbutiamine a few times, and I have really good results with it. I only take it occasionally, when I have a big project I need to get done (because I don't want it to stop working, like I've read that it will if you take it often). I took it today because I had a lot of organization tasks I needed to do, and since I hate these kinds of tasks, I often lack motivation to start or complete them.

When I take my capsule, I can actually feel it start to kick in around 20-30 minutes after taking it. It reminds me a lot of how Adderall worked/felt but without that unexplainable “buzzy” feeling. I felt motivated and energized, and really got into my work. Just thought I'd share for any other noobs out there who haven't tried it yet.

Conclusion

If you decide to use sulbutiamine, be sure to cycle it. When you don’t take the occasional day off from sulbutiamine, it’s likely you’ll build a tolerance to its effects, and the sulbutiamine will stop working unless you increase the dose. [R]

Experiment is key to finding the dosage and cycle that's just right for you and your body composition.

Its a great choice to consider on days where you need extra mental functionality.

Sulbutiamine is becoming more and more popular in the biohacking community. If you’re curious, give it a try and see how you feel.

PRL-8-53 (chemical name Methyl 3-(2-(benzyl(methyl)amino)benzoate) is a synthetic nootropic compound that was discovered in 1972 and patented in 1975 by then Dr. Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska.

What is PRL-8-53?

PRL-8-53 is a synthetic nootropic compound that was discovered in 1972 and patented in 1975 preliminary animal tests showed that the compound was both secure and nootropic, boosting the learning of prevention in rodents without adverse effects. However, a 1978 research on human volunteers triggered sincere interest in PRL-8-53, showing that a single dose of the compound could enhance word retention ratings by more than 200%.

Comments by author and longevity expert Durk Pearson, who was cited in' High Frontiers' as follows, fuelled interest in the compound: “PRL-8-53 is a great memory enhancer. Usually, just looking at them for a second, you can memorize about seven or eight numbers. On average, PRL-8-53 is said to increase memory span of approximately 21 to 22 digits. “Hansel's single human study on PRL-8-53, soon after patenting the compound, highly promotes the potential of the drug as a nootropic.

The research evaluated word retention between the ages of 24 and 86 in a group of 30 healthy volunteers. While participants with good baseline word retention scores showed little improvement after taking PLR-8-53, participants with low initial scores or over 30 showed significant improvement after a 5 mg dose of PLR-8-53, often more than doubling their recall rate.

In the human study, no adverse effects were observed. Anecdotal evidence seems to support claims for safety and nootropic capacities of PRL-8-53, but due to restricted testing, it is still regarded as an experimental drug.

PRL-8-53 is presently an unplanned drug and is legally available for purchase in the United States.

What Are PRL-8-53 Benefits?

The elderly participants showed necessary improvements in memory after taking a single 5 mg dose in the only human research on PRL-8-53. A double-blind study using word memorization as a measure, testing the capacity of the respondents to recall a list of 12 one-syllable phrases, first to create a baseline and then again after PRL-8-53 or placebo has been ingested. The participants were screened for their capacity to remember the phrases 24 hours after hearing them, and then one week later again.

Results of the research show that respondents with higher baseline scores showed the least improvement after PRL-8-53 was ingested, while subjects with imperfect first memory or over 30 years of the era showed significant improvement in recall. Hansl described the impact on elderly respondents in an article on the exam as follows: “This group was 30 years of era or older. Rote memory, as could be anticipated, did not come to this group as readily as it did to younger learners. After 24 hours on placebo, the average retention was just under three words out of a possible 12.

After a week, the average retention was two words. However, the same topics maintained an average of 5.85 phrases after 24 hours and 5.25 words after a week when learning after drug administration.

Again, there were statistically essential increases. The enhancement expressed in percentage of placebo results was 108 percent for the 24-hour test and 152 percent for the one-week recall. “Many individual nootropic users who have attempted PRL-8-53 confirm their memory boosting impacts, sometimes comparing it to a more strong variant of other nootropics such as nefiracetam and Noopept.

