Pending review. Contribute to this article.
Summary: PRL-8-53 (chemical name Methyl 3-(2-(benzyl(methyl)amino)benzoate) is a synthetic nootropic compound that was discovered in 1972 and patented in 1975 by then Dr. Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska.
What is PRL-8-52?
PRL-8-53 is a synthetic nootropic compound that was discovered in 1972 and patented in 1975 preliminary animal tests showed that the compound was both secure and nootropic, boosting the learning of prevention in rodents without adverse effects. However, a 1978 research on human volunteers triggered sincere interest in PRL-8-53, showing that a single dose of the compound could enhance word retention ratings by more than 200%.
Comments by author and longevity expert Durk Pearson, who was cited in' High Frontiers' as follows, fuelled interest in the compound: “PRL-8-53 is a great memory enhancer. Usually, just looking at them for a second, you can memorize about seven or eight numbers. On average, PRL-8-53 is said to increase memory span of approximately 21 to 22 digits. “Hansel's single human study on PRL-8-53, soon after patenting the compound, highly promotes the potential of the drug as a nootropic.
The research evaluated word retention between the ages of 24 and 86 in a group of 30 healthy volunteers. While participants with good baseline word retention scores showed little improvement after taking PLR-8-53, participants with low initial scores or over 30 showed significant improvement after a 5 mg dose of PLR-8-53, often more than doubling their recall rate.
In the human study, no adverse effects were observed. Anecdotal evidence seems to support claims for safety and nootropic capacities of PRL-8-53, but due to restricted testing, it is still regarded as an experimental drug.
PRL-8-53 is presently an unplanned drug and is legally available for purchase in the United States.
Benefits and Effects
The elderly participants showed necessary improvements in memory after taking a single 5 mg dose in the only human research on PRL-8-53. A double-blind study using word memorization as a measure, testing the capacity of the respondents to recall a list of 12 one-syllable phrases, first to create a baseline and then again after PRL-8-53 or placebo has been ingested. The participants were screened for their capacity to remember the phrases 24 hours after hearing them, and then one week later again.
Results of the research show that respondents with higher baseline scores showed the least improvement after PRL-8-53 was ingested, while subjects with imperfect first memory or over 30 years of the era showed significant improvement in recall. Hansl described the impact on elderly respondents in an article on the exam as follows: “This group was 30 years of era or older. Rote memory, as could be anticipated, did not come to this group as readily as it did to younger learners. After 24 hours on placebo, the average retention was just under three words out of a possible 12.
After a week, the average retention was two words. However, the same topics maintained an average of 5.85 phrases after 24 hours and 5.25 words after a week when learning after drug administration.
Again, there were statistically essential increases. The enhancement expressed in percentage of placebo results was 108 percent for the 24-hour test and 152 percent for the one-week recall. “Many individual nootropic users who have attempted PRL-8-53 confirm their memory boosting impacts, sometimes comparing it to a more strong variant of other nootropics such as nefiracetam and Noopept.
Mechanism of Action
How Does PRL-8-53 Work?
The precise mechanisms of action of HOW IT WORKS PRL-8-53 are not well understood, but the production and reaction of the brain to several key neurotransmitters is thought to be regulated. Hansl stated in his reports on human and animal studies that PRL-8-53 potentiates dopamine, partly restricts serotonin production and enhances the reaction of the brain to acetylcholine. While Hansl's research report on the human research of 1978 indicates these activities, the mechanism of action is not delineated.
The fact that older participants saw the most nootropic advantage from taking the drug promotes the notion that modulation of dopamine plays a significant part in the consequences of PLR-853. Upregulating the ordinary age-related reduction in the manufacturing of dopamine associated with cognitive decrease could have a beneficial effect on both learning and memory.
In an article in 1979 entitled “Learning and Memory Improvement Through Chemistry: Dream or Offering Reality?”Hansl said,” PRL-8-53 has been shown to increase the peripheral and central reactions to noradrenaline in the animal model. Therefore, assuming that a comparable feature may be present in humans seems reasonable.
Translated into behavioral effects, it implies that this drug potentially is capable of facilitating the conversion of short-term to long-term memory, resulting in increased storage of information code. “According to Hansl, in the same article,” PRL-8-53 has been shown to improve the response to acetylcholine, the answer being quantitatively similar over a considerable dose range, excluding the likelihood of acetylcholine. In short, we now have a possibly effective drug that will increase a particular chemical system in the brain, the cholinergic system, thereby enhancing our capacity to recall data from a pre-existing data pool.
How to Take PRL-8-53?
The only human study on PRL-8-53 was based on a single 5 mg dose intake. No information is available on the efficacy or prospective toxicity of any other human dosage.
Because of the restricted knowledge of the mechanism of action of PRL-8-53, it may be advisable not to stack it with other nootropics.
What are the side effects of PRL-8-53?
No adverse effects were observed in the human study from a single 5 mg dose of PRL-8-53. Animal studies indicate that the compound has a high therapy threshold, but the proof is very restricted as there have been no extensive toxicity trials.
Keep in mind that this is exceptionally experimental chemistry for studies, so caution is recommended.
PRL-8-53 is a fascinating synthetic nootropic, if mainly unexplored, which many think will eventually prove to be an invaluable smart drug.
Although it gave rise to high concern when it was launched 40 years ago, after a few animal tests and a single human study, research into its opportunities came to a halt; little has been learned about it since the review that sparked such compelling interest in its potential as a memory enhancer.
There does not seem to be any continuing research on the compound at this moment, but nootropic lovers continue to be curious about its opportunities and are regarded one of the most excellent short-term memory boosters on the market.
Back to Nootropics Information homepage.