Summary: Centrophenoxine is an effective nootropic that boosts memory. It can reverse age-related cognitive degeneration amd improve mood and brain function.
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Overview
What is Centrophenoxine?
Centrophenoxine is one of the oldest nootropics studied, also known as Lucidril and Meclofenoxate.
This drug was initially created in 1959 and was commonly used to treat age-related brain disorders such as Alzheimer’s and dementia. Healthy people also use it to improve memory and cognitive function and improve general brain health.
Centrophenoxine is a mixture of two chemicals: dimethyl-aminoethanol (DMAE), a natural substance found in certain foods (fish, seafood) and the brain in tiny quantities. It is a source of choline and has impacts that stimulate the brain.
Parachlorphenoxyacetic acid (pCPA), a synthetic version of plant growth hormones called auxins, is the primary active ingredient of this drug. DMAE is not well crossing the blood-brain barrier. It can, however, pass through the blood-brain barrier within Centrophenoxine and enter the brain efficiently once placed in the body, a part of Centrophenoxine breaks down into DMAE and PCPA in the liver.
DMAE is then transformed to choline, and the remaining Centrophenoxine circulates throughout the body
Benefits and Effects
What are the Benefits of Centrophenoxine?
- Neuroprotective
- Learning and Memory
- Mood
- Stress
- Reverses Brain-Deficits causes by Aging
- Enhance Cancer Treatment
Neuroprotective
Centrophenoxine protects nerve cells from oxidative harm caused by exposure to toxins or strokes. This drug decreased the damage induced by free radicals in rats with different kinds of brain injury and enhanced the resulting memory, cognitive function, and motion deficits.
This drug increases the activity of critical antioxidant enzymes such as glutathione and superoxide dismutase (SOD) in the brain, which can account for its positive consequences.
In 50 elderly patients with dementia (DB-RCT), it also enhanced memory.
Learning and Memory
Centrophenoxine also enhanced ancient mice’s learning and memory.
Mood and Stress
Centrophenoxine in rats subjected to stress considerably decreased anxiety. It also enhance humans ‘ mood.
In a research of 80 healthy topics, three months of taking a drug containing DMAE, increased energy, and improved well-being. Therefore, the active DMAE element of Centrophenoxine can enhance mood.
Reverses Brain-Deficits causes by Aging
It also reverses the brain aging impacts by decreasing free radicals and buildup of lipofuscin in the rat brain (hippocampus), both of which are associated with neurodegenerative disease.
Enhance Cancer Treatment
This medication enhances the action of particular cancer drugs that cause cancer cell DNA damage.
Centrophenoxine is a mixture of PCPA (para-chlorphenoxyacetic) and DMAE (dimethylaminoethanol) synthesized version that has been altered to improve absorption and enhance its capacity to cross the blood-brain barrier. It is a compound that is metabolized in the liver and fat-soluble.
Although Centrophenoxine has been the topic of centuries of studies, it is still not fully grasped its exact mechanisms of action.
Once Centrophenoxine crosses the blood-brain barrier, it eventually raises the quantity of acetylcholine in the synaptic vesicles, either by transforming it into an intermediate phospholipid that is then used to create acetylcholine or by breaking it down into choline that is transformed into acetylcholine.
Acetylcholine is the neurotransmitter most closely connected with memory and overall cognitive.
The capacity of Centrophenoxine to raise concentrations of acetylcholine is the primary means of acting as a nootropic substance.
Centrophenoxine, however, also enhances cognition in other ways, such as improving the accessibility of oxygen and glucose to the brain and reducing levels of cellular waste and cognition-affected toxins.
Centrophenoxine is both anti-aging and nootropic. It is a potent antioxidant capable of flushing cell toxins and helping to repair toxin-related damage.
It is known to decrease levels of lipid peroxidation waste products or oxidative degradation of fats in cell membranes.
Cellular damage caused by lipid peroxidation is connected with aging and is involved in many diseases and disorders, including infections and complications. Lipofuscin buildup is usually discovered in liver, kidney, heart, and retina cells as well as nerve and ganglion cells.
Due to the strong association between lipofuscin buildup and many age-related illnesses, the capacity of Centrophenoxine to decrease or eliminate this buildup makes it an invaluable anti-aging tool.
Dosage
How to Take Centrophenoxine?
Recommended dosages of centrophenoxine range from 250 to 3000 mg daily in two doses and are deemed safe and efficient for most healthy adults.
Although higher doses may be needed to maximize their anti-aging impacts, it is advisable to consult a medical professional before exceeding the suggested daily dosage.
It is best, to begin with, the smallest effective dose possible, as with all supplements, and gradually boost as required.
It is best taken with food due to being fat-soluble.
Side Effects
What Are the Side Effects of Centrophenoxine?
At recommended dosage ranges, Centrophenoxine is secure and nontoxic and is very well tolerated.
However, some customers encountered mild and minor side effects, including nausea, headache, gastrointestinal problems, and sleeplessness.
In most instances, the side effects were correlated with high doses, and decreasing the daily cumulative dosage eliminated unwanted side effects.
User experience
So, as far as I’m worried, I first attempted Centrophenoxine about two months ago. As I’ve written for other compounds, Centrophenoxine won’t make you a genius or scientist at all. It will take you to a defined upper potential stage.
There are a lot of studies available on the Centrophenoxine web here and there. It should clear lipofuscin from your brain, but under these conditions, none of us will verify whether or not I do so. Centrophenoxine does work very well, anyway. You need to discover the correct dosage for yourself; I found it works fantastic when taken with racetams, particularly aniracetam just because it seems to potentiate each other’s impact. Look together uniquely to increase the mood. I propose a 2:1 ratio of racetam-centro. Centrophenoxine is not a type of high-dose compound to be taken… I don’t think it’s more than 1000 mg a day.
Sometimes remember to create a stop. It’s important because the brain gets used to the large number of neurotransmitters very rapidly.