How Does PRL-8-53 Work?

The precise mechanisms of action of PRL-8-53 are not well understood, but the production and reaction of the brain to several key neurotransmitters is thought to be regulated.

In an article in 1979 entitled “Learning and Memory Improvement Through Chemistry: Dream or Offering Reality?”Hansl said,” PRL-8-53 has been shown to increase the peripheral and central reactions to noradrenaline in the animal model. Therefore, assuming that a comparable feature may be present in humans seems reasonable.

Translated into behavioral effects, it implies that this drug potentially is capable of facilitating the conversion of short-term to long-term memory, resulting in increased storage of information code. “According to Hansl, in the same article,” PRL-8-53 has been shown to improve the response to acetylcholine, the answer being quantitatively similar over a considerable dose range, excluding the likelihood of acetylcholine. In short, we now have a possibly effective drug that will increase a particular chemical system in the brain, the cholinergic system, thereby enhancing our capacity to recall data from a pre-existing data pool.

How To Take PRL-8-53?

The only human study on PRL-8-53 was based on a single 5 mg dose intake. No information is available on the efficacy or prospective toxicity of any other human dosage.

What Are PRL-8-53 Side Effects?

No adverse effects were observed in the human study from a single 5 mg dose of PRL-8-53. Animal studies indicate that the compound has a high therapy threshold, but the proof is very restricted as there have been no extensive toxicity trials.

Keep in mind that this is exceptionally experimental chemistry for studies, so caution is recommended.

PRL-8-53 is a fascinating synthetic nootropic, if mainly unexplored, which many think will eventually prove to be an invaluable smart drug.

Although it gave rise to high concern when it was launched 40 years ago, after a few animal tests and a single human study, research into its opportunities came to a halt; little has been learned about it since the review that sparked such compelling interest in its potential as a memory enhancer.

There does not seem to be any continuing research on the compound at this moment, but nootropic lovers continue to be curious about its opportunities and are regarded one of the most excellent short-term memory boosters on the market.

Pramiracetam drew a lot of attention after a study showing an outstanding success rate of 96% in reversing amnesia, surpassing Piracetam. It boosts cognition and improves memory, increases concentration, learning capacity, and supports engaging in – and maintaining – prolonged focus.

Table of Contents

Overview

What is Pramiracetam?

Pramiracetam is one of the best-selling nootropics today due to being the highest in potency out of all racetam nootropics.

It has a distinctive mechanism of action that allows for efficient utilization of brain capabilities, thereby improving memory recall, learning capacity, concentration, and focus. Serves as an excellent supplement on its own and furthermore, a powerful potentiator to other nootropics, intensifying as well as prolonging effects. It is quickly rising towards a well-deserving reputation for its profound effects.

A synthetic derivative of piracetam, Pramiracetam is an invention of Parke-Davis from the 1970s. It is a highly effective nootropic, up to 30 times more potent than piracetam. It is marketed in Europe under brand names Neupramir, Pramistar, and Remen; often as a prescription for individuals with dyslexia, ADHD, dementia, and memory impairment due to neurodegenerative conditions. It was a patent in the US in 1979 but without the support nor the approval of the US FDA.

Regardless, it is popularly used off-label as a different approach to cognitive challenges and memory impairments. Its also undergoing further trials as a potential treatment for a variety of nervous system disorders.

Pramiracetam is a central nervous system stimulant and nootropic agent belonging to the racetam family of drugs. It is marketed by Menarini under the brand name Pramistar as a treatment for memory and attention deficits in aging people with neurodegenerative and vascular dementias in Italy and some Eastern European countries. – Wikipedia

Benefits and Effects

What Are Pramiracetam Benefits?

  • Enhances Overall Cognitive Function
  • Enhances and Supports Memory
  • Reduces Depression and Anxiety
  • Increases Learning Capacity
  • Increases Sense of Clarity
  • Promotes Social Fluency
  • Enhances Sensory Perception
  • Aids Memory Restoration

 

Supporting research:

Enhances Overall Cognitive Function

Pramiracetam optimizes brain performance and produces noticeable cognitive enhancement, especially regarding memory, in both formation of as well as consolidation. Due to the euphoric-like focus, it induces along with a sense of “emotional blunting,” users report the feel of it being comparable to Ritalin.

Enhances and Supports Memory

Due to stimulating the hippocampus, the section of the cerebellum that's accountable toward the formation of new memories, pramiracetam is raising in acknowledgment as a sharp memory enhancer. Users report significant improvement in memory formation and speed of recall; a claim confirmed by animal studies. (R)

Additionally, extensive studies find that it significantly improves long-term memory, and able to reverse amnesia to surprising levels. The findings of that study led to the synthesizing and production the drug.  (R) (R)

Reduces Depression and Anxiety

Pramiracetam reports show it improves cognitive deficits associating with traumatic brain injuries. Studies demonstrate and confirm its neuroprotective effects. Studies show that its overall impact on lowering symptoms of depression and anxiety was higher than improving memory. Nevertheless, it was beneficial for both. (R)

Increases Learning Capacity

Users allegedly report pramiracetam makes learning faster, more efficient, as well as more pleasant. Such finding can be explained, at least in part, by pramiracetam facilitation of higher neuroplasticity and support of long-term memory. The latter seems to be more accurate as per the following study: (R)

Increases Sense of Clarity

Anecdotal reports from the nootropic community tell that pramiracetam provides them with a strong sense of mental awareness, clarity, with a deeper understanding of life; similar to many of those reporting the same effects from piracetam.

Promotes Social Fluency

Furthermore, a lot of people taking pramiracetam report enjoying socializing whereas before, they avoided social settings for lack of interest. This could be due to the cognitive boost or the emotional blunting effect, which is likely to reduce social anxieties. (R)

Enhances Sensory Perception

Another report backed by a clinical study shows that pramiracetam indeed enhances sensory perception and heightens observation. That is including amplified and more vibrant sound and more precise, richer visual perception with distinct color contrast. (R)

Aids Memory Restoration

In clinical experiments, pramiracetam has been noted to be an efficient remedy approach for memory impairment and other cognitive difficulties caused by brain injuries(R). It is also one of the various nootropics that are carried out to examine in the US as a potential treatment for memory impairment associated with Alzheimer’s disease amongst other neurological disorders. There is a study that shows it to be capable of reversing chemically produced amnesia in healthy volunteers of 18-65 years of age. (R)

Mechanism of Action

How Does Pramiracetam Work?

Similar to several nootropics, pramiracetam affects the release of neurotransmitters, brain chemicals that carry signals from one nerve cell to another. Though pramiracetam performs it indirectly, in different fashion than that of other racetams, and it excites the brain in different methods as well. Pramiracetam is fat-soluble which means the bloodstream absorbs it via fatty acids. It reaches peak concentrations and highest bioavailability, usually within 30 minutes, and has a somewhat long half-life of 4 to 6 hours.

Racetams work by directly stimulating neurotransmitter receptor sites, thus increasing production and release of specific neurotransmitters. However;  pramiracetam doesn't directly produce alterations in neurochemical levels, neither does it seem to possess an affinity for any vital neurotransmitter.

Choline is a precursor of acetylcholine, a neurotransmitter thoroughly engaging in cognitive processes including learning pace, thought recall, and attention. By inciting choline uptake, it indirectly modulates the release of acetylcholine and triggers increased activity within the hippocampus. Due to this part of the brain being crucial to revival function, the generalized stimulation that pramiracetam formulates can enhance both the creation of new memories and the retention of reference or long-term memories.

Cerebral Blood Flow

The improving action in the hippocampus also improves cerebral blood flow, which enhances attentiveness and boosts cognitive capabilities. Besides, Pramiracetam has additional mechanisms of action. Neuroscientists hypothesize that in addition to influencing the brain, pramiracetam serves outer sections that rely upon the adrenal glands. (R)

Concerning Membrane Fluidity

Animal studies imply that pramiracetam may additionally improve or repair brain membrane fluidity, which promotes cell signaling (R). Pramiracetam does not seem to alter either alertness or emotional states actively. This advantage is understandable by pramiracetam low impact on the generation and release neurotransmitters that possess the most notable results on tranquility, stress, and anxiety levels such as serotonin, GABA, and dopamine.

Dosage

How To Take Pramiracetam?

Recommended Pramiracetam dosage is 1200 mg per day, split into two 600 mg or three 400 mg doses throughout the day.

This is the lowest effective dose. On an individual level, it should be adjusted as required to accomplishing the desired effect.

Currently, the evidence using pramiracetam in humans uses either 400mg thrice daily or 600mg twice daily; both of these dosing regimens totals 1,200mg of pramiracetam daily.

It is unsure if pramiracetam should be taken with meals, and it is not clear if 1,200mg is the optimal dosage or not. This does, however, does appear effective. – Examine

Side Effects

What Are Pramiracetam Side Effects?

Studies testing Pramiracetam doses found it to be safe and not causing any side effects at doses of 400 mg and up to 1,600 mg (R).

Furthermore, a study concerning Alzheimer's disease shows it's safe even at doses as high as 4,000 mg. (R)

Headache may occur due to low acetylcholine levels in the brain. Therefore, it is wise to pair racetams drugs with a choline source (such as Alpha-GPC).

Not only will choline prevent or eliminate the headache, they will furthermore work synergistically together firing cognitive function. [R]

Conclusion

Pramiracetam is a powerful nootropic that is relatively new to many of the nootropics community.

Yet is rapidly attaining a well-deserved recognition. Due to having more complications in synthesizing, it costs more than most other racetams.

Users often complain about that, however, the distinct potency proposes that lower doses are required to achieve the results.

Users also have mixed reactions to the Ritalin-like emotional blunting outcome of the supplement. For some, it creates refreshing objectivity and easing of social anxiety, while others find it makes them feel somewhat disengaged.

Pramiracetam is generally unique nootropic, notably enhancing memory creation and recollection, learning pace, and overall mental clarity. It's usually a worthy addition to nootropic stacks.

Often existing there as an agent for prolonging their effects. Pramiracetam is safe, effective, fast-acting, and reasonably long-lasting.

Frequently Asked Questions

Pramiracetam is available on many vendors if you simply do a quick Google search. If I had to pick one of the many choices, I would recommend Nootropics Depot because I have personally used almost every racetam they offer, and I trust their product quality.

You can buy Pramiracetam 300mg Capsules as well as many other nootropics in Dubai from Nootropix.

Although it is reportedly possible, it's not recommended due to the large powder amount required as well as the associated pain. Unlike certain substances that yield results with small amount, snorting Pramiracetam wouldn't be worth the effort.

Pramiracetam reaches its peak concentration in about 30 minutes after ingestion and has an average half-life of 5 hours.

Pramiracetam enhances memory formation and memory recall, increases learning ability, reduces social anxiety, and could potentially treat amnesia as well as prevent neurodegeneration.

Ideally, the best timing to take Pramiracetam would be once after breakfast, and another dose after lunch, keeping a 5-hour time interval between the two dosages.

Although it is recommended to take Pramiracetam after food for optimal absorption, it can still be taken without food. So if absorption is your concern, it does not matter much. It depends on your personal preference.

On average, Pramiracetam effect lasts somewhere between 4 to 6 hours.

Personally, I would take and recommend 300 mg of Alpha-GPC with each Pramiracetam dose. If you prefer Citicoline instead (as the choline source) then the recommended dosage would be 250 mg.

For more Frequently Asked Questions, check out the following pages:

Piracetam is a designer nootropic that enhances cognitive brain function. It's the primary and original racetam out of all the ones out there today. Up to date, there has been 20 different derivatives of Piracetam, and counting. It’s a revolutionizing nootropic that improves memory and remarkably boosts cognitive function.https://youtu.be/3A2yTpzFirU

Overview

What is Piracetam?

Piracetam (also known as Nootropil) is a nootropic that enhances memory and brain function. It's been around for a surprisingly long period, thus becoming a “classic” amongst the rest on the list. It allows creative and logical thoughts to run together into a stream of higher-level reasoning. It is the father of all nootropics and often the first choice for individuals looking to improve cognitive abilities.

Nootropics such as AniracetamPhenylpiracetam, FasoracetamSunifiram and Pramiracetam are all derivatives of this compound.

“Synthetic molecule designed to enhance brain function. Piracetam is the basic ‘racetam' molecule of a family of related compounds” Examine

Furthermore, it increases the amount of knowledge the brain can process, as well as preserve, for future reference. Piracetam is an invention by Romanian psychologist and chemist Dr. Corneliu E. Giurgea dating over 50 years ago, to create a supplement to enhance memory and learning capacity. 

It is in medical use in Europe, Russia, and South America, amongst other countries, as a treatment for a type of muscle spasm called molycous. However, due to its nootropic effects, it became one of the most prominent cognitive enhancers. 

Confined studies show that Piracetam reverses the effects of Alzheimer’s disease as well as dementia in elderly individuals. There is also sufficient evidence proposing that it prevents brain damage caused by excessive alcohol intake.

“Piracetam is a medication in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It is approved in the United Kingdom but is not approved in the United States. In the UK, piracetam is prescribed mainly for myoclonus, but is used off-label for other conditions.” Wikipedia

Benefits and Effects

What Are Piracetam Benefits?

  1. Improves Memory
  2. Enhances Cognitive Function
  3. Neuroprotective and Prevents Neurodegeneration
  4. Increases Self-Awareness and Promotes Clarity of Thought
  5. Reduces Anxiety, Stress, and Eases Depression
  6. Improves Verbal Learning and Fluency in Dyslexics
  7. Helps with Schizophrenia

Supporting research:

Improves Memory

Piracetam is popular first and foremost because of its positive, profound impact on improving memory. 

In a meta-analysis of 19 different double-blind studies, Piracetam shows an exceptional improvement relating to memory. 

However, it is important noting that memory improvement effects build up gradually. The studies show minor improvement after a 7-day administration and a significant increase after a 14-day administration. 

Today, most individuals benefiting from Piracetam do so entirely for its memory-enhancing result. [1] [2]

Enhances Cognitive Function

There is a healthy amount of studies administering the effects of piracetam on cognition enhancement. 

Piracetam improves cognitive performance especially in individuals with neurodegenerative conditions. 

While most studies are governing elderly individuals with chronic disease, there is nevertheless sufficient evidence proving it to be beneficial for healthy, young adults. 

Piracetam is especially helpful for individuals suffering from chronic conditions. Healthy individuals tend to embrace it for the nootropic traits. [3] [4] [5]

Neuroprotective and Prevents Neurodegeneration

Piracetam supports neuroprotection as well as encouraging healthy brain growth and protects as well as prevents it from neurodegeneration related to aging. 

In this particular area, it serves greater as a preventative rather than a treatment. 

Prevention is of often the best medicine there is. [6] [7]

Increases Self-Awareness and Promotes Clarity of Thought

There is evidence indicating that piracetam improves sensory perception by increasing acetylcholine activity in the hippocampus. 

In this particular example, it suggests an increase in self-awareness, zen-like state as well as an increased feeling of overall well-being. 

Many report colors are appearing brighter and more vivid. Furthermore, many report a heightened sense of perception and a higher level of vibration, along with a feeling of connectedness to nature and other beings. [8]

Reduces Anxiety, Stress, and Eases Depression

In a study by the Department of Pharmacology in India examining the antianxiety effects of Piracetam taken orally over the period of 7 and 14 days, it confirms that; although a single dose does not seem to induce immediate anxiolytic effect, a delayed anti anxiety impact was rather apparent. 

It is especially evident in individuals with anxiety due to alcohol withdrawal. Anecdotal reports imply piracetam is a useful tool for managing stress and anxiety levels, and to a certain extent, easing depression symptoms. 

However, clinical research is limited relating to depression. Therefore, piracetam should not be a source to rely on should you be clinically diagnosed with depression. 

Use with caution. 

With that said, it is nevertheless useful and worth experimenting if your anxiety is somewhat generalized or social [9] [10] – (high-five btw, makes two of us!)

Improves Verbal Learning and Fluency in Dyslexics

Over a 21 day study, piracetam shows an increase in verbal learning by 8.6% compared to placebo in healthy volunteering individuals. 

In patients with dyslexia, however, verbal learning shows a significant 15% increase. Piracetam, therefore, proves to be beneficial to individuals with dyslexia. 

Moreover, children tests in letter analyzing while receiving 3.3mg per day over 36 weeks showed an increase in letter-matching as well as reaction time. [11] [12]

Helps with Schizophrenia

Piracetam shows to reduce symptoms of uncontrolled movement in individuals with schizophrenia. 

Furthermore, Piracetam may have a protective effect upon glutamatergic receptors within the hippocampus. [13] [14]

Mechanism of Action

How Does Piracetam Work?

Interestingly, piracetam doesn’t seem to show any effect on the GABAergic system even though it is a cyclic derivative of GABA. 

Piracetam' mechanism of action relates to how it increases the activity of acetylcholine, a neurotransmitter involved in memory function. It works to improve memory by making the transfer of acetylcholine more effective. It also affects NMDA glutamate receptors which also play a role in the memory formation and learning processes. 

Scientists believe piracetam works through these possible mechanisms in the brain: compromised neuronal cells experience a loss of fluidity which prevents signaling molecules from crossing the lipid bilayer membrane of the corpus callosum, the part of the brain separating the left and the right hemispheres. 

Piracetam can restore or even increase the membrane fluidity of these neuronal cells, making neurotransmission a more effective and effortless process.

“Overall, Piracetam increases glucose and oxygen consumption in brains which precedes cognitive improvement (as these benefits are global (not favoring certain brain regions) and more significant in cognitively impaired persons, both of which are in accordance with interventions in humans).

Piracetam Nootropic
Piracetam Skeletal Structure

The exact mechanisms underlying the enhancement of glucose and oxygen consumption are currently not established.

Piracetam shows affinity for two subsets of AMPA (glutamate) receptors, Glu2 and Glu3, and may attenuate the rate of action potentials. 

It does not appear to directly act upon the other two glutamate receptors (Kainate and NMDA) although the ability of piracetam to possibly increase receptors in general in aged mice may influence these two receptor classes.” – Examine

Protein synthesis is an essential part of memory-storage in the brain. 

Piracetam can cause an increase in learning and memory when various steroids transport them in the brain. When steroids in the brain are blocked, the effects of nootropics are blocked as well. 

Recruitment of AMPA receptors that are generally not part of synaptic transmissions, essentially making more receptors available, when would undoubtedly cause an increase in learning. 

Moreover, of course, acetylcholine increases and increased transmission of this critical neurotransmitter which is one of the most important in memory storage and learning processes.

Dosage

How to Take Piracetam?

Typically, the Piracetam dosage for adults is between between 1,200 to 4,800 mg per day.

The most effective and agreed upon Piracetam dose is 1,600 mg. It can be taken once per day, or up to three times per day, totaling a maximum of 4,800 mg per day.

If new to Piracetam and taking it for the first time, start with 1,600 mg and wait and observe your reaction to it. 

Few hours later, you can choose whether you want to take another dose, or if one is enough for your needs.

For optimal results pair it with 300mg of Alpha GPCCDP-choline, or your choline source of choice.

Side Effects

What Are Piracetam Side Effects?

Piracetam is considered very safe and side effects rarely occur. [15]

Headaches are often reported. It is due to lowered acetylcholine levels in the brain due to racetams utilizing them.

Therefore, it is very important to pair racetams with a choline source like Citicoline or Alpha-GPC, especially if you notice a headache after supplementing with Piracetam, or if you do so on regular basis.

Not only will choline prevent or eliminate the headache, it will even work synergistically together with Piracetam (or any other racetam) and potentiate both of their cognition benefits. [16]

User Experience

Reddit

A user on reddit shared his following piracetam experience which helped him getting off hard drugs:

So a bit of background. I have ADHD and aspergers and piracetam has been a godsend. Honestly i've never felt better. When I was diagnosed with ADHD and aspergers my life basically turned crappy and I started experimenting with drugs to “alleviate” my conditions.

I've lost friends, lied, cheated and made a fool of myself. Now with piracetam i'ts another story. I always had a fascination with psychotropic substances, and went and abused ritalin for a long while. This lead me to have even worse depression and anxiety.

With piracetam thought, it made me stable and understand that my drug abuse was not amusing, specially for those around me.

Now I focus on what is important and I don't care to get high, drunk or abuse anything. I've started dedicating more time to my hobbies and passions.

I've also noted i'm more honest and don't feel the need to judge others to make me feel better or have to justify myself. I take it when I need and take breaks. Also noted less apathy and dissociative/ antisocial behaviour.

I was actually nice to my neighbours for once(Bc honestly i've been an asshole my whole life) Even so I'm still waiting to see if this change is permanent(I hope it is) If you have ADHD or some ASD I recommend this! But… Research your stuff and stay responsible. Meds are not the solution, they're only one of many tools in your arsenal to improve yourself.

Exercise, healthy diet are essential to getting better as well. ]Sorry if I seem overly exited, I just wanted to share my story to a community that showed me that I don't have to take possibly addictive substances to be a better person. Nootropics worked for me. – an experience and condition very similar to my own.

Reddit II

So I was using Piracetam sporadically for past 2-3 weeks, at the beginning I thought it is just a hyped up nootropic or maybe not potent at 800mg-1200mg dose or ineffective in comparison to other racetams (I have never tried any other racetam.)

But today I can feel the effects, I took CDP choline for the first time this morning with 1 Piracetam 800 mg tab in the morning and and 1 at night sometime earlier. I am able to think quick, able to respond to what my friends say quickly and the music sounds so so good especially the percussions and I am only wanting to listen to fast paced songs, I did not expect a stimulating effect from piracetam, even I am typing this at a great pace, believe me I did not take caffeine. No benefit in terms of focus, I also didn't expect it, in fact I feel a little distracted.

Conclusion

Overall, Piracetam (alongside Noopept, if I may add) is one of the most fundamental brain boosting nootropics out there. It has very noticeable effects on increasing memory and learning capability, and certainly has the potential to enhance cerebral performance.

Student looking to get the edge on academics, or merely wanting to think smarter and faster in their day to day life, this is a great nootropic to start with to introduce you to the world of nootropics. As well as safer than many other alternatives – especially stimulants, that most college students seem to favor.

Frequently Asked Questions

Is Piracetam Legal in the US?

It’s legal to buy, but might not be legal to sell. FDA regulations affecting “dietary supplements” may not apply to piracetam. But regardless, those regulations only control the sale of substances and not the purchase of substances. So buying is OK.

What's the difference between Piracetam and Noopept?

Noopept seems to be effective – and longer lasting than Piracetam, due to its effect on the NMDA receptors. It works in a similar way and has similar mechanisms as Piracetam, but at a much lower dosage – when it comes to whole brain function. The research available along with the anecdotal reports seem to strongly support this claim. “Oral ingestion of Noopept results in a very rapid absorption and metabolism of Noopept, although the kinetics of metabolites (which are thought to be bioactive) is not yet known. A true bioavailability study has not been conducted, although it appears that an oral dose is about the equivalent of one tenth an injected dose (10% bioavailability).”

Whereas Piracetam shows affinity for two subsets of AMPA (glutamate) receptors, Glu2 and Glu3, and may attenuate the rate of action potentials. It does not appear to directly act upon the other two glutamate receptors (Kainate and NMDA) although the ability of piracetam to possibly increase receptors in general in aged mice may influence these two receptor classes.”

What are the long-term possible risks of using piracetam?

Although there is no hard evidence on the matter, some users would say Piracetam as well as many other cholinergic nootropics (with notable exceptions like coluracetam), can subdue mood. It can make you have trouble turning off automatic memory associations, and being ‘locked’ in a particular state of consciousness for many hours.

What is the correct way to take Piracetam?

“The correct way to take piracetam is whatever way works for you. If you cannot abide the bitter taste, taking piracetam in pills or capsules is the better way to go. I found that the bitter taste grew on me, so paying extra for capsules (or pharmaceutical tablets with excipients and dyes) is not worth it. For some, it’s taking it constantly, like 600–1000 mg three times a day. For me, I often take the entire daily dose in the morning, which greatly helps my circadian rhythm sync to the day when it is drifting into my old pattern of night-owl-ism. I know people who only take piracetam in certain circumstances, like before a public talk or interview, or flying on an airplane, or traveling to a high-altitude location for business or vacation. I take it when I’m going to be putting demands on my verbal, editing and writing skills. For people with high cholinergic tone (like me), taking piracetam with minimal cholinergic support is best. For a more cholinergically recessive person, taking piracetam with B5, choline, phosphatidylcholine, etc. is best. So I think there is no one correct answer to your question.”

Why does piracetam take so long to act?

Piracetam does not efficiently cross the blood-brain barrier, so it takes a while to build up enough to modify neurological activity. The time depends on the dose, which is why it is common practice to use a loading dose for the first day or three. When I used an aggressive 6400 mg loading dose (2.6 times the standard daily dose), I got conspicuous effects the first day. The “conservative” escalating loading dose that I suggest is wise for children with Down’s syndrome takes roughly a week to get the level of piracetam into the therapeutic range. The delay with piracetam also depends on the integrity of your blood-brain barrier, which if low facilitates piracetam acting quickly.

Why is piracetam considered a nootropic?

The research done on piracetam actually led to the coining of the term “Nootropic” and is the first member of the “Racetam” class of cognitive enhancers. There are several definitions of Nootropic. Corneliu E. Giurgea, the lead scientist that termed Nootropics, has his own list of qualifiers. More anecdotally, Nootropics must meet two identifying criteria:

1. Enhance some form of cognition.
2. Have either neuroprotective or regenerative effects, or at the very least possess very few side effects and extremely low toxicity.

For the first Qualifier:

Chemically, piracetam is a synthetic derivative of our major inhibitory neurotransmitter, GABA, Piracetam is understood to act primarily on the glutamate system within brain areas specific to memory and learning.

Research suggests that, as a primary mode of action, Piracetam increases neural activity in the hippocampus and cortex by upregulating AMPA and NMDA receptor densities, thereby enhancing glutamate transmission. Piracetam has also been reported to increase cerebral blood flow and the acetylcholine efficacy in the brain, both of which have been suggested to positively influence focusmemory, and learning.

Second Qualifier:

Piracetam is one of the most research nootropics, probably the most researched synthetic one. Piracetam demonstrates relatively low toxicity and shows promise in studies that examine its potential in cognitive decline. [R]

Where can I buy Piracetam and Nootropil in Dubai, UAE?

Nootropix offers 30 & 60ct jars of Piracetam capsules in Dubai, and the UAE.

All products are lab-tested and verified for both product purity and identity. If you buy Piracetam capsules from our shop, expect it to ship within 24 hours for orders placed within Abu Dhabi, Dubai, and the UAE.